{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T00:35:51Z","timestamp":1788568551227,"version":"build-2803163510"},"reference-count":23,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2010,5,1]],"date-time":"2010-05-01T00:00:00Z","timestamp":1272672000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2010,5]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>1) Compare rates of post\u2010tonsillectomy bleeding in pediatric patients with and without von Willebrand disease (vWD). 2) Identify factors that may increase the risk for post\u2010tonsillectomy bleeding in children with and without vWD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Historical cohort study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Tertiary care, university\u2010based pediatric hospital.<\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects and Methods<\/jats:title><jats:p>Medical records were examined for 99 patients with vWD and 99 patients without vWD younger than 18 years who underwent tonsillectomy with or without adenoidectomy from August 1997 to October 2005. Subjects were matched for age, year of surgery, type of surgery, and indication for surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Post\u2010tonsillectomy hemorrhage occurred in eight of 99 (8%) vWD patients and in six of 99 (6%) non\u2010vWD patients (<jats:italic>P<\/jats:italic> = 0.58, odds ratio 1.36, 95% CI 0.45\u20104.08). A two\u2010sample test of proportions demonstrated lower and upper limits of \u22120.051 and 0.092. Four of eight children with vWD and two of six non\u2010vWD patients required surgical intervention for control of bleeding. Ninety\u2010three of 99 vWD patients received desmopressin acetate (DDAVP) preoperatively. In patients with vWD who responded to DDAVP challenge, there was no increased likelihood of post\u2010tonsillectomy bleeding compared with non\u2010vWD patients. No significant difference in the number of bleeding events was noted on the basis of demographics, preoperative laboratories, or use of aminocaproic acid.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Children with vWD undergoing tonsillectomy have a postoperative bleeding rate similar to that of a matched group. However, the sample size was not sufficient to eliminate the possibility of a clinically important difference between the two groups.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.otohns.2010.01.029","type":"journal-article","created":{"date-parts":[[2010,4,22]],"date-time":"2010-04-22T04:39:09Z","timestamp":1271911149000},"page":"715-721","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Post\u2010tonsillectomy bleeding in children with von Willebrand disease: A single\u2010institution experience"],"prefix":"10.1002","volume":"142","author":[{"given":"Kenneth D.","family":"Rodriguez","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery University of Pittsburgh Pittsburgh PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gordon H.","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery University of Cincinnati Cincinnati OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francis","family":"Pike","sequence":"additional","affiliation":[{"name":"Department of Statistics University of Pittsburgh Pittsburgh PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen M.","family":"Mandel","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery University of Pittsburgh Pittsburgh PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaretha L.","family":"Casselbrant","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery University of Pittsburgh Pittsburgh PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David H.","family":"Chi","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery University of Pittsburgh Pittsburgh PA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,5]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cppeds.2004.12.001"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V69.2.454.454"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)47144-5"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra040403"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hoc.2004.07.006"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.125.5.547"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2004.09.007"},{"key":"e_1_2_9_9_1","first-page":"205","article-title":"High levels of plasma von Willebrand factor in hyperthyroidism","volume":"25","author":"Cuianu M","year":"1987","journal-title":"Rev Med Interne"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-97-5-713"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0049-3848(89)90317-4"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(05)80384-1"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.110.1.7"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.127.1.37"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348949009900305"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.133.9.925"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-5876(96)01465-6"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1080\/07853890701513738"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-199801000-00006"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0196-0709(96)90056-3"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1177\/019459989010300310"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200108000-00008"},{"key":"e_1_2_9_23_1","volume-title":"Academy of Otolaryngology\u2013Head and Neck Surgery. 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