{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T19:01:15Z","timestamp":1793905275513,"version":"4.8.0"},"reference-count":48,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2010,6,1]],"date-time":"2010-06-01T00:00:00Z","timestamp":1275350400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2010,6]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Summarize current knowledge of lymphatic malformation medical, sclerotherapy, and surgical treatment; and highlight areas of treatment controversy and treatment difficulty that need improvement.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Panel presentation of various aspects of lymphatic malformation treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The mainstay of lymphatic malformation treatment has been surgical resection, which has been refined through lesion staging and radiographic characterization. Intralesional sclerotherapy in macrocystic lymphatic malformations is effective. Suprahyoid microcystic lymphatic malformations are more difficult to treat than macrocystic lymphatic malformations in the infrahyoid and posterior cervical regions. Bilateral suprahyoid lymphatic malformations require staged treatment to prevent complications. Lymphatic malformation treatment planning is primarily determined by the presence or possibility of functional compromise. Problematic areas include chronic lymphatic malformation inflammation, dental health maintenance, macroglossia, airway obstruction, and dental malocclusion.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Lymphatic malformation treatment improvements have been made through radiographic characterization and staging of lymphatic malformations. Direct malformation involvement of the upper aerodigestive tract can cause significant functional compromise that is difficult to treat.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1016\/j.otohns.2010.02.026","type":"journal-article","created":{"date-parts":[[2010,5,20]],"date-time":"2010-05-20T08:29:25Z","timestamp":1274344165000},"page":"795","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":225,"title":["Lymphatic malformations: Review of current treatment"],"prefix":"10.1002","volume":"142","author":[{"given":"Jonathan A.","family":"Perkins","sequence":"first","affiliation":[{"name":"Division of Pediatric Otolaryngology\u2010Head and Neck Surgery Seattle Children's Hospital Seattle WA"},{"name":"Department of Otolaryngology\u2010Head and Neck Surgery University of Washington Seattle WA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott C.","family":"Manning","sequence":"additional","affiliation":[{"name":"Division of Pediatric Otolaryngology\u2010Head and Neck Surgery Seattle Children's Hospital Seattle WA"},{"name":"Department of Otolaryngology\u2010Head and Neck Surgery University of Washington Seattle WA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard M.","family":"Tempero","sequence":"additional","affiliation":[{"name":"Boys Town National Research Hospital Omaha NE"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Cunningham","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Massachusetts Eye and Ear Infirmary Department of Otology and Laryngology Harvard Medical School Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Joseph L.","family":"Edmonds","sequence":"additional","affiliation":[{"name":"Children's ENT of Houston Houston TX"},{"name":"Department of Otolaryngology and Division of Plastic Surgery Baylor College of Medicine Houston TX"},{"name":"Department of Otolaryngology Weill Cornell College of Medicine New York NY"},{"name":"Department of Otolaryngology University of Texas School of Medicine Houston TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fredric A.","family":"Hoffer","sequence":"additional","affiliation":[{"name":"Department of Radiology Seattle Children's Hospital University of Washington Seattle WA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark A.","family":"Egbert","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery Dental Medicine Seattle Children's Hospital University of Washington Seattle WA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,6]]},"reference":[{"key":"e_1_2_10_3_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200111000-00011"},{"key":"e_1_2_10_3_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1995.01890050065012"},{"key":"e_1_2_10_3_4_1","doi-asserted-by":"publisher","DOI":"10.1067\/mhn.2000.110963"},{"key":"e_1_2_10_3_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1997.01900100035004"},{"key":"e_1_2_10_3_6_1","doi-asserted-by":"publisher","DOI":"10.1089\/lrb.2005.3.58"},{"key":"e_1_2_10_3_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2008.02.016"},{"key":"e_1_2_10_3_8_1","unstructured":"PerkinsJA GarrisonM.Variation in lymphatic malformation treatment in pediatric hospitals(unpublished data).2007."},{"key":"e_1_2_10_3_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.moo.0000143971.19992.2d"},{"key":"e_1_2_10_3_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02010326"},{"key":"e_1_2_10_3_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ocl.2006.04.005"},{"key":"e_1_2_10_3_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.1039"},{"key":"e_1_2_10_3_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1991.01870170092021"},{"key":"e_1_2_10_3_14_1","doi-asserted-by":"publisher","DOI":"10.1080\/000164800454530"},{"key":"e_1_2_10_3_15_1","doi-asserted-by":"crossref","unstructured":"RiechelmannH MuehlfayG KeckT et al.Total subtotal and partial surgical removal of cervicofacial lymphangiomas.Arch Otolaryngol Head Neck Surg1999Jun;125:643\u20138.","DOI":"10.1001\/archotol.125.6.643"},{"key":"e_1_2_10_3_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.126.11.1378"},{"key":"e_1_2_10_3_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.132.11.1251"},{"key":"e_1_2_10_3_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2008.10.022"},{"key":"e_1_2_10_3_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2009.04.016"},{"key":"e_1_2_10_3_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2009.04.016"},{"key":"e_1_2_10_3_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2008.01.034"},{"key":"e_1_2_10_3_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2004.01.017"},{"key":"e_1_2_10_3_23_1","first-page":"1506","volume-title":"Pediatric surgery","author":"Fronkalsrud EW","year":"1986"},{"key":"e_1_2_10_3_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3468(89)80001-6"},{"key":"e_1_2_10_3_25_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215100147176"},{"key":"e_1_2_10_3_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0007-1226(64)80039-4"},{"key":"e_1_2_10_3_27_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1996.01890230041009"},{"key":"e_1_2_10_3_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3468(95)90485-9"},{"key":"e_1_2_10_3_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2006.10.012"},{"key":"e_1_2_10_3_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800740812"},{"key":"e_1_2_10_3_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.20041"},{"key":"e_1_2_10_3_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00270-002-1980-3"},{"key":"e_1_2_10_3_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/0008-8749(82)90102-2"},{"key":"e_1_2_10_3_34_1","first-page":"1","volume-title":"A streptococcal preparation as a potent biological response modifier, OK\u2010432","author":"Ishida N","year":"1985"},{"key":"e_1_2_10_3_35_1","doi-asserted-by":"publisher","DOI":"10.1067\/msy.2003.62"},{"key":"e_1_2_10_3_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00383-003-1058-6"},{"key":"e_1_2_10_3_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-5876(03)00123-X"},{"key":"e_1_2_10_3_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2007.09.049"},{"key":"e_1_2_10_3_39_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.RVI.0000239104.78390.E5"},{"key":"e_1_2_10_3_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00247-006-0392-y"},{"issue":"233","key":"e_1_2_10_3_41_1","first-page":"234","article-title":"An experimental study for efficacy of acetic acid as a sclerosing agent.","volume":"37","author":"Kim YC","year":"1997","journal-title":"J Korean Radiol"},{"key":"e_1_2_10_3_42_1","first-page":"49","article-title":"Acute renal failure requiring haemodialysis after high doses percutaneous acetic acid injection for hepatocellular carcinoma","volume":"62","author":"Van Hoof M","year":"1999","journal-title":"Acta Gastroenterol Belg"},{"key":"e_1_2_10_3_43_1","doi-asserted-by":"publisher","DOI":"10.1177\/153857440503900107"},{"key":"e_1_2_10_3_44_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.204.3.9280239"},{"key":"e_1_2_10_3_45_1","unstructured":"EdmondsJ.Unreleased data from ongoing study at Baylor College of Medicine. 2007. Data accessed September 13 2007."},{"key":"e_1_2_10_3_46_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002341-200103000-00002"},{"key":"e_1_2_10_3_47_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.132.1.93"},{"key":"e_1_2_10_3_48_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-199505000-00001"},{"key":"e_1_2_10_3_49_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.PRS.0000165071.48422.A4"}],"container-title":["Otolaryngology\u2013Head and Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.otohns.2010.02.026","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1016\/j.otohns.2010.02.026","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.otohns.2010.02.026","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T14:18:18Z","timestamp":1760969898000},"score":1,"resource":{"primary":{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/10.1016\/j.otohns.2010.02.026"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,6]]},"references-count":48,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2010,6]]}},"alternative-id":["10.1016\/j.otohns.2010.02.026"],"URL":"https:\/\/doi.org\/10.1016\/j.otohns.2010.02.026","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.5367957.5630068","asserted-by":"object"}]},"ISSN":["0194-5998","1097-6817"],"issn-type":[{"value":"0194-5998","type":"print"},{"value":"1097-6817","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,6]]},"assertion":[{"value":"2009-06-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2010-02-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2010-06-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}