{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,13]],"date-time":"2026-11-13T14:45:35Z","timestamp":1794581135075,"version":"4.9.1"},"reference-count":16,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2010,7,1]],"date-time":"2010-07-01T00:00:00Z","timestamp":1277942400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2010,7]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To describe the epidemiology and comparative survival for minor salivary gland cancer of the oral cavity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Historical cohort study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Academic medical center.<\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects and Methods<\/jats:title><jats:p>Cases of minor salivary gland cancer of the oral cavity were extracted from the Surveillance, Epidemiology, and End Results database (1988\u20102005) and staged. Kaplan\u2010Meier survivals were compared according to histology as well as T stage and N stage. A Cox proportional hazards model incorporating histology, T stage, N stage, age, and sex was analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 639 salivary gland cancers of the oral cavity (55% female; mean age, 56 years) were identified with complete staging information, consisting of 318\u00a0mucoepidermoid, 169 adenoid cystic, 139 adenocarcinoma, and 14 acinic cell cancers. The hard palate and gums were the most common subsites involved (87.6%), followed by lip (7.2%) and tongue (5.2%). At presentation, T1 and T4 tumors predominated (42.6% and 35.2%, respectively); 93.4 percent were N0. Overall mean survival (months) was 157.9 and was similar across histologic subtypes: mucoepidermoid (172.4), adenoid cystic (141.4), acinic cell (138.7), and adenocarcinoma (147.2). Survival for low\u2010 and intermediate\u2010grade mucoepidermoid carcinoma (171.0 and 182.3, respectively) was better than survival for high\u2010grade mucoepidermoid carcinoma (50.3, <jats:italic>P<\/jats:italic> &lt; 0.001). On multivariate analysis, N stage (<jats:italic>P<\/jats:italic> &lt; 0.001) was the most powerful predictor of survival, along with T stage (<jats:italic>P<\/jats:italic> = 0.013), age (<jats:italic>P<\/jats:italic> &lt; 0.001), and sex (<jats:italic>P<\/jats:italic> &lt; 0.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>T stage and N stage are the most powerful predictors of survival in minor salivary gland carcinoma of the oral cavity. With the exception of high\u2010grade mucoepidermoid carcinoma, survival for these lesions is generally favorable.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.otohns.2010.02.033","type":"journal-article","created":{"date-parts":[[2010,6,24]],"date-time":"2010-06-24T04:55:29Z","timestamp":1277355329000},"page":"122-126","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":49,"title":["Survival in oral cavity minor salivary gland carcinoma"],"prefix":"10.1002","volume":"143","author":[{"given":"Kiran","family":"Kakarala","sequence":"first","affiliation":[{"name":"Department of Otolaryngology Massachusetts Eye and Ear Infirmary Boston MA"},{"name":"Department of Otology and Laryngology Harvard Medical School Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil","family":"Bhattacharyya","sequence":"additional","affiliation":[{"name":"Department of Otology and Laryngology Harvard Medical School Boston MA"},{"name":"Division of Otolaryngology\u2010Head and Neck Surgery Brigham and Women's Hospital Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,7]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0030-6665(20)32502-0"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.1711460106"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.2890080309"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/MLG.0b013e3181671b3d"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348940611500806"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/MLG.0b013e318033c800"},{"key":"e_1_2_8_8_1","unstructured":"Surveillance Epidemiology and End Results (SEER) ProgramSEER*Stat Database: Incidence SEER 17 Regs Public\u2010Use Nov 2005 Sub (1973\u20132005 varying). 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