{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T07:03:05Z","timestamp":1778742185197,"version":"3.51.4"},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2010,7,1]],"date-time":"2010-07-01T00:00:00Z","timestamp":1277942400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2010,7]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the clinical factors predicting the significantly elevated high\u2010sensitivity C\u2010reactive protein (hs\u2010CRP) concentrations, defined herein as hs\u2010CRP \u2265 3\u00a0mg\/L, in adult males with untreated obstructive sleep apnea syndrome (OSAS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Cross\u2010sectional study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Tertiary referral center.<\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects and Methods<\/jats:title><jats:p>Sixty\u2010five consecutive male patients with newly diagnosed OSAS were enrolled to receive complete medical history review, physical examination, in\u2010laboratory overnight polysomnography, and hs\u2010CRP test. The patients had no current or history of cardiovascular disease. The patients had a mean age of 38.2 \u00b1 9.9 years, body mass index (BMI) of 27.4 \u00b1 3.5\u00a0kg\/m<jats:sup>2<\/jats:sup>, and Epworth Sleepiness Scale (ESS) of 11.3 \u00b1 4.6. The serum levels of hs\u2010CRP were assessed using peripheral venous blood samples.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010three percent of the overall patients had significantly elevated serum levels of hs\u2010CRP. The increase of hs\u2010CRP correlated fairly with BMI, apnea\u2010hypopnea index (AHI), tonsil size, and ESS (<jats:italic>r<\/jats:italic> = 0.450, 0.398, 0.393, and 0.300, respectively; all <jats:italic>P<\/jats:italic> \u2264 0.05) after adjustment for conventional coronary heart disease risk factors. However, only the AHI could predict for significantly elevated hs\u2010CRP after stepwise multiple linear regression (<jats:italic>R<\/jats:italic> <jats:sup>2<\/jats:sup> = 0.251, <jats:italic>P<\/jats:italic> &lt; 0.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Patients in this study with hs\u2010CRP \u2265 3\u00a0mg\/L were more prevalent in the severe OSAS group. This observation suggests that the severe OSAS patients need to have their cardiovascular statuses evaluated by use of an hs\u2010CRP screening test.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.otohns.2010.04.001","type":"journal-article","created":{"date-parts":[[2010,6,24]],"date-time":"2010-06-24T04:55:29Z","timestamp":1277355329000},"page":"72-77","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Patients with severe obstructive sleep apnea syndrome and elevated high\u2010sensitivity C\u2010reactive protein need priority treatment"],"prefix":"10.1002","volume":"143","author":[{"given":"Li\u2010Ang","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Otolaryngology Chang Gung Memorial Hospital Chang Gung University Taoyuan Taiwan"},{"name":"Sleep Center Chang Gung Memorial Hospital Chang Gung University Taoyuan 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