{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T22:59:59Z","timestamp":1782601199642,"version":"3.54.5"},"reference-count":16,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2010,8,1]],"date-time":"2010-08-01T00:00:00Z","timestamp":1280620800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2010,8]]},"abstract":"<jats:sec><jats:title>OBJECTIVE<\/jats:title><jats:p>1) To classify the appearance of thyroid nodules displayed on ultrasound elastography; 2) to explore the sensitivity and specificity of this examination for differentiating benign and malignant nodules, with histopathologic analysis as the reference standard; and 3) to evaluate its utility for avoiding unnecessary procedures.<\/jats:p><\/jats:sec><jats:sec><jats:title>STUDY DESIGN<\/jats:title><jats:p>Diagnostic test assessment.<\/jats:p><\/jats:sec><jats:sec><jats:title>SETTING<\/jats:title><jats:p>Community hospital.<\/jats:p><\/jats:sec><jats:sec><jats:title>SUBJECTS AND METHODS<\/jats:title><jats:p>Forty\u2010seven thyroid nodules in 44 consecutive patients were examined with ultrasound elastography. The images we obtained were classified into four patterns. In addition, the mean strain index of the thyroid nodule and that of the sternocleidomastoid muscle were measured, and the nodule\u2010tomuscle strain ratio was calculated. As the reference findings, the presence or absence of calcification, irregular margins, and hypoechogenicity of the thyroid nodules were examined using B\u2010mode ultrasound.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Elastography patterns 3 and 4 were predictive of malignancy, with 73 percent sensitivity (95% confidence interval [CI]: 39%\u201094%) and 64 percent specificity (95% CI: 46%\u201079%). Additionally, all nodules without calcification and those that presented with patterns 1 or 2 were benign. A strain ratio greater than 1.5 was set as the predictor of thyroid malignancy. This criterion showed 90 percent sensitivity (95% CI: 59%\u2010100%) and 50 percent specificity (95% CI: 33%\u201067%).<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>Although elastography can assist in the differential diagnosis of thyroid nodules, its diagnostic performance is not ideal at present. Further improvements in the technique and the diagnostic criteria are necessary for this examination to provide a useful contribution to diagnosis.<\/jats:p><jats:p>\u00a9 2010 American Academy of Otolaryngology\u2010Head and Neck Surgery Foundation. All rights reserved.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.otohns.2010.04.006","type":"journal-article","created":{"date-parts":[[2010,7,20]],"date-time":"2010-07-20T05:06:20Z","timestamp":1279602380000},"page":"230-234","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":72,"title":["Utility of elastography for differential diagnosis of benign and malignant thyroid nodules"],"prefix":"10.1002","volume":"143","author":[{"given":"Ryoji","family":"Kagoya","sequence":"first","affiliation":[{"name":"Department of Otolaryngology Hitachi General Hospital Hitachi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroko","family":"Monobe","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Hitachi General Hospital Hitachi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hitoshi","family":"Tojima","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Hitachi General Hospital Hitachi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,8]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcu.1870230306"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.87.5.1938"},{"key":"e_1_2_5_4_1","unstructured":"FukunariN.More accurate and sensitive diagnosis for thyroid tumors with elastography.Medix Suppl2007:16\u20139."},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1995.00430220076008"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.3322\/canjclin.55.1.10"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9610(05)80728-7"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.7863\/jum.2004.23.11.1455"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.87.5.8504"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1530\/eje.0.1380041"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1089\/10507250152740993"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2006.16.109"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/016173469101300201"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10147-007-0669-7"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2391041676"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2007.0323"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2363041248"}],"container-title":["Otolaryngology\u2013Head and Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.otohns.2010.04.006","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1016\/j.otohns.2010.04.006","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.otohns.2010.04.006","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T11:31:56Z","timestamp":1760959916000},"score":1,"resource":{"primary":{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/10.1016\/j.otohns.2010.04.006"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,8]]},"references-count":16,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2010,8]]}},"alternative-id":["10.1016\/j.otohns.2010.04.006"],"URL":"https:\/\/doi.org\/10.1016\/j.otohns.2010.04.006","archive":["Portico"],"relation":{},"ISSN":["0194-5998","1097-6817"],"issn-type":[{"value":"0194-5998","type":"print"},{"value":"1097-6817","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,8]]},"assertion":[{"value":"2010-03-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2010-04-06","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2010-08-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}