{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T07:31:35Z","timestamp":1783063895961,"version":"3.54.6"},"reference-count":20,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2010,9,1]],"date-time":"2010-09-01T00:00:00Z","timestamp":1283299200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2010,9]]},"abstract":"<jats:sec><jats:title>OBJECTIVE<\/jats:title><jats:p>To investigate the hypothesis that eosinophil major basic protein is released in high concentrations in the nasal mucus of patients with polypoid chronic rhinosinusitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>STUDY DESIGN<\/jats:title><jats:p>Single center, open, prospective trial.<\/jats:p><\/jats:sec><jats:sec><jats:title>SETTING<\/jats:title><jats:p>Medical University of Graz, Austria.<\/jats:p><\/jats:sec><jats:sec><jats:title>SUBJECTS AND METHODS<\/jats:title><jats:p>Patients with polypoid chronic rhinosinusitis (n = 23) were compared to three different control groups: patients with chronic rhinosinusitis\u2010like symptoms but without general mucosal thickening, patients who underwent functional endoscopic sinus surgery for reasons other than chronic rhinosinusitis, and patients without sinus disease (total n = 21). Mucus was harvested from each patient using a standardized technique and analyzed for eosinophil major basic protein with an enzyme\u2010linked immunosorbent assay.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>In the patient group with polypoid chronic rhinosinusitis, 20 of 23 (87%) were positive for eosinophil major basic protein. In contrast, only one control patient was positive, whereas the remainder had no detectable amount of eosinophil major basic protein in the mucus (<jats:italic>P<\/jats:italic> = 0.001 vs chronic rhinosinusitis).<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>Toxic eosinophil major basic protein levels are elevated in polypoid chronic rhinosinusitis patients compared to control groups that have similar clinical presentations but upon closer examination turn out not to have chronic rhinosinusitis. In the future, the detection of eosinophil major basic protein in nasal mucus may become a sensitive and specific marker for chronic rhinosinusitis and a helpful diagnostic tool.<\/jats:p><jats:p>\u00a9 2010 American Academy of Otolaryngology\u2010Head and Neck Surgery Foundation. All rights reserved.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.otohns.2010.05.017","type":"journal-article","created":{"date-parts":[[2010,8,18]],"date-time":"2010-08-18T06:28:35Z","timestamp":1282112915000},"page":"386-391","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Released intranasal eosinophilic major basic protein as a diagnostic marker for polypoid chronic rhinosinusitis"],"prefix":"10.1002","volume":"143","author":[{"given":"Christoph","family":"Schmid","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology\u2010Head and Neck Surgery Medical University of Graz Graz Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter","family":"Habermann","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2010Head and Neck Surgery Medical University of Graz Graz Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannes","family":"Braun","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2010Head and Neck Surgery Medical University of Graz Graz Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Gugatschka","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2010Head and Neck Surgery Medical University of Graz Graz Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brad S.","family":"Oriel","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology University at Buffalo The State University of New York Buffalo NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janel A.","family":"Smietana","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology University at Buffalo The State University of New York Buffalo NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heinz","family":"Stammberger","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2010Head and Neck Surgery Medical University of Graz Graz Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,9]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"1","article-title":"Summary health statistics for U.S. adults: National Health Interview Survey, 2006","volume":"10","author":"Pleis JR","year":"2007","journal-title":"Vital Health Stat"},{"key":"e_1_2_6_3_1","unstructured":"Deutsche Gesellschaft f\u00fcr Hals\u2010Nasen\u2010Ohren\u2010Heilkunde Kopf\u2010 und Hals\u2010Chirurgie. AWMF Reg.\u2010Nr. 017\/049. Leitlinie Rhinosinusitis. Available at:http:\/\/www.uni\u2010duesseldorf.de\/awmf\/ll\/017\u2010049.htm. Accessed September 10 2009."},{"key":"e_1_2_6_4_1","first-page":"1","article-title":"European position paper on rhinosinusitis and nasal polyps","volume":"20","author":"Fokkens W","year":"2007","journal-title":"Rhinol Suppl"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11882-002-0027-9"},{"key":"e_1_2_6_6_1","first-page":"177","article-title":"The role of ubiquitous airborne fungi in chronic rhinosinusitis","volume":"20","author":"Ponikau JU","year":"2007","journal-title":"Clin Allergy Immunol"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200302000-00013"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(95)70298-9"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-065X.2001.790118.x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/jlb.52.6.611"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2005.03.049"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/139.3.801"},{"key":"e_1_2_6_13_1","first-page":"183","article-title":"Staging in rhinosinusitus","volume":"31","author":"Lund VJ","year":"1993","journal-title":"Rhinology"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(88)90944-X"},{"key":"e_1_2_6_15_1","first-page":"277","article-title":"The eosinophil granule major basic protein: biological activities and relationship to bronchial asthma","volume":"18","author":"Gleich GJ","year":"1983","journal-title":"Monogr Allergy"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348940411300610"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.04.00014404"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2000.108430"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(86)90341-6"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI115155"},{"key":"e_1_2_6_21_1","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.4049\/jimmunol.140.5.1605","article-title":"Eosinophil granule major basic protein regulates generation of classical and alternative\u2010amplification pathway C3 convertases in vitro","volume":"140","author":"Weiler JM","year":"1988","journal-title":"J Immunol"}],"container-title":["Otolaryngology\u2013Head and Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.otohns.2010.05.017","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1016\/j.otohns.2010.05.017","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.otohns.2010.05.017","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T11:36:00Z","timestamp":1760960160000},"score":1,"resource":{"primary":{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/10.1016\/j.otohns.2010.05.017"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,9]]},"references-count":20,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2010,9]]}},"alternative-id":["10.1016\/j.otohns.2010.05.017"],"URL":"https:\/\/doi.org\/10.1016\/j.otohns.2010.05.017","archive":["Portico"],"relation":{},"ISSN":["0194-5998","1097-6817"],"issn-type":[{"value":"0194-5998","type":"print"},{"value":"1097-6817","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,9]]},"assertion":[{"value":"2009-09-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2010-05-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2010-09-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}