{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T14:47:50Z","timestamp":1773758870481,"version":"3.50.1"},"reference-count":11,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2010,10,1]],"date-time":"2010-10-01T00:00:00Z","timestamp":1285891200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2010,10]]},"abstract":"<jats:sec><jats:title>OBJECTIVE<\/jats:title><jats:p>The safety and clinical effect of a new surgical device for tongue suspension for obstructive sleep apnea (OSA) was assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>STUDY DESIGN<\/jats:title><jats:p>Multicenter phase 2 prospective case series.<\/jats:p><\/jats:sec><jats:sec><jats:title>SETTING<\/jats:title><jats:p>Multicenter academic and private.<\/jats:p><\/jats:sec><jats:sec><jats:title>SUBJECTS AND METHODS<\/jats:title><jats:p>Surgically na\u00efve patients with moderate\u2010to\u2010severe OSA and tongue base obstruction (body mass index &lt; 32, apnea\/hypopnea index [AHI] 15\u201360) underwent surgical insertion of a midline tissue anchor into the posterior tongue and connected to an adjustable mandibular bone anchor with a flexible tether. Outcomes included changes in AHI, sleepiness (Epworth Sleepiness Scale), sleep\u2010related quality\u2010of\u2010life (Functional Outcomes of Sleep Questionnaire), snoring, swallowing, speech, and pain (0\u201310 visual analog scale).<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>After the implant, 42 patients (mean age 50 years, body mass index 28) noted improvement at six months for AHI (mean [SD]: 35.5 [20.4] to 27.3 [18.8]), Epworth Sleepiness Scale (11.5 [3.9] to 7.8 [4.7]), and Functional Outcomes of Sleep Questionnaire (15.5 [2.6] to 17.5 [2.6], all <jats:italic>P<\/jats:italic> &lt; 0.01). Snoring VAS scores improved (7.3 [2.1] to 4.7 [2.9], <jats:italic>P<\/jats:italic> &lt; 0.01). Postimplant pain scores were mild to moderate (4.4) at day one and resolved by day five. Post\u2010titration pain scores were mild (&lt; 2). Device\u2010related adverse events included wound infection (7%) and edema or seroma (5%), which resolved. However, in 31 percent of patients, asymptomatic tissue anchor barb fractures were observed radiographically.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>The tissue anchor failure rate of the tested device precludes its clinical use; however, the study results support that a titratable, tongue\u2010suspension device with low direct surgical morbidity in patients with moderate\u2010to\u2010severe sleep apnea significantly improves multiple measures of sleep apnea. Further investigation is warranted.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.otohns.2010.06.902","type":"journal-article","created":{"date-parts":[[2010,9,24]],"date-time":"2010-09-24T06:24:23Z","timestamp":1285309463000},"page":"585-590","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Multicenter study of a novel adjustable tongue\u2010advancement device for obstructive sleep apnea"],"prefix":"10.1002","volume":"143","author":[{"given":"B. Tucker","family":"Woodson","sequence":"first","affiliation":[{"name":"Department of Otolaryngology Medical College of Wisconsin Milwaukee WI"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David L.","family":"Steward","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology University of Cincinnati Academic Health Center Cincinnati OH"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samuel","family":"Mickelson","sequence":"additional","affiliation":[{"name":"Advanced Ear, Nose &amp; Throat Associates, PC Atlanta GA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tod","family":"Huntley","sequence":"additional","affiliation":[{"name":"Head &amp; Neck Surgery Associates Inc. Carmel IN"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Goldberg","sequence":"additional","affiliation":[{"name":"University of California, San Francisco San Francisco CA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,10]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/019459989310800203"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.132.2.206"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1053\/joms.2001.27111"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.2310\/7070.2003.40315"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1067\/mhn.2000.102119"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1067\/mhn.2001.113661"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0194-5998(00)70152-5"},{"key":"e_1_2_7_9_1","first-page":"274","article-title":"Tongue base suspension technique in obstructive sleep apnea: personal experience","volume":"23","author":"Sorrenti G","year":"2003","journal-title":"Acta Otorhinolaryngol Ital"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000224498.09015.d9"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0194-59980300728-9"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00131106"}],"container-title":["Otolaryngology\u2013Head and Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.otohns.2010.06.902","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1016\/j.otohns.2010.06.902","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.otohns.2010.06.902","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T13:35:16Z","timestamp":1760967316000},"score":1,"resource":{"primary":{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/10.1016\/j.otohns.2010.06.902"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,10]]},"references-count":11,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2010,10]]}},"alternative-id":["10.1016\/j.otohns.2010.06.902"],"URL":"https:\/\/doi.org\/10.1016\/j.otohns.2010.06.902","archive":["Portico"],"relation":{},"ISSN":["0194-5998","1097-6817"],"issn-type":[{"value":"0194-5998","type":"print"},{"value":"1097-6817","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,10]]},"assertion":[{"value":"2009-08-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2010-06-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2010-10-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}