{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:58:12Z","timestamp":1772121492803,"version":"3.50.1"},"reference-count":20,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2010,10,1]],"date-time":"2010-10-01T00:00:00Z","timestamp":1285891200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2010,10]]},"abstract":"<jats:sec>\n                    <jats:title>OBJECTIVE<\/jats:title>\n                    <jats:p>To find out whether the constant preoperative use of a topical corticoid (mometasone furoate [MF]) could really improve the operative field quality and decrease bleeding during endoscopic sinus surgery (ESS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>STUDY DESIGN<\/jats:title>\n                    <jats:p>Double\u2010blind, randomized controlled trial. SETTING: Tertiary referral center.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>SUBJECTS AND METHODS<\/jats:title>\n                    <jats:p>Seventy patients with chronic rhinosinusitis (CRS) with and without polyps underwent ESS under standardized general anesthesia with equal randomization into two groups. During four weeks within the preoperative period, 35 cases were treated with MF, while the other half received placebo matching sprays. Total blood loss, operation time, and surgical field quality were recorded.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      Intraoperative blood loss in the MF\u2010treated group was 142.8\u00a0mL, less than in the control group (170.6\u00a0mL). The difference between the groups is 27.7\u00a0mL (95% confidence interval [CI] 3.5\u201351.92), statistically significant:\n                      <jats:italic>P<\/jats:italic>\n                      = 0.025. Time of surgery was 59\u00a0minutes in the MF group and 70\u00a0minutes in the control group. The difference was 11.2\u00a0minutes (95% CI 2.82\u201319.51), which is statistically significant:\n                      <jats:italic>P<\/jats:italic>\n                      = 0.009. The quality of the endoscopic surgical field was significantly better for patients treated with MF. Treatment with topical corticoid enables significantly reduced bleeding, decreased operation time, and improved endoscopic vision during ESS for CRS.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>The use of topical corticoid (MF) in the preoperative period can improve endoscopic vision, reduce bleeding, and decrease operation time in CRS patients with and without polyps undergoing ESS, but our sample size cannot exclude small, and possibly trivial, group differences.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1016\/j.otohns.2010.06.921","type":"journal-article","created":{"date-parts":[[2010,9,24]],"date-time":"2010-09-24T06:24:23Z","timestamp":1285309463000},"page":"573-578","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":59,"title":["Preoperative treatment with topical corticoids and bleeding during primary endoscopic sinus surgery"],"prefix":"10.1002","volume":"143","author":[{"given":"Silviu","family":"Albu","sequence":"first","affiliation":[{"name":"Second Department of Otolaryngology University of Medicine and Pharmacy Cluj\u2010Napoca Cluj\u2010Napoca Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anamaria","family":"Gocea","sequence":"additional","affiliation":[{"name":"Second Department of Otolaryngology University of Medicine and Pharmacy Cluj\u2010Napoca Cluj\u2010Napoca Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ileana","family":"Mitre","sequence":"additional","affiliation":[{"name":"Department of Maxillofacial Surgery University of Medicine and Pharmacy Cluj\u2010Napoca Cluj\u2010Napoca 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