{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T01:18:55Z","timestamp":1785374335162,"version":"3.55.0"},"reference-count":25,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2018,11,1]],"date-time":"2018-11-01T00:00:00Z","timestamp":1541030400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,11,1]],"date-time":"2018-11-01T00:00:00Z","timestamp":1541030400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,11,2]],"date-time":"2019-11-02T00:00:00Z","timestamp":1572652800000},"content-version":"vor","delay-in-days":366,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Orthopaedics & Traumatology: Surgery & Research"],"published-print":{"date-parts":[[2018,11]]},"DOI":"10.1016\/j.otsr.2018.07.015","type":"journal-article","created":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T12:45:15Z","timestamp":1535805915000},"page":"1043-1048","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":43,"title":["Combined teriparatide and denosumab therapy accelerates spinal fusion following posterior lumbar interbody fusion"],"prefix":"10.1016","volume":"104","author":[{"given":"Manabu","family":"Ide","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsutaka","family":"Yamada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kanichirou","family":"Kaneko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuhiro","family":"Sekiya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenzo","family":"Kanai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takayuki","family":"Higashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoyuki","family":"Saito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.otsr.2018.07.015_bib0130","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1016\/S0736-0266(02)00069-4","article-title":"Pedicular fixation in the osteoporotic spine: a pilot in vivo study on long-term ovariectomized sheep","volume":"20","author":"Nicoli Aldini","year":"2002","journal-title":"J Orthop Res"},{"key":"10.1016\/j.otsr.2018.07.015_bib0135","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1097\/00007632-199009000-00012","article-title":"Influence of bone mineral density on the fixation of thoracolumbar implants a comparative study of transpedicular screws, laminar hooks, and spinous process wires","volume":"15","author":"Coe","year":"1990","journal-title":"Spine"},{"key":"10.1016\/j.otsr.2018.07.015_bib0140","doi-asserted-by":"crossref","first-page":"2200","DOI":"10.1007\/s00586-010-1373-2","article-title":"Fusion mass bone quality after uninstrumented spinal fusion in older patients","volume":"19","author":"Andersen","year":"2010","journal-title":"Eur Spine J"},{"key":"10.1016\/j.otsr.2018.07.015_bib0145","doi-asserted-by":"crossref","first-page":"E1464","DOI":"10.1097\/BRS.0b013e31826ca2a8","article-title":"Teriparatide accelerates lumbar posterolateral fusion in women with postmenopausal osteoporosis","volume":"37","author":"Ohtori","year":"2012","journal-title":"Spine"},{"key":"10.1016\/j.otsr.2018.07.015_bib0150","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/S0140-6736(13)60856-9","article-title":"Teriparatide and denosumab, alone or combined, in women with postmenopausal osteoporosis: the data study randomised trial","volume":"382","author":"Tsai","year":"2013","journal-title":"Lancet"},{"key":"10.1016\/j.otsr.2018.07.015_bib0155","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1097\/01.BRS.0000061988.93175.74","article-title":"Radiologic assessment of interbody fusion using carbon fiber cages","volume":"28","author":"Santos","year":"2003","journal-title":"Spine"},{"key":"10.1016\/j.otsr.2018.07.015_bib0160","doi-asserted-by":"crossref","first-page":"1932","DOI":"10.1359\/jbmr.2003.18.11.1932","article-title":"Recombinant human parathyroid hormone (1\u201334) [teriparatide] improves both cortical and cancellous bone structure","volume":"18","author":"Jiang","year":"2003","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.otsr.2018.07.015_bib0165","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1097\/BRS.0b013e318191e687","article-title":"Parathyroid hormone (1\u201334) augments spinal fusion, fusion mass volume, and fusion mass quality in a rabbit spinal fusion model","volume":"34","author":"O\u2019Loughlin","year":"2009","journal-title":"Spine"},{"key":"10.1016\/j.otsr.2018.07.015_bib0170","doi-asserted-by":"crossref","first-page":"4793","DOI":"10.1210\/endo.141.12.7921","article-title":"In vivo effects of bisphosphonates on the osteoclast mevalonate pathway","volume":"141","author":"Fisher","year":"2000","journal-title":"Endocrinology"},{"key":"10.1016\/j.otsr.2018.07.015_bib0175","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1056\/NEJMoa0809493","article-title":"Denosumab for prevention of fractures in postmenopausal women with osteoporosis","volume":"361","author":"Cummings","year":"2009","journal-title":"N Engl J Med"},{"key":"10.1016\/j.otsr.2018.07.015_bib0180","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1016\/S0140-6736(15)61120-5","article-title":"Denosumab and teriparatide transitions in postmenopausal osteoporosis (the data-switch study): extension of a randomised controlled trial","volume":"386","author":"Leder","year":"2015","journal-title":"Lancet"},{"key":"10.1016\/j.otsr.2018.07.015_bib0185","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1002\/jbmr.2315","article-title":"Comparative effects of teriparatide, denosumab, and combination therapy on peripheral compartmental bone density, microarchitecture, and estimated strength: the data-hrpqct study","volume":"30","author":"Tsai","year":"2015","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.otsr.2018.07.015_bib0190","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1016\/j.spinee.2007.03.013","article-title":"Fusion assessment of posterior lumbar interbody fusion using radiolucent cages: X-ray films and helical computed tomography scans compared with surgical exploration of fusion","volume":"8","author":"Fogel","year":"2008","journal-title":"Spine J"},{"key":"10.1016\/j.otsr.2018.07.015_bib0195","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1097\/BRS.0b013e3181b71a96","article-title":"Effect of teriparatide [rhpth (1, 34)] and calcitonin on intertransverse process fusion in a rabbit model","volume":"35","author":"Lehman","year":"2010","journal-title":"Spine"},{"key":"10.1016\/j.otsr.2018.07.015_bib0200","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1097\/BRS.0000000000000169","article-title":"Quantitative study of parathyroid hormone (1\u201334) and bone morphogenetic protein-2 on spinal fusion outcomes in a rabbit model of lumbar dorsolateral intertransverse process arthrodesis","volume":"39","author":"Lina","year":"2014","journal-title":"Spine"},{"key":"10.1016\/j.otsr.2018.07.015_bib0205","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1097\/BRS.0b013e31824ac089","article-title":"Dose-dependent enhancement of spinal fusion in rats with teriparatide (pth [1\u201334])","volume":"37","author":"Ming","year":"2012","journal-title":"Spine"},{"key":"10.1016\/j.otsr.2018.07.015_bib0210","doi-asserted-by":"crossref","first-page":"e107","DOI":"10.2106\/JBJS.M.01097","article-title":"Effect of intermittent administration of teriparatide (parathyroid hormone 1\u201334) on bone morphogenetic protein-induced bone formation in a rat model of spinal fusion","volume":"96","author":"Morimoto","year":"2014","journal-title":"J Bone Joint Surg Am"},{"key":"10.1016\/j.otsr.2018.07.015_bib0215","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.spinee.2014.08.001","article-title":"Intermittent administration of teriparatide enhances graft bone healing and accelerates spinal fusion in rats with glucocorticoid-induced osteoporosis","volume":"15","author":"Sugiura","year":"2015","journal-title":"Spine J"},{"key":"10.1016\/j.otsr.2018.07.015_bib0220","doi-asserted-by":"crossref","first-page":"82","DOI":"10.4184\/jkss.2015.22.3.82","article-title":"The effect of teriparatide in women with osteoporosis after lumbar posterolateral fusion or posterior lumbar interbody fusion","volume":"22","author":"Seo","year":"2015","journal-title":"J Korean Soc Spine Surg"},{"key":"10.1016\/j.otsr.2018.07.015_bib0225","first-page":"1","article-title":"An effect comparison of teriparatide and bisphosphonate on posterior lumbar interbody fusion in patients with osteoporosis: a prospective cohort study and preliminary data","author":"Cho","year":"2015","journal-title":"Eur Spine J"},{"key":"10.1016\/j.otsr.2018.07.015_bib0230","doi-asserted-by":"crossref","first-page":"500","DOI":"10.3171\/2010.11.SPINE10245","article-title":"Does alendronate disturb the healing process of posterior lumbar interbody fusion? A prospective randomized trial","volume":"14","author":"Nagahama","year":"2011","journal-title":"J Neurosurg Spine"},{"key":"10.1016\/j.otsr.2018.07.015_bib0235","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1002\/jbmr.238","article-title":"Effects of intravenous zoledronic acid plus subcutaneous teriparatide [rhpth (1\u201334)] in postmenopausal osteoporosis","volume":"26","author":"Cosman","year":"2011","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.otsr.2018.07.015_bib0240","doi-asserted-by":"crossref","first-page":"1838","DOI":"10.1210\/jc.2009-1703","article-title":"Effects of teriparatide, alendronate, or both in women with postmenopausal osteoporosis","volume":"95","author":"Finkelstein","year":"2010","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.otsr.2018.07.015_bib0245","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1097\/00003086-200002000-00003","article-title":"Bone graft materials: an overview of the basic science","volume":"371","author":"Bauer","year":"2000","journal-title":"Clin Orthop Relat Res"},{"key":"10.1016\/j.otsr.2018.07.015_bib0250","doi-asserted-by":"crossref","first-page":"E277","DOI":"10.1097\/01.brs.0000216442.12092.01","article-title":"Graft resorption with the use of bone morphogenetic protein: Lessons from anterior lumbar interbody fusion using femoral ring allografts and recombinant human bone morphogenetic protein-2","volume":"31","author":"Pradhan","year":"2006","journal-title":"Spine (Phila Pa 1976)"}],"container-title":["Orthopaedics & Traumatology: Surgery & Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1877056818302433?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1877056818302433?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T03:39:05Z","timestamp":1761795545000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1877056818302433"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11]]},"references-count":25,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2018,11]]}},"alternative-id":["S1877056818302433"],"URL":"https:\/\/doi.org\/10.1016\/j.otsr.2018.07.015","relation":{},"ISSN":["1877-0568"],"issn-type":[{"value":"1877-0568","type":"print"}],"subject":[],"published":{"date-parts":[[2018,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Combined teriparatide and denosumab therapy accelerates spinal fusion following posterior lumbar interbody fusion","name":"articletitle","label":"Article Title"},{"value":"Orthopaedics & Traumatology: Surgery & Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.otsr.2018.07.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Masson SAS.","name":"copyright","label":"Copyright"}]}}