{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T07:31:18Z","timestamp":1787729478994,"version":"build-2784847793"},"reference-count":15,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"vor","delay-in-days":366,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Orthopaedics &amp; Traumatology: Surgery &amp; Research"],"published-print":{"date-parts":[[2019,10]]},"DOI":"10.1016\/j.otsr.2019.04.028","type":"journal-article","created":{"date-parts":[[2019,7,26]],"date-time":"2019-07-26T07:52:57Z","timestamp":1564127577000},"page":"1181-1185","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":44,"title":["Denosumab for treating aneurysmal bone cysts in children"],"prefix":"10.1016","volume":"105","author":[{"given":"S\u00e9bastien","family":"Raux","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amine","family":"Bouhamama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Gaspar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurence","family":"Brugi\u00e8res","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natacha","family":"Entz-Werl\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cindy","family":"Mallet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fr\u00e9d\u00e9rique","family":"Dijoud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Gouin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Perrine","family":"Marec-B\u00e9rard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.otsr.2019.04.028_bib0080","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1097\/BRS.0000000000001350","article-title":"Interest of denosumab for the treatment of giant-cells tumors and aneurysmal bone cysts of the spine. About nine cases","volume":"41","author":"Dubory","year":"2016","journal-title":"Spine"},{"key":"10.1016\/j.otsr.2019.04.028_bib0085","first-page":"139","article-title":"Targeting receptor-activator of nuclear kappaB ligand in aneurysmal bone cysts: verification of target and therapeutic response","volume":"164","author":"Pelle","year":"2014","journal-title":"Transl Res J Lab Clin Med"},{"key":"10.1016\/j.otsr.2019.04.028_bib0090","doi-asserted-by":"crossref","first-page":"527","DOI":"10.2106\/00004623-198567040-00004","article-title":"Aneurysmal bone cyst of the spine","volume":"67","author":"Capanna","year":"1985","journal-title":"J Bone Joint Surg Am"},{"key":"10.1016\/j.otsr.2019.04.028_bib0095","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1007\/s00586-012-2566-7","article-title":"Aneurysmal bone cyst of the mobile spine: the therapeutic role of embolization","volume":"22","author":"Amendola","year":"2013","journal-title":"Eur Spine J"},{"key":"10.1016\/j.otsr.2019.04.028_bib0100","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1097\/00007632-199803010-00018","article-title":"Aneurysmal bone cyst of the spine. Management and outcome","volume":"23","author":"Papagelopoulos","year":"1998","journal-title":"Spine"},{"key":"10.1016\/j.otsr.2019.04.028_bib0105","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1097\/01.bpo.0000158002.30800.8f","article-title":"Aneurysmal bone cysts of the pelvis in children: a multicenter study and literature review","volume":"25","author":"Cottalorda","year":"2005","journal-title":"J Pediatr Orthop"},{"key":"10.1016\/j.otsr.2019.04.028_bib0110","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1359\/jbmr.081112","article-title":"Denosumab, a fully human monoclonal antibody to RANKL, inhibits bone resorption and increases BMD in knock-in mice that express chimeric (murine\/human) RANKL","volume":"24","author":"Kostenuik","year":"2009","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.otsr.2019.04.028_bib0115","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1016\/S1470-2045(13)70277-8","article-title":"Safety and efficacy of denosumab for adults and skeletally mature adolescents with giant cell tumour of bone: interim analysis of an open-label, parallel-group, phase 2 study","volume":"14","author":"Chawla","year":"2013","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.otsr.2019.04.028_bib0120","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1007\/s00586-013-2715-7","article-title":"Denosumab: a potential new and innovative treatment option for aneurysmal bone cysts","volume":"22","author":"Lange","year":"2013","journal-title":"Eur Spine J"},{"key":"10.1016\/j.otsr.2019.04.028_bib0125","doi-asserted-by":"crossref","first-page":"26926","DOI":"10.1002\/pbc.26926","article-title":"Denosumab treatment in aneurysmal bone cyst: Evaluation of nine cases","volume":"65","author":"Kurucu","year":"2018","journal-title":"Pediatr Blood Cancer"},{"key":"10.1016\/j.otsr.2019.04.028_bib0130","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.bone.2013.10.004","article-title":"Bisphosphonate therapy for unresectable symptomatic benign bone tumors: a long-term prospective study of tolerance and efficacy","volume":"58","author":"Cornelis","year":"2014","journal-title":"Bone"},{"key":"10.1016\/j.otsr.2019.04.028_bib0135","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1186\/s12957-016-1034-y","article-title":"Risks and benefits of combining denosumab and surgery in giant cell tumor of bone-a case series","volume":"14","author":"M\u00fcller","year":"2016","journal-title":"World J Surg Oncol"},{"key":"10.1016\/j.otsr.2019.04.028_bib0140","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1007\/s12253-016-0123-0","article-title":"Clinicopathological features of a series of 27 cases of post-denosumab treated giant cell tumors of bones: A single institutional experience at a tertiary cancer referral centre, India","volume":"23","author":"Rekhi","year":"2017","journal-title":"Pathol Oncol Res POR"},{"key":"10.1016\/j.otsr.2019.04.028_bib0145","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1016\/j.ejso.2018.03.020","article-title":"Denosumab treatment of inoperable or locally advanced giant cell tumor of bone - Multicenter analysis outside clinical trial","volume":"44","author":"Rutkowski","year":"2018","journal-title":"Eur J Surg Oncol"},{"key":"10.1016\/j.otsr.2019.04.028_bib0150","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1002\/pbc.25393","article-title":"Critical hypercalcemia following discontinuation of denosumab therapy for metastatic giant cell tumor of bone","volume":"62","author":"Gossai","year":"2015","journal-title":"Pediatr Blood Cancer"}],"container-title":["Orthopaedics &amp; Traumatology: Surgery &amp; Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1877056819302087?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1877056819302087?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T03:41:54Z","timestamp":1761795714000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1877056819302087"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10]]},"references-count":15,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2019,10]]}},"alternative-id":["S1877056819302087"],"URL":"https:\/\/doi.org\/10.1016\/j.otsr.2019.04.028","relation":{},"ISSN":["1877-0568"],"issn-type":[{"value":"1877-0568","type":"print"}],"subject":[],"published":{"date-parts":[[2019,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Denosumab for treating aneurysmal bone cysts in children","name":"articletitle","label":"Article Title"},{"value":"Orthopaedics & Traumatology: Surgery & Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.otsr.2019.04.028","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Masson SAS.","name":"copyright","label":"Copyright"}]}}