{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T23:41:36Z","timestamp":1784590896687,"version":"3.55.0"},"reference-count":46,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Orthopaedics & Traumatology: Surgery & Research"],"published-print":{"date-parts":[[2022,6]]},"DOI":"10.1016\/j.otsr.2021.102966","type":"journal-article","created":{"date-parts":[[2021,5,24]],"date-time":"2021-05-24T04:35:32Z","timestamp":1621830932000},"page":"102966","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"title":["Treatment alternatives and clinical outcomes of bone filling after benign tumour curettage. A systematic review"],"prefix":"10.1016","volume":"108","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9491-3393","authenticated-orcid":false,"given":"Nelson Fabr\u00edcio","family":"Gava","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edgard Eduard","family":"Engel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.otsr.2021.102966_bib0450","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/BF00443468","article-title":"Remodeling of large bone defects in the treatment of space-occupying lesions. Curettage without bone graft for treating benign bone tumors","volume":"111","author":"Chigira","year":"1992","journal-title":"Arch Orthop Trauma Surg"},{"key":"10.1016\/j.otsr.2021.102966_bib0455","first-page":"155","article-title":"Manifestations, diagnosis and surgical treatment of enchondroma\u00a0\u2013\u00a0own experience","volume":"12","author":"Matysiakiewicz","year":"2009","journal-title":"Ortop Traumatol Rehabil"},{"key":"10.1016\/j.otsr.2021.102966_bib0460","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.foot.2013.10.014","article-title":"May bone cement be used to treat benign aggressive bone tumors of the feet with confidence?","volume":"24","author":"\u00d6zer","year":"2014","journal-title":"Foot"},{"key":"10.1016\/j.otsr.2021.102966_bib0465","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1080\/17453670902804505","article-title":"Bone defects following curettage do not necessarily need augmentation","volume":"80","author":"Hirn","year":"2009","journal-title":"Acta Orthop"},{"key":"10.1016\/j.otsr.2021.102966_bib0470","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1097\/00003086-199101000-00007","article-title":"Cryosurgery and acrylic cementation as surgical adjuncts in the treatment of aggressive (benign) bone tumors","volume":"262","author":"Malawer","year":"1991","journal-title":"Clin Orthop Relat Res"},{"key":"10.1016\/j.otsr.2021.102966_bib0475","doi-asserted-by":"crossref","first-page":"S36","DOI":"10.1097\/BOT.0b013e3181cec4a1","article-title":"Autologous bone graft: properties and techniques","volume":"24","author":"Pape","year":"2010","journal-title":"J Orthop Trauma"},{"key":"10.1016\/j.otsr.2021.102966_bib0480","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1080\/00016470412331294485","article-title":"Faster integration of human allograft bone than of the bovine substitute Lubboc: non-randomized evaluation of 20 cases with benign tumors or tumor-like conditions","volume":"75","author":"Hartl","year":"2004","journal-title":"Acta Orthop Scand"},{"key":"10.1016\/j.otsr.2021.102966_bib0485","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/s10561-008-9105-0","article-title":"Fresh cortical autograft versus fresh cortical allograft effects on experimental bone healing in rabbits: radiological, histopathological and biomechanical evaluation","volume":"10","author":"Shafiei","year":"2009","journal-title":"Cell Tissue Bank"},{"key":"10.1016\/j.otsr.2021.102966_bib0490","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1002\/jbm.b.31070","article-title":"Long-term evaluation of blood silicon and ostecalcin in operatively treated patients with benign bone tumors using bioactive glass and autogenous bone","volume":"87B","author":"Lindfors","year":"2008","journal-title":"J Biomed Mater Res B Appl Biomater"},{"key":"10.1016\/j.otsr.2021.102966_bib0495","first-page":"20","article-title":"Effectiveness of ultraporous beta-tricalcium phosphate (vitoss) as bone graft substitute for cavitary defects in benign and low-grade malignant bone tumors","volume":"41","author":"van Hoff","year":"2012","journal-title":"Am J Orthop"},{"key":"10.1016\/j.otsr.2021.102966_bib0500","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1186\/1471-2474-15-330","article-title":"Local control of giant cell tumors of the long bone after aggressive curettage with and without bone cement","volume":"15","author":"Gao","year":"2014","journal-title":"BMC Musculoskelet Disord"},{"key":"10.1016\/j.otsr.2021.102966_bib0505","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2010\/586090","article-title":"High-speed burring with and without the use of surgical adjuvants in the intralesional management of giant cell tumor of bone: a systematic review and meta-analysis","volume":"2010","author":"Ghert","year":"2010","journal-title":"Sarcoma"},{"key":"10.1016\/j.otsr.2021.102966_bib0510","doi-asserted-by":"crossref","first-page":"590","DOI":"10.3109\/17453670903350123","article-title":"Treatment and outcome of giant cell tumors of the pelvis","volume":"80","author":"Balke","year":"2009","journal-title":"Acta Orthop"},{"key":"10.1016\/j.otsr.2021.102966_bib0515","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1007\/s12306-007-0023-2","article-title":"The use of fluoride cement: preliminary experimental study and clinical application","volume":"91","author":"Di Bella","year":"2008","journal-title":"Chir Organi Mov"},{"key":"10.1016\/j.otsr.2021.102966_bib0520","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1302\/0301-620X.95B5.30286","article-title":"Bone graft substitutes currently available in orthopaedic practice: the evidence for their use","volume":"95","author":"Kurien","year":"2013","journal-title":"Bone Joint J"},{"key":"10.1016\/j.otsr.2021.102966_bib0525","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1590\/S0102-36162008000200002","article-title":"Substitutos \u00f3sseos comparados ao enxerto \u00f3sseo aut\u00f3logo em cirurgia ortop\u00e9dica: revis\u00e3o sistem\u00e1tica da literatura","volume":"43","author":"Zabeu","year":"2008","journal-title":"Rev Bras Ortop"},{"key":"10.1016\/j.otsr.2021.102966_bib0530","doi-asserted-by":"crossref","first-page":"2765","DOI":"10.1007\/s11999-010-1445-y","article-title":"Curettage and cryosurgery for low-grade cartilage tumors is associated with low recurrence and high function","volume":"468","author":"Mohler","year":"2010","journal-title":"Clin Orthop Relat Res"},{"key":"10.1016\/j.otsr.2021.102966_bib0535","unstructured":"Higgins J, Green S. Cochrane handbook for systematic reviews of interventions version 5.1.0. http:\/\/handbook.cochrane.org [accessed March 2011]."},{"key":"10.1016\/j.otsr.2021.102966_bib0540","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/1472-6947-10-29","article-title":"Combining classifiers for robust PICO element detection","volume":"10","author":"Boudin","year":"2010","journal-title":"BMC Med Inform Decis Mak"},{"key":"10.1016\/j.otsr.2021.102966_bib0545","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1097\/00003086-199301000-00035","article-title":"A system for the functional evaluation of reconstructive procedures after surgical treatment of tumors of the musculoskeletal system","volume":"286","author":"Enneking","year":"1993","journal-title":"Clin Orthop Relat Res"},{"key":"10.1016\/j.otsr.2021.102966_bib0550","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1097\/PRS.0b013e318219c171","article-title":"The levels of evidence and their role in evidence-based medicine","volume":"128","author":"Burns","year":"2011","journal-title":"Plast Reconstr Surg"},{"key":"10.1016\/j.otsr.2021.102966_bib0555","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1590\/S1807-59322005000600002","article-title":"Functional and radiographic evaluation of 214 aggressive benign bone lesions treated with curettage, cauterization, and cementation: 24 years of follow-up","volume":"60","author":"Camargo","year":"2006","journal-title":"Clinics (Sao Paulo)"},{"key":"10.1016\/j.otsr.2021.102966_bib0560","first-page":"171","article-title":"Reconstruction of noncontained distal femoral defects with polymethylmethacrylate and crossed-screw augmentation: a biomechanical study","volume":"88","author":"Toy","year":"2006","journal-title":"J Bone Joint Surg Am"},{"key":"10.1016\/j.otsr.2021.102966_bib0565","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1186\/1746-1596-9-111","article-title":"Radiological and pathological characteristics of giant cell tumor of bone treated with denosumab","volume":"9","author":"Hakozaki","year":"2014","journal-title":"Diagn Pathol"},{"key":"10.1016\/j.otsr.2021.102966_bib0570","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1590\/S0102-36162009000500003","article-title":"Tumores \u00f3sseos benignos e les\u00f5es \u00f3sseas pseudotumorais: tratamento atual e novas tend\u00eancias","volume":"44","author":"Drumond","year":"2009","journal-title":"Rev Bras Ortop"},{"key":"10.1016\/j.otsr.2021.102966_bib0575","doi-asserted-by":"crossref","first-page":"146","DOI":"10.4103\/1119-3077.84003","article-title":"Surgical consideration for benign bone tumors","volume":"14","author":"Eyesan","year":"2011","journal-title":"Niger J Clin Pract"},{"key":"10.1016\/j.otsr.2021.102966_bib0580","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/S1067-2516(96)80057-3","article-title":"Bone grafting in the surgical management of osseous neoplasms","volume":"35","author":"Leonheart","year":"1996","journal-title":"J Foot Ankle Surg"},{"key":"10.1016\/j.otsr.2021.102966_bib0585","doi-asserted-by":"crossref","first-page":"E13","DOI":"10.3171\/foc.2003.15.2.13","article-title":"Giant cell tumor of the sacrum","volume":"15","author":"Randall","year":"2003","journal-title":"Neurosurg Focus"},{"key":"10.1016\/j.otsr.2021.102966_bib0590","doi-asserted-by":"crossref","first-page":"2159","DOI":"10.2106\/JBJS.H.00657","article-title":"Chondroblastoma of bone in a pediatric population","volume":"91","author":"Sailhan","year":"2009","journal-title":"J Bone Joint Surg Am"},{"key":"10.1016\/j.otsr.2021.102966_bib0595","doi-asserted-by":"crossref","first-page":"72","DOI":"10.4055\/cios.2014.6.1.72","article-title":"Tumor treated by endoscopy","volume":"6","author":"Choi","year":"2014","journal-title":"Clin Orthop Surg"},{"key":"10.1016\/j.otsr.2021.102966_bib0600","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.ejrad.2009.06.012","article-title":"Percutaneous treatment of bone tumors by radiofrequency thermal ablation","volume":"77","author":"Santiago","year":"2011","journal-title":"Eur J Radiol"},{"key":"10.1016\/j.otsr.2021.102966_bib0605","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.main.2009.12.001","article-title":"Treatment of benign bone tumours of the hand using osteoscopy","volume":"29","author":"Taleb","year":"2010","journal-title":"Chir Main"},{"key":"10.1016\/j.otsr.2021.102966_bib0610","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1177\/11207000100200s706","article-title":"Epiphyseal femoral tumour resection under intraosseous endoscopic control","volume":"20","author":"Torres-Egu\u00eda","year":"2010","journal-title":"Hip Int"},{"key":"10.1016\/j.otsr.2021.102966_bib0615","doi-asserted-by":"crossref","first-page":"32","DOI":"10.3109\/10929081003775881","article-title":"Navigation endoscopic assisted tumor (NEAT) surgery for benign bone tumors of the extremities","volume":"15","author":"Wong","year":"2010","journal-title":"Comput Aided Surg"},{"key":"10.1016\/j.otsr.2021.102966_bib0620","first-page":"31","article-title":"Aplicaci\u00f3n de xenoimplante para el tratamiento de defectos \u00f3seos, tumores benignos, seudoartrosis y artrodesis (Reporte preliminar)","volume":"21","author":"del Castillo","year":"2007","journal-title":"Acta Ortop Mex"},{"key":"10.1016\/j.otsr.2021.102966_bib0625","doi-asserted-by":"crossref","first-page":"3101","DOI":"10.1007\/s11999-008-0542-7","article-title":"Knee reconstruction with preservation of the meniscus in tibial giant cell tumor","volume":"466","author":"Li","year":"2008","journal-title":"Clin Orthop Relat Res"},{"key":"10.1016\/j.otsr.2021.102966_bib0630","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1002\/jbm.b.31263","article-title":"Bioactive glass and autogenous bone as bone graft substitutes in benign bone tumors","volume":"90B","author":"Lindfors","year":"2009","journal-title":"J Biomed Mater Res B Appl Biomater"},{"key":"10.1016\/j.otsr.2021.102966_bib0635","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1097\/00003086-199101000-00005","article-title":"Autograft versus allograft for benign lesions in children","volume":"262","author":"Glancy","year":"1991","journal-title":"Clin Orthop Relat Res"},{"key":"10.1016\/j.otsr.2021.102966_bib0640","first-page":"5075","article-title":"A new beta-tricalcium phosphate with uniform triple superporous structure as a filling material after curettage of bone tumor","volume":"33","author":"Seto","year":"2013","journal-title":"Anticancer Res"},{"key":"10.1016\/j.otsr.2021.102966_bib0645","doi-asserted-by":"crossref","first-page":"S313","DOI":"10.1016\/j.otsr.2013.07.006","article-title":"Local recurrence after curettage treatment of giant cell tumors in peripheral bones: retrospective study by the GSF-GETO (French sarcoma and bone tumor study groups)","volume":"99","author":"Gouin","year":"2013","journal-title":"Orthop Traumatol Surg Res"},{"key":"10.1016\/j.otsr.2021.102966_bib0650","doi-asserted-by":"crossref","first-page":"2014","DOI":"10.1007\/s11999-012-2251-5","article-title":"Function after injection of benign bone lesions with a bioceramic","volume":"470","author":"Fillingham","year":"2012","journal-title":"Clin Orthop Relat Res"},{"key":"10.1016\/j.otsr.2021.102966_bib0655","first-page":"69","article-title":"Ethanol as a local adjuvant for giant cell tumor of bone","volume":"26","author":"Jones","year":"2006","journal-title":"Iowa Orthop J"},{"key":"10.1016\/j.otsr.2021.102966_bib0660","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1053\/j.jfas.2014.08.016","article-title":"Giant cell tumors of the foot and ankle bones: high recurrence rates after surgical treatment","volume":"54","author":"Rajani","year":"2015","journal-title":"J Foot Ankle Surg"},{"key":"10.1016\/j.otsr.2021.102966_bib0665","first-page":"645","volume":"47","author":"Puri","year":"2013","journal-title":"Curettage of benign bone tumors and tumor-like lesions: a retrospective analysis. Indian J Orthop"},{"key":"10.1016\/j.otsr.2021.102966_bib0670","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.fas.2008.01.006","article-title":"Healing of ungrafted bone defects of the talus after benign tumour removal","volume":"14","author":"Shears","year":"2008","journal-title":"Foot Ankle Surg"},{"key":"10.1016\/j.otsr.2021.102966_bib0675","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1302\/0301-620X.86B5.14242","article-title":"Calcium hydroxyapatite ceramic implants in bone tumour surgery","volume":"86\u2013B","author":"Matsumine","year":"2004","journal-title":"J Bone Joint Surg Br"}],"container-title":["Orthopaedics & Traumatology: Surgery & Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1877056821001997?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1877056821001997?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T03:47:39Z","timestamp":1761796059000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1877056821001997"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6]]},"references-count":46,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,6]]}},"alternative-id":["S1877056821001997"],"URL":"https:\/\/doi.org\/10.1016\/j.otsr.2021.102966","relation":{},"ISSN":["1877-0568"],"issn-type":[{"value":"1877-0568","type":"print"}],"subject":[],"published":{"date-parts":[[2022,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Treatment alternatives and clinical outcomes of bone filling after benign tumour curettage. A systematic review","name":"articletitle","label":"Article Title"},{"value":"Orthopaedics & Traumatology: Surgery & Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.otsr.2021.102966","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Masson SAS.","name":"copyright","label":"Copyright"}],"article-number":"102966"}}