{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T02:57:47Z","timestamp":1784775467112,"version":"3.55.0"},"reference-count":22,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Orthopaedics & Traumatology: Surgery & Research"],"published-print":{"date-parts":[[2024,9]]},"DOI":"10.1016\/j.otsr.2024.103844","type":"journal-article","created":{"date-parts":[[2024,2,22]],"date-time":"2024-02-22T16:48:48Z","timestamp":1708620528000},"page":"103844","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"title":["The effect of tranexamic acid and epinephrine on visual clarity during arthroscopic shoulder surgery: A meta-analysis of RCTs"],"prefix":"10.1016","volume":"110","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5272-7410","authenticated-orcid":false,"given":"Shahbaz S.","family":"Malik","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muaaz","family":"Tahir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert W.","family":"Jordan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"Kwapisz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4789-4067","authenticated-orcid":false,"given":"Peter","family":"D\u2019Alessandro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter B.","family":"MacDonald","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7303-4365","authenticated-orcid":false,"given":"Jarret M.","family":"Woodmass","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.otsr.2024.103844_bib0115","first-page":"341","article-title":"Aquaflo pump vs. FMS 4 pump for shoulder arthroscopic surgery","volume":"79","author":"Ampat","year":"1997","journal-title":"Ann R Coll Surg Engl"},{"key":"10.1016\/j.otsr.2024.103844_bib0120","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1007\/s00167-004-0573-x","article-title":"Behavior of arthroscopic irrigation systems","volume":"13","author":"Tuijthof","year":"2005","journal-title":"Knee Surg Sports Traumatol Arthrosc"},{"key":"10.1016\/j.otsr.2024.103844_bib0125","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1053\/jars.2001.23590","article-title":"Arthroscopic shoulder surgery with epinephrine saline irrigation","volume":"17","author":"Jensen","year":"2001","journal-title":"Arthroscopy"},{"key":"10.1016\/j.otsr.2024.103844_bib0130","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1016\/j.arthro.2015.08.027","article-title":"Epinephrine diluted saline\u2013irrigation fluid in arthroscopic shoulder surgery: a significant improvement of clarity of visual field and shortening of total operation time. A randomized controlled trial","volume":"32","author":"van Montfoort","year":"2016","journal-title":"Arthroscopy"},{"key":"10.1016\/j.otsr.2024.103844_bib0135","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/0749-8063(95)90131-0","article-title":"The relationship between subacromial space pressure, blood pressure, and visual clarity during arthroscopic subacromial decompression","volume":"11","author":"Morrison","year":"1995","journal-title":"Arthroscopy"},{"key":"10.1016\/j.otsr.2024.103844_bib0140","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1016\/j.jse.2018.10.013","article-title":"Establishing clinically significant outcome after arthroscopic rotator cuff repair","volume":"28","author":"Cvetanovich","year":"2019","journal-title":"J Shoulder Elbow Surg"},{"key":"10.1016\/j.otsr.2024.103844_bib0145","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1302\/0301-620X.99B8.BJJ-2016-1205.R1","article-title":"The effect of intravenous tranexamic acid on blood loss and early post-operative pain in total shoulder arthroplasty","volume":"99-B","author":"Pauzenberger","year":"2017","journal-title":"Bone Joint J"},{"key":"10.1016\/j.otsr.2024.103844_bib0150","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1016\/j.jse.2017.01.005","article-title":"Intravenous tranexamic acid reduces total blood loss in reverse total shoulder arthroplasty: a prospective, double-blinded, randomized, controlled trial","volume":"26","author":"Vara","year":"2017","journal-title":"J Shoulder Elbow Surg"},{"key":"10.1016\/j.otsr.2024.103844_bib0155","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1016\/j.jse.2020.02.013","article-title":"Effect of tranexamic acid on blood loss after reverse total shoulder arthroplasty according to the administration method: a prospective, multicenter, randomized, controlled study","volume":"29","author":"Yoon","year":"2020","journal-title":"J Shoulder Elbow Surg"},{"key":"10.1016\/j.otsr.2024.103844_bib0160","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1016\/j.jse.2022.02.023","article-title":"The effect of single-dose, preoperative intravenous tranexamic acid on early postoperative pain scores after rotator cuff repair: a double-blind, randomized controlled trial","volume":"31","author":"Mackenzie","year":"2022","journal-title":"J Shoulder Elbow Surg"},{"key":"10.1016\/j.otsr.2024.103844_bib0165","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.jse.2020.04.050","article-title":"Administration of tranexamic acid during total shoulder arthroplasty is not associated with increased risk of complications in patients with a history of thrombotic events","volume":"30","author":"Carbone","year":"2021","journal-title":"J Shoulder Elbow Surg"},{"key":"10.1016\/j.otsr.2024.103844_bib0170","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1016\/j.arthro.2020.11.051","article-title":"Tranexamic acid use in knee and shoulder arthroscopy leads to improved outcomes and fewer hemarthrosis-related complications: a systematic review of level I and II studies","volume":"37","author":"Belk","year":"2021","journal-title":"Arthroscopy"},{"key":"10.1016\/j.otsr.2024.103844_bib0175","doi-asserted-by":"crossref","first-page":"c332","DOI":"10.1136\/bmj.c332","article-title":"CONSORT 2010 Statement: updated guidelines for reporting parallel group randomised trials","volume":"340","author":"Schulz","year":"2010","journal-title":"BMJ"},{"key":"10.1016\/j.otsr.2024.103844_bib0210","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1016\/j.jse.2023.10.001","article-title":"The effect of intravenous tranexamic acid on visual clarity in arthroscopic shoulder surgery compared to epinephrine and a placebo: a double-blinded, randomized controlled trial","volume":"33","author":"Suter","year":"2023","journal-title":"J Shoulder Elbow Surg"},{"key":"10.1016\/j.otsr.2024.103844_bib0180","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1016\/j.arthro.2019.10.020","article-title":"Intravenous administration of tranexamic acid significantly improved clarity of the visual field in arthroscopic shoulder surgery. A prospective, double-blind, and randomized controlled trial","volume":"36","author":"Liu","year":"2020","journal-title":"Arthroscopy"},{"key":"10.1016\/j.otsr.2024.103844_bib0185","doi-asserted-by":"crossref","first-page":"115","DOI":"10.5606\/ehc.2021.78393","article-title":"Comparison of the efficacy of irrigation with epinephrine or tranexamic acid on visual clarity during arthroscopic rotator cuff repair: a double-blind, randomized-controlled study","volume":"32","author":"Bayram","year":"2021","journal-title":"Jt Dis Relat Surg"},{"key":"10.1016\/j.otsr.2024.103844_bib0190","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.jse.2022.10.007","article-title":"Arthroscopic rotator cuff repair performed with intraarticular tranexamic acid. Could it provide improved visual clarity and less postoperative pain? A prospective, double blind, randomized study of 63 patients","volume":"32","author":"Bildik","year":"2022","journal-title":"J Shoulder Elbow Surg"},{"key":"10.1016\/j.otsr.2024.103844_bib0195","doi-asserted-by":"crossref","first-page":"572","DOI":"10.5152\/j.aott.2020.19164","article-title":"The effect of intravenous tranexamic acid on visual clarity during arthroscopic rotator cuff repair: a randomized, double-blinded, placebo-controlled pilot study","volume":"54","author":"Ersin","year":"2020","journal-title":"Acta Orthop Traumatol Turc"},{"key":"10.1016\/j.otsr.2024.103844_bib0200","doi-asserted-by":"crossref","first-page":"2211","DOI":"10.1016\/j.jse.2022.06.027","article-title":"The effect of tranexamic acid for visualization on pump pressure and visualization during arthroscopic rotator cuff repair: a blinded, randomized controlled trial","volume":"31","author":"Nicholson","year":"2022","journal-title":"J Shoulder Elbow Surg"},{"key":"10.1016\/j.otsr.2024.103844_bib0205","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.jos.2021.11.015","article-title":"Tranexamic acid administration for arthroscopic rotator cuff repair: a prospective, double-blind, randomized controlled trial","volume":"28","author":"Takahashi","year":"2021","journal-title":"J Orthop Sci"},{"key":"10.1016\/j.otsr.2024.103844_bib0215","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.1016\/j.arthro.2021.10.001","article-title":"Tranexamic acid administration in arthroscopic surgery is a safe adjunct to decrease postoperative pain and swelling: a systematic review and meta-analysis","volume":"38","author":"Goldstein","year":"2022","journal-title":"Arthroscopy"},{"key":"10.1016\/j.otsr.2024.103844_bib0220","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.arthro.2014.08.010","article-title":"Surgeon-rated visualization in shoulder arthroscopy: a randomized blinded controlled trial comparing irrigation fluid with and without epinephrine","volume":"31","author":"Avery","year":"2015","journal-title":"Arthroscopy"}],"container-title":["Orthopaedics & Traumatology: Surgery & Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1877056824000471?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1877056824000471?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T03:14:48Z","timestamp":1756696488000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1877056824000471"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9]]},"references-count":22,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,9]]}},"alternative-id":["S1877056824000471"],"URL":"https:\/\/doi.org\/10.1016\/j.otsr.2024.103844","relation":{},"ISSN":["1877-0568"],"issn-type":[{"value":"1877-0568","type":"print"}],"subject":[],"published":{"date-parts":[[2024,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The effect of tranexamic acid and epinephrine on visual clarity during arthroscopic shoulder surgery: A meta-analysis of RCTs","name":"articletitle","label":"Article Title"},{"value":"Orthopaedics & Traumatology: Surgery & Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.otsr.2024.103844","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Crown Copyright \u00a9 2024 Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}],"article-number":"103844"}}