{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T17:59:49Z","timestamp":1767895189621,"version":"3.49.0"},"reference-count":36,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Orthopaedics &amp; Traumatology: Surgery &amp; Research"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.otsr.2024.104067","type":"journal-article","created":{"date-parts":[[2024,11,22]],"date-time":"2024-11-22T16:05:37Z","timestamp":1732291537000},"page":"104067","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Effects of shear stress on mesenchymal stem cells of patients with osteogenesis imperfecta"],"prefix":"10.1016","volume":"111","author":[{"given":"Agathe","family":"Bedoux","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pauline","family":"Lallemant-Dudek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Morad","family":"Bensidhoum","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esther","family":"Potier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathanael","family":"Larochette","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre","family":"Mary","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rapha\u00ebl","family":"Vialle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thierry","family":"Hoc","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manon","family":"Bachy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.otsr.2024.104067_bib0005","doi-asserted-by":"crossref","first-page":"2393","DOI":"10.1002\/ajmg.a.61366","article-title":"Nosology and classification of genetic skeletal disorders: 2019 revision","volume":"179","author":"Mortier","year":"2019","journal-title":"Am J Med Genet A."},{"key":"10.1016\/j.otsr.2024.104067_bib0010","doi-asserted-by":"crossref","first-page":"S149","DOI":"10.1016\/j.otsr.2015.05.010","article-title":"Pathological fractures in children: diagnosis and treatment options","volume":"102","author":"Canavese","year":"2016","journal-title":"Orthop Traumatol Surg Res."},{"key":"10.1016\/j.otsr.2024.104067_bib0015","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1136\/jmg.16.2.101","article-title":"Genetic heterogeneity in osteogenesis imperfecta","volume":"16","author":"Sillence","year":"1979","journal-title":"J Med Genet"},{"key":"10.1016\/j.otsr.2024.104067_bib0020","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1016\/S0140-6736(15)00728-X","article-title":"Osteogenesis imperfecta","volume":"387","author":"Forlino","year":"2016","journal-title":"Lancet."},{"key":"10.1016\/j.otsr.2024.104067_bib0025","article-title":"Impact of telescopic intramedullary rodding on the growth of tibia: comparative experimental study in dogs","author":"Kononovich","year":"2023","journal-title":"Orthop Traumatol Surg Res."},{"key":"10.1016\/j.otsr.2024.104067_bib0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.otsr.2020.102759","article-title":"Telescopic rodding in children: technical progression from Dubow\u2013Bailey to Fassier\u2013DuvalTM","volume":"107","author":"Fassier","year":"2021","journal-title":"Orthop Traumatol Surg Res."},{"key":"10.1016\/j.otsr.2024.104067_bib0035","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1016\/j.otsr.2017.02.007","article-title":"Flexible intramedullary nailing for treatment of proximal humeral and humeral shaft fractures in children: a retrospective series of 118 cases","volume":"103","author":"Pogoreli\u0107","year":"2017","journal-title":"Orthop Traumatol Surg Res."},{"key":"10.1016\/j.otsr.2024.104067_bib0040","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.metabol.2017.06.001","article-title":"Osteogenesis imperfecta \u2013 A clinical update","volume":"80","author":"Tournis","year":"2018","journal-title":"Metabolism."},{"key":"10.1016\/j.otsr.2024.104067_bib0045","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1002\/jbmr.2410","article-title":"Bisphosphonates for the prevention of fractures in osteogenesis imperfecta: meta-analysis of placebo-controlled trials","volume":"30","author":"Hald","year":"2015","journal-title":"J Bone Miner Res."},{"key":"10.1016\/j.otsr.2024.104067_bib0050","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.1002\/jbmr.3143","article-title":"BPS804 anti-sclerostin antibody in adults with moderate osteogenesis imperfecta: results of a randomized phase 2a trial","volume":"32","author":"Glorieux","year":"2017","journal-title":"J Bone Miner Res."},{"key":"10.1016\/j.otsr.2024.104067_bib0055","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1186\/s13023-019-1222-2","article-title":"The evolving therapeutic landscape of genetic skeletal disorders","volume":"14","author":"Sabir","year":"2019","journal-title":"Orphanet J Rare Dis."},{"key":"10.1016\/j.otsr.2024.104067_bib0060","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.bone.2014.04.030","article-title":"Mechanical and mineral properties of osteogenesis imperfecta human bones at the tissue level","volume":"65","author":"Imbert","year":"2014","journal-title":"Bone."},{"key":"10.1016\/j.otsr.2024.104067_bib0065","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1016\/j.pcl.2014.08.010","article-title":"Update on the evaluation and treatment of osteogenesis imperfecta","volume":"61","author":"Harrington","year":"2014","journal-title":"Pediatr Clin North Am."},{"key":"10.1016\/j.otsr.2024.104067_bib0070","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1038\/nrm.2017.108","article-title":"Mechanical forces direct stem cell behaviour in development and regeneration","volume":"18","author":"Vining","year":"2017","journal-title":"Nat Rev Mol Cell Biol."},{"key":"10.1016\/j.otsr.2024.104067_bib0075","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1002\/term.166","article-title":"Responsiveness of human bone marrow stromal cells to shear stress","volume":"3","author":"Grellier","year":"2009","journal-title":"J Tissue Eng Regen Med."},{"key":"10.1016\/j.otsr.2024.104067_bib0080","doi-asserted-by":"crossref","first-page":"3824","DOI":"10.1038\/s41598-018-22174-3","article-title":"TRPV4-mediates oscillatory fluid shear mechanotransduction in mesenchymal stem cells in part via the primary cilium","volume":"8","author":"Corrigan","year":"2018","journal-title":"Sci Rep."},{"key":"10.1016\/j.otsr.2024.104067_bib0085","doi-asserted-by":"crossref","DOI":"10.3390\/genes9050247","article-title":"Journey into bone models: a review","volume":"9","author":"Scheinpflug","year":"2018","journal-title":"Genes (Basel)."},{"key":"10.1016\/j.otsr.2024.104067_bib0090","doi-asserted-by":"crossref","first-page":"160","DOI":"10.22203\/eCM.v031a11","article-title":"Human mesenchymal stem cell responses to hydrostatic pressure and shear stress","volume":"31","author":"Becquart","year":"2016","journal-title":"Eur Cell Mater"},{"key":"10.1016\/j.otsr.2024.104067_bib0095","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/0021-9290(94)90010-8","article-title":"A model for the excitation of osteocytes by mechanical loading-induced bone fluid shear stresses","volume":"27","author":"Weinbaum","year":"1994","journal-title":"J Biomech"},{"key":"10.1016\/j.otsr.2024.104067_bib0100","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.jbiomech.2017.02.002","article-title":"Oscillatory fluid flow induces The osteogenic lineage commitment of mesenchymal stem cells: the effect of shear stress magnitude, frequency, and duration","volume":"55","author":"Stavenschi","year":"2017","journal-title":"J Biomech."},{"key":"10.1016\/j.otsr.2024.104067_bib0105","doi-asserted-by":"crossref","first-page":"3297","DOI":"10.1007\/s00018-018-2830-z","article-title":"Why the impact of mechanical stimuli on stem cells remains a challenge","volume":"75","author":"Goetzke","year":"2018","journal-title":"Cell Mol Life Sci."},{"key":"10.1016\/j.otsr.2024.104067_bib0110","doi-asserted-by":"crossref","DOI":"10.1242\/bio.057778","article-title":"Design of a 3D printed, motorized, uniaxial cell stretcher for microscopic and biochemical analysis of mechanotransduction","volume":"10","author":"Al-Maslamani","year":"2021","journal-title":"Biol Open."},{"key":"10.1016\/j.otsr.2024.104067_bib0115","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/j.ejcb.2010.10.002","article-title":"Role of the immediate early response 3 (IER3) gene in cellular stress response, inflammation and tumorigenesis","volume":"90","author":"Arlt","year":"2011","journal-title":"Eur J Cell Biol."},{"key":"10.1016\/j.otsr.2024.104067_bib0120","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21051664","article-title":"EGR1 transcription factor is a multifaceted regulator of matrix production in tendons and other connective tissues","volume":"21","author":"Havis","year":"2020","journal-title":"Int J Mol Sci."},{"key":"10.1016\/j.otsr.2024.104067_bib0125","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1007\/s00109-016-1428-x","article-title":"Early growth response-1 in the pathogenesis of cardiovascular disease","volume":"94","author":"Khachigian","year":"2016","journal-title":"J Mol Med (Berl)."},{"key":"10.1016\/j.otsr.2024.104067_bib0130","doi-asserted-by":"crossref","first-page":"1720","DOI":"10.1002\/1873-3468.14407","article-title":"EGR1 plays an important role in BMP9-mediated osteoblast differentiation by promoting SMAD1\/5 phosphorylation","volume":"596","author":"Chiba","year":"2022","journal-title":"FEBS Lett."},{"key":"10.1016\/j.otsr.2024.104067_bib0135","first-page":"521","article-title":"Insulin-like growth factor binding proteins--an update","volume":"13","author":"Bach","year":"2015","journal-title":"Pediatr Endocrinol Rev."},{"key":"10.1016\/j.otsr.2024.104067_bib0140","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.202010524","article-title":"An organoid for Woven Bone","volume":"31","author":"Akiva","year":"2021","journal-title":"Adv Funct Mater"},{"key":"10.1016\/j.otsr.2024.104067_bib0145","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1126\/science.284.5411.143","article-title":"Multilineage potential of adult human mesenchymal stem cells","volume":"284","author":"Pittenger","year":"1999","journal-title":"Science."},{"key":"10.1016\/j.otsr.2024.104067_bib0150","doi-asserted-by":"crossref","first-page":"9369","DOI":"10.1038\/s41598-020-66055-0","article-title":"Low intensity vibrations augment mesenchymal stem cell proliferation and differentiation capacity during in vitro expansion","volume":"10","author":"Bas","year":"2020","journal-title":"Sci Rep."},{"key":"10.1016\/j.otsr.2024.104067_bib0155","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1007\/s11914-015-0294-8","article-title":"Vibration therapy to prevent bone loss and falls: mechanisms and efficacy","volume":"13","author":"Beck","year":"2015","journal-title":"Curr Osteoporos Rep."},{"key":"10.1016\/j.otsr.2024.104067_bib0160","doi-asserted-by":"crossref","first-page":"2734","DOI":"10.1210\/jc.2017-00275","article-title":"The effect of whole body vibration training on bone and muscle function in children with osteogenesis imperfecta","volume":"102","author":"H\u00f6gler","year":"2017","journal-title":"J Clin Endocrinol Metab."},{"key":"10.1016\/j.otsr.2024.104067_bib0165","doi-asserted-by":"crossref","first-page":"e5896","DOI":"10.1097\/MD.0000000000005896","article-title":"The effect of weight bearing on bone mineral density and bone growth in children with cerebral palsy: a randomized controlled preliminary trial","volume":"96","author":"Han","year":"2017","journal-title":"Medicine (Baltimore)."},{"key":"10.1016\/j.otsr.2024.104067_bib0170","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1007\/s11914-020-00608-0","article-title":"Does whole-body vibration treatment make children\u2019s bones stronger?","volume":"18","author":"Swolin-Eide","year":"2020","journal-title":"Curr Osteoporos Rep."},{"key":"10.1016\/j.otsr.2024.104067_bib0175","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.bjpt.2018.09.005","article-title":"Current evidence does not support whole body vibration in clinical practice in children and adolescents with disabilities: a systematic review of randomized controlled trial","volume":"23","author":"Leite","year":"2019","journal-title":"Braz J Phys Ther."},{"key":"10.1016\/j.otsr.2024.104067_bib0180","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.3390\/jcm13041065","article-title":"New perspectives of therapies in osteogenesis imperfecta\u2014A literature review","volume":"13","author":"Dinulescu","year":"2024","journal-title":"J Clin Med."}],"container-title":["Orthopaedics &amp; Traumatology: Surgery &amp; Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1877056824003657?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1877056824003657?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T01:54:54Z","timestamp":1756432494000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1877056824003657"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":36,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["S1877056824003657"],"URL":"https:\/\/doi.org\/10.1016\/j.otsr.2024.104067","relation":{},"ISSN":["1877-0568"],"issn-type":[{"value":"1877-0568","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of shear stress on mesenchymal stem cells of patients with osteogenesis imperfecta","name":"articletitle","label":"Article Title"},{"value":"Orthopaedics & Traumatology: Surgery & Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.otsr.2024.104067","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}],"article-number":"104067"}}