{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T23:57:57Z","timestamp":1789516677662,"version":"build-2803163510"},"reference-count":53,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,11,8]],"date-time":"2021-11-08T00:00:00Z","timestamp":1636329600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000223","name":"Muscular Dystrophy Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000223","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003042","name":"Else Kr\u00f6ner-Fresenius-Stiftung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003042","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018693","name":"Horizon 2020","doi-asserted-by":"publisher","award":["830965"],"award-info":[{"award-number":["830965"]}],"id":[{"id":"10.13039\/100018693","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002784","name":"Canada Excellence Research Chairs","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002784","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007216","name":"FAU SAOT","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007216","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001804","name":"Canada Research Chairs","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001804","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010661","name":"Horizon 2020 Framework Programme","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010661","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001652","name":"Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001652","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009379","name":"Interdisziplin\u00e4res Zentrum f\u00fcr Klinische Forschung, Universit\u00e4tsklinikum W\u00fcrzburg","doi-asserted-by":"publisher","award":["2018_EKMS.03"],"award-info":[{"award-number":["2018_EKMS.03"]}],"id":[{"id":"10.13039\/501100009379","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["FDN-167281"],"award-info":[{"award-number":["FDN-167281"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007601","name":"Horizon 2020","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007601","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"DFG","doi-asserted-by":"publisher","award":["FOR2438"],"award-info":[{"award-number":["FOR2438"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"DFG","doi-asserted-by":"publisher","award":["TRR241"],"award-info":[{"award-number":["TRR241"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000196","name":"Canada Foundation for Innovation","doi-asserted-by":"publisher","award":["CFI-JELF 38412"],"award-info":[{"award-number":["CFI-JELF 38412"]}],"id":[{"id":"10.13039\/501100000196","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Photoacoustics"],"published-print":{"date-parts":[[2022,3]]},"DOI":"10.1016\/j.pacs.2021.100315","type":"journal-article","created":{"date-parts":[[2021,11,9]],"date-time":"2021-11-09T20:44:19Z","timestamp":1636490659000},"page":"100315","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":33,"special_numbering":"C","title":["Multispectral optoacoustic tomography for non-invasive disease phenotyping in pediatric spinal muscular atrophy patients"],"prefix":"10.1016","volume":"25","author":[{"given":"Adrian P.","family":"Regensburger","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra L.","family":"Wagner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vera","family":"Danko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f6rg","family":"J\u00fcngert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Federle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Klett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Schuessler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian","family":"Buehler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus F.","family":"Neurath","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Roos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanns","family":"Lochm\u00fcller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joachim","family":"Woelfle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Regina","family":"Trollmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maximilian J.","family":"Waldner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ferdinand","family":"Knieling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.pacs.2021.100315_bib1","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/0092-8674(95)90460-3","article-title":"Identification and characterization of a spinal muscular atrophy-determining gene","volume":"80","author":"Lefebvre","year":"1995","journal-title":"Cell"},{"key":"10.1016\/j.pacs.2021.100315_bib2","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.nmd.2008.10.004","article-title":"Ramblings in the history of spinal muscular atrophy","volume":"19","author":"Dubowitz","year":"2009","journal-title":"Neuromuscul. Disord."},{"key":"10.1016\/j.pacs.2021.100315_bib3","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1038\/71709","article-title":"A mouse model for spinal muscular atrophy","volume":"24","author":"Hsieh-Li","year":"2000","journal-title":"Nat. Genet"},{"key":"10.1016\/j.pacs.2021.100315_bib4","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1097\/00125817-200201000-00004","article-title":"Molecular analysis of spinal muscular atrophy and modification of the phenotype by SMN2","volume":"4","author":"Mailman","year":"2002","journal-title":"Genet. Med."},{"key":"10.1016\/j.pacs.2021.100315_bib5","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3389\/fmolb.2016.00007","article-title":"Copy number variations in the survival motor neuron genes: implications for spinal muscular atrophy and other neurodegenerative diseases","volume":"3","author":"Butchbach","year":"2016","journal-title":"Front. Mol. Biosci."},{"issue":"2","key":"10.1016\/j.pacs.2021.100315_bib6","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/0960-8966(91)90052-T","article-title":"Workshop report: international SMA collaboration","volume":"1","author":"Munsat","year":"1991","journal-title":"Neuromuscul. Disord."},{"key":"10.1016\/j.pacs.2021.100315_bib7","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1093\/brain\/96.3.463","article-title":"The genetic identity of acute infantile spinal muscular atrophy","volume":"96","author":"Pearn","year":"1973","journal-title":"Brain"},{"key":"10.1016\/j.pacs.2021.100315_bib8","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/0960-8966(94)90090-6","article-title":"The natural history of type I (severe) spinal muscular atrophy","volume":"4","author":"Thomas","year":"1994","journal-title":"Neuromuscul. Disord."},{"key":"10.1016\/j.pacs.2021.100315_bib9","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1212\/WNL.0000000000000741","article-title":"Observational study of spinal muscular atrophy type I and implications for clinical trials","volume":"83","author":"Finkel","year":"2014","journal-title":"Neurology"},{"key":"10.1016\/j.pacs.2021.100315_bib10","first-page":"1","article-title":"Deaths: preliminary data for 2008","volume":"59","author":"Minino","year":"2010","journal-title":"Natl. Vital.-. Stat. Rep."},{"key":"10.1016\/j.pacs.2021.100315_bib11","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1083\/jcb.201207087","article-title":"Antisense-based therapy for the treatment of spinal muscular atrophy","volume":"199","author":"Rigo","year":"2012","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.pacs.2021.100315_bib12","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1056\/NEJMoa1702752","article-title":"Nusinersen versus sham control in infantile-onset spinal muscular atrophy","volume":"377","author":"Finkel","year":"2017","journal-title":"New Engl. J. Med."},{"key":"10.1016\/j.pacs.2021.100315_bib13","doi-asserted-by":"crossref","first-page":"1476","DOI":"10.1038\/s41467-017-01559-4","article-title":"Binding to SMN2 pre-mRNA-protein complex elicits specificity for small molecule splicing modifiers","volume":"8","author":"Sivaramakrishnan","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.pacs.2021.100315_bib14","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3000830","article-title":"Systemic delivery of scAAV9 expressing SMN prolongs survival in a model of spinal muscular atrophy","volume":"2","author":"Valori","year":"2010","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.pacs.2021.100315_bib15","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1038\/nbt.1610","article-title":"Rescue of the spinal muscular atrophy phenotype in a mouse model by early postnatal delivery of SMN","volume":"28","author":"Foust","year":"2010","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.pacs.2021.100315_bib16","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1056\/NEJMoa1706198","article-title":"Single-dose gene-replacement therapy for spinal muscular atrophy","volume":"377","author":"Mendell","year":"2017","journal-title":"New Engl. J. Med."},{"key":"10.1016\/j.pacs.2021.100315_bib17","doi-asserted-by":"crossref","first-page":"3034","DOI":"10.1111\/jcmm.14939","article-title":"Nusinersen treatment and cerebrospinal fluid neurofilaments: an explorative study on spinal muscular atrophy type 3 patients","volume":"24","author":"Faravelli","year":"2020","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.pacs.2021.100315_bib18","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1002\/acn3.406","article-title":"Longitudinal characterization of biomarkers for spinal muscular atrophy","volume":"4","author":"Bonati","year":"2017","journal-title":"Ann. Clin. Transl. Neurol."},{"key":"10.1016\/j.pacs.2021.100315_bib19","doi-asserted-by":"crossref","first-page":"10","DOI":"10.3389\/fneur.2019.00898","article-title":"Biomarkers and the development of a personalized medicine approach in spinal muscular atrophy","volume":"10","author":"Kariyawasam","year":"2019","journal-title":"Front. Neurol."},{"key":"10.1016\/j.pacs.2021.100315_bib20","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0172346","article-title":"Revised hammersmith scale for spinal muscular atrophy: a SMA specific clinical outcome assessment tool","volume":"12","author":"Ramsey","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.pacs.2021.100315_bib21","doi-asserted-by":"crossref","first-page":"2783","DOI":"10.1021\/cr9002566","article-title":"Molecular imaging by means of multispectral optoacoustic tomography (MSOT)","volume":"110","author":"Ntziachristos","year":"2010","journal-title":"Chem. Rev."},{"key":"10.1016\/j.pacs.2021.100315_bib22","doi-asserted-by":"crossref","first-page":"1905","DOI":"10.1038\/s41591-019-0669-y","article-title":"Detection of collagens by multispectral optoacoustic tomography as an imaging biomarker for Duchenne muscular dystrophy","volume":"25","author":"Regensburger","year":"2019","journal-title":"Nat. Med."},{"key":"10.1016\/j.pacs.2021.100315_bib23","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1056\/NEJMc1612455","article-title":"Multispectral optoacoustic tomography for assessment of Crohn\u2019s disease activity","volume":"376","author":"Knieling","year":"2017","journal-title":"New Engl. J. Med."},{"key":"10.1016\/j.pacs.2021.100315_bib24","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1053\/j.gastro.2016.05.047","article-title":"Multispectral optoacoustic tomography in Crohn\u2019s disease: noninvasive imaging of disease activity","volume":"151","author":"Waldner","year":"2016","journal-title":"Gastroenterology"},{"key":"10.1016\/j.pacs.2021.100315_bib25","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1002\/mus.24296","article-title":"Quantitative muscle ultrasound in Duchenne muscular dystrophy: a comparison of techniques","volume":"51","author":"Shklyar","year":"2015","journal-title":"Muscle Nerve"},{"key":"10.1016\/j.pacs.2021.100315_bib26","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1016\/S0022-3476(82)80286-2","article-title":"Ultrasound imaging in the diagnosis of muscle disease","volume":"101","author":"Heckmatt","year":"1982","journal-title":"J. Pedia"},{"key":"10.1016\/j.pacs.2021.100315_bib27","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1002\/mus.21015","article-title":"Muscle ultrasound in neuromuscular disorders","volume":"37","author":"Pillen","year":"2008","journal-title":"Muscle Nerve"},{"key":"10.1016\/j.pacs.2021.100315_bib28","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1038\/nphoton.2009.98","article-title":"Multispectral opto-acoustic tomography of deep-seated \ufb02uorescent proteins in vivo","volume":"3","author":"Razansky","year":"2009","journal-title":"Nat. Photonics"},{"key":"10.1016\/j.pacs.2021.100315_bib29","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1037\/1082-989X.1.1.30","article-title":"Forming inferences about some intraclass correlation coefficients","volume":"1","author":"McGraw","year":"1996","journal-title":"Psychol. Methods"},{"key":"10.1016\/j.pacs.2021.100315_bib30","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.jcm.2016.02.012","article-title":"A guideline of selecting and reporting intraclass correlation coefficients for reliability research","volume":"15","author":"Koo","year":"2016","journal-title":"J. Chiropr. Med."},{"key":"10.1016\/j.pacs.2021.100315_bib31","doi-asserted-by":"crossref","first-page":"159","DOI":"10.2307\/2529310","article-title":"The measurement of observer agreement for categorical data","volume":"33","author":"Landis","year":"1977","journal-title":"Biometrics"},{"key":"10.1016\/j.pacs.2021.100315_bib32","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.pacs.2016.05.003","article-title":"In-vivo handheld optoacoustic tomography of the human thyroid","volume":"4","author":"Dima","year":"2016","journal-title":"Photoacoustics"},{"key":"10.1016\/j.pacs.2021.100315_bib33","doi-asserted-by":"crossref","first-page":"3395","DOI":"10.1364\/BOE.8.003395","article-title":"Flow-mediated dilatation test using optoacoustic imaging: a proof-of-concept","volume":"8","author":"Karlas","year":"2017","journal-title":"Biomed. Opt. Express"},{"key":"10.1016\/j.pacs.2021.100315_bib34","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.pacs.2019.03.001","article-title":"Cardiovascular optoacoustics: from mice to men - a review","volume":"14","author":"Karlas","year":"2019","journal-title":"Photoacoustics"},{"key":"10.1016\/j.pacs.2021.100315_bib35","article-title":"Precision of handheld multispectral optoacoustic tomography for muscle imaging","author":"Wagner","year":"2020","journal-title":"Photoacoustics"},{"key":"10.1016\/j.pacs.2021.100315_bib36","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/s40348-020-00095-4","article-title":"Shedding light on pediatric diseases: multispectral optoacoustic tomography at the doorway to clinical applications","volume":"7","author":"Regensburger","year":"2020","journal-title":"Mol. Cell. Pediatr."},{"key":"10.1016\/j.pacs.2021.100315_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.pacs.2019.100144","article-title":"A review of clinical photoacoustic imaging: current and future trends","volume":"16","author":"Attia","year":"2019","journal-title":"Photoacoustics"},{"key":"10.1016\/j.pacs.2021.100315_bib38","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1109\/TMI.2013.2279994","article-title":"Unmixing molecular agents from absorbing tissue in multispectral optoacoustic tomography","volume":"33","author":"Tzoumas","year":"2014","journal-title":"IEEE Trans. Med. Imaging"},{"key":"10.1016\/j.pacs.2021.100315_bib39","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1038\/nphoton.2015.29","article-title":"Advances in real-time multispectral optoacoustic imaging and its applications","volume":"9","author":"Taruttis","year":"2015","journal-title":"Nat. Photonics"},{"key":"10.1016\/j.pacs.2021.100315_bib40","doi-asserted-by":"crossref","DOI":"10.1117\/1.JBO.18.10.101318","article-title":"Multispectral imaging in the extended near-infrared window based on endogenous chromophores","volume":"18","author":"Cao","year":"2013","journal-title":"J. Biomed. Opt."},{"key":"10.1016\/j.pacs.2021.100315_bib41","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1093\/brain\/87.4.707","article-title":"Infantile muscular atrophy. A prospective study with particular reference to a slowly progressive variety","volume":"87","author":"Dubowitz","year":"1964","journal-title":"Brain"},{"key":"10.1016\/j.pacs.2021.100315_bib42","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/0022-510X(71)90050-5","article-title":"Ultrastructure of muscle in infantile spinal muscular atrophy","volume":"12","author":"Roy","year":"1971","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.pacs.2021.100315_bib43","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1038\/s41556-018-0151-y","article-title":"Denervation-activated STAT3-IL-6 signalling in fibro-adipogenic progenitors promotes myofibres atrophy and fibrosis","volume":"20","author":"Madaro","year":"2018","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.pacs.2021.100315_bib44","first-page":"184","article-title":"The role of fibrosis in Duchenne muscular dystrophy","volume":"31","author":"Klingler","year":"2012","journal-title":"Acta Myol."},{"key":"10.1016\/j.pacs.2021.100315_bib45","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1002\/mus.880110313","article-title":"Muscle imaging in neuromuscular disease using computerized real-time sonography","volume":"11","author":"Fischer","year":"1988","journal-title":"Muscle Nerve"},{"key":"10.1016\/j.pacs.2021.100315_bib46","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1002\/jmri.20804","article-title":"Muscle MRI in inherited neuromuscular disorders: past, present, and future","volume":"25","author":"Mercuri","year":"2007","journal-title":"J. Magn. Reason. Imaging"},{"key":"10.1016\/j.pacs.2021.100315_bib47","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1007\/BF02015357","article-title":"Spinal muscular-atrophy - Mr Evaluation","volume":"22","author":"Liu","year":"1992","journal-title":"Pedia Radio."},{"key":"10.1016\/j.pacs.2021.100315_bib48","first-page":"379","article-title":"Time tracking of standard ultrasound examinations in pediatric hospitals and pediatric medical practices - a multicenter study by the pediatric section of the German society of ultrasound in medicine (DEGUM)","volume":"42","author":"Regensburger","year":"2019","journal-title":"Ultraschall Med."},{"key":"10.1016\/j.pacs.2021.100315_bib49","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1364\/BOE.415481","article-title":"Technical considerations in the Verasonics research ultrasound platform for developing a photoacoustic imaging system","volume":"12","author":"Kratkiewicz","year":"2021","journal-title":"Biomed. Opt. Express"},{"key":"10.1016\/j.pacs.2021.100315_bib50","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1038\/s41566-019-0417-3","article-title":"Addressing photoacoustics standards","volume":"13","author":"Bohndiek","year":"2019","journal-title":"Nat. Photonics"},{"key":"10.1016\/j.pacs.2021.100315_bib51","doi-asserted-by":"crossref","DOI":"10.1016\/j.pacs.2021.100241","article-title":"Deep learning for biomedical photoacoustic imaging: a review","volume":"22","author":"Grohl","year":"2021","journal-title":"Photoacoustics"},{"key":"10.1016\/j.pacs.2021.100315_bib52","doi-asserted-by":"crossref","first-page":"503","DOI":"10.3233\/JND-190428","article-title":"One year of newborn screening for SMA - results of a German pilot project","volume":"6","author":"Vill","year":"2019","journal-title":"J. Neuromuscul. Dis."},{"key":"10.1016\/j.pacs.2021.100315_bib53","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/s13023-019-0998-4","article-title":"SMArtCARE - a platform to collect real-life outcome data of patients with spinal muscular atrophy","volume":"14","author":"Pechmann","year":"2019","journal-title":"Orphanet J. Rare Dis."}],"container-title":["Photoacoustics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213597921000744?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213597921000744?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T15:07:50Z","timestamp":1778857670000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213597921000744"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3]]},"references-count":53,"alternative-id":["S2213597921000744"],"URL":"https:\/\/doi.org\/10.1016\/j.pacs.2021.100315","relation":{},"ISSN":["2213-5979"],"issn-type":[{"value":"2213-5979","type":"print"}],"subject":[],"published":{"date-parts":[[2022,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Multispectral optoacoustic tomography for non-invasive disease phenotyping in pediatric spinal muscular atrophy patients","name":"articletitle","label":"Article Title"},{"value":"Photoacoustics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pacs.2021.100315","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Author(s). Published by Elsevier GmbH.","name":"copyright","label":"Copyright"}],"article-number":"100315"}}