{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T17:39:19Z","timestamp":1781199559594,"version":"3.54.1"},"reference-count":109,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,7,13]],"date-time":"2023-07-13T00:00:00Z","timestamp":1689206400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["320030_179277"],"award-info":[{"award-number":["320030_179277"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008494","name":"Vontobel-Stiftung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008494","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012654","name":"Olga Mayenfisch Stiftung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012654","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008947","name":"Synapsis Foundation - Alzheimer Research Switzerland","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008947","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013850","name":"Helmut Horten Stiftung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013850","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001942","name":"European Coordinated Research on Long-term Challenges in Information and Communication Sciences &amp; Technologies ERA-NET","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001942","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006447","name":"University of Zurich","doi-asserted-by":"publisher","award":["MEDEF-20-021"],"award-info":[{"award-number":["MEDEF-20-021"]}],"id":[{"id":"10.13039\/501100006447","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Photoacoustics"],"published-print":{"date-parts":[[2023,8]]},"DOI":"10.1016\/j.pacs.2023.100532","type":"journal-article","created":{"date-parts":[[2023,7,15]],"date-time":"2023-07-15T12:56:32Z","timestamp":1689425792000},"page":"100532","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Imaging increased metabolism in the spinal cord in mice after middle cerebral artery occlusion"],"prefix":"10.1016","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0793-2113","authenticated-orcid":false,"given":"Ruiqing","family":"Ni","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadja","family":"Straumann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serana","family":"Fazio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xose Luis","family":"Dean-Ben","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgios","family":"Louloudis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Keller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Razansky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Ametamey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linjing","family":"Mu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9sar","family":"Nombela-Arrieta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Klohs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.pacs.2023.100532_bib1","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1084\/jem.20021098","article-title":"Stroke-induced immunodeficiency promotes spontaneous bacterial infections and is mediated by sympathetic activation reversal by poststroke T helper cell type 1-like immunostimulation","volume":"198","author":"Prass","year":"2003","journal-title":"J. Exp. Med"},{"issue":"2 Suppl","key":"10.1016\/j.pacs.2023.100532_bib2","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1161\/01.STR.0000251441.89665.bc","article-title":"Stroke-induced immunodepression: experimental evidence and clinical relevance","volume":"38","author":"Dirnagl","year":"2007","journal-title":"Stroke"},{"issue":"3","key":"10.1016\/j.pacs.2023.100532_bib3","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1016\/j.neuroscience.2008.10.005","article-title":"Non-invasive visualization of CNS inflammation with nuclear and optical imaging","volume":"158","author":"Wunder","year":"2009","journal-title":"Neuroscience"},{"issue":"3","key":"10.1016\/j.pacs.2023.100532_bib4","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1161\/CIRCRESAHA.116.305207","article-title":"Ischemic stroke activates hematopoietic bone marrow stem cells","volume":"116","author":"Courties","year":"2015","journal-title":"Circ. Res"},{"issue":"7","key":"10.1016\/j.pacs.2023.100532_bib5","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1038\/nm.2399","article-title":"The immunology of stroke: from mechanisms to translation","volume":"17","author":"Iadecola","year":"2011","journal-title":"Nat. Med"},{"issue":"5940","key":"10.1016\/j.pacs.2023.100532_bib6","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1126\/science.1175202","article-title":"Identification of splenic reservoir monocytes and their deployment to inflammatory sites","volume":"325","author":"Swirski","year":"2009","journal-title":"Science"},{"issue":"8","key":"10.1016\/j.pacs.2023.100532_bib7","doi-asserted-by":"crossref","first-page":"2833","DOI":"10.1177\/0271678X16676825","article-title":"Non-invasive near-infrared fluorescence imaging of the neutrophil response in a mouse model of transient cerebral ischaemia","volume":"37","author":"Vaas","year":"2017","journal-title":"J. Cereb. Blood Flow. Metab."},{"issue":"15","key":"10.1016\/j.pacs.2023.100532_bib8","doi-asserted-by":"crossref","first-page":"4182","DOI":"10.1523\/JNEUROSCI.4317-15.2016","article-title":"Monocyte-derived macrophages contribute to spontaneous long-term functional recovery after stroke in mice","volume":"36","author":"Wattananit","year":"2016","journal-title":"J. Neurosci."},{"issue":"10","key":"10.1016\/j.pacs.2023.100532_bib9","doi-asserted-by":"crossref","first-page":"2845","DOI":"10.1161\/STROKEAHA.107.509844","article-title":"In vivo imaging of the inflammatory receptor CD40 after cerebral ischemia using a fluorescent antibody","volume":"39","author":"Klohs","year":"2008","journal-title":"Stroke"},{"issue":"8","key":"10.1016\/j.pacs.2023.100532_bib10","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1038\/jcbfm.2014.101","article-title":"Role of spleen-derived monocytes\/macrophages in acute ischemic brain injury","volume":"34","author":"Kim","year":"2014","journal-title":"J. Cereb. Blood Flow. Metab."},{"issue":"1","key":"10.1016\/j.pacs.2023.100532_bib11","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.expneurol.2006.03.017","article-title":"Cord blood rescues stroke-induced changes in splenocyte phenotype and function","volume":"199","author":"Vendrame","year":"2006","journal-title":"Exp. Neurol."},{"issue":"5","key":"10.1016\/j.pacs.2023.100532_bib12","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1038\/sj.jcbfm.9600217","article-title":"Experimental stroke induces massive, rapid activation of the peripheral immune system","volume":"26","author":"Offner","year":"2006","journal-title":"J. Cereb. Blood Flow. Metab."},{"issue":"11","key":"10.1016\/j.pacs.2023.100532_bib13","doi-asserted-by":"crossref","first-page":"6523","DOI":"10.4049\/jimmunol.176.11.6523","article-title":"Splenic atrophy in experimental stroke is accompanied by increased regulatory T cells and circulating macrophages","volume":"176","author":"Offner","year":"2006","journal-title":"J. Immunol."},{"key":"10.1016\/j.pacs.2023.100532_bib14","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1186\/1742-2094-7-92","article-title":"A role for spleen monocytes in post-ischemic brain inflammation and injury","volume":"7","author":"Bao","year":"2010","journal-title":"J. Neuroinflamm."},{"issue":"8","key":"10.1016\/j.pacs.2023.100532_bib15","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1038\/jcbfm.2014.101","article-title":"Role of spleen-derived monocytes\/macrophages in acute ischemic brain injury","volume":"34","author":"Kim","year":"2014","journal-title":"J. Cereb. Blood Flow. Metab."},{"issue":"7","key":"10.1016\/j.pacs.2023.100532_bib16","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1093\/jnen\/nlw040","article-title":"Blood-spinal cord barrier alterations in subacute and chronic stages of a rat model of focal cerebral ischemia","volume":"75","author":"Garbuzova-Davis","year":"2016","journal-title":"J. Neuropathol. Exp. Neurol."},{"issue":"5","key":"10.1016\/j.pacs.2023.100532_bib17","doi-asserted-by":"crossref","first-page":"1952","DOI":"10.1159\/000445556","article-title":"GlyT1 inhibitor NFPS exerts neuroprotection via GlyR Alpha1 subunit in the rat model of transient focal cerebral ischaemia and reperfusion","volume":"38","author":"Huang","year":"2016","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.pacs.2023.100532_bib18","doi-asserted-by":"crossref","first-page":"22655","DOI":"10.1038\/srep22655","article-title":"Dynamic secondary degeneration in the spinal cord and ventral root after a focal cerebral infarction among hypertensive rats","volume":"6","author":"Dang","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.pacs.2023.100532_bib19","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/1742-2094-5-29","article-title":"Transient middle cerebral artery occlusion induces microglial priming in the lumbar spinal cord: a novel model of neuroinflammation","volume":"5","author":"Moisse","year":"2008","journal-title":"J. Neuroinflamm."},{"issue":"6","key":"10.1016\/j.pacs.2023.100532_bib20","first-page":"729","article-title":"Alterations in the spinal cord and ventral root after cerebral infarction in non-human primates","volume":"36","author":"Dang","year":"2018","journal-title":"Restor. Neurol. Neurosci."},{"issue":"4","key":"10.1016\/j.pacs.2023.100532_bib21","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1038\/nrm3772","article-title":"Metabolic requirements for the maintenance of self-renewing stem cells","volume":"15","author":"Ito","year":"2014","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.pacs.2023.100532_bib22","doi-asserted-by":"crossref","first-page":"27","DOI":"10.3389\/fimmu.2011.00027","article-title":"In vivo T cell activation in lymphoid tissues is inhibited in the oxygen-poor microenvironment","volume":"2","author":"Ohta","year":"2011","journal-title":"Front. Immunol."},{"issue":"1","key":"10.1016\/j.pacs.2023.100532_bib23","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1097\/01.rlu.0000191574.30071.d7","article-title":"Diffuse metabolic activation of reticuloendothelium on F-18 FDG PET imaging in a case of visceral leishmania","volume":"31","author":"Lupi","year":"2006","journal-title":"Clin. Nucl. Med"},{"issue":"1","key":"10.1016\/j.pacs.2023.100532_bib24","first-page":"23","article-title":"Increased 18F-FDG uptake within the reticuloendothelial system in patients with active lung cancer on PET imaging may indicate activation of the systemic immune response","volume":"13","author":"Bural","year":"2010","journal-title":"Hell. J. Nucl. Med"},{"issue":"6","key":"10.1016\/j.pacs.2023.100532_bib25","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1007\/s00259-004-1757-9","article-title":"The value of [18F]FDG-PET in the diagnosis of large-vessel vasculitis and the assessment of activity and extent of disease","volume":"32","author":"Walter","year":"2005","journal-title":"Eur. J. Nucl. Med Mol. Imaging"},{"issue":"3","key":"10.1016\/j.pacs.2023.100532_bib26","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1161\/CIRCIMAGING.113.001093","article-title":"Metabolic activity of the spleen and bone marrow in patients with acute myocardial infarction evaluated by 18f-fluorodeoxyglucose positron emission tomograpic imaging","volume":"7","author":"Kim","year":"2014","journal-title":"Circ. Cardiovasc Imaging"},{"issue":"15","key":"10.1016\/j.pacs.2023.100532_bib27","doi-asserted-by":"crossref","first-page":"1911","DOI":"10.1093\/eurheartj\/ehr388","article-title":"Acute myocardial infarction activates progenitor cells and increases Wnt signalling in the bone marrow","volume":"33","author":"Assmus","year":"2012","journal-title":"Eur. Heart J."},{"issue":"1","key":"10.1016\/j.pacs.2023.100532_bib28","doi-asserted-by":"crossref","first-page":"41","DOI":"10.3988\/jcn.2021.17.1.41","article-title":"Decreased (18F)-fluorodeoxyglucose uptake in lumbar vertebrae of stroke patients","volume":"17","author":"Kim","year":"2021","journal-title":"J. Clin. Neurol."},{"key":"10.1016\/j.pacs.2023.100532_bib29","doi-asserted-by":"crossref","DOI":"10.1007\/s00259-021-05207-4","article-title":"Multi-scale optoacoustic molecular imaging of brain diseases","author":"Razansky","year":"2021","journal-title":"Eur. J. Nucl. Med. Mol. Imaging"},{"issue":"8","key":"10.1016\/j.pacs.2023.100532_bib30","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1038\/nprot.2011.351","article-title":"Volumetric real-time multispectral optoacoustic tomography of biomarkers","volume":"6","author":"Razansky","year":"2011","journal-title":"Nat. Protoc."},{"issue":"6075","key":"10.1016\/j.pacs.2023.100532_bib31","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.1126\/science.1216210","article-title":"Photoacoustic tomography: in vivo imaging from organelles to organs","volume":"335","author":"Wang","year":"2012","journal-title":"Science"},{"key":"10.1016\/j.pacs.2023.100532_bib32","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.pacs.2018.04.001","article-title":"Cortical hypoperfusion and reduced cerebral metabolic rate of oxygen in the arcA\u03b2 mouse model of Alzheimer\u2019s disease","volume":"10","author":"Ni","year":"2018","journal-title":"Photoacoustics"},{"key":"10.1016\/j.pacs.2023.100532_bib33","doi-asserted-by":"crossref","unstructured":"X.L. De\u00e1n-Ben, J. Robin, R. Ni, D. Razansky, Noninvasive three-dimensional optoacoustic localization microangiography of deep tissues, arXiv preprint arXiv:2007.00372 (2020).","DOI":"10.21203\/rs.3.rs-536048\/v1"},{"issue":"3","key":"10.1016\/j.pacs.2023.100532_bib34","doi-asserted-by":"crossref","first-page":"253","DOI":"10.55782\/ane-2012-1898","article-title":"Photoacoustic tomography can detect cerebral hemodynamic alterations in a neonatal rodent model of hypoxia-ischemia","volume":"72","author":"Sussman","year":"2012","journal-title":"Acta Neurobiol. Exp."},{"issue":"4","key":"10.1016\/j.pacs.2023.100532_bib35","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0096118","article-title":"Functional real-time optoacoustic imaging of middle cerebral artery occlusion in mice","volume":"9","author":"Kneipp","year":"2014","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.pacs.2023.100532_bib36","doi-asserted-by":"crossref","first-page":"816","DOI":"10.7150\/thno.38554","article-title":"In vivo photoacoustic imaging dynamically monitors the structural and functional changes of ischemic stroke at a very early stage","volume":"10","author":"Lv","year":"2020","journal-title":"Theranostics"},{"issue":"4","key":"10.1016\/j.pacs.2023.100532_bib37","doi-asserted-by":"crossref","DOI":"10.1117\/1.NPh.4.4.045002","article-title":"Integrated treatment modality of cathodal-transcranial direct current stimulation with peripheral sensory stimulation affords neuroprotection in a rat stroke model","volume":"4","author":"Liu","year":"2017","journal-title":"Neurophotonics"},{"key":"10.1016\/j.pacs.2023.100532_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.pacs.2021.100287","article-title":"Photoacoustic imaging for monitoring of stroke diseases: A review","volume":"23","author":"Yang","year":"2021","journal-title":"Photoacoustics"},{"issue":"1","key":"10.1016\/j.pacs.2023.100532_bib39","doi-asserted-by":"crossref","first-page":"3584","DOI":"10.1038\/s41467-023-39069-1","article-title":"Deep optoacoustic localization microangiography of ischemic stroke in mice","volume":"14","author":"De\u00e1n-Ben","year":"2023","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.pacs.2023.100532_bib40","doi-asserted-by":"crossref","DOI":"10.1117\/1.NPh.5.1.015005","article-title":"Non-invasive detection of acute cerebral hypoxia and subsequent matrix-metalloproteinase activity in a mouse model of cerebral ischemia using multispectral-optoacoustic-tomography","volume":"5","author":"Ni","year":"2018","journal-title":"Neurophotonics"},{"key":"10.1016\/j.pacs.2023.100532_bib41","doi-asserted-by":"crossref","first-page":"85","DOI":"10.3389\/fneur.2017.00085","article-title":"Extracerebral tissue damage in the intraluminal filament mouse model of middle cerebral artery occlusion","volume":"8","author":"Vaas","year":"2017","journal-title":"Front Neurol."},{"key":"10.1016\/j.pacs.2023.100532_bib42","article-title":"In vivo imaging of cannabinoid type 2 receptors: functional and structural alterations in mouse model of cerebral ischemia by PET and MRI","author":"Ni","year":"2021","journal-title":"Mol. Imaging Biol."},{"issue":"6","key":"10.1016\/j.pacs.2023.100532_bib43","doi-asserted-by":"crossref","first-page":"1937","DOI":"10.1073\/pnas.0610544104","article-title":"Positron emission tomography with computed tomography imaging of neuroinflammation in experimental autoimmune encephalomyelitis","volume":"104","author":"Radu","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"2","key":"10.1016\/j.pacs.2023.100532_bib44","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1117\/1.NPh.6.2.025001","article-title":"Automated registration of magnetic resonance imaging and optoacoustic tomography data for experimental studies","volume":"6","author":"Ren","year":"2019","journal-title":"Neurophotonics"},{"key":"10.1016\/j.pacs.2023.100532_bib45","doi-asserted-by":"crossref","DOI":"10.1016\/j.pacs.2021.100285","article-title":"In-vitro and in-vivo characterization of CRANAD-2 for multi-spectral optoacoustic tomography and fluorescence imaging of amyloid-beta deposits in Alzheimer mice","volume":"23","author":"Ni","year":"2021","journal-title":"Photoacoustics"},{"key":"10.1016\/j.pacs.2023.100532_bib46","doi-asserted-by":"crossref","unstructured":"Y. Hu, B. Lafci, A. Luzgin, H. Wang, J. Klohs, X.L. Dean-Ben, R. Ni, D. Razansky, W. Ren, Deep learning facilitates fully automated brain image registration of optoacoustic tomography and magnetic resonance imaging, (2021).","DOI":"10.1117\/12.2655214"},{"issue":"17","key":"10.1016\/j.pacs.2023.100532_bib47","doi-asserted-by":"crossref","first-page":"6733","DOI":"10.1088\/0031-9155\/60\/17\/6733","article-title":"Efficient non-negative constrained model-based inversion in optoacoustic tomography","volume":"60","author":"Ding","year":"2015","journal-title":"Phys. Med Biol."},{"key":"10.1016\/j.pacs.2023.100532_bib48","unstructured":"R.C. Team, R: A language and environment for statistical computing, (2013)."},{"issue":"5","key":"10.1016\/j.pacs.2023.100532_bib49","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1016\/j.tranon.2018.07.001","article-title":"Noninvasive anatomical and functional imaging of orthotopic glioblastoma development and therapy using multispectral optoacoustic tomography","volume":"11","author":"Balasundaram","year":"2018","journal-title":"Transl. Oncol."},{"key":"10.1016\/j.pacs.2023.100532_bib50","series-title":"The Spinal Cord","first-page":"308","article-title":"Chapter 16 - Atlas of the Mouse Spinal Cord","author":"Watson","year":"2009"},{"issue":"1","key":"10.1016\/j.pacs.2023.100532_bib51","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1186\/s13550-020-00680-8","article-title":"[(18)F]FDG uptake of the normal spinal cord in PET\/MR imaging: comparison with PET\/CT imaging","volume":"10","author":"Aiello","year":"2020","journal-title":"EJNMMI Res"},{"issue":"1","key":"10.1016\/j.pacs.2023.100532_bib52","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.neuroimage.2011.04.045","article-title":"Longitudinal studies of ischemic penumbra by using 18F-FDG PET and MRI techniques in permanent and transient focal cerebral ischemia in rats","volume":"57","author":"Sobrado","year":"2011","journal-title":"NeuroImage"},{"issue":"8","key":"10.1016\/j.pacs.2023.100532_bib53","doi-asserted-by":"crossref","first-page":"2292","DOI":"10.1161\/STROKEAHA.113.000903","article-title":"Spatiotemporal uptake characteristics of [18]F-2-fluoro-2-deoxy-D-glucose in a rat middle cerebral artery occlusion model","volume":"44","author":"Yuan","year":"2013","journal-title":"Stroke"},{"issue":"4","key":"10.1016\/j.pacs.2023.100532_bib54","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1007\/s12975-019-00765-0","article-title":"Positron emission tomography after ischemic brain injury: current challenges and future developments","volume":"11","author":"Wang","year":"2020","journal-title":"Transl. Stroke Res"},{"issue":"8","key":"10.1016\/j.pacs.2023.100532_bib55","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.2967\/jnumed.111.102608","article-title":"18F-FDG PET detects inflammatory infiltrates in spinal cord experimental autoimmune encephalomyelitis lesions","volume":"53","author":"Buck","year":"2012","journal-title":"J. Nucl. Med"},{"issue":"1","key":"10.1016\/j.pacs.2023.100532_bib56","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1186\/s12974-018-1080-1","article-title":"[(18)F]FSPG-PET reveals increased cystine\/glutamate antiporter (xc-) activity in a mouse model of multiple sclerosis","volume":"15","author":"Hoehne","year":"2018","journal-title":"J. Neuroinflamm."},{"key":"10.1016\/j.pacs.2023.100532_bib57","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2021.676257","article-title":"[ (18) F]FDG PET\/CT studies in transgenic Hualpha-Syn (A53T) Parkinson's disease mouse model of \u03b1-synucleinopathy","volume":"15","author":"Mondal","year":"2021","journal-title":"Front Neurosci."},{"issue":"48","key":"10.1016\/j.pacs.2023.100532_bib58","doi-asserted-by":"crossref","first-page":"17412","DOI":"10.1073\/pnas.0508698102","article-title":"Visualization of a primary anti-tumor immune response by positron emission tomography","volume":"102","author":"Shu","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"7","key":"10.1016\/j.pacs.2023.100532_bib59","doi-asserted-by":"crossref","first-page":"2641","DOI":"10.1172\/JCI41250C1","article-title":"PET probes for distinct metabolic pathways have different cell specificities during immune responses in mice","volume":"120","author":"Nair-Gill","year":"2010","journal-title":"J. Clin. Investig."},{"issue":"1","key":"10.1016\/j.pacs.2023.100532_bib60","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1186\/s13550-018-0435-z","article-title":"In vivo imaging of the immune response upon systemic RNA cancer vaccination by FDG-PET","volume":"8","author":"Pektor","year":"2018","journal-title":"EJNMMI Res"},{"issue":"5","key":"10.1016\/j.pacs.2023.100532_bib61","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0127685","article-title":"Evaluation of avulsion-induced neuropathology in rat spinal cords with 18F-FDG Micro-PET\/CT","volume":"10","author":"Ling","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.pacs.2023.100532_bib62","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.neulet.2016.04.027","article-title":"18)F-FDG-PET imaging of rat spinal cord demonstrates altered glucose uptake acutely after contusion injury","volume":"621","author":"von Leden","year":"2016","journal-title":"Neurosci. Lett."},{"issue":"2","key":"10.1016\/j.pacs.2023.100532_bib63","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1097\/RLU.0b013e31823933a4","article-title":"Visualization of distal spinal cord on F-18 FDG PET\/CT","volume":"37","author":"Greenspan","year":"2012","journal-title":"Clin. Nucl. Med"},{"issue":"1","key":"10.1016\/j.pacs.2023.100532_bib64","doi-asserted-by":"crossref","first-page":"38","DOI":"10.4068\/cmj.2013.49.1.38","article-title":"Changes in (18)f-fluorodeoxyglucose uptake in the spinal cord in a healthy population on serial positron emission tomography\/computed tomography","volume":"49","author":"Chong","year":"2013","journal-title":"Chonnam Med J."},{"issue":"21","key":"10.1016\/j.pacs.2023.100532_bib65","doi-asserted-by":"crossref","first-page":"E1395","DOI":"10.1097\/BRS.0b013e31820a7df8","article-title":"Pattern of 18F-FDG uptake in the spinal cord in patients with non-central nervous system malignancy","volume":"36","author":"Do","year":"2011","journal-title":"Spine"},{"issue":"2","key":"10.1016\/j.pacs.2023.100532_bib66","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.jcmg.2014.10.009","article-title":"Splenic metabolic activity predicts risk of future cardiovascular events: demonstration of a cardiosplenic axis in humans","volume":"8","author":"Emami","year":"2015","journal-title":"JACC Cardiovasc Imaging"},{"issue":"5","key":"10.1016\/j.pacs.2023.100532_bib67","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1161\/CIRCIMAGING.114.001689","article-title":"Characterizing the inflammatory tissue response to acute myocardial infarction by clinical multimodality noninvasive imaging","volume":"7","author":"Wollenweber","year":"2014","journal-title":"Circ. Cardiovasc Imaging"},{"issue":"8","key":"10.1016\/j.pacs.2023.100532_bib68","doi-asserted-by":"crossref","first-page":"1676","DOI":"10.1109\/TMI.2017.2686006","article-title":"Constrained inversion and spectral unmixing in multispectral optoacoustic tomography","volume":"36","author":"Ding","year":"2017","journal-title":"IEEE Trans. Med Imaging"},{"key":"10.1016\/j.pacs.2023.100532_bib69","doi-asserted-by":"crossref","DOI":"10.1038\/s41551-022-00906-1","article-title":"Multiscale optical and optoacoustic imaging of amyloid-\u03b2 deposits in mice","author":"Ni","year":"2022","journal-title":"Nat. Biomed. Eng."},{"key":"10.1016\/j.pacs.2023.100532_bib70","doi-asserted-by":"crossref","DOI":"10.1007\/s00259-022-05708-w","article-title":"Non-invasive imaging of tau-targeted probe uptake by whole brain multi-spectral optoacoustic tomography","author":"Vagenknecht","year":"2022","journal-title":"Eur. J. Nucl. Med Mol. Imaging"},{"key":"10.1016\/j.pacs.2023.100532_bib71","doi-asserted-by":"crossref","unstructured":"N. Straumann, B.F. Combes, X.L. Dean-Ben, R. Sternke-Hoffmann, JA. Gerez, I. Dias, Z. Chen, B. Watts, I. Rostami, K. Shi, A. Rominger, CR. Baumann, J. Luo, D. Noain, RM. Nitsch, N. Okamura, D. Razansky, R. Ni, Visualizing alpha-synuclein and iron deposition in M83 mouse model of Parkinson\u2019s disease in vivo, bioRxiv [Preprint] (2023) 2023\u201306, 2023.06.28.546962.","DOI":"10.1101\/2023.06.28.546962"},{"issue":"7","key":"10.1016\/j.pacs.2023.100532_bib72","doi-asserted-by":"crossref","DOI":"10.1118\/1.4875691","article-title":"Effects of small variations of speed of sound in optoacoustic tomographic imaging","volume":"41","author":"De\u00e1n-Ben","year":"2014","journal-title":"Med Phys."},{"issue":"17","key":"10.1016\/j.pacs.2023.100532_bib73","doi-asserted-by":"crossref","DOI":"10.1063\/1.3564905","article-title":"Statistical optoacoustic image reconstruction using a-priori knowledge on the location of acoustic distortions","volume":"98","author":"De\u00e1n-Ben","year":"2011","journal-title":"Appl. Phys. Lett."},{"issue":"12","key":"10.1016\/j.pacs.2023.100532_bib74","doi-asserted-by":"crossref","first-page":"eabm1444","DOI":"10.1126\/sciadv.abm1444","article-title":"Novel oxygen sensing mechanism in the spinal cord involved in cardiorespiratory responses to hypoxia","volume":"8","author":"Barioni","year":"2022","journal-title":"Sci. Adv."},{"key":"10.1016\/j.pacs.2023.100532_bib75","doi-asserted-by":"crossref","first-page":"22655","DOI":"10.1038\/srep22655","article-title":"Dynamic secondary degeneration in the spinal cord and ventral root after a focal cerebral infarction among hypertensive rats","volume":"6","author":"Dang","year":"2016","journal-title":"Sci. Rep."},{"issue":"7","key":"10.1016\/j.pacs.2023.100532_bib76","doi-asserted-by":"crossref","first-page":"1951","DOI":"10.1161\/STROKEAHA.113.001162","article-title":"Axonal remodeling of the corticospinal tract in the spinal cord contributes to voluntary motor recovery after stroke in adult mice","volume":"44","author":"Liu","year":"2013","journal-title":"Stroke"},{"key":"10.1016\/j.pacs.2023.100532_bib77","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.neuroimage.2012.09.028","article-title":"Simultaneous and noninvasive imaging of cerebral oxygen metabolic rate, blood flow and oxygen extraction fraction in stroke mice","volume":"64","author":"Zhu","year":"2013","journal-title":"Neuroimage"},{"issue":"10","key":"10.1016\/j.pacs.2023.100532_bib78","doi-asserted-by":"crossref","first-page":"2514","DOI":"10.1161\/01.STR.0000239698.50656.3b","article-title":"Effects of cerebral ischemia on evoked cerebral blood oxygenation responses and BOLD contrast functional MRI in stroke patients","volume":"37","author":"Murata","year":"2006","journal-title":"Stroke"},{"issue":"3","key":"10.1016\/j.pacs.2023.100532_bib79","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1177\/0271678X19827944","article-title":"Elevated brain oxygen extraction fraction measured by MRI susceptibility relates to perfusion status in acute ischemic stroke","volume":"40","author":"Fan","year":"2020","journal-title":"J. Cereb. Blood Flow. Metab."},{"issue":"10","key":"10.1016\/j.pacs.2023.100532_bib80","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.1038\/jcbfm.2009.89","article-title":"Direct visualization of mouse brain oxygen distribution by electron paramagnetic resonance imaging: application to focal cerebral ischemia","volume":"29","author":"Shen","year":"2009","journal-title":"J. Cereb. Blood Flow. Metab."},{"issue":"1","key":"10.1016\/j.pacs.2023.100532_bib81","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1186\/s40478-022-01337-4","article-title":"Mapping of neuroinflammation-induced hypoxia in the spinal cord using optoacoustic imaging","volume":"10","author":"Ramos-Vega","year":"2022","journal-title":"Acta Neuropathol. Commun."},{"issue":"24","key":"10.1016\/j.pacs.2023.100532_bib82","doi-asserted-by":"crossref","first-page":"1998","DOI":"10.1089\/neu.2014.3349","article-title":"Assessment of white matter loss using bond-selective photoacoustic imaging in a rat model of contusive spinal cord injury","volume":"31","author":"Wu","year":"2014","journal-title":"J. Neurotrauma"},{"issue":"3","key":"10.1016\/j.pacs.2023.100532_bib83","doi-asserted-by":"crossref","DOI":"10.1117\/1.NPh.7.3.030501","article-title":"In vivo photoacoustic guidance of stem cell injection and delivery for regenerative spinal cord therapies","volume":"7","author":"Kubelick","year":"2020","journal-title":"Neurophotonics"},{"key":"10.1016\/j.pacs.2023.100532_bib84","doi-asserted-by":"crossref","DOI":"10.1016\/j.pacs.2020.100166","article-title":"Prussian blue nanocubes as a multimodal contrast agent for image-guided stem cell therapy of the spinal cord","volume":"18","author":"Kubelick","year":"2020","journal-title":"Photoacoustics"},{"issue":"10","key":"10.1016\/j.pacs.2023.100532_bib85","doi-asserted-by":"crossref","first-page":"6625","DOI":"10.1021\/acs.nanolett.8b03305","article-title":"Photoacoustic image-guided delivery of plasmonic-nanoparticle-labeled mesenchymal stem cells to the spinal cord","volume":"18","author":"Donnelly","year":"2018","journal-title":"Nano Lett."},{"issue":"12","key":"10.1016\/j.pacs.2023.100532_bib86","doi-asserted-by":"crossref","first-page":"3468","DOI":"10.1016\/j.ultrasmedbio.2020.08.026","article-title":"Ultrasound, photoacoustic and magnetic resonance imaging approach for longitudinal post-operative monitoring of stem cells in the spinal cord","volume":"46","author":"Kubelick","year":"2020","journal-title":"Ultrasound Med. Biol."},{"key":"10.1016\/j.pacs.2023.100532_bib87","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.pacs.2019.01.003","article-title":"Photoacoustic-based oxygen saturation assessment of murine femoral bone marrow in a preclinical model of leukemia","volume":"14","author":"Wood","year":"2019","journal-title":"Photoacoustics"},{"issue":"33","key":"10.1016\/j.pacs.2023.100532_bib88","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.aau6085","article-title":"Structure and function of the immune system in the spleen","volume":"4","author":"Lewis","year":"2019","journal-title":"Sci. Immunol."},{"issue":"1","key":"10.1016\/j.pacs.2023.100532_bib89","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1186\/s12974-019-1609-y","article-title":"CD147 as a key mediator of the spleen inflammatory response in mice after focal cerebral ischemia","volume":"16","author":"Jin","year":"2019","journal-title":"J. Neuroinflamm."},{"issue":"11","key":"10.1016\/j.pacs.2023.100532_bib90","doi-asserted-by":"crossref","first-page":"6140","DOI":"10.4049\/jimmunol.167.11.6140","article-title":"Differential effects of physiologically relevant hypoxic conditions on T lymphocyte development and effector functions","volume":"167","author":"Caldwell","year":"2001","journal-title":"J. Immunol."},{"issue":"10","key":"10.1016\/j.pacs.2023.100532_bib91","doi-asserted-by":"crossref","first-page":"2227","DOI":"10.1002\/jnr.21661","article-title":"The spleen contributes to stroke-induced neurodegeneration","volume":"86","author":"Ajmo","year":"2008","journal-title":"J. Neurosci. Res."},{"issue":"1","key":"10.1016\/j.pacs.2023.100532_bib92","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1186\/1742-2094-7-92","article-title":"A role for spleen monocytes in post-ischemic brain inflammation and injury","volume":"7","author":"Bao","year":"2010","journal-title":"J. Neuroinflamm."},{"issue":"2","key":"10.1016\/j.pacs.2023.100532_bib93","doi-asserted-by":"crossref","first-page":"155","DOI":"10.5607\/en20062","article-title":"Dynamics of T lymphocyte between the periphery and the brain from the acute to the chronic phase following ischemic stroke in mice","volume":"30","author":"Kim","year":"2021","journal-title":"Exp. Neurobiol."},{"issue":"2","key":"10.1016\/j.pacs.2023.100532_bib94","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1111\/ijs.12022","article-title":"Changes in spleen size in patients with acute ischemic stroke: a pilot observational study","volume":"8","author":"Sahota","year":"2013","journal-title":"Int J. Stroke"},{"issue":"5","key":"10.1016\/j.pacs.2023.100532_bib95","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0232497","article-title":"Post-stroke infections associated with spleen volume reduction: A pilot study","volume":"15","author":"Nous","year":"2020","journal-title":"PLoS One"},{"issue":"12","key":"10.1016\/j.pacs.2023.100532_bib96","doi-asserted-by":"crossref","first-page":"2958","DOI":"10.1016\/j.jstrokecerebrovasdis.2016.08.012","article-title":"The volume of the spleen and its correlates after acute stroke","volume":"25","author":"Chiu","year":"2016","journal-title":"J. Stroke Cereb. Dis."},{"issue":"1","key":"10.1016\/j.pacs.2023.100532_bib97","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.neulet.2006.12.045","article-title":"Ischaemia-induced sympathoexcitation in spinalyzed rats","volume":"415","author":"Braga","year":"2007","journal-title":"Neurosci. Lett."},{"issue":"1","key":"10.1016\/j.pacs.2023.100532_bib98","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1007\/s12012-018-9473-z","article-title":"Predictive role of the cervical sympathetic trunk ischemia on lower heart rates in an experimentally induced stenoocclusive carotid artery model by bilateral common carotid artery ligation","volume":"19","author":"Koza","year":"2019","journal-title":"Cardiovasc Toxicol."},{"key":"10.1016\/j.pacs.2023.100532_bib99","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.2147\/NDT.S199450","article-title":"Effects of transection of cervical sympathetic trunk on cognitive function of traumatic brain injury rats","volume":"15","author":"Long","year":"2019","journal-title":"Neuropsychiatr. Dis. Treat."},{"issue":"1","key":"10.1016\/j.pacs.2023.100532_bib100","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1109\/TMI.2016.2607199","article-title":"Towards quantitative evaluation of tissue absorption coefficients using light fluence correction in optoacoustic tomography","volume":"36","author":"Brochu","year":"2017","journal-title":"IEEE Trans. Med Imaging"},{"key":"10.1016\/j.pacs.2023.100532_bib101","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.nucmedbio.2017.01.005","article-title":"18)F-fluoro-2-deoxyglucose PET informs neutrophil accumulation and activation in lipopolysaccharide-induced acute lung injury","volume":"48","author":"Rodrigues","year":"2017","journal-title":"Nucl. Med Biol."},{"issue":"1","key":"10.1016\/j.pacs.2023.100532_bib102","doi-asserted-by":"crossref","first-page":"4903","DOI":"10.1038\/s41598-020-61191-z","article-title":"Longitudinal imaging of T cell-based immunotherapy with multi-spectral, multi-scale optoacoustic tomography","volume":"10","author":"Kimm","year":"2020","journal-title":"Sci. Rep."},{"issue":"2","key":"10.1016\/j.pacs.2023.100532_bib103","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1038\/jcbfm.2014.186","article-title":"Sex differences in ischemic stroke sensitivity are influenced by gonadal hormones, not by sex chromosome complement","volume":"35","author":"Manwani","year":"2015","journal-title":"J. Cereb. Blood Flow. Metab."},{"issue":"3","key":"10.1016\/j.pacs.2023.100532_bib104","first-page":"1","article-title":"Multispectral optoacoustic tomography at 64, 128, and 256 channels","volume":"19","author":"Alexander","year":"2014","journal-title":"J. Biomed. Opt."},{"issue":"1","key":"10.1016\/j.pacs.2023.100532_bib105","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0030491","article-title":"Fast multispectral optoacoustic tomography (MSOT) for dynamic imaging of pharmacokinetics and biodistribution in multiple organs","volume":"7","author":"Taruttis","year":"2012","journal-title":"PLOS ONE"},{"issue":"20","key":"10.1016\/j.pacs.2023.100532_bib106","doi-asserted-by":"crossref","first-page":"4576","DOI":"10.1158\/1078-0432.CCR-15-0314","article-title":"Targeting acidity in pancreatic adenocarcinoma: multispectral optoacoustic tomography detects pH-low insertion peptide probes","volume":"21","author":"Kimbrough","year":"2015","journal-title":"Clin. Cancer Res."},{"issue":"1","key":"10.1016\/j.pacs.2023.100532_bib107","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1038\/s41377-019-0130-5","article-title":"Transmission\u2013reflection optoacoustic ultrasound (TROPUS) computed tomography of small animals","volume":"8","author":"Mer\u010dep","year":"2019","journal-title":"Light.: Sci. Appl."},{"key":"10.1016\/j.pacs.2023.100532_bib108","first-page":"271","article-title":"Surgical manipulation compromises leukocyte mobilization responses and inflammation after experimental cerebral ischemia in mice","volume":"7","author":"Denes","year":"2013","journal-title":"Front Neurosci."},{"issue":"7","key":"10.1016\/j.pacs.2023.100532_bib109","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1056\/NEJMra0910283","article-title":"Hypoxia and inflammation","volume":"364","author":"Eltzschig","year":"2011","journal-title":"N. Engl. J. Med"}],"container-title":["Photoacoustics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S221359792300085X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S221359792300085X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T15:09:49Z","timestamp":1778857789000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S221359792300085X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8]]},"references-count":109,"alternative-id":["S221359792300085X"],"URL":"https:\/\/doi.org\/10.1016\/j.pacs.2023.100532","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2022.08.11.503550","asserted-by":"object"}]},"ISSN":["2213-5979"],"issn-type":[{"value":"2213-5979","type":"print"}],"subject":[],"published":{"date-parts":[[2023,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Imaging increased metabolism in the spinal cord in mice after middle cerebral artery occlusion","name":"articletitle","label":"Article Title"},{"value":"Photoacoustics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pacs.2023.100532","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Author(s). Published by Elsevier GmbH.","name":"copyright","label":"Copyright"}],"article-number":"100532"}}