{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T15:15:52Z","timestamp":1792682152215,"version":"4.5.0"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,7,21]],"date-time":"2024-07-21T00:00:00Z","timestamp":1721520000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001826","name":"ZonMw","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001826","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003246","name":"NWO","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003246","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Photoacoustics"],"published-print":{"date-parts":[[2024,8]]},"DOI":"10.1016\/j.pacs.2024.100636","type":"journal-article","created":{"date-parts":[[2024,7,22]],"date-time":"2024-07-22T12:06:59Z","timestamp":1721650019000},"page":"100636","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"special_numbering":"C","title":["Near-infrared multispectral photoacoustic analysis of lipids and intraplaque hemorrhage in human carotid artery atherosclerosis"],"prefix":"10.1016","volume":"38","author":[{"given":"Jonas J.M.","family":"Riksen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sowmiya","family":"Chandramoorthi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonius F.W.","family":"Van der Steen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gijs","family":"Van Soest","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"8","key":"10.1016\/j.pacs.2024.100636_bib1","doi-asserted-by":"crossref","first-page":"e153","DOI":"10.1161\/CIR.0000000000001052","article-title":"Heart disease and stroke statistics\u20142022 update: a report from the American Heart Association","volume":"145","author":"Tsao","year":"2022","journal-title":"Circulation"},{"issue":"6801","key":"10.1016\/j.pacs.2024.100636_bib2","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1038\/35025203","article-title":"Atherosclerosis","volume":"407","author":"Lusis","year":"2000","journal-title":"Nature"},{"issue":"9","key":"10.1016\/j.pacs.2024.100636_bib3","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/j.jacc.2009.12.072","article-title":"Stroke prevention and treatment","volume":"56","author":"Marsh James","year":"2010","journal-title":"J. Am. Coll. Cardiol."},{"issue":"2","key":"10.1016\/j.pacs.2024.100636_bib4","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1053\/ejvs.2002.1946","article-title":"Overview of the principal results and secondary analyses from the European and North American randomised trials of endarterectomy for symptomatic carotid stenosis","volume":"26","author":"Naylor","year":"2003","journal-title":"Eur. J. Vasc. Endovasc. Surg."},{"key":"10.1016\/j.pacs.2024.100636_bib5","doi-asserted-by":"crossref","unstructured":"C. Stegemann, et al., Comparative Lipidomics Profiling of Human Atherosclerotic Plaques, 2011.","DOI":"10.1161\/CIRCGENETICS.110.959098"},{"issue":"3","key":"10.1016\/j.pacs.2024.100636_bib6","first-page":"241","article-title":"Carotid plaque lipid content and fibrous cap status predict systemic CV outcomes: the MRI substudy in AIM-HIGH","volume":"10","author":"Sun","year":"2017","journal-title":"JACC: Cardiovasc. Imaging"},{"issue":"12","key":"10.1016\/j.pacs.2024.100636_bib7","doi-asserted-by":"crossref","DOI":"10.1117\/1.JBO.28.12.121205","article-title":"Photoacoustic imaging on its way toward clinical utility: a tutorial review focusing on practical application in medicine","volume":"28","author":"Riksen","year":"2023","journal-title":"J. Biomed. Opt."},{"key":"10.1016\/j.pacs.2024.100636_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.pacs.2019.100144","article-title":"A review of clinical photoacoustic imaging: current and future trends","volume":"16","author":"Attia","year":"2019","journal-title":"Photoacoustics"},{"key":"10.1016\/j.pacs.2024.100636_bib9","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.pacs.2019.05.001","article-title":"Photoacoustic clinical imaging","volume":"14","author":"Steinberg","year":"2019","journal-title":"Photoacoustics"},{"key":"10.1016\/j.pacs.2024.100636_bib10","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.pacs.2018.05.001","article-title":"Photoacoustic tomography of blood oxygenation: a mini review","volume":"10","author":"Li","year":"2018","journal-title":"Photoacoustics"},{"issue":"13","key":"10.1016\/j.pacs.2024.100636_bib11","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1056\/NEJMc1612455","article-title":"Multispectral optoacoustic tomography for assessment of Crohn's disease activity","volume":"376","author":"Knieling","year":"2017","journal-title":"N. Engl. J. Med."},{"issue":"10","key":"10.1016\/j.pacs.2024.100636_bib12","doi-asserted-by":"crossref","first-page":"4694","DOI":"10.7150\/thno.41211","article-title":"In vivo assessment of inflammation in carotid atherosclerosis by noninvasive photoacoustic imaging","volume":"10","author":"Xie","year":"2020","journal-title":"Theranostics"},{"issue":"3","key":"10.1016\/j.pacs.2024.100636_bib13","doi-asserted-by":"crossref","DOI":"10.3390\/jcm9030815","article-title":"Bedside 3D visualization of lymphatic vessels with a handheld multispectral optoacoustic tomography device","volume":"9","author":"Giacalone","year":"2020","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.pacs.2024.100636_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.pacs.2022.100446","article-title":"LED-based photoacoustic imaging for preoperative visualization of lymphatic vessels in patients with secondary limb lymphedema","volume":"29","author":"Van Heumen","year":"2023","journal-title":"Photoacoustics"},{"issue":"1","key":"10.1016\/j.pacs.2024.100636_bib15","doi-asserted-by":"crossref","DOI":"10.1038\/lsa.2014.18","article-title":"Adding fifth dimension to optoacoustic imaging: volumetric time-resolved spectrally enriched tomography","volume":"3","author":"Lu\u00eds De\u00e1n-Ben","year":"2014","journal-title":"Light: Sci. Appl."},{"issue":"2107","key":"10.1016\/j.pacs.2024.100636_bib16","doi-asserted-by":"crossref","first-page":"20170262","DOI":"10.1098\/rsta.2017.0262","article-title":"Spectral unmixing techniques for optoacoustic imaging of tissue pathophysiology","volume":"375","author":"Tzoumas","year":"2017","journal-title":"Philos. Trans. R. Soc. A: Math. Phys. Eng. Sci."},{"key":"10.1016\/j.pacs.2024.100636_bib17","article-title":"Recent advances in photoacoustic blind source spectral unmixing approaches and the enhanced detection of endogenous tissue chromophores","volume":"2","author":"Grasso","year":"2022","journal-title":"Front. Signal\u00a0Process."},{"issue":"4","key":"10.1016\/j.pacs.2024.100636_bib18","doi-asserted-by":"crossref","first-page":"3175","DOI":"10.1364\/OE.19.003175","article-title":"Blind source unmixing in multi-spectral optoacoustic tomography","volume":"19","author":"Glatz","year":"2011","journal-title":"Opt. Express"},{"issue":"1","key":"10.1016\/j.pacs.2024.100636_bib19","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1148\/radiol.2019181325","article-title":"Real-time volumetric assessment of the human carotid artery: handheld multispectral optoacoustic tomography","volume":"291","author":"Ivankovic","year":"2019","journal-title":"Radiology"},{"issue":"22","key":"10.1016\/j.pacs.2024.100636_bib20","doi-asserted-by":"crossref","DOI":"10.1364\/OE.20.025044","article-title":"Non-invasive carotid imaging using optoacoustic tomography","volume":"20","author":"Dima","year":"2012","journal-title":"Opt. Express"},{"key":"10.1016\/j.pacs.2024.100636_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.pacs.2019.100140","article-title":"Unmixing multi-spectral photoacoustic sources in human carotid plaques using non-negative independent component analysis","volume":"15","author":"Arabul","year":"2019","journal-title":"Photoacoustics"},{"issue":"4","key":"10.1016\/j.pacs.2024.100636_bib22","article-title":"Toward the detection of intraplaque hemorrhage in carotid artery lesions using photoacoustic imaging","volume":"22","author":"Mustafa Umit","year":"2016","journal-title":"J. Biomed. Opt."},{"issue":"7","key":"10.1016\/j.pacs.2024.100636_bib23","doi-asserted-by":"crossref","first-page":"4207","DOI":"10.1364\/BOE.430064","article-title":"Towards in vivo photoacoustic imaging of vulnerable plaques in the carotid artery","volume":"12","author":"Muller","year":"2021","journal-title":"Biomed. Opt. Express"},{"key":"10.1016\/j.pacs.2024.100636_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.pacs.2021.100283","article-title":"Multispectral optoacoustic tomography of lipid and hemoglobin contrast in human carotid atherosclerosis","volume":"23","author":"Karlas","year":"2021","journal-title":"Photoacoustics"},{"issue":"5","key":"10.1016\/j.pacs.2024.100636_bib25","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1364\/OL.36.000597","article-title":"Intravascular photoacoustic imaging of human coronary atherosclerosis","volume":"36","author":"Jansen","year":"2011","journal-title":"Opt. Lett."},{"issue":"6","key":"10.1016\/j.pacs.2024.100636_bib26","doi-asserted-by":"crossref","DOI":"10.1117\/1.JBO.17.6.061209","article-title":"Spectroscopic photoacoustic imaging of lipid-rich plaques in the human aorta in the 740\u20131400\u2009nm wavelength range","volume":"17","author":"Allen","year":"2012","journal-title":"J. Biomed. Opt."},{"key":"10.1016\/j.pacs.2024.100636_bib27","doi-asserted-by":"crossref","unstructured":"T.J. Allen, P.C. Beard, Photoacoustic characterisation of vascular tissue at NIR wavelengths, in: Photons Plus Ultrasound: Imaging and Sensing 2009. SPIE, San Jose, CA, USA, 2009.","DOI":"10.1117\/12.808777"},{"issue":"15","key":"10.1016\/j.pacs.2024.100636_bib28","doi-asserted-by":"crossref","first-page":"2543","DOI":"10.1088\/0022-3727\/38\/15\/004","article-title":"Optical properties of human skin, subcutaneous and mucous tissues in the wavelength range from 400 to 2000\u2009nm","volume":"38","author":"Bashkatov","year":"2005","journal-title":"J. Phys. D: Appl. Phys."},{"issue":"11","key":"10.1016\/j.pacs.2024.100636_bib29","doi-asserted-by":"crossref","DOI":"10.1117\/1.JBO.19.11.110504","article-title":"Photoacoustic imaging of carotid artery atherosclerosis","volume":"19","author":"Kruizinga","year":"2014","journal-title":"J. Biomed. Opt."},{"issue":"1","key":"10.1016\/j.pacs.2024.100636_bib30","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.pacs.2013.11.003","article-title":"Photoacoustic imaging of human coronary atherosclerosis in two spectral bands","volume":"2","author":"Jansen","year":"2014","journal-title":"Photoacoustics"},{"key":"10.1016\/j.pacs.2024.100636_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.pacs.2021.100261","article-title":"Micro spectroscopic photoacoustic (\u03bcsPA) imaging of advanced carotid atherosclerosis","volume":"22","author":"Iskander-Rizk","year":"2021","journal-title":"Photoacoustics"},{"issue":"2","key":"10.1016\/j.pacs.2024.100636_bib32","doi-asserted-by":"crossref","first-page":"I","DOI":"10.1177\/23969873211012121","article-title":"European Stroke Organisation guideline on endarterectomy and stenting for carotid artery stenosis","volume":"6","author":"Bonati","year":"2021","journal-title":"Eur. Stroke J."},{"issue":"9","key":"10.1016\/j.pacs.2024.100636_bib33","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1021\/ac60141a039","article-title":"Absorbance of liquid water and deuterium oxide between 0.6 and 1.8 microns. Comparison of absorbance and effect of temperature","volume":"30","author":"Waggener","year":"1958","journal-title":"Anal. Chem."},{"issue":"1 Pt 2","key":"10.1016\/j.pacs.2024.100636_bib34","article-title":"Universal back-projection algorithm for photoacoustic computed tomography","volume":"71","author":"Xu","year":"2005","journal-title":"Phys. Rev. E Stat. Nonlinear Soft Matter Phys."},{"issue":"1","key":"10.1016\/j.pacs.2024.100636_bib35","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1109\/TMI.2013.2279994","article-title":"Unmixing molecular agents from absorbing tissue in multispectral optoacoustic tomography","volume":"33","author":"Tzoumas","year":"2014","journal-title":"IEEE Trans. Med. Imaging"},{"issue":"1","key":"10.1016\/j.pacs.2024.100636_bib36","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.csda.2006.11.006","article-title":"Algorithms and applications for approximate nonnegative matrix factorization","volume":"52","author":"Berry","year":"2007","journal-title":"Comput. Stat. Data Anal."},{"issue":"2","key":"10.1016\/j.pacs.2024.100636_bib37","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1161\/01.ATV.8.2.103","article-title":"George Lyman Duff memorial lecture. Progression and regression of atherosclerotic lesions. Insights from lipid physical biochemistry","volume":"8","author":"Small","year":"1988","journal-title":"Arteriosclerosis"},{"issue":"9","key":"10.1016\/j.pacs.2024.100636_bib38","doi-asserted-by":"crossref","DOI":"10.15252\/emmm.202013490","article-title":"Functional multispectral optoacoustic tomography imaging of hepatic steatosis development in mice","volume":"13","author":"Huang","year":"2021","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.pacs.2024.100636_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.pacs.2023.100454","article-title":"Non-invasive multispectral optoacoustic tomography resolves intrahepatic lipids in patients with hepatic steatosis","volume":"29","author":"Fasoula","year":"2023","journal-title":"Photoacoustics"},{"key":"10.1016\/j.pacs.2024.100636_bib40","unstructured":"T.R. Max, T. Anjali, F. Kalloor Joseph, Quantifying photoacoustic model utilizing blood as a fluence marker for carotid plaque composition imaging, in: Proc. SPIE, 2024."},{"issue":"2","key":"10.1016\/j.pacs.2024.100636_bib41","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1364\/JOSAA.26.000443","article-title":"Estimating chromophore distributions from multiwavelength photoacoustic images","volume":"26","author":"Cox","year":"2009","journal-title":"J. Opt. Soc. Am. A"}],"container-title":["Photoacoustics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213597924000533?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213597924000533?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,10,9]],"date-time":"2024-10-09T20:51:55Z","timestamp":1728507115000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213597924000533"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8]]},"references-count":41,"alternative-id":["S2213597924000533"],"URL":"https:\/\/doi.org\/10.1016\/j.pacs.2024.100636","relation":{},"ISSN":["2213-5979"],"issn-type":[{"value":"2213-5979","type":"print"}],"subject":[],"published":{"date-parts":[[2024,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Near-infrared multispectral photoacoustic analysis of lipids and intraplaque hemorrhage in human carotid artery atherosclerosis","name":"articletitle","label":"Article Title"},{"value":"Photoacoustics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pacs.2024.100636","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Author(s). Published by Elsevier GmbH.","name":"copyright","label":"Copyright"}],"article-number":"100636"}}