{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T12:05:50Z","timestamp":1784549150592,"version":"3.55.0"},"reference-count":88,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T00:00:00Z","timestamp":1781136000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100019018","name":"Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100019018","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012165","name":"Key Technologies Research and Development Program","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012165","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Photoacoustics"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.pacs.2026.100848","type":"journal-article","created":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T23:41:30Z","timestamp":1781566890000},"page":"100848","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Noninvasive multimodal photoacoustic-ultrasound imaging for dynamic assessment of placental hypoxia and perfusion in preeclampsia"],"prefix":"10.1016","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4526-7924","authenticated-orcid":false,"given":"Sirui","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yixiu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenyang","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanwen","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji","family":"Fei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huazhen","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxin","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.pacs.2026.100848_bib1","first-page":"24","article-title":"International Society for the Study of Hypertension in Pregnancy (ISSHP), Hypertensive Disorders of Pregnancy: ISSHP Classification, Diagnosis, and Management Recommendations for International Practice","volume":"72","author":"Brown","year":"2018","journal-title":"Hypertens. Dallas Tex. 1979"},{"key":"10.1016\/j.pacs.2026.100848_bib2","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1161\/CIRCRESAHA.118.313276","article-title":"Preeclampsia: Pathophysiology, Challenges, and Perspectives","volume":"124","author":"Rana","year":"2019","journal-title":"Circ. Res."},{"key":"10.1016\/j.pacs.2026.100848_bib3","first-page":"1","article-title":"ACOG Practice Bulletin No. 202: Gestational Hypertension and Preeclampsia","volume":"133","year":"2019","journal-title":"Obstet. Gynecol."},{"key":"10.1016\/j.pacs.2026.100848_bib4","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/j.semnephrol.2017.05.011","article-title":"Preeclampsia: Pathogenesis, Prevention, and Long-Term Complications","volume":"37","author":"Jim","year":"2017","journal-title":"Semin. Nephrol."},{"key":"10.1016\/j.pacs.2026.100848_bib5","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1097\/MNH.0000000000000105","article-title":"Pathogenesis of preeclampsia","volume":"24","author":"Sircar","year":"2015","journal-title":"Curr. Opin. Nephrol. Hypertens."},{"key":"10.1016\/j.pacs.2026.100848_bib6","doi-asserted-by":"crossref","first-page":"l2381","DOI":"10.1136\/bmj.l2381","article-title":"Pre-eclampsia: pathophysiology and clinical implications","author":"Burton","year":"2019","journal-title":"BMJ 366"},{"key":"10.1016\/j.pacs.2026.100848_bib7","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/S0140-6736(20)32335-7","article-title":"Pre-eclampsia","volume":"398","author":"Chappell","year":"2021","journal-title":"Lancet Lond. Engl."},{"key":"10.1016\/j.pacs.2026.100848_bib8","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.118.009595","article-title":"Phenotypes of Pregnant Women Who Subsequently Develop Hypertension in Pregnancy","volume":"7","author":"McLaughlin","year":"2018","journal-title":"J. Am. Heart Assoc."},{"key":"10.1016\/j.pacs.2026.100848_bib9","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.placenta.2016.04.006","article-title":"Revisiting decidual vasculopathy","volume":"42","author":"Hecht","year":"2016","journal-title":"Placenta"},{"key":"10.1016\/j.pacs.2026.100848_bib10","first-page":"177","article-title":"The role of the spiral arteries in the pathogenesis of preeclampsia","volume":"1","author":"Brosens","year":"1972","journal-title":"Obstet. Gynecol. Annu."},{"key":"10.1016\/j.pacs.2026.100848_bib11","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1038\/s41581-019-0119-6","article-title":"Pre-eclampsia: pathogenesis, novel diagnostics and therapies","volume":"15","author":"Phipps","year":"2019","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.pacs.2026.100848_bib12","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1016\/0002-9378(56)90437-9","article-title":"The relationship of hydatidiform mole to pre-eclampsia and eclampsia; a study of 85 cases","volume":"71","author":"Acosta-Sison","year":"1956","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.pacs.2026.100848_bib13","doi-asserted-by":"crossref","DOI":"10.1117\/1.JBO.17.6.061220","article-title":"vivo photoacoustic imaging of mouse embryos","volume":"17","author":"Laufer","year":"2012","journal-title":"J. Biomed. Opt."},{"issue":"1","key":"10.1016\/j.pacs.2026.100848_bib14","doi-asserted-by":"crossref","first-page":"S20","DOI":"10.1016\/j.placenta.2014.12.017","article-title":"IFPA G\u00e1bor Than Award Lecture: Recognition of placental failure is key to saving babies\u2019 lives","volume":"36","author":"Heazell","year":"2015","journal-title":"Placenta"},{"key":"10.1016\/j.pacs.2026.100848_bib15","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1038\/s41598-018-37310-2","article-title":"Spectral photoacoustic imaging to estimate in vivo placental oxygenation during preeclampsia","volume":"9","author":"Lawrence","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.pacs.2026.100848_bib16","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.siny.2010.09.001","article-title":"Dynamic contrast-enhanced magnetic resonance imaging: definitive imaging of placental function?","volume":"16","author":"Chalouhi","year":"2011","journal-title":"Semin. Fetal Neonatal Med."},{"key":"10.1016\/j.pacs.2026.100848_bib17","doi-asserted-by":"crossref","DOI":"10.1002\/uog.27609","article-title":"Static and dynamic responses to hyperoxia of normal placenta across gestation with T2*-weighted sequences, Ultrasound Obstet. Gynecol. Off. J. Int. Soc","author":"Bartin","year":"2024","journal-title":"Ultrasound Obstet. Gynecol."},{"key":"10.1016\/j.pacs.2026.100848_bib18","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1148\/radiol.2019190751","article-title":"Hemodynamic Responses of the Placenta and Brain to Maternal Hyperoxia in Fetuses with Congenital Heart Disease by Using Blood Oxygen-Level Dependent MRI","volume":"294","author":"You","year":"2020","journal-title":"Radiology"},{"key":"10.1016\/j.pacs.2026.100848_bib19","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.placenta.2017.09.005","article-title":"BOLD-MRI demonstrates acute placental and fetal organ hypoperfusion with fetal brain sparing during hypercapnia","volume":"63","author":"Ginosar","year":"2018","journal-title":"Placenta"},{"key":"10.1016\/j.pacs.2026.100848_bib20","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/s41572-023-00425-6","article-title":"Pre-eclampsia","volume":"9","year":"2023","journal-title":"Nat. Rev. Dis. Prim."},{"key":"10.1016\/j.pacs.2026.100848_bib21","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1038\/s41377-024-01644-6","article-title":"Dynamic synthetic-scanning photoacoustic tracking monitors hepatic and renal clearance pathway of exogeneous probes in vivo","volume":"13","author":"Lv","year":"2024","journal-title":"Light. Sci. Appl."},{"key":"10.1016\/j.pacs.2026.100848_bib22","doi-asserted-by":"crossref","DOI":"10.1148\/radiol.241275","article-title":"Quantification of Vascular Remodeling and Sinusoidal Capillarization to Assess Liver Fibrosis with Photoacoustic Imaging","volume":"314","author":"Li","year":"2025","journal-title":"Radiology"},{"key":"10.1016\/j.pacs.2026.100848_bib23","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1148\/radiol.2021204134","article-title":"Quantitative Functional Evaluation of Liver Fibrosis in Mice with Dynamic Contrast-enhanced Photoacoustic Imaging","volume":"300","author":"Lv","year":"2021","journal-title":"Radiology"},{"key":"10.1016\/j.pacs.2026.100848_bib24","first-page":"261","article-title":"Application of superb micro-vascular imaging (SMI) in obstetrics","volume":"31","author":"Hasegawa","year":"2018","journal-title":"J. Matern. -Fetal Neonatal Med. Off. J. Eur. Assoc. Perinat. Med. Fed. Asia Ocean. Perinat. Soc. Int. Soc. Perinat. Obstet."},{"key":"10.1016\/j.pacs.2026.100848_bib25","doi-asserted-by":"crossref","first-page":"5551","DOI":"10.1364\/BOE.469747","article-title":"Validation of photoacoustic\/ultrasound dual imaging in evaluating blood oxygen saturation","volume":"13","author":"Liu","year":"2022","journal-title":"Biomed. Opt. Express"},{"key":"10.1016\/j.pacs.2026.100848_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.pacs.2024.100615","article-title":"Multimodal PA\/US imaging in Rheumatoid Arthritis: Enhanced correlation with clinical scores","volume":"38","author":"Huang","year":"2024","journal-title":"Photoacoustics"},{"key":"10.1016\/j.pacs.2026.100848_bib27","doi-asserted-by":"crossref","first-page":"3542","DOI":"10.1007\/s00330-020-07353-z","article-title":"Multimodal photoacoustic\/ultrasonic imaging system: a promising imaging method for the evaluation of disease activity in rheumatoid arthritis","volume":"31","author":"Zhao","year":"2021","journal-title":"Eur. Radiol."},{"key":"10.1016\/j.pacs.2026.100848_bib28","doi-asserted-by":"crossref","first-page":"1722","DOI":"10.4103\/0366-6999.209885","article-title":"Role of Contrast-enhanced Ultrasound in the Evaluation of Inflammatory Arthritis","volume":"130","author":"Zhao","year":"2017","journal-title":"Chin. Med. J. (Engl. )"},{"key":"10.1016\/j.pacs.2026.100848_bib29","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1364\/BOE.411215","article-title":"Functional photoacoustic\/ultrasound imaging for the assessment of breast intraductal lesions: preliminary clinical findings","volume":"12","author":"Wang","year":"2021","journal-title":"Biomed. Opt. Express"},{"key":"10.1016\/j.pacs.2026.100848_bib30","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1364\/BOE.417056","article-title":"Exploring the diagnostic value of photoacoustic imaging for breast cancer: the identification of regional photoacoustic signal differences of breast tumors","volume":"12","author":"Zhang","year":"2021","journal-title":"Biomed. Opt. Express"},{"key":"10.1016\/j.pacs.2026.100848_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.pacs.2025.100730","article-title":"Local oxygen concentration reversal from hyperoxia to hypoxia monitored by optical-resolution photoacoustic microscopy in inflammation-resolution process","volume":"44","author":"Tan","year":"2025","journal-title":"Photoacoustics"},{"key":"10.1016\/j.pacs.2026.100848_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.pacs.2025.100771","article-title":"Muscle oxygen saturation stratification by photoacoustic imaging in diabetic sarcopenia: Association with disease status","volume":"46","author":"Yang","year":"2025","journal-title":"Photoacoustics"},{"key":"10.1016\/j.pacs.2026.100848_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.pacs.2023.100569","article-title":"vivo liver function reserve assessments in alcoholic liver disease by scalable photoacoustic imaging","volume":"34","author":"Sun","year":"2023","journal-title":"Photoacoustics"},{"key":"10.1016\/j.pacs.2026.100848_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.pacs.2023.100499","article-title":"Testicular torsion diagnosis and injury assessment using photoacoustic oxygenation imaging","volume":"31","author":"Yang","year":"2023","journal-title":"Photoacoustics"},{"key":"10.1016\/j.pacs.2026.100848_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.pacs.2025.100706","article-title":"Photoacoustic oxygenation imaging to identify ischemia\/hypoxia injury and necrosis of intestine after acute intussusception: A comparative study with CDFI\/CEUS","volume":"43","author":"Yan","year":"2025","journal-title":"Photoacoustics"},{"key":"10.1016\/j.pacs.2026.100848_bib36","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.pacs.2019.05.001","article-title":"Photoacoustic clinical imaging","volume":"14","author":"Steinberg","year":"2019","journal-title":"Photoacoustics"},{"key":"10.1016\/j.pacs.2026.100848_bib37","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1148\/radiol.212257","article-title":"Synovial Oxygenation at Photoacoustic Imaging to Assess Rheumatoid Arthritis Disease Activity","volume":"306","author":"Yang","year":"2023","journal-title":"Radiology"},{"key":"10.1016\/j.pacs.2026.100848_bib38","doi-asserted-by":"crossref","first-page":"3449","DOI":"10.1364\/BOE.8.003449","article-title":"Photoacoustic\/ultrasound dual imaging of human thyroid cancers: an initial clinical study","volume":"8","author":"Yang","year":"2017","journal-title":"Biomed. Opt. Express"},{"key":"10.1016\/j.pacs.2026.100848_bib39","doi-asserted-by":"crossref","first-page":"8047","DOI":"10.1038\/s41598-020-64966-6","article-title":"Quantitative analysis of breast tumours aided by three-dimensional photoacoustic\/ultrasound functional imaging","volume":"10","author":"Yang","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.pacs.2026.100848_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.pacs.2021.100302","article-title":"Activity of keloids evaluated by multimodal photoacoustic\/ultrasonic imaging system","volume":"24","author":"Chen","year":"2021","journal-title":"Photoacoustics"},{"key":"10.1016\/j.pacs.2026.100848_bib41","doi-asserted-by":"crossref","DOI":"10.1016\/j.pacs.2024.100596","article-title":"Pre-transplant kidney quality evaluation using photoacoustic imaging during normothermic machine perfusion","volume":"36","author":"Nikolaev","year":"2024","journal-title":"Photoacoustics"},{"key":"10.1016\/j.pacs.2026.100848_bib42","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1095\/biolreprod.112.103705","article-title":"Change of genes in calcium transport channels caused by hypoxic stress in the placenta, duodenum, and kidney of pregnant rats","volume":"88","author":"Yang","year":"2013","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.pacs.2026.100848_bib43","first-page":"401","article-title":"Tumor angiogenesis correlates with metastasis in invasive prostate carcinoma","volume":"143","author":"Weidner","year":"1993","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.pacs.2026.100848_bib44","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1016\/j.biopha.2018.06.032","article-title":"Protective effect of human umbilical cord mesenchymal stem cell exosomes on preserving the morphology and angiogenesis of placenta in rats with preeclampsia, Biomed. Pharmacother","volume":"105","author":"Xiong","year":"2018","journal-title":"Biomedecine Pharmacother."},{"key":"10.1016\/j.pacs.2026.100848_bib45","first-page":"402","article-title":"Inventory of Novel Animal Models Addressing Etiology of Preeclampsia in the Development of New Therapeutic\/Intervention Opportunities","volume":"75","author":"Erlandsson","year":"2016","journal-title":"Am. J. Reprod. Immunol. N. Y. N. 1989"},{"key":"10.1016\/j.pacs.2026.100848_bib46","doi-asserted-by":"crossref","first-page":"S973","DOI":"10.1016\/j.ajog.2020.10.025","article-title":"Animal models of preeclampsia: investigating pathophysiology and therapeutic targets","volume":"226","author":"Bakrania","year":"2022","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.pacs.2026.100848_bib47","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.placenta.2011.11.026","article-title":"Rat placentation: An experimental model for investigating the hemochorial maternal-fetal interface","volume":"33","author":"Soares","year":"2012","journal-title":"Placenta"},{"key":"10.1016\/j.pacs.2026.100848_bib48","doi-asserted-by":"crossref","first-page":"a023473","DOI":"10.1101\/cshperspect.a023473","article-title":"Molecular Mechanisms of Preeclampsia","volume":"5","author":"Hod","year":"2015","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"10.1016\/j.pacs.2026.100848_bib49","doi-asserted-by":"crossref","first-page":"2775","DOI":"10.1172\/JCI70431","article-title":"Preeclampsia: a link between trophoblast dysregulation and an antiangiogenic state","volume":"123","author":"Romero","year":"2013","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.pacs.2026.100848_bib50","doi-asserted-by":"crossref","first-page":"2950","DOI":"10.2353\/ajpath.2010.090800","article-title":"Effects of hypoxia-inducible factor-1alpha overexpression in pregnant mice: possible implications for preeclampsia and intrauterine growth restriction","volume":"177","author":"Tal","year":"2010","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.pacs.2026.100848_bib51","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1093\/humupd\/dmp046","article-title":"Beyond oxygen: complex regulation and activity of hypoxia inducible factors in pregnancy","volume":"16","author":"Pringle","year":"2010","journal-title":"Hum. Reprod. Update"},{"key":"10.1016\/j.pacs.2026.100848_bib52","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1016\/j.placenta.2004.02.011","article-title":"Evidence for the functional activity of hypoxia-inducible transcription factors overexpressed in preeclamptic placentae","volume":"25","author":"Rajakumar","year":"2004","journal-title":"Placenta"},{"key":"10.1016\/j.pacs.2026.100848_bib53","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1093\/molehr\/gau105","article-title":"Energy status and HIF signalling in chorionic villi show no evidence of hypoxic stress during human early placental development","volume":"21","author":"Cindrova-Davies","year":"2015","journal-title":"Mol. Hum. Reprod."},{"key":"10.1016\/j.pacs.2026.100848_bib54","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1111\/j.1469-7580.2008.00978.x","article-title":"Oxygen, the Janus gas; its effects on human placental development and function","volume":"215","author":"Burton","year":"2009","journal-title":"J. Anat."},{"key":"10.1016\/j.pacs.2026.100848_bib55","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1016\/j.placenta.2010.08.008","article-title":"Regulation of hypoxia inducible factors (HIF) in hypoxia and normoxia during placental development","volume":"31","author":"Patel","year":"2010","journal-title":"Placenta"},{"key":"10.1016\/j.pacs.2026.100848_bib56","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/293271","article-title":"Oxidative Stress in Placenta: Health and Diseases","volume":"2015","author":"Wu","year":"2015","journal-title":"BioMed. Res. Int."},{"key":"10.1016\/j.pacs.2026.100848_bib57","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.adk1278","article-title":"Longitudinal intravital imaging of mouse placenta","volume":"10","author":"Zhu","year":"2024","journal-title":"Sci. Adv."},{"key":"10.1016\/j.pacs.2026.100848_bib58","doi-asserted-by":"crossref","first-page":"3670","DOI":"10.3390\/ijms24043670","article-title":"The Oxygen Cascade from Atmosphere to Mitochondria as a Tool to Understand the (Mal)adaptation to Hypoxia","volume":"24","author":"Samaja","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.pacs.2026.100848_bib59","article-title":"VEGF is essential for hypoxia-inducible factor-mediated neovascularization but dispensable for endothelial sprouting","volume":"108","author":"O","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.pacs.2026.100848_bib60","article-title":"Trophoblast invasion: tuning through LIF, signalling via Stat","volume":"3","author":"Tg","year":"2005","journal-title":"Placenta 26 Suppl. A"},{"key":"10.1016\/j.pacs.2026.100848_bib61","doi-asserted-by":"crossref","first-page":"3961","DOI":"10.1007\/s00330-022-09296-z","article-title":"Whole-tumor histogram analysis of diffusion-weighted imaging and dynamic contrast-enhanced MRI for soft tissue sarcoma: correlation with HIF-1alpha expression","volume":"33","author":"Li","year":"2023","journal-title":"Eur. Radiol."},{"key":"10.1016\/j.pacs.2026.100848_bib62","first-page":"2751","article-title":"Three-dimensional echocardiography in the diagnosis of myocardial infarction and its correlation with the expressions of serum HIF-1\u03b1, HO-1 and VEGF","volume":"22","author":"Yu","year":"2018","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"10.1016\/j.pacs.2026.100848_bib63","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1002\/jmri.25195","article-title":"MRI In rectal cancer: Correlations between MRI features and molecular markers Ki-67, HIF-1\u03b1, and VEGF","volume":"44","author":"Meng","year":"2016","journal-title":"J. Magn. Reson. Imaging JMRI"},{"key":"10.1016\/j.pacs.2026.100848_bib64","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1007\/s11307-018-1283-y","article-title":"Histogram Analysis Parameters Derived from Conventional T1- and T2-Weighted Images Can Predict Different Histopathological Features Including Expression of Ki67, EGFR, VEGF, HIF-1\u03b1, and p53 and Cell Count in Head and Neck Squamous Cell Carcinoma","volume":"21","author":"Meyer","year":"2019","journal-title":"Mol. Imaging Biol."},{"key":"10.1016\/j.pacs.2026.100848_bib65","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.ejrad.2017.08.026","article-title":"Correlations between the iodine concentrations from dual energy computed tomography and molecular markers Ki-67 and HIF-1\u03b1 in rectal cancer: A preliminary study","volume":"96","author":"Fan","year":"2017","journal-title":"Eur. J. Radiol."},{"key":"10.1016\/j.pacs.2026.100848_bib66","doi-asserted-by":"crossref","first-page":"2464","DOI":"10.1016\/j.ejrad.2015.09.013","article-title":"Correlations between ADC values and molecular markers of Ki-67 and HIF-1\u03b1 in hepatocellular carcinoma","volume":"84","author":"Huang","year":"2015","journal-title":"Eur. J. Radiol."},{"key":"10.1016\/j.pacs.2026.100848_bib67","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1097\/MNM.0000000000000010","article-title":"Correlation of (18)F-fluoromisonidazole PET findings with HIF-1\u03b1 and p53 expressions in head and neck cancer: comparison with (18)F-FDG PET","volume":"35","author":"Norikane","year":"2014","journal-title":"Nucl. Med. Commun."},{"key":"10.1016\/j.pacs.2026.100848_bib68","doi-asserted-by":"crossref","first-page":"1870","DOI":"10.1007\/s00259-014-2776-9","article-title":"Correlation between 18F-fluoromisonidazole PET and expression of HIF-1\u03b1 and VEGF in newly diagnosed and recurrent malignant gliomas","volume":"41","author":"Kawai","year":"2014","journal-title":"Eur. J. Nucl. Med. Mol. Imaging"},{"key":"10.1016\/j.pacs.2026.100848_bib69","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1007\/s11307-018-1223-x","article-title":"Associations Between [18F]FDG-PET and Complex Histopathological Parameters Including Tumor Cell Count and Expression of KI 67, EGFR, VEGF, HIF-1\u03b1, and p53 in Head and Neck Squamous Cell Carcinoma","volume":"21","author":"Surov","year":"2019","journal-title":"Mol. Imaging Biol."},{"key":"10.1016\/j.pacs.2026.100848_bib70","doi-asserted-by":"crossref","DOI":"10.1002\/nbm.3884","article-title":"Apparent diffusion coefficients in prostate cancer: correlation with molecular markers Ki-67, HIF-1\u03b1 and VEGF","volume":"31","author":"Ma","year":"2018","journal-title":"NMR Biomed."},{"key":"10.1016\/j.pacs.2026.100848_bib71","article-title":"18F-HX4\/18F-FMISO-based micro PET for imaging of tumor hypoxia and radiotherapy-associated changes in mice, Biomed. Pharmacother","volume":"119","author":"Yu","year":"2019","journal-title":"Biomedecine Pharmacother."},{"key":"10.1016\/j.pacs.2026.100848_bib72","doi-asserted-by":"crossref","first-page":"4823","DOI":"10.21037\/qims-22-75","article-title":"Soft tissue sarcoma: correlation of dynamic contrast-enhanced magnetic resonance imaging features with HIF-1\u03b1 expression and patient outcomes","volume":"12","author":"Li","year":"2022","journal-title":"Quant. Imaging Med. Surg."},{"key":"10.1016\/j.pacs.2026.100848_bib73","doi-asserted-by":"crossref","first-page":"14004","DOI":"10.1073\/pnas.0901194106","article-title":"Longitudinal and multimodal in vivo imaging of tumor hypoxia and its downstream molecular events","volume":"106","author":"Lehmann","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.pacs.2026.100848_bib74","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1097\/CM9.0000000000000616","article-title":"vivo longitudinal and multimodal imaging of hypoxia-inducible factor 1\u03b1 and angiogenesis in breast cancer","volume":"133","author":"Tang","year":"2020","journal-title":"Chin. Med. J. (Engl. )"},{"key":"10.1016\/j.pacs.2026.100848_bib75","article-title":"Evaluation of HIF-1\u03b1 Expression in a Rat Glioma Model Using Intravoxel Incoherent Motion and R2* Mapping","volume":"12","author":"Wang","year":"2022","journal-title":"Front. Oncol."},{"key":"10.1016\/j.pacs.2026.100848_bib76","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.tranon.2018.08.018","article-title":"Combined Metabolo-Volumetric Parameters of 18F-FDG-PET and MRI Can Predict Tumor Cellularity, Ki67 Level and Expression of HIF 1alpha in Head and Neck Squamous Cell Carcinoma: A Pilot Study","volume":"12","author":"Surov","year":"2019","journal-title":"Transl. Oncol."},{"key":"10.1016\/j.pacs.2026.100848_bib77","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1016\/j.tranon.2018.02.004","article-title":"Can Imaging Parameters Provide Information Regarding Histopathology in Head and Neck Squamous Cell Carcinoma? A Meta-Analysis","volume":"11","author":"Surov","year":"2018","journal-title":"Transl. Oncol."},{"key":"10.1016\/j.pacs.2026.100848_bib78","article-title":"BOLD-MRI of breast invasive ductal carcinoma: correlation of R2* value and the expression of HIF-1\u03b1","volume":"23","author":"M","year":"2013","journal-title":"Eur. Radiol."},{"key":"10.1016\/j.pacs.2026.100848_bib79","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.placenta.2017.09.005","article-title":"BOLD-MRI demonstrates acute placental and fetal organ hypoperfusion with fetal brain sparing during hypercapnia","volume":"63","author":"Ginosar","year":"2018","journal-title":"Placenta"},{"key":"10.1016\/j.pacs.2026.100848_bib80","doi-asserted-by":"crossref","first-page":"962","DOI":"10.3390\/jcm11040962","article-title":"A Prospective Investigation of Tumor Hypoxia Imaging with 68Ga-Nitroimidazole PET\/CT in Patients with Carcinoma of the Cervix Uteri and Comparison with 18F-FDG PET\/CT: Correlation with Immunohistochemistry","volume":"11","author":"Mokoala","year":"2022","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.pacs.2026.100848_bib81","doi-asserted-by":"crossref","DOI":"10.1016\/j.pacs.2026.100803","article-title":"Early identification of umbilical blood flow restriction and maternal placental hypoperfusion with photoacoustic imaging","volume":"48","author":"Zhang","year":"2026","journal-title":"Photoacoustics"},{"key":"10.1016\/j.pacs.2026.100848_bib82","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.placenta.2022.06.006","article-title":"Photoacoustic imaging provides an in vivo assessment of the preeclamptic placenta remodeling and function in response to therapy","volume":"126","author":"Lawrence","year":"2022","journal-title":"Placenta"},{"key":"10.1016\/j.pacs.2026.100848_bib83","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0169850","article-title":"Real-Time Monitoring of Placental Oxygenation during Maternal Hypoxia and Hyperoxygenation Using Photoacoustic Imaging","volume":"12","author":"Arthuis","year":"2017","journal-title":"PLoS. ONE"},{"key":"10.1016\/j.pacs.2026.100848_bib84","doi-asserted-by":"crossref","first-page":"5520","DOI":"10.1096\/fj.201700047RR","article-title":"Photoacoustic imaging for in vivo quantification of placental oxygenation in mice","volume":"31","author":"Yamaleyeva","year":"2017","journal-title":"FASEB J."},{"key":"10.1016\/j.pacs.2026.100848_bib85","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1364\/BOE.8.000757","article-title":"Ultrasound-guided spectral photoacoustic imaging of hemoglobin oxygenation during development","volume":"8","author":"Bayer","year":"2017","journal-title":"Biomed. Opt. Express"},{"key":"10.1016\/j.pacs.2026.100848_bib86","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0169850","article-title":"Real-Time Monitoring of Placental Oxygenation during Maternal Hypoxia and Hyperoxygenation Using Photoacoustic Imaging","volume":"12","author":"Arthuis","year":"2017","journal-title":"PloS. One"},{"key":"10.1016\/j.pacs.2026.100848_bib87","doi-asserted-by":"crossref","DOI":"10.1002\/jbio.202070009","article-title":"Photoacoustic imaging of the human placental vasculature","volume":"13","author":"Maneas","year":"2020","journal-title":"J. Biophotonics"},{"key":"10.1016\/j.pacs.2026.100848_bib88","doi-asserted-by":"crossref","DOI":"10.1016\/j.pacs.2024.100662","article-title":"Ultrasound-guided photoacoustic image annotation toolkit in MATLAB (PHANTOM) for preclinical applications","volume":"41","author":"Sweeney","year":"2025","journal-title":"Photoacoustics"}],"container-title":["Photoacoustics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213597926000546?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213597926000546?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T11:21:02Z","timestamp":1784546462000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213597926000546"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":88,"alternative-id":["S2213597926000546"],"URL":"https:\/\/doi.org\/10.1016\/j.pacs.2026.100848","relation":{},"ISSN":["2213-5979"],"issn-type":[{"value":"2213-5979","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Noninvasive multimodal photoacoustic-ultrasound imaging for dynamic assessment of placental hypoxia and perfusion in preeclampsia","name":"articletitle","label":"Article Title"},{"value":"Photoacoustics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pacs.2026.100848","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Published by Elsevier GmbH.","name":"copyright","label":"Copyright"}],"article-number":"100848"}}