{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T08:40:06Z","timestamp":1793176806122,"version":"4.5.0"},"reference-count":54,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T00:00:00Z","timestamp":1787443200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["RS-2026-25486008"],"award-info":[{"award-number":["RS-2026-25486008"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["RS-2023-00210682"],"award-info":[{"award-number":["RS-2023-00210682"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["RS-2025-00560665"],"award-info":[{"award-number":["RS-2025-00560665"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["RS-2024-00462912"],"award-info":[{"award-number":["RS-2024-00462912"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["RS-2020-NR049544"],"award-info":[{"award-number":["RS-2020-NR049544"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Photoacoustics"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.pacs.2026.100875","type":"journal-article","created":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T16:18:21Z","timestamp":1787588301000},"page":"100875","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Label-free ultraviolet photoacoustic microscopy for multiscale structural phenotyping of epithelial morphogenesis in organoid-derived intestinal epithelial wrinkle tissue"],"prefix":"10.1016","volume":"51","author":[{"given":"Linbin","family":"Zha","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-5854-3008","authenticated-orcid":false,"given":"Jangwon","family":"Yoon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santanu","family":"Misra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyunjun","family":"Kye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2542-0234","authenticated-orcid":false,"given":"Jeesu","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaesung","family":"Youn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong Sung","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2949-1419","authenticated-orcid":false,"given":"Byullee","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.pacs.2026.100875_bib1","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1038\/s41567-018-0046-7","article-title":"Human brain organoids on a chip reveal the physics of folding","volume":"14","author":"Karzburn","year":"2018","journal-title":"Nat. Phys."},{"key":"10.1016\/j.pacs.2026.100875_bib2","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1038\/s41556-021-00699-6","article-title":"Mechanical compartmentalization of the intestinal organoid enable crypt folding and collective cell migration","volume":"23","author":"Gonzalez","year":"2021","journal-title":"Nat. Cell. Biol."},{"key":"10.1016\/j.pacs.2026.100875_bib3","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1038\/s41556-017-0001-3","article-title":"A homeostatic apical microtubule network shortens cells for epithelial folding via a basal polarity shift","volume":"20","author":"Takeda","year":"2018","journal-title":"Nat. Cell. Biol."},{"key":"10.1016\/j.pacs.2026.100875_bib4","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.gde.2020.02.014","article-title":"Divergent and combinatorial mechanical strategies that promote epithelial folding during morphogenesis","volume":"63","author":"Denk-Lobnig","year":"2020","journal-title":"Curr. Opin. Genet. Dev."},{"key":"10.1016\/j.pacs.2026.100875_bib5","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2023.1223032","article-title":"Human organoids are superior to cell culture models for intestinal barrier research","volume":"11","author":"Kollmann","year":"2023","journal-title":"Front. Cell. Dev. Biol."},{"key":"10.1016\/j.pacs.2026.100875_bib6","doi-asserted-by":"crossref","first-page":"6244","DOI":"10.1038\/s41467-020-20052-z","article-title":"A bioengineering perspective on modeling the intestinal epithelial physiology in vitro","volume":"11","author":"Antfolk","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.pacs.2026.100875_bib7","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1038\/s41596-021-00674-3","article-title":"3D in vitro morphogenesis of human intestinal epithelium in a gut-on-a-chip or a hybrid chip with a cell culture insert","volume":"17","author":"Shin","year":"2022","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.pacs.2026.100875_bib8","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1126\/science.aat0835","article-title":"Intestinal barrier protect against disease","volume":"259","author":"Citi","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.pacs.2026.100875_bib9","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1038\/nature10208","article-title":"Intestinal homeostasis and its breakdown in inflammatory bowel disease","volume":"474","author":"Maloy","year":"2011","journal-title":"Nature"},{"issue":"2024","key":"10.1016\/j.pacs.2026.100875_bib10","doi-asserted-by":"crossref","first-page":"7118","DOI":"10.1038\/s41467-024-51437-z","article-title":"Tissue-scale in vitro epithelial wrinkling and wrinkle-to-fold transition","volume":"15","author":"Youn","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.pacs.2026.100875_bib11","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.actbio.2022.03.022","article-title":"Epithelial folding of alveolar cells derived from human induced pluripotent stem cells on artificial basement membrane","volume":"163","author":"Rofaani","year":"2023","journal-title":"Acta Biomater."},{"key":"10.1016\/j.pacs.2026.100875_bib12","doi-asserted-by":"crossref","first-page":"7503","DOI":"10.1073\/pnas.1802361115","article-title":"Folding artificial mucosa with cell-laden hydrogels guided by mechanics models","volume":"115","author":"Chan","year":"2018","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.pacs.2026.100875_bib13","doi-asserted-by":"crossref","first-page":"E10539","DOI":"10.1073\/pnas.1810819115","article-title":"Intestinal barrier dysfunction orchestrates the onset of inflammatory host-microbiome cross-talk in a human gut inflammation-on-a-chip","volume":"115","author":"Shin","year":"2018","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.pacs.2026.100875_bib14","article-title":"Self-organized intestinal epithelial monolayers in crypt and villus-like domains show effective barrier function","volume":"9","author":"Altay","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.pacs.2026.100875_bib15","article-title":"Programmable tissue folding patterns in structured hydrogels","volume":"36","author":"Roy","year":"2023","journal-title":"Adv. Mater."},{"key":"10.1016\/j.pacs.2026.100875_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.pacs.2024.100610","article-title":"On-demand expansion fluorescence and photoacoustic microscopy (ExFLPAM)","volume":"38","author":"Mu","year":"2024","journal-title":"Photoacoustics"},{"key":"10.1016\/j.pacs.2026.100875_bib17","doi-asserted-by":"crossref","first-page":"7379","DOI":"10.1021\/acs.chemrev.2c00627","article-title":"Recent advances in contrast-enhanced photoacoustic imaging: overcoming the physical and practical challenges","volume":"123","author":"Choi","year":"2023","journal-title":"Chem. Rev."},{"key":"10.1016\/j.pacs.2026.100875_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.pacs.2019.100141","article-title":"Review on practical photoacoustic microscopy","volume":"15","author":"Jeon","year":"2019","journal-title":"Photoacoustics"},{"key":"10.1016\/j.pacs.2026.100875_bib19","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1002\/lpor.201200060","article-title":"Photoacoustic microscopy","volume":"7","author":"Yao","year":"2013","journal-title":"Laser Photonics Rev."},{"key":"10.1016\/j.pacs.2026.100875_bib20","doi-asserted-by":"crossref","first-page":"55","DOI":"10.36922\/ijb.5732","article-title":"3D bioprinting and label-free imaging:bridging innovations for organoid research","volume":"11","author":"Zha","year":"2024","journal-title":"Int. J. Bioprint"},{"key":"10.1016\/j.pacs.2026.100875_bib21","article-title":"Label-free 3D photoacoustic imaging of tumor organoids for volumetric drug screening","volume":"12","author":"Luo","year":"2025","journal-title":"Adv. Sci."},{"key":"10.1016\/j.pacs.2026.100875_bib22","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.ady6173","article-title":"Smarter Biopsy decisions in thyroid nodules via dual-modal photoacoustic and ultrasound imaging","volume":"11","author":"Ahn","year":"2025","journal-title":"Sci. Adv."},{"key":"10.1016\/j.pacs.2026.100875_bib23","doi-asserted-by":"crossref","first-page":"7323","DOI":"10.1038\/s41467-025-62747-1","article-title":"Light in, sound keys out: photoacoustic PUFs from stochastic nanocomposites","volume":"16","author":"Park","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.pacs.2026.100875_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.pacs.2025.100725","article-title":"Wavelength-time-division multiplexed fiber-optic sensor array for wide-field photoacoustic microscopy","volume":"43","author":"Li","year":"2025","journal-title":"Photoacoustics"},{"key":"10.1016\/j.pacs.2026.100875_bib25","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.ado0518","article-title":"Optical-resolution parallel ultraviolet photoacoustic microscopy for slide-free histology","volume":"10","author":"Cao","year":"2024","journal-title":"Sci. Adv."},{"key":"10.1016\/j.pacs.2026.100875_bib26","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.adz1820","article-title":"Rapid cancer diagnosis using deep learning\u2013powered label-free subcellular-resolution photoacoustic histology","volume":"11","author":"Park","year":"2025","journal-title":"Sci. Adv."},{"key":"10.1016\/j.pacs.2026.100875_bib27","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.1602168","article-title":"Fast label-free multilayered histology-like imaging of human breast cancer by photoacoustic microscopy","volume":"3","author":"Wong","year":"2017","journal-title":"Sci. Adv."},{"key":"10.1016\/j.pacs.2026.100875_bib28","article-title":"Simultaneous ultraviolet photoacoustic and auto-fluorescence microscopy for high-contrast histological imaging","volume":"19","author":"Li","year":"2025","journal-title":"Laser Photonics Rev."},{"key":"10.1016\/j.pacs.2026.100875_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.pacs.2023.100525","article-title":"Ultraviolet metasurface-assisted photoacoustic microscopy with great enhancement in DOF for fast histology imaging","volume":"32","author":"Song","year":"2023","journal-title":"Photoacoustics"},{"key":"10.1016\/j.pacs.2026.100875_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.pacs.2021.100308","article-title":"Deep learning enables ultraviolet photoacoustic microscopy based histological imaging with near real-time virtual staining","volume":"25","author":"Kang","year":"2022","journal-title":"Photoacoustics"},{"key":"10.1016\/j.pacs.2026.100875_bib31","doi-asserted-by":"crossref","first-page":"a029199","DOI":"10.1101\/cshperspect.a029199","article-title":"Tuning collective cell migration by cell-cell junction regulation","volume":"9","author":"Friedl","year":"2017","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.pacs.2026.100875_bib32","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/j.ceb.2012.08.002","article-title":"Cadherins in collective cell migration of mesenchymal cells","volume":"24","author":"Theveneau","year":"2012","journal-title":"Curr. Opin. Cell. Biol."},{"key":"10.1016\/j.pacs.2026.100875_bib33","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1038\/s41377-024-01554-7","article-title":"Deep learning-based virtual staining, segmentation, and classification in label-free photoacoustic histology of human specimens","volume":"13","author":"Yoon","year":"2024","journal-title":"Light Sci. Appl."},{"key":"10.1016\/j.pacs.2026.100875_bib34","doi-asserted-by":"crossref","DOI":"10.1117\/1.APN.2.5.054001","article-title":"Recent advances in deep-learning-enhanced photoacoustic imaging","volume":"2","author":"Yang","year":"2023","journal-title":"Adv. Photon. Nexus"},{"key":"10.1016\/j.pacs.2026.100875_bib35","first-page":"1559","article-title":"Classification and mutation prediction from non\u2013small cell lung cancer histopathology images using deep learning","volume":"24","author":"Courday","year":"2018","journal-title":"Nat. Methods"},{"key":"10.1016\/j.pacs.2026.100875_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.media.2025.103865","article-title":"Deep learning based label-free virtual staining and classification of human tissues using digital slide scanner","volume":"108","author":"Misra","year":"2026","journal-title":"Med. Image Anal."},{"key":"10.1016\/j.pacs.2026.100875_bib37","first-page":"839","article-title":"Grad-CAM++: Generalized gradient-based visual explanations for deep convolutional networks","volume":"2018","author":"Chattopadhay","year":"2018","journal-title":"IEEE Winter Conf. Appl. Comput. Vision. (WACV)"},{"key":"10.1016\/j.pacs.2026.100875_bib38","doi-asserted-by":"crossref","DOI":"10.1148\/ryai.2020190043","article-title":"On the interpretability of artificial intelligence in radiology: challenges and opportunities","volume":"2","author":"Reyes","year":"2020","journal-title":"Radiol. Artif. Intell."},{"key":"10.1016\/j.pacs.2026.100875_bib39","article-title":"A biohybrid system to reconstruct epithelial morphpmechanics in vitro","volume":"37","author":"Yoon","year":"2026","journal-title":"Mater. Today Bio"},{"key":"10.1016\/j.pacs.2026.100875_bib40","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/s43074-025-00171-w","article-title":"Ensemble deep learning-enabled single\u2011shot composite structured illumination microscopy (eDL\u2011cSIM)","volume":"6","author":"Qian","year":"2025","journal-title":"PhotoniX"},{"key":"10.1016\/j.pacs.2026.100875_bib41","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1364\/OPTICA.561661","article-title":"Nonlinear flying focus pulses for ultrafast 3D nonlinear microscopy","volume":"12","author":"Mansuryan","year":"2025","journal-title":"Optica"},{"key":"10.1016\/j.pacs.2026.100875_bib42","first-page":"770","article-title":"Deep residual learning for image recognition","author":"He","year":"2016","journal-title":"Proc. CVPR"},{"key":"10.1016\/j.pacs.2026.100875_bib43","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1038\/nri2653","article-title":"Intestinal mucosal barrier function in health and disease","volume":"9","author":"Turner","year":"2009","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.pacs.2026.100875_bib44","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1038\/s41392-023-01501-9","article-title":"Cellular mechanotransduction in health and diseases: from molecular mechanism to therapeutic targets","volume":"8","author":"Di","year":"2023","journal-title":"Signal. Transduct. Target. Ther."},{"key":"10.1016\/j.pacs.2026.100875_bib45","first-page":"4278","article-title":"Inception-v4, Inception-ResNet and the impact of residual connections on learning","author":"Szegedy","year":"2017","journal-title":"Proc. AAAI"},{"key":"10.1016\/j.pacs.2026.100875_bib46","article-title":"Application of ResNet in medical image processing: a review","volume":"241","author":"Xu","year":"2023","journal-title":"Comput. Methods Prog. Biomed."},{"key":"10.1016\/j.pacs.2026.100875_bib47","article-title":"High-speed and high-SNR photoacoustic microscopy based on a galvanometer mirror in non-conducting liquid","volume":"6","author":"Kim","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.pacs.2026.100875_bib48","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1109\/TMI.2019.2938518","article-title":"Super wide-field photoacoustic microscopy of animals and humans in vivo","volume":"39","author":"Baik","year":"2020","journal-title":"IEEE Trans. Med. Imaging"},{"key":"10.1016\/j.pacs.2026.100875_bib49","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1038\/s41566-022-01112-w","article-title":"Optical-resolution photoacoustic microscopy with a needle-shaped beam","volume":"17","author":"Cao","year":"2023","journal-title":"Nat. Photon."},{"key":"10.1016\/j.pacs.2026.100875_bib50","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.adr0654","article-title":"Axially multifocal metalens for 3D volumetric photoacoustic imaging of neuromelanin in live brain organoid","volume":"11","author":"Barulin","year":"2025","journal-title":"Sci. Adv."},{"key":"10.1016\/j.pacs.2026.100875_bib51","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.1038\/s41467-017-01649-3","article-title":"Label-free automated three-dimensional imaging of whole organs by microtomy-assisted photoacoustic microsocpy","volume":"8","author":"Wong","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.pacs.2026.100875_bib52","article-title":"Intraoperative label-free photoacoustic histopathology of clinical specimens","volume":"15","author":"Baik","year":"2021","journal-title":"Laser Photonics Rev."},{"key":"10.1016\/j.pacs.2026.100875_bib53","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1038\/s41551-022-00940-z","article-title":"Label-free intraoperative histology of bone tissue via deep-learning-assisted ultraviolet photoacoustic microscopy","volume":"7","author":"Cao","year":"2023","journal-title":"Nat. Biomed. Eng."},{"key":"10.1016\/j.pacs.2026.100875_bib54","article-title":"An ultraviolet-transparent ultrasound transducer enables high-resolution label-free photoacoustic histopathology","volume":"18","author":"Kim","year":"2024","journal-title":"Laser Photonics Rev."}],"container-title":["Photoacoustics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213597926000819?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213597926000819?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T08:28:40Z","timestamp":1793176120000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213597926000819"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":54,"alternative-id":["S2213597926000819"],"URL":"https:\/\/doi.org\/10.1016\/j.pacs.2026.100875","relation":{},"ISSN":["2213-5979"],"issn-type":[{"value":"2213-5979","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Label-free ultraviolet photoacoustic microscopy for multiscale structural phenotyping of epithelial morphogenesis in organoid-derived intestinal epithelial wrinkle tissue","name":"articletitle","label":"Article Title"},{"value":"Photoacoustics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pacs.2026.100875","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier GmbH.","name":"copyright","label":"Copyright"}],"article-number":"100875"}}