{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T08:39:56Z","timestamp":1793176796607,"version":"4.5.0"},"reference-count":78,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T00:00:00Z","timestamp":1789344000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100006369","name":"George Mason University","doi-asserted-by":"publisher","award":["G00002563"],"award-info":[{"award-number":["G00002563"]}],"id":[{"id":"10.13039\/100006369","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100024256","name":"Toronto Metropolitan University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100024256","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["RGPIN-2022-04143"],"award-info":[{"award-number":["RGPIN-2022-04143"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100019828","name":"Virginia Innovation Partnership Corporation","doi-asserted-by":"publisher","award":["CCF23-0092-HE"],"award-info":[{"award-number":["CCF23-0092-HE"]}],"id":[{"id":"10.13039\/100019828","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Photoacoustics"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.pacs.2026.100885","type":"journal-article","created":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T16:53:30Z","timestamp":1790096010000},"page":"100885","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Transcranial photoacoustic imaging of indocyanine green J-aggregates reveals cerebral signal changes in lipopolysaccharide-induced systemic inflammation"],"prefix":"10.1016","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1637-8054","authenticated-orcid":false,"given":"Filip J.","family":"Bodera","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Berndl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shrishti","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony","family":"Tay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Greeshma","family":"Tarimala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel K.","family":"Jensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parag V.","family":"Chitnis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Remi","family":"Veneziano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark J.","family":"McVey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael C.","family":"Kolios","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.pacs.2026.100885_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2021.153712","article-title":"Cascade of immune mechanism and consequences of inflammatory disorders","volume":"91","author":"Megha","year":"2021","journal-title":"Phytomedicine"},{"key":"10.1016\/j.pacs.2026.100885_bib2","doi-asserted-by":"crossref","first-page":"a016345","DOI":"10.1101\/cshperspect.a016345","article-title":"Inflammation and the blood microvascular system","volume":"7","author":"Pober","year":"2015","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.pacs.2026.100885_bib3","series-title":"Chronic inflammation. StatPearls","author":"Pahwa","year":"2025"},{"key":"10.1016\/j.pacs.2026.100885_bib4","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/S2213-2600(23)00330-2","article-title":"Profiling the dysregulated immune response in sepsis: overcoming challenges to achieve the goal of precision medicine","volume":"12","author":"Cajander","year":"2024","journal-title":"Lancet Respir. Med."},{"key":"10.1016\/j.pacs.2026.100885_bib5","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.ccc.2016.08.006","article-title":"Postinjury inflammation and organ dysfunction","volume":"33","author":"Sauaia","year":"2017","journal-title":"Crit. Care Clin."},{"key":"10.1016\/j.pacs.2026.100885_bib6","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1038\/s41586-024-07469-y","article-title":"A body\u2013brain circuit that regulates body inflammatory responses","volume":"630","author":"Jin","year":"2024","journal-title":"Nature"},{"key":"10.1016\/j.pacs.2026.100885_bib7","doi-asserted-by":"crossref","DOI":"10.3389\/fnmol.2022.1013933","article-title":"New insight into neurological degeneration: inflammatory cytokines and blood\u2013brain barrier","volume":"15","author":"Yang","year":"2022","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.pacs.2026.100885_bib8","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1177\/0271678X231171991","article-title":"Candidate neuroinflammatory markers of cerebral autoregulation dysfunction in human acute brain injury","volume":"43","author":"Smith","year":"2023","journal-title":"J. Cereb. Blood Flow. Metab."},{"key":"10.1016\/j.pacs.2026.100885_bib9","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.brainresbull.2011.10.004","article-title":"Role of pro-inflammatory cytokines released from microglia in neurodegenerative diseases","volume":"87","author":"Smith","year":"2012","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.pacs.2026.100885_bib10","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1097\/00004647-199906000-00004","article-title":"Cerebrovascular hemodynamics and ischemic tolerance: lipopolysaccharide-induced resistance to focal cerebral ischemia is not due to changes in severity of the initial ischemic insult, but is associated with preservation of microvascular perfusion","volume":"19","author":"Dawson","year":"1999","journal-title":"J. Cereb. Blood Flow. Metab."},{"key":"10.1016\/j.pacs.2026.100885_bib11","doi-asserted-by":"crossref","first-page":"1937","DOI":"10.1073\/pnas.0610544104","article-title":"Positron emission tomography with computed tomography imaging of neuroinflammation in experimental autoimmune encephalomyelitis","volume":"104","author":"Radu","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.pacs.2026.100885_bib12","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1159\/000070857","article-title":"Assessment of neuroinflammation and microglial activation in Alzheimer\u2019s disease with radiolabelled PK11195 and single photon emission computed tomography: a pilot study","volume":"50","author":"Versijpt","year":"2003","journal-title":"Eur. Neurol."},{"key":"10.1016\/j.pacs.2026.100885_bib13","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/j.jtcvs.2009.08.022","article-title":"Brain immaturity is associated with MRI brain injury before and after neonatal cardiac surgery with high-flow bypass and cerebral oxygenation monitoring","volume":"139","author":"Andropoulos","year":"2010","journal-title":"J. Thorac. Cardiovasc. Surg."},{"key":"10.1016\/j.pacs.2026.100885_bib14","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1007\/s11307-017-1113-7","article-title":"Translocator protein PET imaging in a preclinical prostate cancer model","volume":"20","author":"Tantawy","year":"2018","journal-title":"Mol. Imaging Biol."},{"key":"10.1016\/j.pacs.2026.100885_bib15","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1021\/acs.molpharmaceut.7b00961","article-title":"PET imaging of VCAM-1 expression and monitoring therapy response in tumor with a 68Ga-labeled single chain variable fragment","volume":"15","author":"Zhang","year":"2018","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.pacs.2026.100885_bib16","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.3390\/cancers11071039","article-title":"vivo assessment of VCAM-1 expression by SPECT\/CT imaging in mice models of human triple negative breast cancer","volume":"11","author":"Montemagno","year":"2019","journal-title":"Cancers"},{"key":"10.1016\/j.pacs.2026.100885_bib17","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/j.ebiom.2018.10.021","article-title":"Surgery, neuroinflammation and cognitive impairment","volume":"37","author":"Alam","year":"2018","journal-title":"EBioMedicine"},{"key":"10.1016\/j.pacs.2026.100885_bib18","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1089\/sur.2016.021","article-title":"Current murine models of sepsis","volume":"17","author":"Lewis","year":"2016","journal-title":"Surg. Infect."},{"key":"10.1016\/j.pacs.2026.100885_bib19","doi-asserted-by":"crossref","first-page":"137","DOI":"10.3892\/ijmm.2020.4787","article-title":"Toll\u2011like receptor 4 activates the NLRP3 inflammasome pathway and periodontal inflammaging by inhibiting Bmi\u20111 expression","volume":"47","author":"Qin","year":"2021","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.pacs.2026.100885_bib20","article-title":"NF-\u03baB signaling in inflammation","volume":"2","author":"Liu","year":"2017","journal-title":"Signal. Transduct. Target. Ther."},{"key":"10.1016\/j.pacs.2026.100885_bib21","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1111\/cei.12835","article-title":"Investigation of JAKs\/STAT-3 in lipopolysaccharide-induced intestinal epithelial cells","volume":"186","author":"Fu","year":"2016","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.pacs.2026.100885_bib22","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1007\/s13277-014-2639-9","article-title":"NADPH oxidase 1-dependent ROS is crucial for TLR4 signaling to promote tumor metastasis of non-small cell lung cancer","volume":"36","author":"Liu","year":"2015","journal-title":"Tumour Biol."},{"key":"10.1016\/j.pacs.2026.100885_bib23","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1177\/15353702211073684","article-title":"Photoacoustic imaging systems based on clinical ultrasound platform","volume":"247","author":"Park","year":"2022","journal-title":"Exp. Biol. Med."},{"key":"10.1016\/j.pacs.2026.100885_bib24","series-title":"2023 IEEE Int. Ultrason. Symp.","article-title":"Photoacoustic imaging of vascular hyperpermeability","author":"Ashi","year":"2023"},{"key":"10.1016\/j.pacs.2026.100885_bib25","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1007\/s11307-019-01397-4","article-title":"Transcranial photoacoustic detection of blood\u2013brain barrier disruption following focused ultrasound-mediated nanoparticle delivery","volume":"22","author":"Le Floc\u2019h","year":"2020","journal-title":"Mol. Imaging Biol."},{"key":"10.1016\/j.pacs.2026.100885_bib26","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.cyto.2008.01.006","article-title":"LPS\/TLR4 signal transduction pathway","volume":"42","author":"Lu","year":"2008","journal-title":"Cytokine"},{"key":"10.1016\/j.pacs.2026.100885_bib27","series-title":"StatPearls","article-title":"Biochemistry, lipopolysaccharide","author":"Farhana","year":"2026"},{"key":"10.1016\/j.pacs.2026.100885_bib28","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1038\/nbt839","article-title":"Noninvasive laser-induced photoacoustic tomography for structural and functional in vivo imaging of the brain","volume":"21","author":"Wang","year":"2003","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.pacs.2026.100885_bib29","doi-asserted-by":"crossref","first-page":"2617","DOI":"10.1016\/j.biomaterials.2009.12.007","article-title":"Photoacoustic imaging of living mouse brain vasculature using hollow gold nanospheres","volume":"31","author":"Lu","year":"2010","journal-title":"Biomaterials"},{"key":"10.1016\/j.pacs.2026.100885_bib30","doi-asserted-by":"crossref","DOI":"10.1117\/1.JBO.17.6.061222","article-title":"Gold-nanorod contrast-enhanced photoacoustic micro-imaging of focused-ultrasound induced blood-brain-barrier opening in a rat model","volume":"17","author":"Wang","year":"2012","journal-title":"J. Biomed. Opt."},{"key":"10.1016\/j.pacs.2026.100885_bib31","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.2217\/nnm.12.165","article-title":"Gold nanoparticle imaging and radiotherapy of brain tumors in mice","volume":"8","author":"Hainfeld","year":"2013","journal-title":"Nanomed"},{"key":"10.1016\/j.pacs.2026.100885_bib32","article-title":"Photoacoustic microscopy for multiscale biological system visualization and clinical translation","volume":"13","author":"Wang","year":"2026","journal-title":"Adv. Sci."},{"key":"10.1016\/j.pacs.2026.100885_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.pacs.2026.100854","article-title":"Optoacoustic brain imaging: a systematic review and field mapping","volume":"51","author":"Wang","year":"2026","journal-title":"Photoacoustics"},{"key":"10.1016\/j.pacs.2026.100885_bib34","article-title":"Multiparametric brain hemodynamics imaging using a combined ultrafast ultrasound and photoacoustic system","volume":"11","author":"Chen","year":"2024","journal-title":"Adv. Sci."},{"key":"10.1016\/j.pacs.2026.100885_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.pacs.2024.100671","article-title":"Multimodal fluorescence-optoacoustic in vivo imaging of the near-infrared calcium ion indicator NIR-GECO2G","volume":"41","author":"Shaykevich","year":"2025","journal-title":"Photoacoustics"},{"key":"10.1016\/j.pacs.2026.100885_bib36","doi-asserted-by":"crossref","DOI":"10.1142\/S1793545825500154","article-title":"Photoacoustic detecting of brain lymphatic dysfunction in inflammatory models","volume":"18","author":"Wang","year":"2025","journal-title":"J. Innov. Opt. Health Sci."},{"key":"10.1016\/j.pacs.2026.100885_bib37","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1364\/OL.475578","article-title":"Coregistered transcranial optoacoustic and magnetic resonance angiography of the human brain","volume":"48","author":"Ni","year":"2023","journal-title":"Opt. Lett."},{"key":"10.1016\/j.pacs.2026.100885_bib38","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.taap.2017.07.019","article-title":"Dynamic and accurate assessment of acetaminophen-induced hepatotoxicity by integrated photoacoustic imaging and mechanistic biomarkers in vivo","volume":"332","author":"Brillant","year":"2017","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.pacs.2026.100885_bib39","doi-asserted-by":"crossref","first-page":"11","DOI":"10.3389\/fsurg.2019.00011","article-title":"Indocyanine green for fluorescence-guided surgery of brain tumors: evidence, techniques, and practical experience","volume":"6","author":"Cho","year":"2019","journal-title":"Front. Surg."},{"key":"10.1016\/j.pacs.2026.100885_bib40","doi-asserted-by":"crossref","first-page":"5410","DOI":"10.1038\/s41467-021-25452-3","article-title":"Clinically translatable quantitative molecular photoacoustic imaging with liposome-encapsulated ICG J-aggregates","volume":"12","author":"Wood","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.pacs.2026.100885_bib41","doi-asserted-by":"crossref","first-page":"317","DOI":"10.4103\/tcmj.tcmj_216_20","article-title":"Indocyanine green: An old drug with novel applications","volume":"33","author":"Lu","year":"2021","journal-title":"Tzu Chi Med. J."},{"key":"10.1016\/j.pacs.2026.100885_bib42","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/S0002-8703(66)80008-X","article-title":"Optical behavior of indocyanine green dye in blood and in aqueous solution","volume":"72","author":"Sutterer","year":"1966","journal-title":"Am. Heart J."},{"key":"10.1016\/j.pacs.2026.100885_bib43","doi-asserted-by":"crossref","DOI":"10.1016\/j.pacs.2022.100437","article-title":"Size-tunable ICG-based contrast agent platform for targeted near-infrared photoacoustic imaging","volume":"29","author":"Singh","year":"2023","journal-title":"Photoacoustics"},{"key":"10.1016\/j.pacs.2026.100885_bib44","doi-asserted-by":"crossref","first-page":"2293","DOI":"10.3390\/ijms20092293","article-title":"Lipopolysaccharide-induced neuroinflammation as a bridge to understand neurodegeneration","volume":"20","author":"Batista","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.pacs.2026.100885_bib45","doi-asserted-by":"crossref","first-page":"15863","DOI":"10.1039\/C5NR03626G","article-title":"Nanoparticle distribution during systemic inflammation is size-dependent and organ-specific","volume":"7","author":"Chen","year":"2015","journal-title":"Nanoscale"},{"key":"10.1016\/j.pacs.2026.100885_bib46","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.1023\/A:1012194721763","article-title":"Activation of the mononuclear phagocyte system by Poloxamine 908: its implications for targeted drug delivery","volume":"14","author":"Armstrong","year":"1997","journal-title":"Pharm. Res."},{"key":"10.1016\/j.pacs.2026.100885_bib47","doi-asserted-by":"crossref","first-page":"913","DOI":"10.4049\/jimmunol.133.2.913","article-title":"Stimulation of phagocytosis in bone marrow-derived mouse macrophages by bacterial lipopolysaccharide: correlation with biochemical and functional parameters","volume":"133","author":"Cooper","year":"1984","journal-title":"J. Immunol."},{"key":"10.1016\/j.pacs.2026.100885_bib48","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1111\/cns.13619","article-title":"Central nervous system diseases related to pathological microglial phagocytosis","volume":"27","author":"Wang","year":"2021","journal-title":"CNS Neurosci. Ther."},{"key":"10.1016\/j.pacs.2026.100885_bib49","series-title":"Capillary perfusion. Inflamm. Microcirc","author":"Granger","year":"2010"},{"key":"10.1016\/j.pacs.2026.100885_bib50","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.jneuroim.2008.06.023","article-title":"Lipopolysaccharide-induced hypotension is mediated by a neural pathway involving the vagus nerve, the nucleus tractus solitarius and alpha-adrenergic receptors in the preoptic anterior hypothalamic area","volume":"203","author":"Yilmaz","year":"2008","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.pacs.2026.100885_bib51","series-title":"StatPearls","article-title":"Physiology, cerebral autoregulation","author":"Silverman","year":"2026"},{"key":"10.1016\/j.pacs.2026.100885_bib52","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1186\/s13195-024-01444-5","article-title":"Neuroinflammation increases oxygen extraction in a mouse model of Alzheimer\u2019s disease","volume":"16","author":"Liu","year":"2024","journal-title":"Alzheimers Res. Ther."},{"key":"10.1016\/j.pacs.2026.100885_bib53","doi-asserted-by":"crossref","first-page":"H492","DOI":"10.1152\/ajpheart.01135.2009","article-title":"Endotoxin impairs cardiac hemodynamics by affecting loading conditions but not by reducing cardiac inotropism","volume":"299","author":"Li","year":"2010","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.pacs.2026.100885_bib54","doi-asserted-by":"crossref","first-page":"1404","DOI":"10.3390\/nano13081404","article-title":"Micro- and nanoplastics breach the blood\u2013brain barrier (BBB): biomolecular corona\u2019s role revealed","volume":"13","author":"Kopatz","year":"2023","journal-title":"Nanomaterials"},{"key":"10.1016\/j.pacs.2026.100885_bib55","doi-asserted-by":"crossref","first-page":"8587","DOI":"10.1523\/JNEUROSCI.1098-20.2020","article-title":"Aging-exacerbated acute axon and myelin injury is associated with microglia-derived reactive oxygen species and is alleviated by the generic medication indapamide","volume":"40","author":"Michaels","year":"2020","journal-title":"J. Neurosci."},{"key":"10.1016\/j.pacs.2026.100885_bib56","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.ajpath.2011.10.001","article-title":"LPS-induced murine systemic inflammation is driven by parenchymal cell activation and exclusively predicted by early MCP-1 plasma levels","volume":"180","author":"Juskewitch","year":"2012","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.pacs.2026.100885_bib57","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1186\/s12929-017-0370-8","article-title":"Comprehensive comparison of three different animal models for systemic inflammation","volume":"24","author":"Seemann","year":"2017","journal-title":"J. Biomed. Sci."},{"key":"10.1016\/j.pacs.2026.100885_bib58","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0083045","article-title":"Imaging of an Inflammatory Injury in the Newborn Rat Brain with Photoacoustic Tomography","volume":"8","author":"Guevara","year":"2013","journal-title":"PLOS ONE"},{"key":"10.1016\/j.pacs.2026.100885_bib59","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.trsl.2007.03.013","article-title":"Re-evaluation of Evans Blue dye as a marker of albumin clearance in murine models of acute lung injury","volume":"150","author":"Moitra","year":"2007","journal-title":"Transl. Res."},{"key":"10.1016\/j.pacs.2026.100885_bib60","doi-asserted-by":"crossref","first-page":"2303","DOI":"10.1177\/0271678X221112278","article-title":"Disturbed microcirculation and hyperaemic response in a murine model of systemic inflammation","volume":"42","author":"Fruekilde","year":"2022","journal-title":"J. Cereb. Blood Flow. Metab."},{"key":"10.1016\/j.pacs.2026.100885_bib61","author":"Lee","year":"2024","journal-title":"Funct. Assess. Cereb. capillaries Using. Single Capill. Report. Ultrasound Local. Microsc."},{"key":"10.1016\/j.pacs.2026.100885_bib62","doi-asserted-by":"crossref","DOI":"10.1002\/jbio.201800251","article-title":"Photoacoustic microscopy for evaluating a lipopolysaccharide-induced inflammation model in mice","volume":"12","author":"Guo","year":"2019","journal-title":"J. Biophotonics"},{"key":"10.1016\/j.pacs.2026.100885_bib63","doi-asserted-by":"crossref","DOI":"10.1117\/1.NPh.11.3.035003","article-title":"Evaluation of cerebral microcirculation in a mouse model of systemic inflammation","volume":"11","author":"Zhang","year":"2024","journal-title":"Neurophotonics"},{"key":"10.1016\/j.pacs.2026.100885_bib64","doi-asserted-by":"crossref","first-page":"16345","DOI":"10.3390\/ijms242216345","article-title":"Intravital microscopy of lipopolysaccharide-induced inflammatory changes in different organ systems\u2014a scoping review","volume":"24","author":"Scott","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.pacs.2026.100885_bib65","doi-asserted-by":"crossref","first-page":"610","DOI":"10.3748\/wjg.v10.i4.610","article-title":"Effects of lipopolysaccharides stimulated Kupffer cells on activation of rat hepatic stellate cells","volume":"10","author":"Zhang","year":"2004","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.pacs.2026.100885_bib66","doi-asserted-by":"crossref","first-page":"159","DOI":"10.2170\/physiolsci.RP003407","article-title":"Time-course changes of hormones and cytokines by lipopolysaccharide and its relation with anorexia","volume":"57","author":"Kim","year":"2007","journal-title":"J. Physiol. Sci."},{"key":"10.1016\/j.pacs.2026.100885_bib67","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.pneurobio.2013.04.001","article-title":"Brain development in rodents and humans: identifying benchmarks of maturation and vulnerability to injury across species","volume":"106\u2013107","author":"Semple","year":"2013","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.pacs.2026.100885_bib68","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1146\/annurev-neuro-071714-033835","article-title":"Neuronal and vascular interactions","volume":"38","author":"Andreone","year":"2015","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.pacs.2026.100885_bib69","doi-asserted-by":"crossref","first-page":"1777","DOI":"10.1177\/0271678X221111600","article-title":"Cerebral ischemia in the developing brain","volume":"42","author":"Dietz","year":"2022","journal-title":"J. Cereb. Blood Flow. Metab."},{"key":"10.1016\/j.pacs.2026.100885_bib70","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.neuroscience.2015.06.035","article-title":"Age and sex differences in c-Fos expression and serum corticosterone concentration following LPS treatment","volume":"305","author":"Girard-Joyal","year":"2015","journal-title":"Neuroscience"},{"key":"10.1016\/j.pacs.2026.100885_bib71","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-72537-y","article-title":"Sex differences of inflammatory and immune response in pups of Wistar rats with SIRS","volume":"10","author":"Kosyreva","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.pacs.2026.100885_bib72","doi-asserted-by":"crossref","first-page":"972","DOI":"10.3390\/brainsci12080972","article-title":"Lipopolysaccharide exposure differentially alters plasma and brain inflammatory markers in adult male and female rats","volume":"12","author":"Nonoguchi","year":"2022","journal-title":"Brain Sci."},{"key":"10.1016\/j.pacs.2026.100885_bib73","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.ady6275","article-title":"Multidimensional dynamic optical imaging unveils anesthetic-driven hemispheric lateralization in blood\u2013brain barrier homeostasis","volume":"11","author":"Li","year":"2025","journal-title":"Sci. Adv."},{"key":"10.1016\/j.pacs.2026.100885_bib74","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.1021\/nl049126a","article-title":"Photoacoustic tomography of a nanoshell contrast agent in the in vivo rat brain","volume":"4","author":"Wang","year":"2004","journal-title":"Nano Lett."},{"key":"10.1016\/j.pacs.2026.100885_bib75","doi-asserted-by":"crossref","DOI":"10.1063\/1.2195024","article-title":"Photoacoustic imaging in biomedicine","volume":"77","author":"Xu","year":"2006","journal-title":"Rev. Sci. Instrum."},{"key":"10.1016\/j.pacs.2026.100885_bib76","series-title":"ANSI Z136.1-2022: American National Standard for Safe Use of Lasers","author":"American National Standards Institute","year":"2022"},{"key":"10.1016\/j.pacs.2026.100885_bib77","doi-asserted-by":"crossref","DOI":"10.1016\/j.pacs.2020.100179","article-title":"Low-toxicity FePt nanoparticles for the targeted and enhanced diagnosis of breast tumors using few centimeters deep whole-body photoacoustic imaging","volume":"19","author":"Liu","year":"2020","journal-title":"Photoacoustics"},{"key":"10.1016\/j.pacs.2026.100885_bib78","author":"Singh","year":"2026","journal-title":"Direct Synth. Target. nanosized ICG J. -Aggreg. Photoacoust. Imaging"}],"container-title":["Photoacoustics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213597926000911?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213597926000911?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T08:28:12Z","timestamp":1793176092000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213597926000911"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":78,"alternative-id":["S2213597926000911"],"URL":"https:\/\/doi.org\/10.1016\/j.pacs.2026.100885","relation":{},"ISSN":["2213-5979"],"issn-type":[{"value":"2213-5979","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Transcranial photoacoustic imaging of indocyanine green J-aggregates reveals cerebral signal changes in lipopolysaccharide-induced systemic inflammation","name":"articletitle","label":"Article Title"},{"value":"Photoacoustics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pacs.2026.100885","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier GmbH.","name":"copyright","label":"Copyright"}],"article-number":"100885"}}