{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T07:26:24Z","timestamp":1790839584369,"version":"4.1.0"},"reference-count":31,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2004,7]]},"DOI":"10.1016\/j.pain.2004.04.020","type":"journal-article","created":{"date-parts":[[2004,5,29]],"date-time":"2004-05-29T13:36:16Z","timestamp":1085837776000},"page":"385-392","source":"Crossref","is-referenced-by-count":117,"title":["Chronic fentanyl or buprenorphine infusion in the mouse: similar analgesic profile but different effects on immune responses"],"prefix":"10.1097","volume":"110","author":[{"given":"Cataldo","family":"Martucci","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto E","family":"Panerai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Sacerdote","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-47-20210126","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/0165-5728(95)00159-X","article-title":"Inhibition of primary murine macrophage cytokine production in vitro following treatement with the kappa-opioid agonist U50-488H.","volume":"64","author":"Alicea","year":"1996","journal-title":"J Neuroimmunol"},{"key":"R2-47-20210126","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1124\/jpet.103.053264","article-title":"Antagonism of N-methyl d aspartate receptors reduces the vulnerability of the immune system to stress after chronic morphine.","volume":"2","author":"Alonzo","year":"2003","journal-title":"J Pharmacol Exp Ther"},{"key":"R3-47-20210126","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1093\/bja\/57.2.192","article-title":"Clinical action of fentanyl and buprenorphine. The significance of receptor binding.","volume":"57","author":"Boas","year":"1985","journal-title":"Br J Anesth"},{"key":"R4-47-20210126","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/S0014-2999(96)00960-0","article-title":"Magnitude of tolerance to fentanyl is independent on mu-opioid receptor density.","volume":"319","author":"Chang","year":"1997","journal-title":"Eur J Pharmacol"},{"key":"R5-47-20210126","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/S1521-6616(03)00177-3","article-title":"No detrimental effect from chronic exposure to buprenorphine on corticosteroid-binding globulin and corticosensitive immune parameters.","volume":"109","author":"DElia","year":"2003","journal-title":"Clin Immunol"},{"key":"R6-47-20210126","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1097\/00000542-199505000-00018","article-title":"The effect of intrinsic efficacy on opioid tolerance.","volume":"82","author":"Duttory","year":"1995","journal-title":"Anesthesiology"},{"key":"R7-47-20210126","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/S0165-5728(97)00219-1","article-title":"Opioid modulation of immune responses: effects on phagocyte and lymphoid cell populations.","volume":"83","author":"Eisenstein","year":"1998","journal-title":"J Neuroimmunol"},{"key":"R8-47-20210126","doi-asserted-by":"crossref","first-page":"1999","DOI":"10.2165\/00003495-200363190-00003","article-title":"Transdermal buprenorphine.","volume":"63","author":"Evans","year":"2003","journal-title":"Drugs"},{"key":"R9-47-20210126","first-page":"626","article-title":"Assessment of the involvement of central nervous system and peripheral opioid receptors in the immunomodulatory effects of acute morphine treatment in rats.","volume":"276","author":"Fecho","year":"1996","journal-title":"J Pharmacol Exp Ther"},{"key":"R10-47-20210126","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/S0014-2999(96)00788-1","article-title":"Potential role of the autonomic nervous system in the immunosuppressive effects of the acute morphine administration.","volume":"318","author":"Flores","year":"1996","journal-title":"Eur J Pharmacol"},{"key":"R11-47-20210126","first-page":"633","article-title":"A mechanism of action for morphine-induced immunosuppression: corticosterone mediates morphine-induced suppression of natural killer activity.","volume":"277","author":"Freier","year":"1994","journal-title":"J Pharmacol Exp Ther"},{"key":"R12-47-20210126","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/S0165-5728(02)00419-8","article-title":"Enhanced humoral response in kappa-opioid receptor knock-out mice.","volume":"134","author":"Gaveriaux Ruff","year":"2003","journal-title":"J Neuroimmunol"},{"key":"R13-47-20210126","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/S0162-3109(00)00198-3","article-title":"Differential effects of buprenorphine and morphine on immune and neuroendocrine functions folowing acute administration in the rat mesencephalon periacqueductal gray.","volume":"48","author":"Gomez-Flores","year":"2000","journal-title":"Immunopharmacology"},{"key":"R14-47-20210126","doi-asserted-by":"crossref","first-page":"109","DOI":"10.2165\/00003495-199753010-00011","article-title":"Transdermal fentanyl: a review of its pharmacological properties and therapeutic efficacy in pain control.","volume":"53","author":"Jeal","year":"1997","journal-title":"Drugs"},{"key":"R15-47-20210126","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/S0192-0561(99)00025-9","article-title":"Effects of fentanyl on celllar immune functios in man.","volume":"21","author":"Karst","year":"1999","journal-title":"Int J Immunopharmacol"},{"key":"R16-47-20210126","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1189\/jlb.72.1.43","article-title":"Differential tolerance development in the modulation of macrophage cytokine production in mice.","volume":"72","author":"Limiroli","year":"2002","journal-title":"J Leukoc Biol"},{"key":"R17-47-20210126","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/S0376-8716(00)00181-2","article-title":"Opioids, opioid receptors and the immune response.","volume":"62","author":"Mc Carthy","year":"2001","journal-title":"Drug Alcohol Depend"},{"key":"R18-47-20210126","first-page":"1112","article-title":"Effect of morphine and methadone acute treatment on immunologicals activity in mice, pharmacokinetics and pharmacodynamic correlates.","volume":"269","author":"Pacifici","year":"1994","journal-title":"J Pharmacol Exp Ther"},{"key":"R19-47-20210126","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1007\/BF02244991","article-title":"Sensitization and tolerance to the discriminative stimulus effects of mu-opioid agonists.","volume":"114","author":"Paronis","year":"1994","journal-title":"Psychopharmacology"},{"key":"R20-47-20210126","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/S0165-5728(97)00216-6","article-title":"Opiates and infections.","volume":"83","author":"Risdahl","year":"1998","journal-title":"J Neuroimmunol"},{"key":"R21-47-20210126","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1038\/sj.bjp.0701138","article-title":"Antinociceptive and immunosuppressive effects of opiate drugs: a structure-related activity study.","volume":"121","author":"Sacerdote","year":"1997","journal-title":"Br J Pharmacol"},{"key":"R22-47-20210126","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/S0304-3959(97)00055-9","article-title":"Effects of tramadol on immune responses and nociceptive thresholds in mice.","volume":"72","author":"Sacerdote","year":"1997","journal-title":"Pain"},{"key":"R23-47-20210126","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1097\/00000539-200006000-00028","article-title":"Effects of tramadol and morphine on immune responses and pain after surgery in cancer patients.","volume":"90","author":"Sacerdote","year":"2000","journal-title":"Anesth Analg"},{"key":"R24-47-20210126","doi-asserted-by":"crossref","first-page":"2031","DOI":"10.1182\/blood.V95.6.2031","article-title":"The opioid antagonist naloxone induces a shift from type 1 cytokine pattern to type 2 cytokine pattern in balbcJmice.","volume":"95","author":"Sacerdote","year":"2000","journal-title":"Blood"},{"key":"R25-47-20210126","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1189\/jlb.71.5.782","article-title":"The immunosuppressive effects of chronic morphine treatement are partially dependent on corticosterone and mediated by the mu opioid receptor.","volume":"71","author":"Wang","year":"2002","journal-title":"J Leukoc Biol"},{"key":"R26-47-20210126","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/S0376-8716(97)00059-8","article-title":"Tolerance development to morphine-induced alterations of immune status.","volume":"46","author":"West","year":"1997","journal-title":"Drug Alcohol Depend"},{"key":"R27-47-20210126","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S0376-8716(98)00109-4","article-title":"Differential tolerance to morphines immunomodulatory effects following continuous administration.","volume":"53","author":"West","year":"1998","journal-title":"Drug Alcohol Depend"},{"key":"R28-47-20210126","first-page":"404","article-title":"Non peptide opioids: in vivo effects on the immune system.","volume":"105","author":"Williams","year":"1991","journal-title":"NIDA Res Monogr"},{"key":"R29-47-20210126","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1001\/archsurg.1991.01410280056007","article-title":"Effect of morphine on growth of metastatic colon cancer in vivo.","volume":"126","author":"Yeager","year":"1991","journal-title":"Arch Surg"},{"key":"R30-47-20210126","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1097\/00000542-199509000-00008","article-title":"Morphine inhibits spontaneous and cytokine enhanced natural killer cell cytotoxicity in volunteers.","volume":"83","author":"Yeager","year":"1995","journal-title":"Anesthesiology"},{"key":"R31-47-20210126","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1213\/00000539-200201000-00018","article-title":"Intravenous fentanyl increases natural killer cell cytotoxixity and circulating CD16lymphocytes in human.","volume":"94","author":"Yeager","year":"2002","journal-title":"Anesth Analg"}],"container-title":["Pain"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/00006396-200407000-00047","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T19:10:43Z","timestamp":1785784243000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00006396-200407000-00047"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,7]]},"references-count":31,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2004]]}},"URL":"https:\/\/doi.org\/10.1016\/j.pain.2004.04.020","relation":{},"ISSN":["0304-3959"],"issn-type":[{"value":"0304-3959","type":"print"}],"subject":[],"published":{"date-parts":[[2004,7]]}}}