{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T12:20:30Z","timestamp":1791980430748,"version":"4.4.0"},"reference-count":43,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2004,9]]},"DOI":"10.1016\/j.pain.2004.06.008","type":"journal-article","created":{"date-parts":[[2004,7,30]],"date-time":"2004-07-30T05:37:34Z","timestamp":1091165854000},"page":"116-124","source":"Crossref","is-referenced-by-count":382,"title":["Reactive oxygen species (ROS) play an important role in a rat model of neuropathic pain"],"prefix":"10.1097","volume":"111","author":[{"given":"Hee Kee","family":"Kim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soon Kwon","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun-Li","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulio","family":"Taglialatela","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyungsoon","family":"Chung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard E.","family":"Coggeshall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin Mo","family":"Chung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-15-20210126","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/S0959-4388(00)00216-6","article-title":"NMDA receptor regulation by Src kinase signalling in excitatory synaptic transmission and plasticity.","volume":"11","author":"Ali","year":"2001","journal-title":"Curr Opin Neurobiol"},{"key":"R2-15-20210126","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/S1526-5900(03)00617-5","article-title":"Peripheral norepinephrine exacerbates neuritis-induced hyperalgesia.","volume":"4","author":"Baik","year":"2003","journal-title":"J Pain"},{"key":"R3-15-20210126","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1007\/BF00965146","article-title":"Evidence of an oxidative challenge in the Alzheimers brain.","volume":"19","author":"Balazs","year":"1994","journal-title":"Neurochem Res"},{"key":"R4-15-20210126","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0165-0270(94)90144-9","article-title":"Quantitative assessment of tactile allodynia in the rat paw.","volume":"53","author":"Chaplan","year":"1994","journal-title":"J Neurosci Methods"},{"key":"R5-15-20210126","doi-asserted-by":"crossref","first-page":"317","DOI":"10.3109\/10715769009145690","article-title":"Excretion, metabolism and tissue distribution of a spin trapping agent, Phenyl-N-tert-butyl-nitrone (PBN) in rats.","volume":"9","author":"Chen","year":"1990","journal-title":"Free Radic Res Commun"},{"key":"R6-15-20210126","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/0022-510X(95)00325-V","article-title":"Neuropathic pain in rats is associated with altered nitric oxide synthase activity in neural tissue.","volume":"138","author":"Choi","year":"1996","journal-title":"J Neurol Sci"},{"key":"R7-15-20210126","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1046\/j.1533-2500.2002.02011.x","article-title":"Importance of hyperexcitability of DRG neurons in neuropathic pain.","volume":"2","author":"Chung","year":"2002","journal-title":"Pain Pract"},{"key":"R8-15-20210126","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1126\/science.7901908","article-title":"Oxidative stress, glutamate, and neurodegenerative disorders.","volume":"262","author":"Coyle","year":"1993","journal-title":"Science"},{"key":"R9-15-20210126","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/S0304-3959(01)00345-1","article-title":"Reversible analgesia, atonia, and loss of consciousness on bilateral intracerebral microinjection of pentobarbital.","volume":"94","author":"Devor","year":"2001","journal-title":"Pain"},{"key":"R10-15-20210126","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1146\/annurev.pa.20.040180.002301","article-title":"Efficient analysis of experimental observations.","volume":"20","author":"Dixon","year":"1980","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"R11-15-20210126","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1046\/j.1471-4159.1994.63030793.x","article-title":"Altered brain metabolism of iron as a cause of neurodegenerative diseases?","volume":"63","author":"Gerlach","year":"1994","journal-title":"J Neurochem"},{"key":"R12-15-20210126","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/0163-7258(94)90055-8","article-title":"Oxidative stress: free radical production in neural degeneration.","volume":"63","author":"Gotz","year":"1994","journal-title":"Pharmacol Ther"},{"key":"R13-15-20210126","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/0304-3959(92)90259-E","article-title":"Painful neuropathy: altered central processing maintained dynamically by peripheral input.","volume":"51","author":"Gracely","year":"1992","journal-title":"Pain"},{"key":"R14-15-20210126","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/0028-3908(92)90175-O","article-title":"Electrophysiological evidence for a role of nitric oxide in prolonged chemical nociception in the rat.","volume":"31","author":"Haley","year":"1992","journal-title":"Neuropharmacology"},{"key":"R16-15-20210126","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/S0304-3959(99)00219-5","article-title":"Characteristics of ectopic discharges in a rat neuropathic pain model.","volume":"84","author":"Han","year":"2000","journal-title":"Pain"},{"key":"R17-15-20210126","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/0304-3959(96)03039-4","article-title":"Treatment of a chronic allodynia-like response in spinally injured rats: effects of systemically administered nitric oxide synthase inhibitors.","volume":"66","author":"Hao","year":"1996","journal-title":"Pain"},{"key":"R19-15-20210126","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/S0197-4580(98)00096-7","article-title":"NSAIDs and incident Alzheimers disease. The Rotterdam Study.","volume":"19","author":"Int Veld","year":"1998","journal-title":"Neurobiol Aging"},{"key":"R20-15-20210126","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1016\/S0140-6736(94)92347-7","article-title":"Oxidative damage in neurodegenerative disease.","volume":"344","author":"Jenner","year":"1994","journal-title":"Lancet"},{"key":"R21-15-20210126","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1006\/nbdi.2000.0360","article-title":"Neuronal plasticity and signal transduction in nociceptive neurons: implications for the initiation and maintenance of pathological pain.","volume":"8","author":"Ji","year":"2001","journal-title":"Neurobiol Dis"},{"key":"R22-15-20210126","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1093\/bja\/86.1.110","article-title":"Lazaroids: efficacy and mechanism of action of the 21-aminosteroids in neuroprotection.","volume":"86","author":"Kavanagh","year":"2001","journal-title":"Br J Anaesth"},{"key":"R23-15-20210126","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S0304-3959(98)00143-2","article-title":"Free radicals contribute to the reduction in peripheral vascular responses and the maintenance of thermal hyperalgesia in rats with chronic constriction injury.","volume":"79","author":"Khalil","year":"1999","journal-title":"Pain"},{"key":"R24-15-20210126","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/0304-3959(92)90041-9","article-title":"An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat.","volume":"50","author":"Kim","year":"1992","journal-title":"Pain"},{"key":"R28-15-20210126","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1089\/ars.1999.1.4-481","article-title":"Pharmacologic properties of phenyl N-tert-butylnitrone.","volume":"1","author":"Kotake","year":"1999","journal-title":"Antioxid Redox Signal"},{"key":"R29-15-20210126","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1089\/neu.2000.17.871","article-title":"Free radical pathways in CNS injury.","volume":"17","author":"Lewen","year":"2000","journal-title":"J Neurotrauma"},{"key":"R30-15-20210126","doi-asserted-by":"crossref","first-page":"3293","DOI":"10.1523\/JNEUROSCI.17-09-03293.1997","article-title":"Involvement of cGMP in nociceptive processing by and sensitization of spinothalamic neurons in primates.","volume":"17","author":"Lin","year":"1997","journal-title":"J Neurosci"},{"key":"R31-15-20210126","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/S0006-8993(99)02165-4","article-title":"Ectopic discharges and adrenergic sensitivity of sensory neurons after spinal nerve injury.","volume":"849","author":"Liu","year":"1999","journal-title":"Brain Res"},{"key":"R32-15-20210126","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/S0006-8993(01)02274-0","article-title":"Ion channels associated with the ectopic discharges generated after segmental spinal nerve injury in the rat.","volume":"900","author":"Liu","year":"2001","journal-title":"Brain Res"},{"key":"R33-15-20210126","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/0306-4522(94)90250-X","article-title":"The role of nitric oxide in the development and maintenance of the hyperalgesia produced by intraplantar injection of carrageenan in the rat.","volume":"60","author":"Meller","year":"1994","journal-title":"Neuroscience"},{"key":"R34-15-20210126","doi-asserted-by":"crossref","first-page":"S2","DOI":"10.1002\/ana.410320703","article-title":"An introduction to the free radical hypothesis in Parkinsons disease.","volume":"32","author":"Olanow","year":"1992","journal-title":"Ann Neurol"},{"key":"R35-15-20210126","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/S0304-3959(03)00138-6","article-title":"Anti-hyperalgesic and morphine-sparing actions of propentofylline following peripheral nerve injury in rats: mechanistic implications of spinal glia and proinflammaotry cytokines.","volume":"104","author":"Raghavendra","year":"2003","journal-title":"Pain"},{"key":"R36-15-20210126","doi-asserted-by":"crossref","first-page":"269","DOI":"10.3109\/10611869308996085","article-title":"Application of a biophysical-kinetic model to understand the roles of protein binding and membrane partitioning on passive diffusion of highly lipophilic molecules across cellular barriers.","volume":"1","author":"Raub","year":"1993","journal-title":"J Drug Target"},{"key":"R37-15-20210126","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/0306-4522(96)00060-7","article-title":"The nitric oxide-cyclic GMP pathway is required for nociceptive signalling at specific loci within the somatosensory pathway.","volume":"73","author":"Salter","year":"1996","journal-title":"Neuroscience"},{"key":"R38-15-20210126","first-page":"1133","article-title":"Mitochondrial function in neurodegeneration and aging.","volume":"275","author":"Schapira","year":"1992","journal-title":"Mutat Res"},{"key":"R39-15-20210126","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1097\/00001756-199605310-00010","article-title":"A novel antioxidant alleviates heat hyperalgesia in rats with an experimental painful peripheral neuropathy.","volume":"7","author":"Tal","year":"1996","journal-title":"Neuroreport"},{"key":"R40-15-20210126","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/S0304-3959(01)00402-X","article-title":"Therapeutic administration of nitric oxide synthase inhibitors reverses hyperalgesia but not inflammation in a rat model of polyarthritis.","volume":"95","author":"Tedesco","year":"2002","journal-title":"Pain"},{"key":"R41-15-20210126","first-page":"1365","article-title":"Performance of multiple comparisons in repeated measures designs under nonsphericity.","volume":"15","author":"Thomson","year":"1990","journal-title":"SAS Users Group Int Proc"},{"key":"R42-15-20210126","doi-asserted-by":"crossref","first-page":"2165","DOI":"10.1021\/jm991154w","article-title":"Synthesis, structure, and neuroprotective properties of novel imidazolyl nitrones.","volume":"43","author":"Tizot","year":"2000","journal-title":"J Med Chem"},{"key":"R43-15-20210126","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1124\/dmd.31.2.147","article-title":"Pharmacokinetics and metabolism of the reactive oxygen scavenger -phenyl-N-tert-butylnitrone in the male Sprague-Dawley rat.","volume":"31","author":"Trudeau-Lame","year":"2003","journal-title":"Drug Metab Dispos"},{"key":"R44-15-20210126","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/S0304-3959(98)00091-8","article-title":"Wallerian degeneration and hyperalgesia after peripheral nerve injury are glutathione-dependent.","volume":"77","author":"Wagner","year":"1998","journal-title":"Pain"},{"key":"R46-15-20210126","doi-asserted-by":"crossref","first-page":"7723","DOI":"10.1073\/pnas.96.14.7723","article-title":"Transcriptional and posttranslational plasticity and the generation of inflammatory pain.","volume":"96","author":"Woolf","year":"1999","journal-title":"Proc Natl Acad Sci USA"},{"key":"R47-15-20210126","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1126\/science.288.5472.1765","article-title":"Neuronal plasticity: increasing the gain in pain.","volume":"288","author":"Woolf","year":"2000","journal-title":"Science"},{"key":"R48-15-20210126","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1097\/00001756-199802160-00002","article-title":"Nitric oxide mediates behavioral signs of neuropathic pain in an experimental rat model.","volume":"9","author":"Yoon","year":"1998","journal-title":"Neuroreport"},{"key":"R49-15-20210126","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.pain.2003.09.002","article-title":"The effects of protein phosphatase inhibitions on nociceptive behavioral responses of rats following intradermal injection of capsaicin.","volume":"106","author":"Zhang","year":"2003","journal-title":"Pain"}],"container-title":["Pain"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/journals.lww.com\/00006396-200409000-00015","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,8]],"date-time":"2021-04-08T22:37:09Z","timestamp":1617921429000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/00006396-200409000-00015"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,9]]},"references-count":43,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2004]]}},"URL":"https:\/\/doi.org\/10.1016\/j.pain.2004.06.008","relation":{},"ISSN":["0304-3959"],"issn-type":[{"value":"0304-3959","type":"print"}],"subject":[],"published":{"date-parts":[[2004,9]]}}}