{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T14:47:33Z","timestamp":1785854853486,"version":"3.56.0"},"reference-count":9,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2005,6]]},"DOI":"10.1016\/j.pain.2005.03.004","type":"journal-article","created":{"date-parts":[[2005,4,21]],"date-time":"2005-04-21T07:41:09Z","timestamp":1114069269000},"page":"284-295","source":"Crossref","is-referenced-by-count":84,"title":["MorphiDex\u00ae (morphine sulfate\/dextromethorphan hydrobromide combination) in the treatment of chronic pain: Three multicenter, randomized, double-blind, controlled clinical trials fail to demonstrate enhanced opioid analgesia or reduction in tolerance"],"prefix":"10.1097","volume":"115","author":[{"given":"Bradley S.","family":"Galer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tina","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Nagle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas G.","family":"Schlagheck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-9-20210126","doi-asserted-by":"crossref","first-page":"S31","DOI":"10.1016\/S0885-3924(99)00128-1","article-title":"MorphiDex pharmacokinetic studies and single-dose analgesic efficacy studies in patients with postoperative pain.","volume":"19","author":"Caruso","year":"2000","journal-title":"J Pain Symptom Manage"},{"key":"R2-9-20210126","doi-asserted-by":"crossref","first-page":"S42","DOI":"10.1016\/S0885-3924(99)00130-X","article-title":"Morphine with dextromethorphan: conversion from other opioid analgesics.","volume":"19","author":"Chevlen","year":"2000","journal-title":"J Pain Symptom Manage"},{"key":"R3-9-20210126","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1046\/j.1365-201X.1996.566309000.x","article-title":"N-methyl-D-aspartate receptor antagonists potentiate morphines antinociceptive effect in the rat.","volume":"158","author":"Grass","year":"1996","journal-title":"Acta Physiol Scand"},{"key":"R6-9-20210126","doi-asserted-by":"crossref","first-page":"S26","DOI":"10.1016\/S0885-3924(99)00127-X","article-title":"Abuse potential of morphinedextromethorphan combinations.","volume":"19","author":"Jansinski","year":"2000","journal-title":"J Pain Symptom Manage"},{"key":"R7-9-20210126","doi-asserted-by":"crossref","first-page":"S37","DOI":"10.1016\/S0885-3924(99)00129-3","article-title":"MorphiDex (MS:DM) double-blind, multiple-dose studies in chronic pain patients.","volume":"19","author":"Katz","year":"2000","journal-title":"J Pain Symptom Manage"},{"key":"R8-9-20210126","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/0304-3959(95)00073-2","article-title":"Mechanisms of hyperalgesia and morphine tolerance: a current view of their possible interactions.","volume":"62","author":"Mao","year":"1995","journal-title":"Pain"},{"key":"R9-9-20210126","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/0304-3959(96)03120-X","article-title":"Oral administration of dextromethorphan prevents the development of morphine tolerance and dependence in rats.","volume":"67","author":"Mao","year":"1996","journal-title":"Pain"},{"key":"R10-9-20210126","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1213\/01.ANE.0000081061.12235.55","article-title":"The role of N-methyl-D-aspartate (NMDA) receptors in pain: a review.","volume":"97","author":"Petrenko","year":"2003","journal-title":"Anesth Analg"},{"key":"R11-9-20210126","doi-asserted-by":"crossref","first-page":"S7","DOI":"10.1016\/S0885-3924(99)00121-9","article-title":"NMDA-receptor antagonists and opioid receptor interactions as related to analgesia and tolerance.","volume":"19","author":"Price","year":"2000","journal-title":"J Pain Symptom Manage"}],"container-title":["Pain"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/00006396-200506000-00009","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T13:49:50Z","timestamp":1785851390000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00006396-200506000-00009"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,6]]},"references-count":9,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2005]]}},"URL":"https:\/\/doi.org\/10.1016\/j.pain.2005.03.004","relation":{},"ISSN":["0304-3959"],"issn-type":[{"value":"0304-3959","type":"print"}],"subject":[],"published":{"date-parts":[[2005,6]]}}}