{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T15:15:42Z","timestamp":1789139742787,"version":"build-2803163510"},"reference-count":39,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006,7]]},"DOI":"10.1016\/j.pain.2006.02.006","type":"journal-article","created":{"date-parts":[[2006,4,5]],"date-time":"2006-04-05T15:29:05Z","timestamp":1144250945000},"page":"28-36","source":"Crossref","is-referenced-by-count":137,"title":["A comparative study of oxycodone and morphine in a multi-modal, tissue-differentiated experimental pain model"],"prefix":"10.1097","volume":"123","author":[{"given":"Camilla","family":"Staahl","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lona Louring","family":"Christrup","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sren Due","family":"Andersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Arendt-Nielsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asbjrn Mohr","family":"Drewes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-6-20210112","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1097\/00000542-200002000-00011","article-title":"Lumbar epidural morphine in humans and supraspinal analgesia to experimental heat pain.","volume":"92","author":"Angst","year":"2000","journal-title":"Anesthesiology"},{"key":"R2-6-20210112","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1002\/(SICI)1097-4598(199710)20:10<1311::AID-MUS15>3.0.CO;2-5","article-title":"Temporal summation in muscles and referred pain areas: an experimental human study.","volume":"20","author":"Arendt-Nielsen","year":"1997","journal-title":"Muscle Nerve"},{"key":"R3-6-20210112","first-page":"101","article-title":"Analgesic studies of codeine and oxycodone in patients with cancer. II. Comparisons of intramuscular oxycodone with intramuscular morphine and codeine.","volume":"207","author":"Beaver","year":"1978","journal-title":"J Pharmacol Exp Ther"},{"key":"R4-6-20210112","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/0304-3959(93)90117-8","article-title":"Quantitative sensory examination during epidural anaesthesia and analgesia in man: effects of morphine.","volume":"52","author":"Brennum","year":"1993","journal-title":"Pain"},{"key":"R5-6-20210112","first-page":"707","article-title":"Effects of kappa-opioid receptor agonists on responses to colorectal distension in rats with and without acute colonic inflammation.","volume":"285","author":"Burton","year":"1998","journal-title":"J Pharmacol Exp Ther"},{"key":"R6-6-20210112","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1002\/neu.20084","article-title":"Understanding the signaling and transmission of visceral nociceptive events.","volume":"61","author":"Cervero","year":"2004","journal-title":"J Neurobiol"},{"key":"R7-6-20210112","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/S0885-3924(99)00068-8","article-title":"Steady-state kinetics and dynamics of morphine in cancer patients: is sedation related to the absorption rate of morphine?","volume":"18","author":"Christrup","year":"1999","journal-title":"J Pain Symptom Manage"},{"key":"R8-6-20210112","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1093\/bja\/85.4.529","article-title":"Remifentanil inhibits muscular more than cutaneous pain in humans.","volume":"85","author":"Curatolo","year":"2000","journal-title":"Br J Anaesth"},{"key":"R9-6-20210112","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1007\/s002280050651","article-title":"Relative potency of controlled-release oxycodone and controlled-release morphine in a postoperative pain model.","volume":"55","author":"Curtis","year":"1999","journal-title":"Eur J Clin Pharmacol"},{"key":"R10-6-20210112","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1111\/j.1365-2982.2004.00513.x","article-title":"Opioids and the gut: pharmacology and current clinical experience.","volume":"16","author":"De Schepper","year":"2004","journal-title":"Neurogastroenterol Motil"},{"key":"R11-6-20210112","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1080\/00365520310004399","article-title":"Experimental pain in gastroenterology: a reappraisal of human studies.","volume":"38","author":"Drewes","year":"2003","journal-title":"Scand J Gastroenterol"},{"key":"R12-6-20210112","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/S1090-3801(03)00053-3","article-title":"Multi-modal induction and assessment of allodynia and hyperalgesia in the human oesophagus.","volume":"7","author":"Drewes","year":"2003","journal-title":"Eur J Pain"},{"key":"R13-6-20210112","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/S0304-3959(03)00039-3","article-title":"Gut pain and hyperalgesia induced by capsaicin: a human experimental model.","volume":"104","author":"Drewes","year":"2003","journal-title":"Pain"},{"key":"R14-6-20210112","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/S0304-3959(02)00259-2","article-title":"Analgesia from a peripherally active kappa-opioid receptor agonist in patients with chronic pancreatitis.","volume":"101","author":"Eisenach","year":"2003","journal-title":"Pain"},{"key":"R15-6-20210112","doi-asserted-by":"crossref","first-page":"G461","DOI":"10.1152\/ajpgi.00456.2001","article-title":"Sensory and biomechanical responses to ramp-controlled distension of the human duodenum.","volume":"284","author":"Gao","year":"2003","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"R16-6-20210112","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1152\/physrev.1993.73.3.639","article-title":"Psychophysiology of experimentally induced pain.","volume":"73","author":"Handwerker","year":"1993","journal-title":"Physiol Rev"},{"key":"R17-6-20210112","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1046\/j.1365-2125.2002.01602.x","article-title":"Assessment of the effect of dextromethorphan and ketamine on the acute nociceptive threshold and wind-up of the second pain response in healthy male volunteers.","volume":"53","author":"Hughes","year":"2002","journal-title":"Br J Clin Pharmacol"},{"key":"R18-6-20210112","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.jpainsymman.2005.01.010","article-title":"Oxycodone.","volume":"29","author":"Kalso","year":"2005","journal-title":"J Pain Symptom Manage"},{"key":"R19-6-20210112","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1111\/j.1399-6576.1991.tb03364.x","article-title":"Intravenous morphine and oxycodone for pain after abdominal surgery.","volume":"35","author":"Kalso","year":"1991","journal-title":"Acta Anaesthesiol Scand"},{"key":"R20-6-20210112","first-page":"173","article-title":"Health status of the German population: results of a representative survey using the EuroQol questionnaire.","volume":"67","author":"Konig","year":"2005","journal-title":"Gesundheitswesen"},{"key":"R21-6-20210112","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1097\/00000542-200307000-00025","article-title":"Differential modulation of remifentanil-induced analgesia and postinfusion hyperalgesia by S-ketamine and clonidine in humans.","volume":"99","author":"Koppert","year":"2003","journal-title":"Anesthesiology"},{"key":"R22-6-20210112","first-page":"597","article-title":"Animal models of nociception.","volume":"53","author":"Le Bars","year":"2001","journal-title":"Pharmacol Rev"},{"key":"R23-6-20210112","doi-asserted-by":"crossref","first-page":"2011","DOI":"10.1016\/S0024-3205(99)00148-4","article-title":"Opioid binding profiles of new hydrazone, oxime, carbazone and semicarbazone derivatives of 14-alkoxymorphinans.","volume":"64","author":"Monory","year":"1999","journal-title":"Life Sci"},{"key":"R24-6-20210112","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/S0304-3959(03)00163-5","article-title":"The analgesic effect of oral delta-9-tetrahydrocannabinol (THC), morphine, and a THC-morphine combination in healthy subjects under experimental pain conditions.","volume":"105","author":"Naef","year":"2003","journal-title":"Pain"},{"key":"R25-6-20210112","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.ejphar.2005.09.051","article-title":"Antinociceptive effect of oxycodone in diabetic mice.","volume":"524","author":"Nozaki","year":"2005","journal-title":"Eur J Pharmacol"},{"key":"R26-6-20210112","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/S0966-6532(03)00024-6","article-title":"Oxycodone and ketobemidone for oral premedication.","volume":"10","author":"Ohquist","year":"2004","journal-title":"J Ambul Surg"},{"key":"R27-6-20210112","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/S1526-5900(03)00718-1","article-title":"A randomized study of the effect of oral lamotrigine and hydromorphone on pain and hyperalgesia following heatcapsaicin sensitization.","volume":"4","author":"Petersen","year":"2003","journal-title":"J Pain"},{"key":"R28-6-20210112","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1007\/s002280050200","article-title":"Codeine and morphine in extensive and poor metabolizers of sparteine: pharmacokinetics, analgesic effect and side effects.","volume":"51","author":"Poulsen","year":"1996","journal-title":"Eur J Clin Pharmacol"},{"key":"R29-6-20210112","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/0885-3924(93)90101-Z","article-title":"A review of oxycodones clinical pharmacokinetics and pharmacodynamics.","volume":"8","author":"Poyhia","year":"1993","journal-title":"J Pain Symptom Manage"},{"key":"R30-6-20210112","first-page":"143","article-title":"Dissociation of morphine analgesia and sedation evaluated by EEG measures in healthy volunteers.","volume":"54","author":"Quante","year":"2004","journal-title":"Arzneimittelforschung"},{"key":"R31-6-20210112","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/S0304-3959(97)00093-6","article-title":"The intrinsic antinociceptive effects of oxycodone appear to be kappa-opioid receptor mediated.","volume":"73","author":"Ross","year":"1997","journal-title":"Pain"},{"key":"R32-6-20210112","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1034\/j.1399-6576.2003.00204.x","article-title":"Pharmacological modulation of experimental phasic and tonic muscle pain by morphine, alfentanil and ketamine in healthy volunteers.","volume":"47","author":"Schulte","year":"2003","journal-title":"Acta Anaesthesiol Scand"},{"key":"R33-6-20210112","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1093\/emboj\/17.4.886","article-title":"Disruption of the kappa-opioid receptor gene in mice enhances sensitivity to chemical visceral pain, impairs pharmacological actions of the selective kappa-agonist U-50,488H and attenuates morphine withdrawal.","volume":"17","author":"Simonin","year":"1998","journal-title":"EMBO J"},{"key":"R34-6-20210112","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1067\/mcp.2003.5","article-title":"Analgesic effects of morphine and morphine-6-glucuronide in a transcutaneous electrical pain model in healthy volunteers.","volume":"73","author":"Skarke","year":"2003","journal-title":"Clin Pharmacol Ther"},{"key":"R35-6-20210112","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1053\/eujp.2001.0301","article-title":"Oxycodone has a distinctly different pharmacology from morphine.","volume":"5","author":"Smith","year":"2001","journal-title":"Eur J Pain"},{"key":"R36-6-20210112","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1111\/j.1742-7843.2004.950301.x","article-title":"Experimental human pain models: a review of standardised methods for preclinical testing of analgesics.","volume":"95","author":"Staahl","year":"2004","journal-title":"Basic Clin Pharmacol Toxicol"},{"key":"R38-6-20210112","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1038\/nm908","article-title":"Attacking pain at its source: new perspectives on opioids.","volume":"9","author":"Stein","year":"2003","journal-title":"Nat Med"},{"key":"R39-6-20210112","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1111\/j.1399-6576.1994.tb03859.x","article-title":"Morphine does not affect laser induced warmth and pin prick pain thresholds.","volume":"38","author":"van der BM, Rasmussen","year":"1994","journal-title":"Acta Anaesthesiol Scand"},{"key":"R40-6-20210112","first-page":"384","article-title":"Pain-evoked potentials: what do they really measure?","volume":"100","author":"Zaslansky","year":"1996","journal-title":"Electroencephalogr Clin Neurophysiol"}],"container-title":["Pain"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/journals.lww.com\/00006396-200607000-00006","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,8]],"date-time":"2021-04-08T22:42:38Z","timestamp":1617921758000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/00006396-200607000-00006"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,7]]},"references-count":39,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2006]]}},"URL":"https:\/\/doi.org\/10.1016\/j.pain.2006.02.006","relation":{},"ISSN":["0304-3959"],"issn-type":[{"value":"0304-3959","type":"print"}],"subject":[],"published":{"date-parts":[[2006,7]]}}}