{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T16:09:59Z","timestamp":1786118999210,"version":"build-2736575974"},"reference-count":26,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,1]]},"DOI":"10.1016\/j.pain.2008.10.025","type":"journal-article","created":{"date-parts":[[2008,12,7]],"date-time":"2008-12-07T05:30:31Z","timestamp":1228627831000},"page":"135-142","source":"Crossref","is-referenced-by-count":92,"title":["Hydrogen peroxide is a novel mediator of inflammatory hyperalgesia, acting via transient receptor potential vanilloid 1-dependent and independent mechanisms"],"prefix":"10.1097","volume":"141","author":[{"given":"Julie Elizabeth","family":"Keeble","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer Victoria","family":"Bodkin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lihuan","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Wodarski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meirion","family":"Davies","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth Soares","family":"Fernandes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carly de Faria","family":"Coelho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fiona","family":"Russell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rabea","family":"Graepel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo Nicolas","family":"Muscara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marzia","family":"Malcangio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan Diana","family":"Brain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-22-20210112","doi-asserted-by":"crossref","first-page":"2485","DOI":"10.1523\/JNEUROSCI.5369-07.2008","article-title":"Transient receptor potential A1 is a sensory receptor for multiple products of oxidative stress.","volume":"28","author":"Andersson","year":"2008","journal-title":"J Neurosci"},{"key":"R2-22-20210112","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1183\/09031936.97.10061235","article-title":"Increased hydrogen peroxide and thiobarbituric acid-reactive products in expired breath condensate of asthmatic patients.","volume":"10","author":"Antczak","year":"1997","journal-title":"Eur Respir J"},{"key":"R3-22-20210112","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/S0304-3959(98)00114-6","article-title":"Nerve growth factor induced hyperalgesia in the rat hind paw is dependent on circulating neutrophils.","volume":"77","author":"Bennett","year":"1998","journal-title":"Pain"},{"key":"R4-22-20210112","doi-asserted-by":"crossref","first-page":"1899","DOI":"10.1172\/JCI34192","article-title":"TRPA1 is a major oxidant sensor in murine airway sensory neurons.","volume":"118","author":"Bessac","year":"2008","journal-title":"J Clin Invest"},{"key":"R5-22-20210112","first-page":"105","article-title":"Comparative studies on different methods of malondyaldehyde determination.","volume":"90","author":"Bird","year":"1984","journal-title":"Meth Enzymol"},{"key":"R6-22-20210112","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1038\/39807","article-title":"The capsaicin receptor: a heat-activated ion channel in the pain pathway.","volume":"389","author":"Caterina","year":"1997","journal-title":"Nature"},{"key":"R7-22-20210112","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1126\/science.288.5464.306","article-title":"Impaired nociception and pain sensation in mice lacking the capsaicin receptor.","volume":"288","author":"Caterina","year":"2000","journal-title":"Science"},{"key":"R8-22-20210112","doi-asserted-by":"crossref","first-page":"3747","DOI":"10.1096\/fj.06-7460com","article-title":"The transient receptor potential vanilloid 1 (TRPV1) receptor protects against the onset of sepsis after endotoxin.","volume":"21","author":"Clark","year":"2007","journal-title":"FASEB J"},{"key":"R9-22-20210112","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/0003-9861(89)90010-6","article-title":"Damage to protein synthesis concurrent with lipid peroxidation in rat liver slices: effect of halogenated compounds, peroxides, and vitamin E1.","volume":"270","author":"Fraga","year":"1989","journal-title":"Arch Biochem Biophys"},{"key":"R10-22-20210112","doi-asserted-by":"crossref","first-page":"2451","DOI":"10.2146\/ajhp050514","article-title":"Treatment of rheumatoid arthritis.","volume":"63","author":"Gaffo","year":"2006","journal-title":"Am J Health Syst Pharm"},{"key":"R11-22-20210112","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1213\/00000539-199910000-00029","article-title":"The effect of a sciatic nerve block on the development of inflammation in carrageenan injected rats.","volume":"89","author":"Gentili","year":"1999","journal-title":"Anesth Analg"},{"key":"R12-22-20210112","first-page":"541","article-title":"Protective effects of early treatment with lipoic acid in LPS-induced lung injury in rats.","volume":"58","author":"Goraca","year":"2007","journal-title":"J Physiol Pharmacol"},{"key":"R13-22-20210112","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/0304-3959(88)90026-7","article-title":"A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia.","volume":"32","author":"Hargreaves","year":"1988","journal-title":"Pain"},{"key":"R14-22-20210112","doi-asserted-by":"crossref","first-page":"R154","DOI":"10.1186\/ar2048","article-title":"Evidence for chronic, peripheral activation of neutrophils in polyarticular juvenile rheumatoid arthritis.","volume":"8","author":"Jarvis","year":"2006","journal-title":"Arthritis Res Ther"},{"key":"R15-22-20210112","doi-asserted-by":"crossref","first-page":"3248","DOI":"10.1002\/art.21297","article-title":"Involvement of transient receptor potential vanilloid 1 in the vascular and hyperalgesic components of joint inflammation.","volume":"52","author":"Keeble","year":"2005","journal-title":"Arthritis Rheum"},{"key":"R17-22-20210112","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.ejphar.2006.08.007","article-title":"TEMPOL, a membrane-permeable radical scavenger, attenuates peroxynitrite- and superoxide anion-enhanced carrageenan-induced paw edema and hyperalgesia: a key role for superoxide anion.","volume":"548","author":"Khattab","year":"2006","journal-title":"Eur J Pharmacol"},{"key":"R18-22-20210112","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/S1090-3801(98)90015-5","article-title":"Anatomical basis for the dynamic processing of nociceptive input.","volume":"2","author":"Lima","year":"1998","journal-title":"Eur J Pain"},{"key":"R19-22-20210112","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1136\/ard.2005.050641","article-title":"Examining the exhaled levels of hydrogen peroxide in rheumatoid arthritis: a pilot study.","volume":"65","author":"Mikuls","year":"2006","journal-title":"Ann Rheum Dis"},{"key":"R20-22-20210112","doi-asserted-by":"crossref","first-page":"2003","DOI":"10.1002\/art.21111","article-title":"Intracellular free radical production in synovial T lymphocytes from patients with rheumatoid arthritis.","volume":"52","author":"Remans","year":"2005","journal-title":"Arthritis Rheum"},{"key":"R21-22-20210112","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1152\/japplphysiol.00192.2006","article-title":"Mediator mechanisms involved in TRPV1 and P2X receptor-mediated, ROS-evoked bradypneic reflex in anesthetized rats.","volume":"101","author":"Ruan","year":"2006","journal-title":"J Appl Physiol"},{"key":"R22-22-20210112","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1111\/j.1460-9568.2008.06093.x","article-title":"Activation of transient receptor potential ankyrin 1 by hydrogen peroxide.","volume":"27","author":"Sawada","year":"2008","journal-title":"Eur J Neurosci"},{"key":"R23-22-20210112","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/0160-5402(90)90061-O","article-title":"Improved method for quantification of tissue PMN accumulation measured by myeloperoxidase activity.","volume":"23","author":"Schierwagen","year":"1990","journal-title":"Pharmacol Methods"},{"key":"R24-22-20210112","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1124\/mol.106.023069","article-title":"Reducing and oxidizing agents sensitize heat-activated vanilloid receptor (TRPV1) current.","volume":"70","author":"Susankova","year":"2006","journal-title":"Mol Pharmacol"},{"key":"R25-22-20210112","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1002\/neu.20079","article-title":"Thermosensation and pain.","volume":"61","author":"Tominaga","year":"2004","journal-title":"J Neurobiol"},{"key":"R26-22-20210112","doi-asserted-by":"crossref","first-page":"13519","DOI":"10.1073\/pnas.0705923104","article-title":"4-Hydroxynonenal, an endogenous aldehyde, causes pain and neurogenic inflammation through activation of the irritant receptor TRPA1.","volume":"104","author":"Trevisani","year":"2007","journal-title":"Proc Natl Acad Sci USA"},{"key":"R27-22-20210112","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1124\/jpet.103.064154","article-title":"A newly identified role for superoxide in inflammatory pain.","volume":"309","author":"Wang","year":"2004","journal-title":"J Pharmacol Exp Ther"}],"container-title":["Pain"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/00006396-200901000-00022","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T17:31:18Z","timestamp":1786037478000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00006396-200901000-00022"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,1]]},"references-count":26,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2009]]}},"URL":"https:\/\/doi.org\/10.1016\/j.pain.2008.10.025","relation":{},"ISSN":["0304-3959"],"issn-type":[{"value":"0304-3959","type":"print"}],"subject":[],"published":{"date-parts":[[2009,1]]}}}