{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T10:55:10Z","timestamp":1791111310128,"version":"4.1.0"},"reference-count":64,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","license":[{"start":{"date-parts":[[2009,6,1]],"date-time":"2009-06-01T00:00:00Z","timestamp":1243814400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,6]]},"DOI":"10.1016\/j.pain.2008.12.027","type":"journal-article","created":{"date-parts":[[2009,3,12]],"date-time":"2009-03-12T06:56:11Z","timestamp":1236840971000},"page":"172-178","source":"Crossref","is-referenced-by-count":254,"title":["Deficiency in endogenous modulation of prolonged heat pain in patients with Irritable Bowel Syndrome and Temporomandibular Disorder"],"prefix":"10.1097","volume":"143","author":[{"given":"Christopher D.","family":"King","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fong","family":"Wong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom","family":"Currie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andre P.","family":"Mauderli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger B.","family":"Fillingim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph L.","family":"Riley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-6-20210112","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1523\/JNEUROSCI.2500-07.2008","article-title":"Reduced brainstem inhibition during anticipated pelvic visceral pain correlates with enhanced brain response to the visceral stimulus in women with irritable bowel syndrome.","volume":"28","author":"Berman","year":"2008","journal-title":"J Neurosci"},{"key":"R2-6-20210112","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/S0304-3959(01)00451-1","article-title":"Group differences in pain modulation: pain-free women compared to pain-free men and to women with TMD.","volume":"96","author":"Bragdon","year":"2002","journal-title":"Pain"},{"key":"R3-6-20210112","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/0006-8993(93)90938-J","article-title":"The ability of inhibitory controls to switch-off activity in dorsal horn convergent neurones in the rat.","volume":"628","author":"Cadden","year":"1993","journal-title":"Brain Res"},{"key":"R4-6-20210112","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1017\/S0140525X97251484","article-title":"Peripheral and central hyperexcitability: differential signs and symptoms in persistent pain.","volume":"20","author":"Coderre","year":"1997","journal-title":"Behav Brain Sci"},{"key":"R5-6-20210112","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1152\/jn.1993.69.3.703","article-title":"Wide dynamic range but not nociceptive-specific neurons encode multidimensional features of prolonged repetitive heat pain.","volume":"69","author":"Coghill","year":"1993","journal-title":"J Neurophysiol"},{"key":"R6-6-20210112","first-page":"301","article-title":"Research diagnostic criteria for temporomandibular disorders: review, criteria, examinations and specifications, critique.","volume":"6","author":"Dworkin","year":"1992","journal-title":"J Craniomandib Disord"},{"key":"R7-6-20210112","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1212\/01.wnl.0000171862.17301.84","article-title":"Individual differences in endogenous pain modulation as a risk factor for chronic pain.","volume":"65","author":"Edwards","year":"2005","journal-title":"Neurology"},{"key":"R8-6-20210112","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/S0304-3959(02)00324-X","article-title":"Age-related differences in endogenous pain modulation: a comparison of diffuse noxious inhibitory controls in healthy older and younger adults.","volume":"101","author":"Edwards","year":"2003","journal-title":"Pain"},{"key":"R9-6-20210112","doi-asserted-by":"crossref","first-page":"679","DOI":"10.2466\/PMS.99.6.679-687","article-title":"Endogenous opioids, blood pressure, and diffuse noxious inhibitory controls: a preliminary study.","volume":"99","author":"Edwards","year":"2004","journal-title":"Percept Mot Skills"},{"key":"R10-6-20210112","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.pain.2003.09.005","article-title":"Individual differences in diffuse noxious inhibitory controls (DNIC): association with clinical variables.","volume":"106","author":"Edwards","year":"2003","journal-title":"Pain"},{"key":"R11-6-20210112","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.pain.2005.01.007","article-title":"Quantitative assessment of experimental pain perception: multiple domains of clinical relevance.","volume":"114","author":"Edwards","year":"2005","journal-title":"Pain"},{"key":"R12-6-20210112","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1053\/eujp.1999.0154","article-title":"Wind-up and the NMDA receptor complex from a clinical perspective.","volume":"4","author":"Eide","year":"2000","journal-title":"Eur J Pain"},{"key":"R13-6-20210112","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/0049-0172(94)90030-2","article-title":"The fibromyalgia syndrome: musculoskeletal pathophysiology.","volume":"23","author":"Geel","year":"1994","journal-title":"Semin Arthritis Rheum"},{"key":"R14-6-20210112","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.pain.2004.12.035","article-title":"Cigarette smoking, stress-induced analgesia and pain perception in men and women.","volume":"114","author":"Girdler","year":"2005","journal-title":"Pain"},{"key":"R15-6-20210112","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.pain.2006.11.011","article-title":"Descending analgesia - when the spine echoes what the brain expects.","volume":"130","author":"Goffaux","year":"2007","journal-title":"Pain"},{"key":"R16-6-20210112","doi-asserted-by":"crossref","first-page":"2205","DOI":"10.1152\/jn.00730.2001","article-title":"Transient analgesia evoked by noxious stimulus offset.","volume":"87","author":"Grill","year":"2002","journal-title":"J Neurophysiol"},{"key":"R17-6-20210112","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/S0304-3959(00)00310-9","article-title":"Lack of pressure pain modulation by heterotopic noxious conditioning stimulation in patients with painful osteoarthritis before, but not following, surgical pain relief.","volume":"88","author":"Kosek","year":"2000","journal-title":"Pain"},{"key":"R18-6-20210112","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S0304-3959(96)03295-2","article-title":"Modulatory influence on somatosensory perception from vibration and heterotopic noxious conditioning stimulation (HNCS) in fibromyalgia patients and healthy subjects.","volume":"70","author":"Kosek","year":"1997","journal-title":"Pain"},{"key":"R19-6-20210112","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.pain.2003.11.007","article-title":"Effects of stimulus duration on heat induced pain: the relationship between real-time and post-stimulus pain ratings.","volume":"107","author":"Koyama","year":"2004","journal-title":"Pain"},{"key":"R20-6-20210112","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1097\/00002508-199709000-00003","article-title":"Possible deficiencies of pain modulation in fibromyalgia.","volume":"13","author":"Lautenbacher","year":"1997","journal-title":"Clin J Pain"},{"key":"R21-6-20210112","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/0006-8993(81)90506-0","article-title":"The effect of systemic morphine upon diffuse noxious inhibitory controls (DNIC) in the rat: evidence for a lifting of certain descending inhibitory controls of dorsal horn convergent neurons.","volume":"215","author":"Le Bars","year":"1981","journal-title":"Brain Res"},{"key":"R22-6-20210112","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/0304-3959(79)90049-6","article-title":"Diffuse noxious inhibitory controls (DNIC). I. Effects on dorsal horn convergent neurones in the rat.","volume":"6","author":"Le Bars","year":"1979","journal-title":"Pain"},{"key":"R23-6-20210112","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/S0031-6997(24)01514-X","article-title":"Diffuse noxious inhibitory controls (DNIC). II. Lack of effect on non-convergent neurones, supraspinal involvement and theoretical implications. Pain 1979;6:305-327.Bars D, Gozariu M, Cadden SW. Animal models of nociception.","volume":"53","author":"Le Bars","year":"2001","journal-title":"Pharmacol Rev"},{"key":"R24-6-20210112","first-page":"55","article-title":"Diffuse noxious inhibitory controls (DNIC) in animals and in man.","volume":"4","author":"Le Bars","year":"1992","journal-title":"Patol Fiziol Eksp Ter"},{"key":"R25-6-20210112","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1053\/j.gastro.2005.11.061","article-title":"Functional bowel disorders.","volume":"130","author":"Longstreth","year":"2006","journal-title":"Gastroenterology"},{"key":"R26-6-20210112","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/0304-3959(95)00068-2","article-title":"Sensitivity of patients with painful temporomandibular disorders to experimentally evoked pain.","volume":"63","author":"Maixner","year":"1995","journal-title":"Pain"},{"key":"R27-6-20210112","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/S0304-3959(98)00028-1","article-title":"Sensitivity of patients with painful temporomandibular disorders to experimentally evoked pain: evidence for altered temporal summation of pain.","volume":"76","author":"Maixner","year":"1998","journal-title":"Pain"},{"key":"R28-6-20210112","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1016\/j.neuroscience.2007.07.053","article-title":"Neural mechanisms of pelvic organ cross-sensitization.","volume":"149","author":"Malykhina","year":"2007","journal-title":"Neuroscience"},{"key":"R29-6-20210112","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1097\/01.psy.0000188466.14546.68","article-title":"African Americans show alterations in endogenous pain regulatory mechanisms and reduced pain tolerance to experimental pain procedures.","volume":"67","author":"Mechlin","year":"2005","journal-title":"Psychosom Med"},{"key":"R30-6-20210112","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1097\/AJP.0b013e318032e496","article-title":"Thermal and visceral hypersensitivity in irritable bowel syndrome patients with and without fibromyalgia.","volume":"23","author":"Moshiree","year":"2007","journal-title":"Clin J Pain"},{"key":"R31-6-20210112","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.pain.2007.11.018","article-title":"Characterization of a novel model of tonic heat pain stimulation in healthy volunteers.","volume":"138","author":"Naert","year":"2008","journal-title":"Pain"},{"key":"R32-6-20210112","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.pain.2005.08.019","article-title":"Impairment of pain inhibition in chronic tension-type headache.","volume":"118","author":"Pielsticke","year":"2005","journal-title":"Pain"},{"key":"R33-6-20210112","doi-asserted-by":"crossref","first-page":"1769","DOI":"10.1126\/science.288.5472.1769","article-title":"Psychological and neural mechanisms of the affective dimension of pain.","volume":"288","author":"Price","year":"2000","journal-title":"Science"},{"key":"R34-6-20210112","first-page":"34252","article-title":"Effects of heterotopic conditioning stimuli on first and second pain: a psychophysical evaluation in humans.","volume":"34245-","author":"Price","year":"1988","journal-title":"Pain"},{"key":"R35-6-20210112","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/S0079-6123(06)57020-7","article-title":"Plasticity in brain processing and modulation of pain.","volume":"157","author":"Price","year":"2006","journal-title":"Prog Brain Res"},{"key":"R36-6-20210112","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/0304-3959(77)90035-5","article-title":"Peripheral suppression of first pain and central summation of second pain evoked by noxious heat pulses.","volume":"3","author":"Price","year":"1977","journal-title":"Pain"},{"key":"R37-6-20210112","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/j.jpain.2005.12.011","article-title":"Peripheral and central contributions to hyperalgesia in irritable bowel syndrome.","volume":"7","author":"Price","year":"2006","journal-title":"J Pain"},{"key":"R38-6-20210112","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/S0304-3959(02)00053-2","article-title":"Enhanced temporal summation of second pain and its central modulation in fibromyalgia patients.","volume":"99","author":"Price","year":"2002","journal-title":"Pain"},{"key":"R39-6-20210112","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.pain.2008.05.015","article-title":"Oral opioid use alters DNIC but not cold pain perception in patients with chronic pain - new perspective of opioid-induced hyperalgesia.","volume":"139","author":"Ram","year":"2008","journal-title":"Pain"},{"key":"R40-6-20210112","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.pain.2005.01.023","article-title":"Hypersensitivity to cutaneous thermal nociceptive stimuli in irritable bowel syndrome.","volume":"115","author":"Rodrigues","year":"2005","journal-title":"Pain"},{"key":"R41-6-20210112","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1111\/j.1468-2982.2006.01130.x","article-title":"Abnormal modulatory influence of diffuse noxious inhibitory controls in migraine and chronic tension-type headache patients.","volume":"26","author":"Sandrini","year":"2006","journal-title":"Cephalalgia"},{"key":"R42-6-20210112","first-page":"309","article-title":"Temporal summation of pain characterizes women but not men with temporomandibular disorders.","volume":"21","author":"Sarlani","year":"2007","journal-title":"J Orofac Pain"},{"key":"R43-6-20210112","first-page":"41","article-title":"Evidence for up-regulated central nociceptive processing in patients with masticatory myofascial pain.","volume":"18","author":"Sarlani","year":"2004","journal-title":"J Orofac Pain"},{"key":"R44-6-20210112","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/0304-3959(94)90002-7","article-title":"Effects of experimental and clinical noxious counterirritants on pain perception.","volume":"57","author":"Sigurdsson","year":"1994","journal-title":"Pain"},{"key":"R46-6-20210112","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.pain.2006.06.017","article-title":"Cortical effects of anticipation and endogenous modulation of visceral pain assessed by functional brain MRI in irritable bowel syndrome patients and healthy controls.","volume":"126","author":"Song","year":"2006","journal-title":"Pain"},{"key":"R47-6-20210112","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/S0304-3959(02)00325-1","article-title":"Diffuse noxious inhibitory controls (DNIC) attenuate temporal summation of second pain in normal males but not in normal females or fibromyalgia patients.","volume":"101","author":"Staud","year":"2003","journal-title":"Pain"},{"key":"R48-6-20210112","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/S0304-3959(03)00208-2","article-title":"Ratings of experimental pain and pain-related negative affect predict clinical pain in patients with fibromyalgia syndrome.","volume":"105","author":"Staud","year":"2003","journal-title":"Pain"},{"key":"R49-6-20210112","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/S0304-3959(00)00432-2","article-title":"Abnormal sensitization and temporal summation of second pain (wind-up) inpatients with fibromyalgia syndrome.","volume":"91","author":"Staud","year":"2001","journal-title":"Pain"},{"key":"R50-6-20210112","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/S0304-3959(01)00284-6","article-title":"Analysis of stimulus-evoked pain in patients with myofascial temporomandibular pain disorders.","volume":"92","author":"Svensson","year":"2001","journal-title":"Pain"},{"key":"R51-6-20210112","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/0304-3959(89)90028-6","article-title":"Effects of diffuse noxious inhibitory controls (DNICs) on the sensory-discriminative dimension of pain perception.","volume":"36","author":"Talbot","year":"1989","journal-title":"Pain"},{"key":"R52-6-20210112","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/0304-3959(87)91078-5","article-title":"Diffuse noxious inhibitory controls (DNICs): psychophysical evidence in man for intersegmental suppression of noxious heat perception by cold pressor pain.","volume":"30","author":"Talbot","year":"1987","journal-title":"Pain"},{"key":"R53-6-20210112","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1113\/jphysiol.1995.sp020619","article-title":"Evidence for two different heat transduction mechanisms in nociceptive primary afferents innervating monkey skin.","volume":"483","author":"Treede","year":"1995","journal-title":"J Physiol"},{"key":"R54-6-20210112","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/S0304-3959(01)00285-8","article-title":"Hypersensitivity to visceral and cutaneous pain in the irritable bowel syndrome.","volume":"93","author":"Verne","year":"2001","journal-title":"Pain"},{"key":"R55-6-20210112","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/S0304-3959(02)00416-5","article-title":"Central representation of visceral and cutaneous hypersensitivity in the irritable bowel syndrome.","volume":"103","author":"Verne","year":"2003","journal-title":"Pain"},{"key":"R56-6-20210112","first-page":"113","article-title":"The activation of bulbo-spinal controls by peripheral nociceptive inputs: diffuse noxious inhibitory controls.","volume":"28","author":"Villanueva","year":"1995","journal-title":"Biol Res"},{"key":"R57-6-20210112","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/S0304-3959(00)00352-3","article-title":"Age-related differences in the endogenous analgesic response to repeated coldwater immersion in human volunteers.","volume":"89","author":"Washington","year":"2000","journal-title":"Pain"},{"key":"R58-6-20210112","doi-asserted-by":"crossref","first-page":"3699","DOI":"10.3748\/wjg.v13.i27.3699","article-title":"Abnormal endogenous pain modulation and somatic and visceral hypersensitivity in female patients with irritable bowel syndrome.","volume":"13","author":"Wilder-Smith","year":"2007","journal-title":"World J Gastroenterol"},{"key":"R59-6-20210112","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1136\/gut.2003.028514","article-title":"Brain functional magnetic resonance imaging of rectal pain and activation of endogenous inhibitory mechanisms in irritable bowel syndrome patient subgroups and healthy controls.","volume":"53","author":"Wilder-Smith","year":"2004","journal-title":"Gut"},{"key":"R60-6-20210112","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/0006-8993(80)90755-6","article-title":"Electrophysiological evidence for a release of endogenous opiates in stress-induced analgesia in man.","volume":"198","author":"Willer","year":"1980","journal-title":"Brain Res"},{"key":"R61-6-20210112","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1152\/jn.1989.62.5.1028","article-title":"Encoding of nociceptive thermal stimuli by diffuse noxious inhibitory controls in humans.","volume":"62","author":"Willer","year":"1989","journal-title":"J Neurophysiol"},{"key":"R62-6-20210112","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1126\/science.6261330","article-title":"Stress-induced analgesia in humans: endogenous opioids and naloxone-reversible depression of pain reflexes.","volume":"212","author":"Willer","year":"1981","journal-title":"Science"},{"key":"R63-6-20210112","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/0014-2999(90)90293-F","article-title":"Diffuse noxious inhibitory controls in man: involvement of an opioidergic link.","volume":"182","author":"Willer","year":"1990","journal-title":"Eur J Pharmacol"},{"key":"R64-6-20210112","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1093\/brain\/107.4.1095","article-title":"Psychophysical and electrophysiological approaches to the pain-relieving effects of heterotopic nociceptive stimuli.","volume":"107","author":"Willer","year":"1984","journal-title":"Brain"},{"key":"R65-6-20210112","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/0166-4328(94)00150-E","article-title":"Stress-induced behavioral responses and multiple opioid systems in the brain.","volume":"67","author":"Yamada","year":"1995","journal-title":"Behav Brain Res"}],"container-title":["Pain"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/journals.lww.com\/00006396-200906000-00006","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,8]],"date-time":"2025-02-08T10:08:55Z","timestamp":1739009335000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/00006396-200906000-00006"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,6]]},"references-count":64,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2009]]}},"URL":"https:\/\/doi.org\/10.1016\/j.pain.2008.12.027","relation":{},"ISSN":["0304-3959"],"issn-type":[{"value":"0304-3959","type":"print"}],"subject":[],"published":{"date-parts":[[2009,6]]}}}