{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T00:14:54Z","timestamp":1792109694449,"version":"4.4.0"},"reference-count":48,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,4]]},"DOI":"10.1016\/j.pain.2009.01.010","type":"journal-article","created":{"date-parts":[[2009,2,13]],"date-time":"2009-02-13T13:18:15Z","timestamp":1234531095000},"page":"225-235","source":"Crossref","is-referenced-by-count":51,"title":["Involvement of voltage-gated sodium channels blockade in the analgesic effects of orphenadrine"],"prefix":"10.1097","volume":"142","author":[{"given":"Jean-Fran\u00e7ois","family":"Desaphy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonella","family":"Dipalma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michela","family":"De Bellis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"Costanza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christelle","family":"Gaudioso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Delmas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfred L.","family":"George","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana Conte","family":"Camerino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-12-20210112","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1038\/9195","article-title":"The tetrodotoxin-resistant sodium channel SNS has a specialized function in pain pathways.","volume":"2","author":"Akopian","year":"1999","journal-title":"Nat Neurosci"},{"key":"R2-12-20210112","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1085\/jgp.81.5.613","article-title":"Lidocaine block of cardiac sodium channels.","volume":"81","author":"Bean","year":"1983","journal-title":"J Gen Physiol"},{"key":"R3-12-20210112","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.pain.2003.12.035","article-title":"Changes in the expression of tetrodotoxin-sensitive sodium channels within dorsal root ganglia neurons in inflammatory pain.","volume":"108","author":"Black","year":"2004","journal-title":"Pain"},{"key":"R4-12-20210112","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1124\/pr.57.4.5","article-title":"International Union of Pharmacology XLVIII. Nomenclature and structure-function relationships of voltage-gated calcium channels.","volume":"57","author":"Catterall","year":"2005","journal-title":"Pharmacol Rev"},{"key":"R5-12-20210112","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1007\/BF00585952","article-title":"Functional expression and properties of the human skeletal muscle sodium channel.","volume":"427","author":"Chahine","year":"1994","journal-title":"Pflugers Arch"},{"key":"R6-12-20210112","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.jpainsymman.2004.05.002","article-title":"Comparative efficacy and safety of skeletal muscle relaxants for spasticity and musculoskeletal conditions: a systematic review.","volume":"28","author":"Chou","year":"2004","journal-title":"J Pain Symptom Manage"},{"key":"R7-12-20210112","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1085\/jgp.200609665","article-title":"Pharmacological dissection and distribution of NaNNav1.9, T-type Ca2 currents, and mechanically activated cation currents in different populations of DRG neurons.","volume":"129","author":"Coste","year":"2007","journal-title":"J Gen Physiol"},{"key":"R8-12-20210112","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.mcn.2004.01.015","article-title":"Gating and modulation of presumptive NaV1.9 channels in enteric and spinal sensory neurons.","volume":"26","author":"Coste","year":"2004","journal-title":"Mol Cell Neurosci"},{"key":"R9-12-20210112","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1038\/nature05413","article-title":"An SCN9A channelopathy causes congenital inability to experience pain.","volume":"444","author":"Cox","year":"2006","journal-title":"Nature"},{"key":"R10-12-20210112","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.pain.2007.07.026","article-title":"The roles of sodium channels in nociception: implications for mechanisms of pain.","volume":"131","author":"Cummins","year":"2007","journal-title":"Pain"},{"key":"R11-12-20210112","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/0736-4679(91)90217-4","article-title":"Reversal of orphenadrine-induced ventricular tachycardia with physostigmine.","volume":"9","author":"Danze","year":"1991","journal-title":"J Emerg Med"},{"key":"R12-12-20210112","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1212\/WNL.57.10.1849","article-title":"Gating of myotonic Na channel mutants defines the response to mexiletine and a potent derivative.","volume":"57","author":"Desaphy","year":"2001","journal-title":"Neurology"},{"key":"R13-12-20210112","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1113\/jphysiol.2003.046995","article-title":"Different flecainide sensitivity of hNav1.4 channels and myotonic mutants explained by state-dependent block.","volume":"554","author":"Desaphy","year":"2004","journal-title":"J Physiol"},{"key":"R14-12-20210112","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/0304-3959(92)90067-L","article-title":"Systemic lidocaine silences ectopic neuroma and DRG discharge without blocking nerve conduction.","volume":"48","author":"Devor","year":"1992","journal-title":"Pain"},{"key":"R15-12-20210112","doi-asserted-by":"crossref","first-page":"3603","DOI":"10.1172\/JCI33297","article-title":"Mutations in sodium-channel gene SCN9A cause a spectrum of human genetic pain disorders.","volume":"117","author":"Drenth","year":"2007","journal-title":"J Clin Invest"},{"key":"R16-12-20210112","first-page":"640","article-title":"Acute poisoning by orphenadrine.","volume":"136","author":"Elmalem","year":"1985","journal-title":"Ann Med Interne (Paris)"},{"key":"R17-12-20210112","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/s00726-001-0106-6","article-title":"Nefopam, an analogue of orphenadrine, protects against both NMDA receptor-dependent and independent veratridine-induced neurotoxicity.","volume":"23","author":"Fernandez-Sanchez","year":"2002","journal-title":"Amino Acids"},{"key":"R19-12-20210112","first-page":"271","article-title":"Treatment of low back syndrome with oral orphenadrine citrate.","volume":"23","author":"Gold","year":"1978","journal-title":"Curr Ther Res"},{"key":"R20-12-20210112","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1085\/jgp.69.4.497","article-title":"Local anesthetic: hydrophilic and hydrophobic pathways for the drug receptor reaction.","volume":"69","author":"Hille","year":"1977","journal-title":"J Gen Physiol"},{"key":"R21-12-20210112","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1177\/030006059101900201","article-title":"Clinical and pharmacological review of the efficacy of orphenadrine and its combination with paracetamol in painful conditions.","volume":"19","author":"Hunskaar","year":"1991","journal-title":"J Int Med Res"},{"key":"R22-12-20210112","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/S0006-8993(00)02860-2","article-title":"Block of sodium currents in rat dorsal root ganglion neurons by diphenhydramine.","volume":"881","author":"Kim","year":"2000","journal-title":"Brain Res"},{"key":"R23-12-20210112","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1002\/j.1460-2075.1995.tb07091.x","article-title":"Structure and functional expression of a new member of the tetrodotoxin-sensitive voltage-activated sodium channel family from human neuroendocrine cells.","volume":"14","author":"Klugbauer","year":"1995","journal-title":"EMBO J"},{"key":"R24-12-20210112","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1007\/BF01281158","article-title":"Orphenadrine is an uncompetitive N-methyl-d-aspartate (NMDA) receptor antagonist: binding and patch clamp studies.","volume":"2","author":"Kornhuber","year":"1995","journal-title":"J Neural Trans Gen Sect"},{"key":"R25-12-20210112","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S0026-895X(24)26451-8","article-title":"Inhibition of Na current by diphenhydramine and other diphenyl compounds: molecular determinants of selective binding to the inactivated channels.","volume":"57","author":"Kuo","year":"2000","journal-title":"Mol Pharmacol"},{"key":"R26-12-20210112","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1007\/BF00637624","article-title":"Difference between single and multiple dose pharmacokinetics of orphenadrine hydrochloride in man.","volume":"21","author":"Labout","year":"1982","journal-title":"Eur J Clin Pharmacol"},{"key":"R27-12-20210112","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/S0959-4388(03)00074-6","article-title":"The role of voltage-gated sodium channels in neuropathic pain.","volume":"13","author":"Lai","year":"2003","journal-title":"Curr Opin Neurobiol"},{"key":"R28-12-20210112","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.jchromb.2006.02.056","article-title":"Pharmacokinetic study of orphenadrine using high-performance liquid chromatography-tandem mass spectrometry (HPLC-MSMS).","volume":"839","author":"Lee","year":"2006","journal-title":"J Chromatogr B Anal Technol Biomed Life Sci"},{"key":"R29-12-20210112","doi-asserted-by":"crossref","first-page":"731","DOI":"10.2165\/00002512-200522090-00002","article-title":"Alternatives to levodopa in the initial treatment of early Parkinsons disease.","volume":"22","author":"Lees","year":"2005","journal-title":"Drugs Aging"},{"key":"R30-12-20210112","first-page":"429","article-title":"Treatment of familial erythermalgia with the association of lidocaine and mexiletine.","volume":"130","author":"Legroux-Crespel","year":"2003","journal-title":"Ann Dermatol Venereol"},{"key":"R31-12-20210112","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1016\/S0896-6273(02)00714-6","article-title":"Molecular basis of an inherited epilepsy.","volume":"34","author":"Lossin","year":"2002","journal-title":"Neuron"},{"key":"R32-12-20210112","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1111\/j.1368-5031.2006.00764.x","article-title":"Torsades de pointes in congenital long QT syndrome following low-dose orphenadrine.","volume":"60","author":"Luzza","year":"2006","journal-title":"Int J Clin Pract"},{"key":"R33-12-20210112","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1085\/jgp.200709935","article-title":"Inflammatory mediators increase Nav1.9 current and excitability in nociceptors through a coincident detection mechanism.","volume":"131","author":"Maingret","year":"2008","journal-title":"J Gen Physiol"},{"key":"R34-12-20210112","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1007\/s00424-004-1315-0","article-title":"Electrophysiological characterization of the tetrodotoxin-resistant Na channel, Nav(1.9), in mouse dorsal root ganglion neurons.","volume":"449","author":"Maruyama","year":"2004","journal-title":"Pflugers Arch"},{"key":"R35-12-20210112","doi-asserted-by":"crossref","first-page":"9382","DOI":"10.1073\/pnas.0501549102","article-title":"Contribution of the tetrodotoxin-resistant voltage-gated sodium channel Nav1.9 to sensory transmission and nociceptive behavior.","volume":"102","author":"Priest","year":"2005","journal-title":"Proc Natl Acad Sci USA"},{"key":"R36-12-20210112","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1517\/14728222.11.3.291","article-title":"Blocking sodium channels to treat neuropathic pain.","volume":"11","author":"Priest","year":"2007","journal-title":"Exp Opin Ther Targets"},{"key":"R37-12-20210112","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1211\/0022357991772303","article-title":"Assessment of the adrenergic effects of orphenadrine in rat vas deferens.","volume":"51","author":"Pubill","year":"1999","journal-title":"J Pharm Pharmacol"},{"key":"R38-12-20210112","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1136\/bmj.289.6445.612","article-title":"Anticholinergic drug abuse: a common problem?","volume":"289","author":"Pullen","year":"1984","journal-title":"Br Med J"},{"key":"R39-12-20210112","doi-asserted-by":"crossref","first-page":"1724","DOI":"10.1126\/science.8085162","article-title":"Molecular determinants of state-dependent block of Na channels by local anesthetic.","volume":"265","author":"Ragsdale","year":"1994","journal-title":"Science"},{"key":"R40-12-20210112","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1113\/jphysiol.2003.046110","article-title":"The tetrodotoxin-resistant Na channel Nav1.8 is essential for the expression of spontaneous activity in damaged sensory axons of mice.","volume":"550","author":"Roza","year":"2003","journal-title":"J Physiol"},{"key":"R41-12-20210112","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/0024-3205(85)90252-8","article-title":"Analgesic effects of antihistaminics.","volume":"36","author":"Rumore","year":"1985","journal-title":"Life Sci"},{"key":"R42-12-20210112","first-page":"673","article-title":"Analgesic effects of low-dose intravenous orphenadrine in the state of capsaicin hyperalgesia. A randomised, placebo-controlled, double-blind cross-over study using laser somatosensory-evoked potentials obtained from capsaicin-irritated skin in healthy volunteers.","volume":"54","author":"Schaffler","year":"2004","journal-title":"Arzneimittelforschung"},{"key":"R43-12-20210112","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1007\/s00210-007-0202-6","article-title":"Anticholinergic antiparkinson drug orphenadrine inhibits HERG channels: block attenuation by mutations of the pore residues Y652 or F656.","volume":"376","author":"Scholz","year":"2007","journal-title":"Naunyn-Schmiedebergs Arch Pharmacol"},{"key":"R45-12-20210112","first-page":"24","article-title":"Parkinsons disease: managing symptoms and preserving function.","volume":"509","author":"Sweeney","year":"1995","journal-title":"Geriatrics"},{"key":"R46-12-20210112","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1111\/j.1600-0773.1988.tb01852.x","article-title":"Effects of antiparkinsonian drugs on muscarinic receptor binding in rat brain, heart and lung.","volume":"62","author":"Syvalahti","year":"1988","journal-title":"Pharmacol Toxicol"},{"key":"R47-12-20210112","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/S0165-6147(99)01437-6","article-title":"Cardiotoxic potential and CNS effects of first-generation antihistamines.","volume":"21","author":"Taglialatela","year":"2000","journal-title":"Trends Pharmacol Sci"},{"key":"R48-12-20210112","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/S0006-3495(96)79566-8","article-title":"Comparison of heterologously expressed human cardiac and skeletal muscle sodium channels.","volume":"70","author":"Wang","year":"1996","journal-title":"Biophys J"},{"key":"R49-12-20210112","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1212\/01.wnl.0000268068.02343.37","article-title":"Nav1.7, its mutations, and the syndromes that they cause.","volume":"69","author":"Waxman","year":"2007","journal-title":"Neurology"},{"key":"R50-12-20210112","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1016\/S0006-3495(97)78110-4","article-title":"Differences in steady-state inactivation between Na channel isoforms affect local anesthetic binding affinity.","volume":"73","author":"Wright","year":"1997","journal-title":"Biophys J"}],"container-title":["Pain"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/10.1016\/j.pain.2009.01.010","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,7]],"date-time":"2025-02-07T18:09:55Z","timestamp":1738951795000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/00006396-200904000-00012"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,4]]},"references-count":48,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2009]]}},"URL":"https:\/\/doi.org\/10.1016\/j.pain.2009.01.010","relation":{},"ISSN":["0304-3959"],"issn-type":[{"value":"0304-3959","type":"print"}],"subject":[],"published":{"date-parts":[[2009,4]]}}}