{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T21:38:14Z","timestamp":1791581894410,"version":"4.3.4"},"reference-count":46,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,8]]},"DOI":"10.1016\/j.pain.2009.04.033","type":"journal-article","created":{"date-parts":[[2009,5,27]],"date-time":"2009-05-27T04:51:49Z","timestamp":1243399909000},"page":"303-313","source":"Crossref","is-referenced-by-count":84,"title":["The role of enhanced cutaneous IL-1\u03b2 signaling in a rat tibia fracture model of complex regional pain syndrome"],"prefix":"10.1097","volume":"144","author":[{"given":"Wen-wu","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilya","family":"Sabsovich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian-Zhi","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wade S.","family":"Kingery","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Clark","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-15-20210126","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1097\/01.brs.0000257556.90850.53","article-title":"Proinflammatory cytokines stimulate the expression of nerve growth factor by human intervertebral disc cells.","volume":"32","author":"Abe","year":"2007","journal-title":"Spine"},{"key":"R2-15-20210126","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.pain.2005.07.017","article-title":"Role of peripheral group I and II metabotropic glutamate receptors in IL-1beta-induced mechanical allodynia in the orofacial area of conscious rats.","volume":"118","author":"Ahn","year":"2005","journal-title":"Pain"},{"key":"R3-15-20210126","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1302\/0301-620X.72B1.2298766","article-title":"Features of algodystrophy after colles fracture.","volume":"72B","author":"Atkins","year":"1990","journal-title":"J Bone Joint Surg"},{"key":"R4-15-20210126","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/j.lfs.2007.07.003","article-title":"Antihyperalgesic effects induced by the IL-1 receptor antagonist anakinra and increased IL-1beta levels in inflamed and osteosarcoma-bearing mice.","volume":"81","author":"Baamonde","year":"2007","journal-title":"Life Sci"},{"key":"R5-15-20210126","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1034\/j.1600-0404.2000.101004262x.\/","article-title":"Neurological findings in complex regional pain syndromes - analysis of 145 cases.","volume":"101","author":"Birklein","year":"2000","journal-title":"Acta Neurol Scand"},{"key":"R6-15-20210126","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/S0304-3959(00)00286-4","article-title":"Experimental tissue acidosis leads to increased pain in complex regional pain syndrome (CRPS).","volume":"87","author":"Birklein","year":"2000","journal-title":"Pain"},{"key":"R7-15-20210126","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.1038\/sj.bjp.0703434","article-title":"Cytokine-mediated inflammatory hyperalgesia limited by interleukin-1 receptor antagonist.","volume":"130","author":"Cunha","year":"2000","journal-title":"Br J Pharmacol"},{"key":"R8-15-20210126","doi-asserted-by":"crossref","first-page":"1755","DOI":"10.1073\/pnas.0409225102","article-title":"A cascade of cytokines mediates mechanical inflammatory hypernociception in mice.","volume":"102","author":"Cunha","year":"2005","journal-title":"Proc Natl Acad Sci USA"},{"key":"R9-15-20210126","doi-asserted-by":"crossref","first-page":"2095","DOI":"10.1182\/blood.V87.6.2095.bloodjournal8762095","article-title":"Biologic basis for interleukin-1 in disease.","volume":"87","author":"Dinarello","year":"1996","journal-title":"Blood"},{"key":"R10-15-20210126","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1038\/334698a0","article-title":"Interleukin-1 beta as a potent hyperalgesic agent antagonized by a tripeptide analogue.","volume":"334","author":"Ferreira","year":"1988","journal-title":"Nature"},{"key":"R11-15-20210126","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/0006-8993(94)90960-1","article-title":"Cutaneous hyperalgesia induced by peripheral injection of interleukin-1 beta in the rat.","volume":"657","author":"Fukuoka","year":"1994","journal-title":"Brain Res"},{"key":"R12-15-20210126","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1186\/1471-2474-7-91","article-title":"Increased endothelin-1 and diminished nitric oxide levels in blister fluids of patients with intermediate cold type complex regional pain syndrome type 1.","volume":"7","author":"Groeneweg","year":"2006","journal-title":"BMC musculoskelet disord"},{"key":"R13-15-20210126","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.pain.2003.12.010","article-title":"Substance P signaling contributes to the vascular and nociceptive abnormalities observed in a tibial fracture rat model of complex regional pain syndrome type I.","volume":"108","author":"Guo","year":"2004","journal-title":"Pain"},{"key":"R14-15-20210126","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.pain.2005.12.022","article-title":"Glucocorticoid inhibition of vascular abnormalities in a tibia fracture rat model of complex regional pain syndrome type I.","volume":"121","author":"Guo","year":"2006","journal-title":"Pain"},{"key":"R15-15-20210126","doi-asserted-by":"crossref","first-page":"6006","DOI":"10.1523\/JNEUROSCI.0176-07.2007","article-title":"Glial-cytokine-neuronal interactions underlying the mechanisms of persistent pain.","volume":"27","author":"Guo","year":"2007","journal-title":"J Neurosci"},{"key":"R16-15-20210126","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.bbr.2005.09.024","article-title":"Interleukin-1alphabeta gene-deficient mice show reduced nociceptive sensitivity in models of inflammatory and neuropathic pain but not post-operative pain.","volume":"167","author":"Honore","year":"2006","journal-title":"Behav Brain Res"},{"key":"R17-15-20210126","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1080\/09629350210307","article-title":"Evidence for local inflammation in complex regional pain syndrome type 1.","volume":"11","author":"Huygen","year":"2002","journal-title":"Mediators Inflamm"},{"key":"R18-15-20210126","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.imlet.2003.11.013","article-title":"Mast cells are involved in inflammatory reactions during Complex Regional Pain Syndrome type 1.","volume":"91","author":"Huygen","year":"2004","journal-title":"Immunol Lett"},{"key":"R19-15-20210126","doi-asserted-by":"crossref","first-page":"1959","DOI":"10.1172\/JCI117187","article-title":"Interleukin-1 receptor antagonist decreases bone loss and bone resorption in ovariectomized rats.","volume":"93","author":"Kimble","year":"1994","journal-title":"J Clin Invest"},{"key":"R20-15-20210126","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S0304-3959(02)00467-0","article-title":"A substance P receptor (NK1) antagonist can reverse vascular and nociceptive abnormalities in a rat model of complex regional pain syndrome type II.","volume":"104","author":"Kingery","year":"2003","journal-title":"Pain"},{"key":"R21-15-20210126","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.bbi.2007.07.009","article-title":"IL-1 beta signaling is required for mechanical allodynia induced by nerve injury and for the ensuing reduction in spinal cord neuronal GRK2.","volume":"22","author":"Kleibeuker","year":"2008","journal-title":"Brain Behav Immun"},{"key":"R22-15-20210126","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1097\/WNR.0b013e3280586839","article-title":"Interleukin-1ra inhibits Fos expression and hyperalgesia in rats.","volume":"18","author":"Li","year":"2007","journal-title":"Neuroreport"},{"key":"R23-15-20210126","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/8756-3282(93)90242-3","article-title":"Musculoskeletal recovery following hindlimb immobilization in adult female rats.","volume":"14","author":"Maeda","year":"1993","journal-title":"Bone"},{"key":"R24-15-20210126","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1523\/JNEUROSCI.23-03-01026.2003","article-title":"Spinal glia and proinflammatory cytokines mediate mirror-image neuropathic pain in rats.","volume":"23","author":"Milligan","year":"2003","journal-title":"J Neurosci"},{"key":"R25-15-20210126","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1155\/MI.2005.366","article-title":"Intermediate stage complex regional pain syndrome type 1 is unrelated to proinflammatory cytokines.","volume":"2005","author":"Munnikes","year":"2005","journal-title":"Mediators Inflamm"},{"key":"R26-15-20210126","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/j.neuroscience.2007.10.039","article-title":"Role of interleukin-1beta and tumor necrosis factor-alpha-dependent expression of cyclooxygenase-2 mRNA in thermal hyperalgesia induced by chronic inflammation in mice.","volume":"152","author":"Narita","year":"2008","journal-title":"Neuroscience"},{"key":"R27-15-20210126","first-page":"R453","article-title":"Interleukin 1-receptor antagonist blocks interleukin 1-induced sleep and fever.","volume":"260","author":"Opp","year":"1991","journal-title":"Am J Physiol"},{"key":"R28-15-20210126","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1007\/s00586-005-0058-8","article-title":"Effects of interleukin-1 beta, interleukin-6, and tumor necrosis factor on sensitivity of dorsal root ganglion and peripheral receptive fields in rats.","volume":"15","author":"Ozaktay","year":"2006","journal-title":"Eur Spine J"},{"key":"R29-15-20210126","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1242\/dev.115.2.535","article-title":"PDGF receptors in the rat CNS: during late neurogenesis, PDGF alpha-receptor expression appears to be restricted to glial cells of the oligodendrocyte lineage.","volume":"115","author":"Pringle","year":"1992","journal-title":"Development"},{"key":"R30-15-20210126","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/j.pain.2007.10.013","article-title":"TNF signaling contributes to the development of nociceptive sensitization in a tibia fracture model of complex regional pain syndrome type I.","volume":"137","author":"Sabsovich","year":"2008","journal-title":"Pain"},{"key":"R31-15-20210126","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.pain.2007.11.004","article-title":"Effect of anti-NGF antibodies in a rat tibia fracture model of complex regional pain syndrome type I.","volume":"138","author":"Sabsovich","year":"2008","journal-title":"Pain"},{"key":"R32-15-20210126","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1111\/j.1476-5381.1995.tb15035.x","article-title":"Contribution of interleukin-1 beta to the inflammation-induced increase in nerve growth factor levels and inflammatory hyperalgesia.","volume":"115","author":"Safieh-Garabedian","year":"1995","journal-title":"Br J Pharmacol"},{"key":"R33-15-20210126","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1302\/0301-620X.75B3.8496220","article-title":"Algodystrophy and osteoporosis after tibial fractures.","volume":"75","author":"Sarangi","year":"1993","journal-title":"J Bone Joint Surg Br"},{"key":"R34-15-20210126","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1097\/01.ajp.0000169672.49438.67","article-title":"Complex regional pain syndromes: the influence of cutaneous and deep somatic sympathetic innervation on pain.","volume":"22","author":"Schattschneider","year":"2006","journal-title":"The Clin J Pain"},{"key":"R35-15-20210126","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0304-3940(99)00450-4","article-title":"Neutralizing antibodies to interleukin 1-receptor reduce pain associated behavior in mice with experimental neuropathy.","volume":"270","author":"Sommer","year":"1999","journal-title":"Neurosci Lett"},{"key":"R36-15-20210126","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.pharmthera.2006.04.001","article-title":"Hypernociceptive role of cytokines and chemokines: targets for analgesic drug development?","volume":"112","author":"Verri","year":"2006","journal-title":"Pharmacol Ther"},{"key":"R37-15-20210126","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1111\/j.1365-2826.2006.01478.x","article-title":"Nerve growth factor secretion in cultured enteric glia cells is modulated by proinflammatory cytokines.","volume":"18","author":"von Boyen","year":"2006","journal-title":"J Neuroendocrinol"},{"key":"R38-15-20210126","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.ejpain.2008.04.014","article-title":"Pentoxifylline attenuates nociceptive sensitization and cytokine expression in a tibia fracture rat model of complex regional pain syndrome.","volume":"13","author":"Wei","year":"2009","journal-title":"Eur J Pain"},{"key":"R39-15-20210126","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1016\/j.bbi.2008.03.005","article-title":"Interleukin-1 signaling is required for induction and maintenance of postoperative incisional pain: genetic and pharmacological studies in mice.","volume":"22","author":"Wolf","year":"2008","journal-title":"Brain Behav Immun"},{"key":"R40-15-20210126","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1038\/sj.bjp.0701148","article-title":"Cytokines, nerve growth factor and inflammatory hyperalgesia: the contribution of tumour necrosis factor alpha.","volume":"121","author":"Woolf","year":"1997","journal-title":"Br J Pharmacol"},{"key":"R41-15-20210126","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.pain.2005.04.018","article-title":"Intraneural injection of interleukin-1beta and tumor necrosis factor-alpha into rat sciatic nerve at physiological doses induces signs of neuropathic pain.","volume":"116","author":"Zelenka","year":"2005","journal-title":"Pain"},{"key":"R42-15-20210126","doi-asserted-by":"crossref","first-page":"1482","DOI":"10.1213\/01.ane.0000284705.34629.c5","article-title":"Electroacupuncture attenuates bone cancer pain and inhibits spinal interleukin-1 beta expression in a rat model.","volume":"105","author":"Zhang","year":"2007","journal-title":"Anesth Analg"},{"key":"R43-15-20210126","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.pain.2007.05.023","article-title":"IL-1ra alleviates inflammatory hyperalgesia through preventing phosphorylation of NMDA receptor NR-1 subunit in rats.","volume":"135","author":"Zhang","year":"2008","journal-title":"Pain"},{"key":"R44-15-20210126","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1016\/j.neuroscience.2008.04.072","article-title":"Interleukin 1beta facilitates bone cancer pain in rats by enhancing NMDA receptor NR-1 subunit phosphorylation.","volume":"154","author":"Zhang","year":"2008","journal-title":"Neuroscience"},{"key":"R45-15-20210126","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.pain.2005.08.001","article-title":"Spinal glial activation in a new rat model of bone cancer pain produced by prostate cancer cell inoculation of the tibia.","volume":"118","author":"Zhang","year":"2005","journal-title":"Pain"},{"key":"R46-15-20210126","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/0304-3959(83)90201-4","article-title":"Ethical guidelines for investigations of experimental pain in conscious animals.","volume":"16","author":"Zimmermann","year":"1983","journal-title":"Pain"}],"container-title":["Pain"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.1016\/j.pain.2009.04.033","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T17:54:12Z","timestamp":1786038852000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00006396-200908000-00015"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,8]]},"references-count":46,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2009]]}},"URL":"https:\/\/doi.org\/10.1016\/j.pain.2009.04.033","relation":{},"ISSN":["0304-3959"],"issn-type":[{"value":"0304-3959","type":"print"}],"subject":[],"published":{"date-parts":[[2009,8]]}}}