{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T02:20:46Z","timestamp":1789006846297,"version":"build-2803163510"},"reference-count":36,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,12]]},"DOI":"10.1016\/j.pain.2009.06.024","type":"journal-article","created":{"date-parts":[[2009,7,22]],"date-time":"2009-07-22T05:08:09Z","timestamp":1248239289000},"page":"253-260","source":"Crossref","is-referenced-by-count":226,"title":["Duloxetine, a centrally acting analgesic, in the treatment of patients with osteoarthritis knee pain: A 13-week, randomized, placebo-controlled trial"],"prefix":"10.1097","volume":"146","author":[{"given":"Amy S.","family":"Chappell","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa J.","family":"Ossanna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Liu-Seifert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Smriti","family":"Iyengar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladimir","family":"Skljarevski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda Chunhong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert M.","family":"Bennett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harry","family":"Collins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-9-20210112","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1002\/art.1780290816","article-title":"Development of criteria for the classification and reporting of osteoarthritis. Classification of osteoarthritis of the knee. Diagnostic and Therapeutic Criteria Committee of the American Rheumatism Association.","volume":"29","author":"Altman","year":"1986","journal-title":"Arthritis Rheum"},{"key":"R2-9-20210112","doi-asserted-by":"crossref","first-page":"2974","DOI":"10.1002\/art.20485","article-title":"A double-blind, multicenter trial comparing duloxetine with placebo in the treatment of fibromyalgia patients with or without major depressive disorder.","volume":"50","author":"Arnold","year":"2004","journal-title":"Arthritis Rheum"},{"key":"R3-9-20210112","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.pain.2005.06.031","article-title":"A randomized, double-blind, placebo-controlled trial of duloxetine in the treatment of women with fibromyalgia with or without major depressive disorder.","volume":"119","author":"Arnold","year":"2005","journal-title":"Pain"},{"key":"R4-9-20210112","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1093\/rheumatology\/38.10.959","article-title":"The effects of dothiepin on subjects with rheumatoid arthritis and depression.","volume":"38","author":"Ash","year":"1999","journal-title":"Rheumatology (Oxford)"},{"key":"R5-9-20210112","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/S0304-3959(01)00300-1","article-title":"Osteoarthritis and its association with muscle hyperalgesia: an experimental controlled study.","volume":"93","author":"Bajaj","year":"2001","journal-title":"Pain"},{"key":"R6-9-20210112","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1037\/0022-006X.56.6.893","article-title":"An inventory for measuring clinical anxiety: psychometric properties.","volume":"56","author":"Beck","year":"1988","journal-title":"J Consult Clin Psychol"},{"key":"R7-9-20210112","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1037\/0022-006X.47.2.343","article-title":"Assessment of suicidal intention: the scale for suicide ideation.","volume":"47","author":"Beck","year":"1979","journal-title":"J Consult Clin Psychol"},{"key":"R8-9-20210112","first-page":"1833","article-title":"Validation study of WOMAC: a health status instrument for measuring clinically important patient relevant outcomes to antirheumatic drug therapy in patients with osteoarthritis of the hip or knee.","volume":"15","author":"Bellamy","year":"1988","journal-title":"J Rheumatol"},{"key":"R9-9-20210112","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1002\/0470867639.ch17","article-title":"Lessons from fibromyalgia: abnormal pain sensitivity in knee osteoarthritis.","volume":"260","author":"Bradley","year":"2004","journal-title":"Novartis Found Symp"},{"key":"R10-9-20210112","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.jpsychires.2004.04.011","article-title":"Duloxetine 60 mg once-daily in the treatment of painful physical symptoms in patients with major depressive disorder.","volume":"39","author":"Brannan","year":"2005","journal-title":"J Psychiatr Res"},{"key":"R11-9-20210112","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1002\/art.24326","article-title":"Pain and rheumatology: thinking outside the joint.","volume":"60","author":"Clauw","year":"2009","journal-title":"Arthritis Rheum"},{"key":"R12-9-20210112","first-page":"129","article-title":"Pain assessment: global use of the Brief Pain Inventory.","volume":"23","author":"Cleeland","year":"1994","journal-title":"Ann Acad Med Singapore"},{"key":"R14-9-20210112","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S0304-3959(01)00349-9","article-title":"Clinical importance of changes in chronic pain intensity measured on an 11-point numerical pain rating scale.","volume":"94","author":"Farrar","year":"2001","journal-title":"Pain"},{"key":"R15-9-20210112","doi-asserted-by":"crossref","first-page":"635","DOI":"10.7326\/0003-4819-133-8-200010170-00016","article-title":"Osteoarthritis: new insights. Part 1: The disease and its risk factors.","volume":"133","author":"Felson","year":"2000","journal-title":"Ann Intern Med"},{"key":"R16-9-20210112","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1146\/annurev.ne.14.030191.001251","article-title":"Neurotransmitters in nociceptive modulatory circuits.","volume":"14","author":"Fields","year":"1991","journal-title":"Annu Rev Neurosci"},{"key":"R17-9-20210112","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1185\/030079906X162719","article-title":"A retrospective pooled analysis of duloxetine safety in 23,983 subjects.","volume":"23","author":"Gahimer","year":"2007","journal-title":"Curr Med Res Opin"},{"key":"R18-9-20210112","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1176\/appi.psy.45.1.17","article-title":"Effects of duloxetine on painful physical symptoms associated with depression.","volume":"45","author":"Goldstein","year":"2004","journal-title":"Psychosomatics"},{"key":"R19-9-20210112","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.pain.2005.03.029","article-title":"Duloxetine vs. placebo in patients with painful diabetic neuropathy.","volume":"116","author":"Goldstein","year":"2005","journal-title":"Pain"},{"key":"R21-9-20210112","first-page":"197","article-title":"Implications of pain in generalized anxiety disorder: efficacy of duloxetine. Prim care companion.","volume":"10","author":"Hartford","year":"2008","journal-title":"J Clin Psychiatry"},{"key":"R22-9-20210112","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1002\/art.24120","article-title":"Impact of nervous system hyperalgesia on pain, disability, and quality of life in patients with knee osteoarthritis: a controlled analysis.","volume":"59","author":"Imamura","year":"2008","journal-title":"Arthritis Rheum"},{"key":"R23-9-20210112","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1124\/jpet.104.070656","article-title":"Efficacy of duloxetine, a potent and balanced serotonin-norepinephrine reuptake inhibitor in persistent pain models in rats.","volume":"311","author":"Iyengar","year":"2004","journal-title":"J Pharmacol Exp Ther"},{"key":"R24-9-20210112","doi-asserted-by":"crossref","first-page":"427","DOI":"10.2522\/ptj.20060300","article-title":"Investigation of clinical effects of high- and low-resistance training for patients with knee osteoarthritis: a randomized controlled trial.","volume":"88","author":"Jan","year":"2008","journal-title":"Phys Ther"},{"key":"R25-9-20210112","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/S0304-3959(02)00239-7","article-title":"Measuring the population impact of knee pain and disability with the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC).","volume":"100","author":"Jinks","year":"2002","journal-title":"Pain"},{"key":"R26-9-20210112","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1124\/jpet.104.075960","article-title":"Efficacy of duloxetine, a potent and balanced serotonergic and noradrenergic reuptake inhibitor, in inflammatory and acute pain models in rodents.","volume":"312","author":"Jones","year":"2005","journal-title":"J Pharmacol Exp Ther"},{"key":"R27-9-20210112","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.pain.2006.04.009","article-title":"Osteoarthritis and joint pain.","volume":"123","author":"Kidd","year":"2006","journal-title":"Pain"},{"key":"R29-9-20210112","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1002\/1529-0131(199805)41:5<778::AID-ART4>3.0.CO;2-V","article-title":"Estimates of the prevalence of arthritis and selected musculoskeletal disorders in the United States.","volume":"41","author":"Lawrence","year":"1998","journal-title":"Arthritis Rheum"},{"key":"R30-9-20210112","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1007\/BF03324833","article-title":"Physical exercise and comorbidity. Results from the Fitness and Arthritis in Seniors Trial (FAST).","volume":"18","author":"Mangani","year":"2006","journal-title":"Aging Clin Exp Res"},{"key":"R31-9-20210112","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1136\/ard.52.4.258","article-title":"Determinants of disability in osteoarthritis of the knee.","volume":"52","author":"McAlindon","year":"1993","journal-title":"Ann Rheum Dis"},{"key":"R32-9-20210112","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1111\/j.1526-4637.2007.00305.x","article-title":"Duloxetine for the management of diabetic peripheral neuropathic pain: response profile.","volume":"8","author":"Pritchett","year":"2007","journal-title":"Pain Med"},{"key":"R33-9-20210112","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1111\/j.1526-4637.2005.00061.x","article-title":"A double-blind, randomized multicenter trial comparing duloxetine with placebo in the management of diabetic peripheral neuropathic pain.","volume":"6","author":"Raskin","year":"2005","journal-title":"Pain Med"},{"key":"R34-9-20210112","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.jpain.2008.08.009","article-title":"A single-blind, placebo run-in study of duloxetine for activity-limiting osteoarthritis pain.","volume":"10","author":"Sullivan","year":"2009","journal-title":"J Pain"},{"key":"R35-9-20210112","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1002\/art.24175","article-title":"A functional polymorphism in the catechol-O-methyltransferase gene is associated with osteoarthritis-related pain.","volume":"60","author":"van Meurs","year":"2009","journal-title":"Arthritis Rheum"},{"key":"R37-9-20210112","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1212\/01.wnl.0000240225.04000.1a","article-title":"A randomized controlled trial of duloxetine in diabetic peripheral neuropathic pain.","volume":"67","author":"Wernicke","year":"2006","journal-title":"Neurology"},{"key":"R38-9-20210112","doi-asserted-by":"crossref","first-page":"1921","DOI":"10.4088\/JCP.v68n1213","article-title":"A comparison of initial duloxetine dosing strategies in patients with major depressive disorder.","volume":"68","author":"Whitmyer","year":"2007","journal-title":"J Clin Psychiatry"},{"key":"R40-9-20210112","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.joca.2007.12.013","article-title":"OARSI recommendations for the management of hip and knee osteoarthritis. Part II: OARSI evidence-based, expert consensus guidelines.","volume":"16","author":"Zhang","year":"2008","journal-title":"Osteoarthritis Cartilage"},{"key":"R41-9-20210112","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1111\/j.1600-0447.1983.tb09716.x","article-title":"The hospital anxiety and depression scale.","volume":"67","author":"Zigmond","year":"1983","journal-title":"Acta Psychiatr Scand"}],"container-title":["Pain"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/00006396-200912050-00009","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T17:58:18Z","timestamp":1786039098000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00006396-200912050-00009"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,12]]},"references-count":36,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2009]]}},"URL":"https:\/\/doi.org\/10.1016\/j.pain.2009.06.024","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1163108.2305054","asserted-by":"object"}]},"ISSN":["0304-3959"],"issn-type":[{"value":"0304-3959","type":"print"}],"subject":[],"published":{"date-parts":[[2009,12]]}}}