{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T13:58:03Z","timestamp":1787579883272,"version":"build-2736575974"},"reference-count":60,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,10]]},"DOI":"10.1016\/j.pain.2009.06.035","type":"journal-article","created":{"date-parts":[[2009,7,31]],"date-time":"2009-07-31T12:48:41Z","timestamp":1249044521000},"page":"332-340","source":"Crossref","is-referenced-by-count":56,"title":["Electroacupuncture suppresses capsaicin-induced secondary hyperalgesia through an endogenous spinal opioid mechanism"],"prefix":"10.1097","volume":"145","author":[{"given":"Hee Young","family":"Kim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jigong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inhyung","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hee Kee","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyungsoon","family":"Chung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin Mo","family":"Chung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-14-20210126","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.1001\/jama.280.17.1518","article-title":"Acupuncture.","volume":"280","year":"1998","journal-title":"JAMA"},{"key":"R3-14-20210126","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1046\/j.1440-1681.2001.03561.x","article-title":"Effect of alpha-adrenoceptor blockade on the 0.4 Hz sympathetic rhythm in conscious rats.","volume":"28","author":"Barres","year":"2001","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"R4-14-20210126","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1152\/jn.1991.66.1.212","article-title":"Neurogenic hyperalgesia: the search for the primary cutaneous afferent fibers that contribute to capsaicin-induced pain and hyperalgesia.","volume":"66","author":"Baumann","year":"1991","journal-title":"J Neurophysiol"},{"key":"R5-14-20210126","doi-asserted-by":"crossref","first-page":"3391","DOI":"10.1016\/j.peptides.2006.07.011","article-title":"Endogenous opiates and behavior: 2005.","volume":"27","author":"Bodnar","year":"2006","journal-title":"Peptides"},{"key":"R6-14-20210126","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0165-0270(94)90144-9","article-title":"Quantitative assessment of tactile allodynia in the rat paw.","volume":"53","author":"Chaplan","year":"1994","journal-title":"J Neurosci Methods"},{"key":"R7-14-20210126","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.brainres.2006.01.053","article-title":"Blocking mu opioid receptors in the spinal cord prevents the analgesic action by subsequent systemic opioids.","volume":"1081","author":"Chen","year":"2006","journal-title":"Brain Res"},{"key":"R8-14-20210126","doi-asserted-by":"crossref","first-page":"19","DOI":"10.3727\/036012908803861212","article-title":"Electro-acupuncture improves survival and migration of transplanted neural stem cells in injured spinal cord in rats.","volume":"33","author":"Chen","year":"2008","journal-title":"Acupunct Electrother Res"},{"key":"R9-14-20210126","first-page":"16","article-title":"fMRI neurophysiological evidence of acupuncture mechanisms.","volume":"14","author":"Cho","year":"2003","journal-title":"Med Acupunct"},{"key":"R11-14-20210126","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/0006-8993(87)91359-X","article-title":"Cutaneous hyperalgesia: contributions of the peripheral and central nervous systems to the increase in pain sensitivity after injury.","volume":"404","author":"Coderre","year":"1987","journal-title":"Brain Res"},{"key":"R12-14-20210126","first-page":"58","article-title":"Basic science of pain.","volume":"88","author":"DeLeo","year":"2006","journal-title":"J Bone Joint Surg Am"},{"key":"R13-14-20210126","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1146\/annurev.pa.20.040180.002301","article-title":"Efficient analysis of experimental observations.","volume":"20","author":"Dixon","year":"1980","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"R14-14-20210126","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/S0304-3959(99)00304-8","article-title":"Is acupuncture effective for the treatment of chronic pain? A systematic review.","volume":"86","author":"Ezzo","year":"2000","journal-title":"Pain"},{"key":"R15-14-20210126","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1053\/apmr.2000.5576","article-title":"Effect of varying frequency, intensity, and pulse duration of transcutaneous electrical nerve stimulation on primary hyperalgesia in inflamed rats.","volume":"81","author":"Gopalkrishnan","year":"2000","journal-title":"Arch Phys Med Rehabil"},{"key":"R16-14-20210126","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1016\/S0022-3565(25)38828-2","article-title":"Effects of mu, delta and kappa opioid antagonists on the depression of a C-fiber reflex by intrathecal morphine and dago in the rat.","volume":"269","author":"Guirimand","year":"1994","journal-title":"J Pharmacol Exp Ther"},{"key":"R17-14-20210126","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.neulet.2003.12.019","article-title":"Acupuncture and endorphins.","volume":"361","author":"Han","year":"2004","journal-title":"Neurosci Lett"},{"key":"R18-14-20210126","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S0166-2236(02)00006-1","article-title":"Acupuncture: neuropeptide release produced by electrical stimulation of different frequencies.","volume":"26","author":"Han","year":"2003","journal-title":"Trends Neurosci"},{"key":"R19-14-20210126","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/0304-3959(91)90218-M","article-title":"Effect of low- and high-frequency TENS on Met-enkephalin-Arg-Phe and dynorphin A immunoreactivity in human lumbar CSF.","volume":"47","author":"Han","year":"1991","journal-title":"Pain"},{"key":"R20-14-20210126","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.brainresbull.2004.01.006","article-title":"Attenuation of mechanical but not thermal hyperalgesia by electroacupuncture with the involvement of opioids in rat model of chronic inflammatory pain.","volume":"63","author":"Huang","year":"2004","journal-title":"Brain Res Bull"},{"key":"R21-14-20210126","first-page":"240","article-title":"Effects of acupuncture at SI3, BL40, SI3-BL40 on neuropathic pain control and c-Fos protein expression in rats.","volume":"21","author":"Jeong","year":"2004","journal-title":"J Kor Soc Acu Mox"},{"key":"R22-14-20210126","doi-asserted-by":"crossref","first-page":"193","DOI":"10.4142\/jvs.2002.3.3.193","article-title":"Effects of electroacupuncture on minimum alveolar concentration of isoflurane and cardiovascular system in isoflurane anesthetized dogs.","volume":"3","author":"Jeong","year":"2002","journal-title":"J Vet Sci"},{"key":"R23-14-20210126","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/S0022-3565(24)29376-9","article-title":"Blockade of opioid receptors in rostral ventral medulla prevents antihyperalgesia produced by transcutaneous electrical nerve stimulation (TENS).","volume":"298","author":"Kalra","year":"2001","journal-title":"J Pharmacol Exp Ther"},{"key":"R26-14-20210126","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.neulet.2005.07.007","article-title":"Effect of acupuncture on behavioral hyperactivity and dopamine release in the nucleus accumbens in rats sensitized to morphine.","volume":"387","author":"Kim","year":"2005","journal-title":"Neurosci Lett"},{"key":"R27-14-20210126","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1054\/jpai.2001.19963","article-title":"The effect of varying frequency and intensity of transcutaneous electrical nerve stimulation on secondary mechanical hyperalgesia in an animal model of inflammation.","volume":"2","author":"King","year":"2001","journal-title":"J Pain"},{"key":"R28-14-20210126","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.pain.2007.04.034","article-title":"Electroacupuncture-induced analgesia in a rat model of ankle sprain pain is mediated by spinal alpha-adrenoceptors.","volume":"135","author":"Koo","year":"2008","journal-title":"Pain"},{"key":"R29-14-20210126","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/S0304-3959(02)00164-1","article-title":"Acupuncture analgesia in a new rat model of ankle sprain pain.","volume":"99","author":"Koo","year":"2002","journal-title":"Pain"},{"key":"R30-14-20210126","first-page":"255","article-title":"Study on combined acupuncture with general anesthesia in pneumonectomy.","volume":"2","author":"Kuang","year":"1996","journal-title":"Chin J Integr Med"},{"key":"R31-14-20210126","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1111\/j.0001-6349.2004.0215.x","article-title":"Acupuncture relieves pelvic and low-back pain in late pregnancy.","volume":"83","author":"Kvorning","year":"2004","journal-title":"Acta Obstet Gynecol Scand"},{"key":"R32-14-20210126","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.brainres.2004.01.092","article-title":"A parametric study of electroacupuncture on persistent hyperalgesia and Fos protein expression in rats.","volume":"1020","author":"Lao","year":"2004","journal-title":"Brain Res"},{"key":"R33-14-20210126","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.pain.2007.01.035","article-title":"The role of reactive oxygen species in capsaicin-induced mechanical hyperalgesia and in the activities of dorsal horn neurons.","volume":"133","author":"Lee","year":"2007","journal-title":"Pain"},{"key":"R34-14-20210126","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1089\/acm.2005.11.653","article-title":"The effect of ting point (tendinomuscular meridians) electroacupuncture on thermal pain: a model for studying the neuronal mechanism of acupuncture analgesia.","volume":"11","author":"Leung","year":"2005","journal-title":"J Altern Complement Med"},{"key":"R35-14-20210126","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/0006-8993(91)91446-8","article-title":"Stimulation of the periaqueductal gray matter of the rat produces a preferential ipsilateral antinociception.","volume":"567","author":"Levine","year":"1991","journal-title":"Brain Res"},{"key":"R36-14-20210126","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.brainres.2007.10.022","article-title":"Electroacupuncture suppresses hyperalgesia and spinal Fos expression by activating the descending inhibitory system.","volume":"1186","author":"Li","year":"2007","journal-title":"Brain Res"},{"key":"R37-14-20210126","doi-asserted-by":"crossref","first-page":"339","DOI":"10.2170\/jjphysiol.RP001505","article-title":"Analgesic effect of electroacupuncture on complete Freunds adjuvant-induced inflammatory pain in mice: a model of antipain treatment by acupuncture in mice.","volume":"55","author":"Li","year":"2005","journal-title":"Jpn J Physiol"},{"key":"R38-14-20210126","first-page":"436","article-title":"Effects of electroacupuncture on GDNF positive cell immunoreactivity in local dermal tissue of the inflammatory pain focus in the rat of adjuvant arthritis.","volume":"26","author":"Liu","year":"2006","journal-title":"Zhongguo Zhen Jiu"},{"key":"R39-14-20210126","first-page":"250","article-title":"Effects of electroacupuncture on glutamate and aspartic acid contents in the dorsal root ganglion and spinal cord in rats with neuropathic pain.","volume":"33","author":"Ma","year":"2008","journal-title":"Zhen Ci Yan Jiu"},{"key":"R40-14-20210126","doi-asserted-by":"crossref","first-page":"9453","DOI":"10.1523\/JNEUROSCI.18-22-09453.1998","article-title":"A lateralized deficit in morphine antinociception after unilateral inactivation of the central amygdala.","volume":"18","author":"Manning","year":"1998","journal-title":"J Neurosci"},{"key":"R41-14-20210126","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/s00540-006-0443-4","article-title":"Effects of traditional Juci (contralateral acupuncture) on orofacial nociceptive behavior in the rat.","volume":"21","author":"Miura","year":"2007","journal-title":"J Anesth"},{"key":"R42-14-20210126","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1155\/2007\/730785","article-title":"Pharmacological management of chronic neuropathic pain - consensus statement and guidelines from the Canadian Pain Society.","volume":"12","author":"Moulin","year":"2007","journal-title":"Pain Res Manag"},{"key":"R43-14-20210126","first-page":"244","article-title":"Induction of local and general analgesia by electroacupuncture in dogs.","volume":"14","author":"Nam","year":"1997","journal-title":"J Vet Clin"},{"key":"R44-14-20210126","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.pain.2006.12.003","article-title":"Hypothalamus and amygdala response to acupuncture stimuli in Carpal Tunnel Syndrome.","volume":"130","author":"Napadow","year":"2007","journal-title":"Pain"},{"key":"R45-14-20210126","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1002\/hbm.20081","article-title":"Effects of electroacupuncture versus manual acupuncture on the human brain as measured by fMRI.","volume":"24","author":"Napadow","year":"2005","journal-title":"Hum Brain Mapp"},{"key":"R46-14-20210126","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/0304-3959(89)90079-1","article-title":"Dose-dependent pain and mechanical hyperalgesia in humans after intradermal injection of capsaicin.","volume":"38","author":"Simone","year":"1989","journal-title":"Pain"},{"key":"R47-14-20210126","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.expneurol.2005.11.011","article-title":"Disruption of glial function enhances electroacupuncture analgesia in arthritic rats.","volume":"198","author":"Sun","year":"2006","journal-title":"Exp Neurol"},{"key":"R48-14-20210126","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/0361-9230(93)90039-E","article-title":"The acupuncture point and its connecting central pathway for producing acupuncture analgesia.","volume":"30","author":"Takeshige","year":"1993","journal-title":"Brain Res Bull"},{"key":"R49-14-20210126","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/0361-9230(92)90131-G","article-title":"Descending pain inhibitory system involved in acupuncture analgesia.","volume":"29","author":"Takeshige","year":"1992","journal-title":"Brain Res Bull"},{"key":"R50-14-20210126","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1016\/0895-4356(90)90020-P","article-title":"Acupuncture and chronic pain: a criteria-based meta-analysis.","volume":"43","author":"ter Riet","year":"1990","journal-title":"J Clin Epidemiol"},{"key":"R51-14-20210126","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.brainres.2006.03.014","article-title":"Electro-acupuncture attenuates stress-induced defecation in rats with chronic visceral hypersensitivity via serotonergic pathway.","volume":"1088","author":"Tian","year":"2006","journal-title":"Brain Res"},{"key":"R52-14-20210126","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/0301-0082(92)90027-C","article-title":"Peripheral and central mechanisms of cutaneous hyperalgesia.","volume":"38","author":"Treede","year":"1992","journal-title":"Prog Neurobiol"},{"key":"R53-14-20210126","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/S0306-4522(99)00002-0","article-title":"Descending facilitatory influences from the rostral medial medulla mediate secondary, but not primary hyperalgesia in the rat.","volume":"90","author":"Urban","year":"1999","journal-title":"Neuroscience"},{"key":"R54-14-20210126","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1002\/cne.903090303","article-title":"Subregions of the periaqueductal gray topographically innervate the rostral ventral medulla in the rat.","volume":"309","author":"Van Bockstaele","year":"1991","journal-title":"J Comp Neurol"},{"key":"R55-14-20210126","doi-asserted-by":"crossref","first-page":"117","DOI":"10.3109\/00207459209003283","article-title":"Comparison of the antinociceptive effects induced by electroacupuncture and transcutaneous electrical nerve stimulation in the rat.","volume":"65","author":"Wang","year":"1992","journal-title":"Int J Neurosci"},{"key":"R56-14-20210126","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.brainres.2006.08.077","article-title":"Electroacupuncture (EA) modulates the expression of NMDA receptors in primary sensory neurons in relation to hyperalgesia in rats.","volume":"1120","author":"Wang","year":"2006","journal-title":"Brain Res"},{"key":"R57-14-20210126","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.expneurol.2004.11.003","article-title":"Effects of synchronous or asynchronous electroacupuncture stimulation with low versus high frequency on spinal opioid release and tail flick nociception.","volume":"192","author":"Wang","year":"2005","journal-title":"Exp Neurol"},{"key":"R58-14-20210126","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1136\/aim.24.1.39","article-title":"A review of acupuncture clinical trials indexed during 2005.","volume":"24","author":"White","year":"2006","journal-title":"Acupunct Med"},{"key":"R60-14-20210126","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1148\/radiology.212.1.r99jl04133","article-title":"Central nervous pathway for acupuncture stimulation: localization of processing with functional MR imaging of the brain - preliminary experience.","volume":"212","author":"Wu","year":"1999","journal-title":"Radiology"},{"key":"R61-14-20210126","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.rvsc.2007.04.004","article-title":"A proposed transpositional acupoint system in a mouse and rat model.","volume":"84","author":"Yin","year":"2008","journal-title":"Res Vet Sci"},{"key":"R62-14-20210126","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/S0006-8993(02)02743-9","article-title":"Involvement of endogenous opioid systems in nociception-induced spinal antinociception in rats.","volume":"945","author":"Yu","year":"2002","journal-title":"Brain Res"},{"key":"R63-14-20210126","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.brainres.2004.05.067","article-title":"Involvement of opioid receptors in electroacupuncture-produced anti-hyperalgesia in rats with peripheral inflammation.","volume":"1020","author":"Zhang","year":"2004","journal-title":"Brain Res"},{"key":"R64-14-20210126","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.brainres.2004.03.034","article-title":"A C-fiber reflex inhibition induced by electroacupuncture with different intensities applied at homotopic and heterotopic acupoints in rats selectively destructive effects on myelinated and unmyelinated afferent fibers.","volume":"1011","author":"Zhu","year":"2004","journal-title":"Brain Res"},{"key":"R65-14-20210126","first-page":"221","article-title":"Ethical considerations in relation to pain in animal experimentation.","volume":"554","author":"Zimmermann","year":"1986","journal-title":"Acta Physiol Scand Suppl"}],"container-title":["Pain"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/10.1016\/j.pain.2009.06.035","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,11]],"date-time":"2025-02-11T10:58:55Z","timestamp":1739271535000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/00006396-200910000-00014"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,10]]},"references-count":60,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2009]]}},"URL":"https:\/\/doi.org\/10.1016\/j.pain.2009.06.035","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1325992.796100","asserted-by":"object"}]},"ISSN":["0304-3959"],"issn-type":[{"value":"0304-3959","type":"print"}],"subject":[],"published":{"date-parts":[[2009,10]]}}}