{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T15:35:41Z","timestamp":1791905741556,"version":"4.3.4"},"reference-count":58,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2009,12,1]],"date-time":"2009-12-01T00:00:00Z","timestamp":1259625600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Department of Veteran Affairs, Veterans Health Administration, Rehabilitation Research and Development Service","award":["F4516I"],"award-info":[{"award-number":["F4516I"]}]},{"name":"NIH","award":["GM079126"],"award-info":[{"award-number":["GM079126"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,12]]},"DOI":"10.1016\/j.pain.2009.09.032","type":"journal-article","created":{"date-parts":[[2009,10,23]],"date-time":"2009-10-23T05:05:32Z","timestamp":1256274332000},"page":"277-286","source":"Crossref","is-referenced-by-count":63,"title":["The NALP1 inflammasome controls cytokine production and nociception in a rat fracture model of complex regional pain syndrome"],"prefix":"10.1097","volume":"147","author":[{"given":"Wen-Wu","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian-Zhi","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deyong","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyou","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tzuping","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wade S.","family":"Kingery","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Clark","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-42-20210227","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1302\/0301-620X.72B1.2298766","article-title":"Features of algodystrophy after Colles fracture.","volume":"72","author":"Atkins","year":"1990","journal-title":"J Bone Joint Surg Br"},{"key":"R2-42-20210227","doi-asserted-by":"crossref","first-page":"e338","DOI":"10.1371\/journal.pmed.0030338","article-title":"Regulation of peripheral inflammation by spinal p38 MAP kinase in rats.","volume":"3","author":"Boyle","year":"2006","journal-title":"PLoS Med"},{"key":"R3-42-20210227","doi-asserted-by":"crossref","first-page":"25900","DOI":"10.1074\/jbc.M707692200","article-title":"Interleukin (IL) 1beta induction of IL-6 is mediated by a novel phosphatidylinositol 3-kinase-dependent AKTIkappaB kinase alpha pathway targeting activator protein-1.","volume":"283","author":"Cahill","year":"2008","journal-title":"J Biol Chem"},{"key":"R4-42-20210227","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1002\/path.2271","article-title":"Nod-like proteins in inflammation and disease.","volume":"214","author":"Carneiro","year":"2008","journal-title":"J Pathol"},{"key":"R5-42-20210227","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1038\/ncprheum0681","article-title":"Primer: inflammasomes and interleukin 1beta in inflammatory disorders.","volume":"4","author":"Church","year":"2008","journal-title":"Nat Clin Pract Rheumatol"},{"key":"R6-42-20210227","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.npep.2006.06.002","article-title":"Effects of the neuropeptides substance P, calcitonin gene-related peptide, vasoactive intestinal polypeptide and galanin on the production of nerve growth factor and inflammatory cytokines in cultured human keratinocytes.","volume":"40","author":"Dallos","year":"2006","journal-title":"Neuropeptides"},{"key":"R7-42-20210227","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1749-6632.1998.tb08307.x","article-title":"Interleukin-1 beta, interleukin-18, and the interleukin-1 beta converting enzyme.","volume":"856","author":"Dinarello","year":"1998","journal-title":"Ann NY Acad Sci"},{"key":"R8-42-20210227","doi-asserted-by":"crossref","first-page":"21924","DOI":"10.1074\/jbc.M401178200","article-title":"Cryopyrin-induced interleukin 1beta secretion in monocytic cells: enhanced activity of disease-associated mutants and requirement for ASC.","volume":"279","author":"Dowds","year":"2004","journal-title":"J Biol Chem"},{"key":"R9-42-20210227","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.tcb.2007.10.004","article-title":"Sunburned skin activates inflammasomes.","volume":"18","author":"Faustin","year":"2008","journal-title":"Trends Cell Biol"},{"key":"R10-42-20210227","doi-asserted-by":"crossref","first-page":"3100","DOI":"10.1002\/art.23866","article-title":"Spinal interleukin-1beta in a mouse model of arthritis and joint pain.","volume":"58","author":"Fiorentino","year":"2008","journal-title":"Arthritis Rheum"},{"key":"R11-42-20210227","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1038\/ni.1703","article-title":"The inflammasome: a caspase-1-activation platform that regulates immune responses and disease pathogenesis.","volume":"10","author":"Franchi","year":"2009","journal-title":"Nat Immunol"},{"key":"R12-42-20210227","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1186\/1471-2474-7-91","article-title":"Increased endothelin-1 and diminished nitric oxide levels in blister fluids of patients with intermediate cold type complex regional pain syndrome type 1.","volume":"7","author":"Groeneweg","year":"2006","journal-title":"BMC Musculoskelet Disord"},{"key":"R13-42-20210227","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.pain.2003.12.010","article-title":"Substance P signaling contributes to the vascular and nociceptive abnormalities observed in a tibial fracture rat model of complex regional pain syndrome type I.","volume":"108","author":"Guo","year":"2004","journal-title":"Pain"},{"key":"R14-42-20210227","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.pain.2005.12.022","article-title":"Glucocorticoid inhibition of vascular abnormalities in a tibia fracture rat model of complex regional pain syndrome type I.","volume":"121","author":"Guo","year":"2006","journal-title":"Pain"},{"key":"R15-42-20210227","doi-asserted-by":"crossref","first-page":"28398","DOI":"10.1155\/MI\/2006\/28398","article-title":"Multiplex bead array assay for detection of 25 soluble cytokines in blister fluid of patients with complex regional pain syndrome type 1.","volume":"2006","author":"Heijmans-Antonissen","year":"2006","journal-title":"Mediators Inflamm"},{"key":"R16-42-20210227","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1080\/09629350210307","article-title":"Evidence for local inflammation in complex regional pain syndrome type 1.","volume":"11","author":"Huygen","year":"2002","journal-title":"Mediators Inflamm"},{"key":"R17-42-20210227","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.imlet.2003.11.013","article-title":"Mast cells are involved in inflammatory reactions during Complex Regional Pain Syndrome type 1.","volume":"91","author":"Huygen","year":"2004","journal-title":"Immunol Lett"},{"key":"R18-42-20210227","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1586\/14737159.8.6.697","article-title":"Inflammasomes and inflammatory caspases in skin inflammation.","volume":"8","author":"Iversen","year":"2008","journal-title":"Expert Rev Mol Diagn"},{"key":"R19-42-20210227","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1056\/NEJMoa061592","article-title":"NALP1 in vitiligo-associated multiple autoimmune disease.","volume":"356","author":"Jin","year":"2007","journal-title":"N Engl J Med"},{"key":"R20-42-20210227","doi-asserted-by":"crossref","first-page":"2857","DOI":"10.1038\/sj.jid.5700922","article-title":"The activity of caspase-1 is increased in lesional psoriatic epidermis.","volume":"127","author":"Johansen","year":"2007","journal-title":"J Invest Dermatol"},{"key":"R21-42-20210227","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S0304-3959(02)00467-0","article-title":"A substance P receptor (NK1) antagonist can reverse vascular and nociceptive abnormalities in a rat model of complex regional pain syndrome type II.","volume":"104","author":"Kingery","year":"2003","journal-title":"Pain"},{"key":"R22-42-20210227","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1369\/jhc.6A7101.2006","article-title":"Inflammasome components NALP 1 and 3 show distinct but separate expression profiles in human tissues suggesting a site-specific role in the inflammatory response.","volume":"55","author":"Kummer","year":"2007","journal-title":"J Histochem Cytochem"},{"key":"R23-42-20210227","doi-asserted-by":"crossref","first-page":"2038","DOI":"10.1002\/art.22635","article-title":"Amelioration of pain and histopathologic joint abnormalities in the Col1-IL-1beta(XAT) mouse model of arthritis by intraarticular induction of mu-opioid receptor into the temporomandibular joint.","volume":"56","author":"Kyrkanides","year":"2007","journal-title":"Arthritis Rheum"},{"key":"R24-42-20210227","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S0014-4886(03)00163-8","article-title":"Substance-P-induced protein extravasation is bilaterally increased in complex regional pain syndrome.","volume":"183","author":"Leis","year":"2003","journal-title":"Exp Neurol"},{"key":"R25-42-20210227","doi-asserted-by":"crossref","first-page":"3423","DOI":"10.1523\/JNEUROSCI.06-12-03423.1986","article-title":"Contribution of sensory afferents and sympathetic efferents to joint injury in experimental arthritis.","volume":"6","author":"Levine","year":"1986","journal-title":"J Neurosci"},{"key":"R26-42-20210227","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.pain.2009.04.033","article-title":"The role of enhanced cutaneous IL-1beta signaling in a rat tibia fracture model of complex regional pain syndrome.","volume":"144","author":"Li","year":"2009","journal-title":"Pain"},{"key":"R27-42-20210227","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/nri1997","article-title":"Inflammasome adaptors and sensors: intracellular regulators of infection and inflammation.","volume":"7","author":"Mariathasan","year":"2007","journal-title":"Nat Rev Immunol"},{"key":"R28-42-20210227","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1038\/nature04515","article-title":"Cryopyrin activates the inflammasome in response to toxins and ATP.","volume":"440","author":"Mariathasan","year":"2006","journal-title":"Nature"},{"key":"R29-42-20210227","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/S1097-2765(02)00599-3","article-title":"The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta.","volume":"10","author":"Martinon","year":"2002","journal-title":"Mol Cell"},{"key":"R30-42-20210227","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1146\/annurev.immunol.021908.132715","article-title":"The inflammasomes: guardians of the body.","volume":"27","author":"Martinon","year":"2009","journal-title":"Annu Rev Immunol"},{"key":"R31-42-20210227","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1038\/nature04516","article-title":"Gout-associated uric acid crystals activate the NALP3 inflammasome.","volume":"440","author":"Martinon","year":"2006","journal-title":"Nature"},{"key":"R32-42-20210227","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1172\/JCI115067","article-title":"Human keratinocytes produce but do not process pro-interleukin-1 (IL-1) beta. Different strategies of IL-1 production and processing in monocytes and keratinocytes.","volume":"87","author":"Mizutani","year":"1991","journal-title":"J Clin Invest"},{"key":"R33-42-20210227","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1155\/MI.2005.366","article-title":"Intermediate stage complex regional pain syndrome type 1 is unrelated to proinflammatory cytokines.","volume":"2005","author":"Munnikes","year":"2005","journal-title":"Mediators Inflamm"},{"key":"R34-42-20210227","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/0304-3959(93)90144-E","article-title":"Reflex sympathetic dystrophy of the hand: an excessive inflammatory response?","volume":"55","author":"Oyen","year":"1993","journal-title":"Pain"},{"key":"R35-42-20210227","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.coi.2009.01.006","article-title":"Sensing pathogens and danger signals by the inflammasome.","volume":"21","author":"Pedra","year":"2009","journal-title":"Curr Opin Immunol"},{"key":"R36-42-20210227","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/j.coi.2007.09.002","article-title":"The inflammasome: a danger sensing complex triggering innate immunity.","volume":"19","author":"Petrilli","year":"2007","journal-title":"Curr Opin Immunol"},{"key":"R37-42-20210227","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1111\/j.1365-2133.2006.07656.x","article-title":"Nine procaspases are expressed in normal human epidermis, but only caspase-14 is fully processed.","volume":"156","author":"Raymond","year":"2007","journal-title":"Br J Dermatol"},{"key":"R38-42-20210227","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.brainresrev.2008.12.020","article-title":"Role of interleukin-1beta during pain and inflammation.","volume":"60","author":"Ren","year":"2009","journal-title":"Brain Res Rev"},{"key":"R39-42-20210227","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/j.pain.2007.10.013","article-title":"TNF signaling contributes to the development of nociceptive sensitization in a tibia fracture model of complex regional pain syndrome type I.","volume":"137","author":"Sabsovich","year":"2008","journal-title":"Pain"},{"key":"R40-42-20210227","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.pain.2007.11.004","article-title":"Effect of anti-NGF antibodies in a rat tibia fracture model of complex regional pain syndrome type I.","volume":"138","author":"Sabsovich","year":"2008","journal-title":"Pain"},{"key":"R41-42-20210227","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1111\/j.1476-5381.1995.tb15035.x","article-title":"Contribution of interleukin-1 beta to the inflammation-induced increase in nerve growth factor levels and inflammatory hyperalgesia.","volume":"115","author":"Safieh-Garabedian","year":"1995","journal-title":"Br J Pharmacol"},{"key":"R42-42-20210227","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.pain.2009.06.037","article-title":"Role of substance P signaling in enhanced nociceptive sensitization and local cytokine production after incision.","volume":"145","author":"Sahbaie","year":"2009","journal-title":"Pain"},{"key":"R43-42-20210227","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1302\/0301-620X.75B3.8496220","article-title":"Algodystrophy and osteoporosis after tibial fractures.","volume":"75","author":"Sarangi","year":"1993","journal-title":"J Bone Joint Surg Br"},{"key":"R44-42-20210227","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/S0014-4886(03)00102-X","article-title":"Regulation of peripheral inflammation by spinal adenosine: role of somatic afferent fibers.","volume":"184","author":"Sorkin","year":"2003","journal-title":"Exp Neurol"},{"key":"R45-42-20210227","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1038\/356768a0","article-title":"A novel heterodimeric cysteine protease is required for interleukin-1 beta processing in monocytes.","volume":"356","author":"Thornberry","year":"1992","journal-title":"Nature"},{"key":"R46-42-20210227","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.pharmthera.2006.04.001","article-title":"Hypernociceptive role of cytokines and chemokines: targets for analgesic drug development?","volume":"112","author":"Verri","year":"2006","journal-title":"Pharmacol Ther"},{"key":"R47-42-20210227","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.bbi.2006.11.005","article-title":"Antigen-induced inflammatory mechanical hypernociception in mice is mediated by IL-18.","volume":"21","author":"Verri","year":"2007","journal-title":"Brain Behav Immun"},{"key":"R48-42-20210227","doi-asserted-by":"crossref","first-page":"2723","DOI":"10.1073\/pnas.0712116105","article-title":"IL-33 mediates antigen-induced cutaneous and articular hypernociception in mice.","volume":"105","author":"Verri","year":"2008","journal-title":"Proc Natl Acad Sci USA"},{"key":"R49-42-20210227","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1007\/BF02505049","article-title":"Substance P and keratinocyte activation markers: an in vitro approach.","volume":"288","author":"Viac","year":"1996","journal-title":"Arch Dermatol Res"},{"key":"R50-42-20210227","doi-asserted-by":"crossref","first-page":"1956","DOI":"10.1038\/sj.jid.5700819","article-title":"Activation of the IL-1beta-processing inflammasome is involved in contact hypersensitivity.","volume":"127","author":"Watanabe","year":"2007","journal-title":"J Invest Dermatol"},{"key":"R51-42-20210227","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/S0304-3959(00)00445-0","article-title":"Facilitated neurogenic inflammation in complex regional pain syndrome.","volume":"91","author":"Weber","year":"2001","journal-title":"Pain"},{"key":"R52-42-20210227","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.pain.2009.04.020","article-title":"Post-junctional facilitation of Substance P signaling in a tibia fracture rat model of complex regional pain syndrome type I.","volume":"144","author":"Wei","year":"2009","journal-title":"Pain"},{"key":"R53-42-20210227","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.ejpain.2008.04.014","article-title":"Pentoxifylline attenuates nociceptive sensitization and cytokine expression in a tibia fracture rat model of complex regional pain syndrome.","volume":"13","author":"Wei","year":"2009","journal-title":"Eur J Pain"},{"key":"R54-42-20210227","doi-asserted-by":"crossref","first-page":"469439","DOI":"10.1155\/2008\/469439","article-title":"Six years follow-up of the levels of TNF-alpha and IL-6 in patients with complex regional pain syndrome type 1.","volume":"2008","author":"Wesseldijk","year":"2008","journal-title":"Mediators Inflamm"},{"key":"R55-42-20210227","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1016\/j.ejpain.2007.10.010","article-title":"Tumor necrosis factor-alpha and interleukin-6 are not correlated with the characteristics of Complex Regional Pain Syndrome type 1 in 66 patients.","volume":"12","author":"Wesseldijk","year":"2008","journal-title":"Eur J Pain"},{"key":"R56-42-20210227","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1016\/j.bbi.2008.03.005","article-title":"Interleukin-1 signaling is required for induction and maintenance of postoperative incisional pain: genetic and pharmacological studies in mice.","volume":"22","author":"Wolf","year":"2008","journal-title":"Brain Behav Immun"},{"key":"R57-42-20210227","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.chom.2008.08.007","article-title":"The caspase-1 inflammasome: a pilot of innate immune responses.","volume":"4","author":"Yu","year":"2008","journal-title":"Cell Host Microbe"},{"key":"R58-42-20210227","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/0304-3959(83)90201-4","article-title":"Ethical guidelines for investigations of experimental pain in conscious animals.","volume":"16","author":"Zimmermann","year":"1983","journal-title":"Pain"}],"container-title":["Pain"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/00006396-200912150-00042","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T18:06:51Z","timestamp":1786039611000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00006396-200912150-00042"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,12]]},"references-count":58,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2009]]}},"URL":"https:\/\/doi.org\/10.1016\/j.pain.2009.09.032","relation":{},"ISSN":["0304-3959"],"issn-type":[{"value":"0304-3959","type":"print"}],"subject":[],"published":{"date-parts":[[2009,12]]}}}