{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T01:59:17Z","timestamp":1790906357445,"version":"4.1.0"},"reference-count":71,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,2]]},"DOI":"10.1016\/j.pain.2009.11.017","type":"journal-article","created":{"date-parts":[[2009,12,18]],"date-time":"2009-12-18T10:29:27Z","timestamp":1261132167000},"page":"309-319","source":"Crossref","is-referenced-by-count":149,"title":["The c-Jun N-terminal kinase 1 (JNK1) in spinal astrocytes is required for the maintenance of bilateral mechanical allodynia under a persistent inflammatory pain condition"],"prefix":"10.1097","volume":"148","author":[{"given":"Yong-Jing","family":"Gao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen-Zhong","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yen-Chin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yeong-Ray","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Decosterd","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ru-Rong","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-19-20210112","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0301-0082(97)00093-2","article-title":"Central neuron-glial and glial-glial interactions following axon injury.","volume":"55","author":"Aldskogius","year":"1998","journal-title":"Prog Neurobiol"},{"key":"R2-19-20210112","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/0304-3959(93)90156-J","article-title":"Mirror pain in the formalin test: behavioral and 2-deoxyglucose studies.","volume":"55","author":"Aloisi","year":"1993","journal-title":"Pain"},{"key":"R3-19-20210112","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1016\/j.neuroscience.2006.08.015","article-title":"Muscle inflammation induces a rapid increase in calcitonin gene-related peptide (CGRP) mRNA that temporally relates to CGRP immunoreactivity and nociceptive behavior.","volume":"143","author":"Ambalavanar","year":"2006","journal-title":"Neuroscience"},{"key":"R4-19-20210112","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1523\/JNEUROSCI.19-02-00859.1999","article-title":"Peripheral inflammation facilitates Abeta fiber-mediated synaptic input to the substantia gelatinosa of the adult rat spinal cord.","volume":"19","author":"Baba","year":"1999","journal-title":"J Neurosci"},{"key":"R5-19-20210112","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1038\/sj.bjp.0702884","article-title":"Nociceptin and the ORL-1 ligand Phe1psi (CH2-NH)Gly2nociceptin(1-13)NH2 exert anti-opioid effects in the Freunds adjuvant-induced arthritic rat model of chronic pain.","volume":"128","author":"Bertorelli","year":"1999","journal-title":"Br J Pharmacol"},{"key":"R6-19-20210112","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1038\/nm911","article-title":"A peptide inhibitor of c-Jun N-terminal kinase protects against excitotoxicity and cerebral ischemia.","volume":"9","author":"Borsello","year":"2003","journal-title":"Nat Med"},{"key":"R7-19-20210112","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/0304-3959(92)90133-V","article-title":"A limited arthritic model for chronic pain studies in the rat.","volume":"48","author":"Butler","year":"1992","journal-title":"Pain"},{"key":"R8-19-20210112","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1097\/00001756-199601310-00036","article-title":"Mechanisms of allodynia: interactions between sensitive mechanoreceptors and nociceptors.","volume":"7","author":"Cervero","year":"1996","journal-title":"Neuroreport"},{"key":"R9-19-20210112","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0165-0270(94)90144-9","article-title":"Quantitative assessment of tactile allodynia in the rat paw.","volume":"53","author":"Chaplan","year":"1994","journal-title":"J Neurosci Methods"},{"key":"R10-19-20210112","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S0304-3940(00)00955-1","article-title":"Contralateral heat hyperalgesia induced by unilaterally intraplantar bee venom injection is produced by central changes: a behavioral study in the conscious rat.","volume":"284","author":"Chen","year":"2000","journal-title":"Neurosci Lett"},{"key":"R11-19-20210112","doi-asserted-by":"crossref","first-page":"9068","DOI":"10.1523\/JNEUROSCI.2260-07.2007","article-title":"Astroglial glutamate-glutamine shuttle is involved in central sensitization of nociceptive neurons in rat medullary dorsal horn.","volume":"22","author":"Chiang","year":"2007","journal-title":"J Neurosci"},{"key":"R12-19-20210112","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S0165-0270(03)00147-X","article-title":"Characterisation of a Freunds complete adjuvant-induced model of chronic arthritis in mice.","volume":"128","author":"Chillingworth","year":"2003","journal-title":"J Neurosci Methods"},{"key":"R13-19-20210112","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/0304-3940(91)90339-U","article-title":"Central neural mediators of secondary hyperalgesia following heat injury in rats: neuropeptides and excitatory amino acids.","volume":"131","author":"Coderre","year":"1991","journal-title":"Neurosci Lett"},{"key":"R14-19-20210112","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1177\/1073858403259950","article-title":"Neuroimmune activation and neuroinflammation in chronic pain and opioid tolerancehyperalgesia.","volume":"10","author":"DeLeo","year":"2004","journal-title":"Neuroscientist"},{"key":"R15-19-20210112","first-page":"31","article-title":"Temporal analysis of increases in c-fos, preprodynorphin and preproenkephalin mRNAs in rat spinal cord.","volume":"6","author":"Draisci","year":"1989","journal-title":"Brain Res"},{"key":"R16-19-20210112","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/0166-2236(92)90019-5","article-title":"Activity-dependent neuronal plasticity following tissue injury and inflammation.","volume":"15","author":"Dubner","year":"1992","journal-title":"Trends Neurosci"},{"key":"R17-19-20210112","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.neulet.2008.03.017","article-title":"Activation of JNK pathway in persistent pain.","volume":"437","author":"Gao","year":"2008","journal-title":"Neurosci Lett"},{"key":"R18-19-20210112","doi-asserted-by":"crossref","first-page":"4096","DOI":"10.1523\/JNEUROSCI.3623-08.2009","article-title":"JNK-induced MCP-1 production in spinal cord astrocytes contributes to central sensitization and neuropathic pain.","volume":"1","author":"Gao","year":"2009","journal-title":"J Neurosci"},{"key":"R19-19-20210112","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/0166-2236(96)10046-1","article-title":"Control of gap-junctional communication in astrocytic networks.","volume":"19","author":"Giaume","year":"1996","journal-title":"Trends Neurosci"},{"key":"R20-19-20210112","doi-asserted-by":"crossref","first-page":"6006","DOI":"10.1523\/JNEUROSCI.0176-07.2007","article-title":"Glial-cytokine-neuronal interactions underlying the mechanisms of persistent pain.","volume":"27","author":"Guo","year":"2007","journal-title":"J Neurosci"},{"key":"R21-19-20210112","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1016\/j.neuroscience.2007.12.038","article-title":"Roles of peripheral mitogen-activated protein kinases in melittin-induced nociception and hyperalgesia.","volume":"152","author":"Hao","year":"2008","journal-title":"Neuroscience"},{"key":"R22-19-20210112","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/0304-3959(88)90026-7","article-title":"A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia.","volume":"32","author":"Hargreaves","year":"1988","journal-title":"Pain"},{"key":"R23-19-20210112","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1038\/35058528","article-title":"GLIA: listening and talking to the synapse.","volume":"2","author":"Haydon","year":"2001","journal-title":"Nat Rev Neurosci"},{"key":"R24-19-20210112","doi-asserted-by":"crossref","first-page":"2073","DOI":"10.1097\/00007632-200110010-00005","article-title":"Repeated injury to the lumbar nerve roots produces enhanced mechanical allodynia and persistent spinal neuroinflammation.","volume":"26","author":"Hunt","year":"2001","journal-title":"Spine"},{"key":"R25-19-20210112","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1523\/JNEUROSCI.22-02-00478.2002","article-title":"ERK MAP kinase activation in superficial spinal cord neurons induces prodynorphin and NK-1 upregulation and contributes to persistent inflammatory pain hypersensitivity.","volume":"22","author":"Ji","year":"2002","journal-title":"J Neurosci"},{"key":"R26-19-20210112","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.brainresrev.2008.12.011","article-title":"4th, Malcangio M, Strichartz GR. MAP kinase and pain.","volume":"60","author":"Ji","year":"2009","journal-title":"Brain Res Rev"},{"key":"R27-19-20210112","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1017\/S1740925X07000403","article-title":"Possible role of spinal astrocytes in maintaining chronic pain sensitization: review of current evidence with focus on bFGFJNK pathway.","volume":"2","author":"Ji","year":"2006","journal-title":"Neuron Glia Biol"},{"key":"R28-19-20210112","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1007\/978-3-540-33823-9_13","article-title":"Protein kinases as potential targets for the treatment of pathological pain.","volume":"177","author":"Ji","year":"2007","journal-title":"Handb Exp Pharmacol"},{"key":"R29-19-20210112","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1016\/j.tins.2003.09.017","article-title":"Central sensitization and LTP: do pain and memory share similar mechanisms?","volume":"26","author":"Ji","year":"2003","journal-title":"Trends Neurosci"},{"key":"R30-19-20210112","doi-asserted-by":"crossref","first-page":"1776","DOI":"10.1523\/JNEUROSCI.17-05-01776.1997","article-title":"Phosphorylation of transcription factor CREB in rat spinal cord after formalin-induced hyperalgesia: relationship to c-fos induction.","volume":"17","author":"Ji","year":"1997","journal-title":"J Neurosci"},{"key":"R31-19-20210112","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0896-6273(02)00908-X","article-title":"p38 MAPK activation by NGF in primary sensory neurons after inflammation increases TRPV1 levels and maintains heat hyperalgesia.","volume":"26","author":"Ji","year":"2002","journal-title":"Neuron"},{"key":"R32-19-20210112","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1152\/jn.00673.2004","article-title":"Cannabinoid agonist, CP 55,940, prevents capsaicin-induced sensitization of spinal cord dorsal horn neurons.","volume":"93","author":"Johanek","year":"2005","journal-title":"J Neurophysiol"},{"key":"R33-19-20210112","doi-asserted-by":"crossref","first-page":"1911","DOI":"10.1126\/science.1072682","article-title":"Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases.","volume":"298","author":"Johnson","year":"2002","journal-title":"Science"},{"key":"R34-19-20210112","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1038\/35093019","article-title":"Molecular mechanisms of nociception.","volume":"413","author":"Julius","year":"2001","journal-title":"Nature"},{"key":"R35-19-20210112","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1002\/glia.20648","article-title":"Transforming growth factor-activated kinase 1 induced in spinal astrocytes contributes to mechanical hypersensitivity after nerve injury.","volume":"56","author":"Katsura","year":"2008","journal-title":"Glia"},{"key":"R36-19-20210112","doi-asserted-by":"crossref","first-page":"1614","DOI":"10.1111\/j.1471-4159.2007.04698.x","article-title":"Activation of extracellular signal-regulated protein kinases 5 in primary afferent neurons contributes to heat and cold hyperalgesia after inflammation.","volume":"102","author":"Katsura","year":"2007","journal-title":"J Neurochem"},{"key":"R37-19-20210112","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1074\/jbc.M410127200","article-title":"C-Jun N-terminal kinase 3 deficiency protects neurons from axotomy-induced death in vivo through mechanisms independent of c-Jun phosphorylation.","volume":"280","author":"Keramaris","year":"2005","journal-title":"J Biol Chem"},{"key":"R38-19-20210112","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/S0166-2236(98)01302-2","article-title":"Does the right side know what the left is doing?","volume":"22","author":"Koltzenburg","year":"1999","journal-title":"Trends Neurosci"},{"key":"R39-19-20210112","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/S0896-6273(00)80727-8","article-title":"The Jnk1 and Jnk2 protein kinases are required for regional specific apoptosis during early brain development.","volume":"22","author":"Kuan","year":"1999","journal-title":"Neuron"},{"key":"R40-19-20210112","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/S0304-3959(00)00394-8","article-title":"Role of central and peripheral tachykinin NK1 receptors in capsaicin-induced pain and hyperalgesia in mice.","volume":"90","author":"Laird","year":"2001","journal-title":"Pain"},{"key":"R41-19-20210112","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1113\/jphysiol.1992.sp019068","article-title":"Pain, hyperalgesia and activity in nociceptive C units in humans after intradermal injection of capsaicin.","volume":"448","author":"LaMotte","year":"1992","journal-title":"J Physiol"},{"key":"R42-19-20210112","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/S0304-3959(02)00097-0","article-title":"Partial sciatic nerve ligation induces increase in the phosphorylation of extracellular signal-regulated kinase (ERK) and c-Jun N-terminal kinase (JNK) in astrocytes in the lumbar spinal dorsal horn and the gracile nucleus.","volume":"99","author":"Ma","year":"2002","journal-title":"Pain"},{"key":"R43-19-20210112","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/S0304-3959(00)00332-8","article-title":"Patterns of spread in complex regional pain syndrome, type I (reflex sympathetic dystrophy).","volume":"88","author":"Maleki","year":"2000","journal-title":"Pain"},{"key":"R44-19-20210112","first-page":"47","article-title":"Developmental expression in the mouse nervous system of the p493F12 SAP kinase.","volume":"35","author":"Martin","year":"1996","journal-title":"Brain Res"},{"key":"R45-19-20210112","first-page":"260","article-title":"Transcription factor regulation of prodynorphin gene expression following rat hindpaw inflammation.","volume":"53","author":"Messersmith","year":"1998","journal-title":"Brain Res"},{"key":"R46-19-20210112","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1097\/00005072-199712000-00006","article-title":"C-Jun, JNKSAPK kinases and transcription factor NF-kappa B are selectively activated in astrocytes, but not motor neurons, in amyotrophic lateral sclerosis.","volume":"56","author":"Migheli","year":"1997","journal-title":"J Neuropathol Exp Neurol"},{"key":"R47-19-20210112","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1523\/JNEUROSCI.23-03-01026.2003","article-title":"Spinal glia and proinflammatory cytokines mediate mirror-image neuropathic pain in rats.","volume":"23","author":"Milligan","year":"2003","journal-title":"J Neurosci"},{"key":"R48-19-20210112","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1038\/nrn2533","article-title":"Pathological and protective roles of glia in chronic pain.","volume":"10","author":"Milligan","year":"2009","journal-title":"Nat Rev Neurosci"},{"key":"R49-19-20210112","doi-asserted-by":"crossref","first-page":"e1116","DOI":"10.1371\/journal.pone.0001116","article-title":"Glycine inhibitory dysfunction turns touch into pain through PKCgamma interneurons.","volume":"2","author":"Miraucourt","year":"2007","journal-title":"PLoS ONE"},{"key":"R50-19-20210112","doi-asserted-by":"crossref","first-page":"2519","DOI":"10.1523\/JNEUROSCI.3923-08.2009","article-title":"Glycine inhibitory dysfunction induces a selectively dynamic, morphine-resistant, and neurokinin 1 receptor-independent mechanical allodynia.","volume":"29","author":"Miraucourt","year":"2009","journal-title":"J Neurosci"},{"key":"R51-19-20210112","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1124\/jpet.103.050781","article-title":"Allodynia and hyperalgesia in adjuvant-induced arthritic rats: time course of progression and efficacy of analgesics.","volume":"306","author":"Nagakura","year":"2003","journal-title":"J Pharmacol Exp Ther"},{"key":"R52-19-20210112","doi-asserted-by":"crossref","first-page":"7936","DOI":"10.1523\/JNEUROSCI.1259-08.2008","article-title":"Innocuous, not noxious, input activates PKCgamma interneurons of the spinal dorsal horn via myelinated afferent fibers.","volume":"28","author":"Neumann","year":"2008","journal-title":"J Neurosci"},{"key":"R53-19-20210112","doi-asserted-by":"crossref","first-page":"2643","DOI":"10.1016\/j.lfs.2004.01.007","article-title":"MAPK activation in nociceptive neurons and pain hypersensitivity.","volume":"74","author":"Obata","year":"2004","journal-title":"Life Sci"},{"key":"R54-19-20210112","doi-asserted-by":"crossref","first-page":"10211","DOI":"10.1523\/JNEUROSCI.3388-04.2004","article-title":"Role of mitogen-activated protein kinase activation in injured and intact primary afferent neurons for mechanical and heat hypersensitivity after spinal nerve ligation.","volume":"24","author":"Obata","year":"2004","journal-title":"J Neurosci"},{"key":"R55-19-20210112","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S0304-3959(98)00187-0","article-title":"Lack of involvement of capsaicin-sensitive primary afferents in nerve-ligation injury induced tactile allodynia in rats.","volume":"79","author":"Ossipov","year":"1999","journal-title":"Pain"},{"key":"R56-19-20210112","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1523\/JNEUROSCI.10-01-00323.1990","article-title":"Systemic morphine suppresses noxious stimulus-evoked Fos protein-like immunoreactivity in the rat spinal cord.","volume":"10","author":"Presley","year":"1990","journal-title":"J Neurosci"},{"key":"R57-19-20210112","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1111\/j.1460-9568.2004.03514.x","article-title":"Complete Freunds adjuvant-induced peripheral inflammation evokes glial activation and proinflammatory cytokine expression in the CNS.","volume":"20","author":"Raghavendra","year":"2004","journal-title":"Eur J Neurosci"},{"key":"R58-19-20210112","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/0304-3959(94)90082-5","article-title":"Inflammation and hyperalgesia in rats neonatally treated with capsaicin: effects on two classes of nociceptive neurons in the superficial dorsal horn.","volume":"59","author":"Ren","year":"1994","journal-title":"Pain"},{"key":"R59-19-20210112","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1038\/35068566","article-title":"Interleukin-1beta-mediated induction of Cox-2 in the CNS contributes to inflammatory pain hypersensitivity.","volume":"410","author":"Samad","year":"2001","journal-title":"Nature"},{"key":"R60-19-20210112","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/0304-3959(90)91074-S","article-title":"A novel behavioral model of neuropathic pain disorders produced in rats by partial sciatic nerve injury.","volume":"43","author":"Seltzer","year":"1990","journal-title":"Pain"},{"key":"R61-19-20210112","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/S0304-3959(98)00245-0","article-title":"Differential efficacy of intravenous lidocaine in alleviating ipsilateral versus contralateral neuropathic pain in the rat.","volume":"80","author":"Sinnott","year":"1999","journal-title":"Pain"},{"key":"R62-19-20210112","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/j.jpain.2004.06.006","article-title":"Spinal gap junctions: potential involvement in pain facilitation.","volume":"5","author":"Spataro","year":"2004","journal-title":"J Pain"},{"key":"R63-19-20210112","doi-asserted-by":"crossref","first-page":"1508","DOI":"10.1111\/j.1471-4159.2004.02996.x","article-title":"Spinal p38beta isoform mediates tissue injury-induced hyperalgesia and spinal sensitization.","volume":"92","author":"Svensson","year":"2005","journal-title":"J Neurochem"},{"key":"R64-19-20210112","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/0304-3959(94)90013-2","article-title":"Extra-territorial pain in rats with a peripheral mononeuropathy: mechano-hyperalgesia and mechano-allodynia in the territory of an uninjured nerve.","volume":"57","author":"Tal","year":"1994","journal-title":"Pain"},{"key":"R65-19-20210112","first-page":"287","article-title":"COX2 in CNS neural cells mediates mechanical inflammatory pain hypersensitivity in mice.","volume":"119","author":"Vardeh","year":"2009","journal-title":"J Clin Invest"},{"key":"R66-19-20210112","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/S0166-2236(00)01854-3","article-title":"Glial activation: a driving force for pathological pain.","volume":"24","author":"Watkins","year":"2001","journal-title":"Trends Neurosci"},{"key":"R67-19-20210112","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1126\/science.288.5472.1765","article-title":"Neuronal plasticity: increasing the gain in pain.","volume":"288","author":"Woolf","year":"2000","journal-title":"Science"},{"key":"R68-19-20210112","doi-asserted-by":"crossref","first-page":"14087","DOI":"10.1523\/JNEUROSCI.2406-08.2008","article-title":"Activation of the neuronal extracellular signal-regulated kinase 2 in the spinal cord dorsal horn is required for complete Freunds adjuvant-induced pain hypersensitivity.","volume":"28","author":"Xu","year":"2008","journal-title":"J Neurosci"},{"key":"R69-19-20210112","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1038\/39899","article-title":"Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene.","volume":"389","author":"Yang","year":"1997","journal-title":"Nature"},{"key":"R70-19-20210112","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.pain.2004.12.022","article-title":"ERK is sequentially activated in neurons, microglia, and astrocytes by spinal nerve ligation and contributes to mechanical allodynia in this neuropathic pain model.","volume":"114","author":"Zhuang","year":"2005","journal-title":"Pain"},{"key":"R71-19-20210112","doi-asserted-by":"crossref","first-page":"3551","DOI":"10.1523\/JNEUROSCI.5290-05.2006","article-title":"A peptide c-Jun N-terminal kinase (JNK) inhibitor blocks mechanical allodynia after spinal nerve ligation: respective roles of JNK activation in primary sensory neurons and spinal astrocytes for neuropathic pain development and maintenance.","volume":"26","author":"Zhuang","year":"2006","journal-title":"J Neurosci"}],"container-title":["Pain"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/00006396-201002000-00019","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T18:11:32Z","timestamp":1786039892000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00006396-201002000-00019"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,2]]},"references-count":71,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2010]]}},"URL":"https:\/\/doi.org\/10.1016\/j.pain.2009.11.017","relation":{},"ISSN":["0304-3959"],"issn-type":[{"value":"0304-3959","type":"print"}],"subject":[],"published":{"date-parts":[[2010,2]]}}}