{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T16:21:01Z","timestamp":1786119661532,"version":"build-2736575974"},"reference-count":58,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","license":[{"start":{"date-parts":[[2011,7,1]],"date-time":"2011-07-01T00:00:00Z","timestamp":1309478400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"crossref","award":["MOP-53278"],"award-info":[{"award-number":["MOP-53278"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,7]]},"DOI":"10.1016\/j.pain.2011.02.035","type":"journal-article","created":{"date-parts":[[2011,3,13]],"date-time":"2011-03-13T04:37:41Z","timestamp":1299991061000},"page":"1502-1510","source":"Crossref","is-referenced-by-count":38,"title":["GDNF levels in the lower lip skin in a rat model of trigeminal neuropathic pain: Implications for nonpeptidergic fiber reinnervation and parasympathetic sprouting"],"prefix":"10.1097","volume":"152","author":[{"given":"Anna M.W.","family":"Taylor","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfredo","family":"Ribeiro-da-Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R5-13-20210112","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1006\/mcne.1999.0754","article-title":"GDNF family neurotrophic factor signaling: four masters, one servant?","volume":"13","author":"Airaksinen","year":"1999","journal-title":"Mol Cell Neurosci"},{"key":"R10-13-20210112","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/0301-0082(80)90007-6","article-title":"Catecholamines, acetylcholine and excitability of mechanoreceptors.","volume":"15","author":"Akoev","year":"1980","journal-title":"Prog Neurobiol"},{"key":"R15-13-20210112","doi-asserted-by":"crossref","first-page":"2981","DOI":"10.1523\/JNEUROSCI.4863-05.2006","article-title":"Glial cell line-derived neurotrophic factor expression in skin alters the mechanical sensitivity of cutaneous nociceptors.","volume":"26","author":"Albers","year":"2006","journal-title":"J Neurosci"},{"key":"R20-13-20210112","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/S0304-3959(00)00327-4","article-title":"Intradermal injection of norepinephrine evokes pain in patients with sympathetically maintained pain.","volume":"88","author":"Ali","year":"2000","journal-title":"Pain"},{"key":"R25-13-20210112","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1007\/s11916-000-0069-4","article-title":"Nociceptors for the 21st century.","volume":"4","author":"Alvarez","year":"2000","journal-title":"Curr Rev Pain"},{"key":"R30-13-20210112","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/S0079-6123(03)46030-5","article-title":"Neurotrophic factors and their receptors in human sensory neuropathies.","volume":"146","author":"Anand","year":"2004","journal-title":"Progr Brain Res"},{"key":"R35-13-20210112","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/0304-3959(91)90229-Q","article-title":"The spectrum of fiber loss in a model of neuropathic pain in the rat: an electron microscopic study.","volume":"47","author":"Basbaum","year":"1991","journal-title":"Pain"},{"key":"R40-13-20210112","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1523\/JNEUROSCI.20-01-00427.2000","article-title":"The glial cell line-derived neurotrophic factor family receptor components are differentially regulated within sensory neurons after nerve injury.","volume":"20","author":"Bennett","year":"2000","journal-title":"J Neurosci"},{"key":"R45-13-20210112","doi-asserted-by":"crossref","first-page":"3059","DOI":"10.1523\/JNEUROSCI.18-08-03059.1998","article-title":"A distinct subgroup of small DRG cells express GDNF receptor components and GDNF is protective for these neurons after nerve injury.","volume":"18","author":"Bennett","year":"1998","journal-title":"J Neurosci"},{"key":"R50-13-20210112","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/0304-3959(88)90209-6","article-title":"A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man.","volume":"33","author":"Bennett","year":"1988","journal-title":"Pain"},{"key":"R55-13-20210112","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/0304-3959(89)90229-7","article-title":"On central pain and central pain mechanisms.","volume":"38","author":"Boivie","year":"1989","journal-title":"Pain"},{"key":"R60-13-20210112","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1126\/science.290.5489.124","article-title":"Potent analgesic effects of GDNF in neuropathic pain states.","volume":"290","author":"Boucher","year":"2000","journal-title":"Science"},{"key":"R65-13-20210112","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1006\/mcne.1998.0719","article-title":"The expression of P2X 3 purinoreceptors in sensory neurons: effects of axotomy and glial-derived neurotrophic factor.","volume":"12","author":"Bradbury","year":"1998","journal-title":"Mol Cell Neurosci"},{"key":"R70-13-20210112","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1016\/j.neuron.2005.08.015","article-title":"Parallel pain pathways arise from subpopulations of primary afferent nociceptor.","volume":"47","author":"Braz","year":"2005","journal-title":"Neuron"},{"key":"R75-13-20210112","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1152\/jn.1973.36.1.101","article-title":"Specific regeneration of cutaneous fibers in the cat.","volume":"36","author":"Burgess","year":"1973","journal-title":"J Neurophysiol"},{"key":"R80-13-20210112","first-page":"7","article-title":"The fifth Heymans memorial lectureGhent, February 17, 1990. Co-transmission.","volume":"304","author":"Burnstock","year":"1990","journal-title":"Arch Int Pharmacodyn Ther"},{"key":"R85-13-20210112","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/0304-3959(92)90181-A","article-title":"Pain response to perineuromal injection of normal saline, epinephrine, and lidocaine in humans.","volume":"49","author":"Chabal","year":"1992","journal-title":"Pain"},{"key":"R90-13-20210112","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0165-0270(94)90144-9","article-title":"Quantitative assessment of tactile allodynia in the rat paw.","volume":"53","author":"Chaplan","year":"1994","journal-title":"J Neurosci Methods"},{"key":"R95-13-20210112","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1038\/377428a0","article-title":"A P2X purinoceptor expressed by a subset of sensory neurons.","volume":"377","author":"Chen","year":"1995","journal-title":"Nature"},{"key":"R100-13-20210112","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/S0165-0173(97)00010-6","article-title":"Receptor localization in the mammalian dorsal horn and primary afferent neurons.","volume":"24","author":"Coggeshall","year":"1997","journal-title":"Brain Res Rev"},{"key":"R105-13-20210112","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/0304-3959(93)90136-D","article-title":"Is large myelinated fiber loss associated with hyperalgesia in a model of experimental peripheral neuropathy in the rat.","volume":"52","author":"Coggeshall","year":"1993","journal-title":"Pain"},{"key":"R110-13-20210112","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1080\/01621459.1965.10480843","article-title":"The up-and-down method for small samples.","volume":"60","author":"Dixon","year":"1994","journal-title":"J Am Stat Assoc"},{"key":"R115-13-20210112","doi-asserted-by":"crossref","first-page":"2147","DOI":"10.1097\/00001756-199609020-00017","article-title":"Growth-associated protein (GAP-43) in terminal Schwann cells of rat Pacinian corpuscles.","volume":"7","author":"Dubovy","year":"1996","journal-title":"Neuroreport"},{"key":"R120-13-20210112","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/S0304-3940(98)00656-9","article-title":"Distribution of P2X3 receptors in the rat trigeminal ganglion after inferior alveolar nerve injury.","volume":"254","author":"Eriksson","year":"1998","journal-title":"Neurosci Lett"},{"key":"R125-13-20210112","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/0304-3940(90)90339-B","article-title":"Alterations in myelinated fibres in the sciatic nerve of rats after constriction: possible relationships between the presence of abnormal small myelinated fibres and pain-related behaviour.","volume":"111","author":"Gautron","year":"1990","journal-title":"Neurosci Lett"},{"key":"R130-13-20210112","doi-asserted-by":"crossref","first-page":"2179","DOI":"10.1523\/JNEUROSCI.16-07-02179.1996","article-title":"Expression of the putative vesicular acetylcholine transporter in rat brain and localization in cholinergic synaptic vesicles.","volume":"16","author":"Gilmor","year":"1996","journal-title":"J Neurosci"},{"key":"R135-13-20210112","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.neulet.2005.07.056","article-title":"Changes in nociceptive sensory innervation in the epidermis of the rat lower lip skin in a model of neuropathic pain.","volume":"389","author":"Grelik","year":"2005","journal-title":"Neurosci Lett"},{"key":"R140-13-20210112","doi-asserted-by":"crossref","first-page":"2475","DOI":"10.1111\/j.1460-9568.2005.04089.x","article-title":"Autonomic fibre sprouting and changes in nociceptive sensory innervation in the rat lower lip skin following chronic constriction injury.","volume":"21","author":"Grelik","year":"2005","journal-title":"Eur J Neurosci"},{"key":"R150-13-20210112","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1097\/00001756-199603220-00004","article-title":"GDNF mRNA in Schwann cells and DRG satellite cells after chronic sciatic nerve injury.","volume":"7","author":"Hammarberg","year":"1996","journal-title":"Neuroreport"},{"key":"R155-13-20210112","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1097\/00001756-200006050-00011","article-title":"Expression of glial cell line-derived neurotrophic factor family of growth factors in peripheral nerve injury in rats.","volume":"11","author":"Hoke","year":"2000","journal-title":"Neuroreport"},{"key":"R160-13-20210112","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1098\/rstb.1985.0028","article-title":"Peptide- and non-peptide-containing unmyelinated primary sensory afferents: the parallel processing of nociceptive information.","volume":"308","author":"Hunt","year":"1985","journal-title":"Phil Trans R Soc Lond B Biol Sci"},{"key":"R165-13-20210112","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/S0079-6123(08)61087-0","article-title":"Interactions of sympathetic and primary afferent neurons following nerve injury and tissue trauma.","volume":"113","author":"Janig","year":"1996","journal-title":"Prog Brain Res"},{"key":"R170-13-20210112","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1007\/s004410050693","article-title":"Conditioned medium from aged monkey fibroblasts stably expressing GDNF and BDNF improves survival of embryonic dopamine neurons in vitro.","volume":"286","author":"Kaddis","year":"1996","journal-title":"Cell Tissue Res"},{"key":"R175-13-20210112","first-page":"584","article-title":"Changes in skin levels of two neurotrophins (glial cell line derived neurotrophic factor and neurotrophin-3) cause alterations in cutaneous neuron responses to mechanical stimuli.","volume":"60","author":"Lawson","year":"2008","journal-title":"Sheng Li Xue Bao"},{"key":"R180-13-20210112","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1038\/377432a0","article-title":"Coexpression of P2X2 and P2X3 receptor subunits can account for ATP-gated currents in sensory neurons.","volume":"377","author":"Lewis","year":"1995","journal-title":"Nature"},{"key":"R185-13-20210112","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/S0304-3940(98)00434-0","article-title":"GDNF expression is increased in denervated human skeletal muscle.","volume":"250","author":"Lie","year":"1998","journal-title":"Neurosci Lett"},{"key":"R190-13-20210112","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1126\/science.8493557","article-title":"GDNF: a glial cell line-derived neurotrophic factor for midbrain dopaminergic neurons.","volume":"260","author":"Lin","year":"1993","journal-title":"Science"},{"key":"R195-13-20210112","doi-asserted-by":"crossref","first-page":"8858","DOI":"10.1523\/JNEUROSCI.1726-06.2006","article-title":"Glial cell line-derived neurotrophic factor family members sensitize nociceptors in vitro and produce thermal hyperalgesia in vivo.","volume":"26","author":"Malin","year":"2006","journal-title":"J Neurosci"},{"key":"R200-13-20210112","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/0306-4522(89)90311-4","article-title":"Quantitative analysis of peptide levels and neurogenic extravasation following regeneration of afferents to appropriate and inappropriate targets.","volume":"33","author":"McMahon","year":"1989","journal-title":"Neuroscience"},{"key":"R205-13-20210112","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1002\/(SICI)1096-9861(19970519)381:4<428::AID-CNE3>3.0.CO;2-4","article-title":"Nerve growth factor receptor TrkA is down-regulated during postnatal development by a subset of dorsal root ganglion neurons.","volume":"381","author":"Molliver","year":"1997","journal-title":"J Comp Neurol"},{"key":"R210-13-20210112","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.1111\/j.1460-9568.1997.tb01499.x","article-title":"Differential regulation of mRNAs for GDNF and its receptors Ret and GDNFR alpha after sciatic nerve lesion in the mouse.","volume":"9","author":"Naveilhan","year":"1997","journal-title":"Eur J Neurosci"},{"key":"R215-13-20210112","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.neulet.2005.01.079","article-title":"Noradrenergic receptor mRNA expression in adult rat superficial dorsal horn and dorsal root ganglion neurons.","volume":"380","author":"Nicholson","year":"2005","journal-title":"Neurosci Lett"},{"key":"R220-13-20210112","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/S0896-6273(00)80899-5","article-title":"Development of sensory neurons in the absence of NGFTrkA signaling in vivo.","volume":"25","author":"Patel","year":"2000","journal-title":"Neuron"},{"key":"R225-13-20210112","doi-asserted-by":"crossref","first-page":"2713","DOI":"10.1111\/j.1460-9568.2003.03012.x","article-title":"Glial cell line-derived neurotrophic factor increases calcitonin gene-related peptide immunoreactivity in sensory and motoneurons in vivo.","volume":"18","author":"Ramer","year":"2003","journal-title":"Eur J Neurosci"},{"key":"R230-13-20210112","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1002\/cne.10998","article-title":"Parasympathetic nerve fibers invade the upper dermis following sensory denervation of the rat lower lip skin.","volume":"469","author":"Ramien","year":"2004","journal-title":"J Comp Neurol"},{"key":"R235-13-20210112","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1523\/JNEUROSCI.11-04-01068.1991","article-title":"Substance P- and enkephalin-like immunoreactivities are colocalized in certain neurons of the substantia gelatinosa of the rat spinal cord. An ultrastructural double-labeling study.","volume":"11","author":"Ribeiro-da-Silva","year":"1991","journal-title":"J Neurosci"},{"key":"R240-13-20210112","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1002\/(SICI)1096-9861(20000626)422:2<287::AID-CNE9>3.0.CO;2-E","article-title":"Peripheral nerve injury leads to the establishment of a novel pattern of sympathetic fibre innervation in the rat skin.","volume":"422","author":"Ruocco","year":"2000","journal-title":"J Comp Neurol"},{"key":"R245-13-20210112","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/S0306-4522(97)80196-0","article-title":"Cholinergic neurons and terminal fields revealed by immunohistochemistry for the vesicular acetylcholine transporter. II. The peripheral nervous system.","volume":"84","author":"Schafer","year":"1998","journal-title":"Neuroscience"},{"key":"R250-13-20210112","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1016\/j.cell.2009.04.019","article-title":"Dissociation of the opioid receptor mechanisms that control mechanical and heat pain.","volume":"137","author":"Scherrer","year":"2009","journal-title":"Cell"},{"key":"R255-13-20210112","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1111\/j.1748-1716.1951.tb00836.x","article-title":"Sensitization of pain receptor by cholinergic substances.","volume":"24","author":"Skouby","year":"1951","journal-title":"Acta Physiol Scand"},{"key":"R260-13-20210112","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/S0896-6273(00)80039-2","article-title":"Neurotrophins cause a new sensation.","volume":"16","author":"Snider","year":"1996","journal-title":"Neuron"},{"key":"R265-13-20210112","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1002\/cne.22048","article-title":"Distribution of P2X(3)-immunoreactive fibers in hairy and glabrous skin of the rat.","volume":"514","author":"Taylor","year":"2009","journal-title":"J Comp Neurol"},{"key":"R270-13-20210112","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/0304-3959(95)00140-N","article-title":"Noradrenaline-evoked pain in neuralgia.","volume":"63","author":"Torebjork","year":"1995","journal-title":"Pain"},{"key":"R275-13-20210112","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1083\/jcb.130.1.137","article-title":"Peripheral expression and biological activities of GDNF, a new neurotrophic factor for avian and mammalian peripheral neurons.","volume":"130","author":"Trupp","year":"1995","journal-title":"J Cell Biol"},{"key":"R280-13-20210112","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1016\/S0028-3908(97)00126-3","article-title":"Immunohistochemical study of the P2X2 and P2X3 receptor subunits in rat and monkey sensory neurons and their central terminals.","volume":"36","author":"Vulchanova","year":"1997","journal-title":"Neuropharmacology"},{"key":"R285-13-20210112","doi-asserted-by":"crossref","first-page":"3470","DOI":"10.1046\/j.1460-9568.1998.00355.x","article-title":"P2X3 is expressed by DRG neurons that terminate in inner lamina II.","volume":"10","author":"Vulchanova","year":"1998","journal-title":"Eur J Neurosci"},{"key":"R290-13-20210112","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/S0169-328X(01)00201-7","article-title":"Differential expression of alpha1-adrenoceptor subtype mRNAs in the dorsal root ganglion after spinal nerve ligation.","volume":"93","author":"Xie","year":"2001","journal-title":"Mol Brain Res"},{"key":"R295-13-20210112","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1002\/cne.20899","article-title":"Sympathetic sprouting and changes in nociceptive sensory innervation in the glabrous skin of the rat hind paw following partial peripheral nerve injury.","volume":"495","author":"Yen","year":"2006","journal-title":"J Comp Neurol"}],"container-title":["Pain"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/00006396-201107000-00013","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T18:46:35Z","timestamp":1786041995000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00006396-201107000-00013"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,7]]},"references-count":58,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2011]]}},"URL":"https:\/\/doi.org\/10.1016\/j.pain.2011.02.035","relation":{},"ISSN":["0304-3959"],"issn-type":[{"value":"0304-3959","type":"print"}],"subject":[],"published":{"date-parts":[[2011,7]]}}}