{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T08:01:13Z","timestamp":1789977673657,"version":"4.0.1"},"reference-count":64,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,6]]},"DOI":"10.1016\/j.pain.2012.03.008","type":"journal-article","created":{"date-parts":[[2012,4,10]],"date-time":"2012-04-10T01:32:05Z","timestamp":1334021525000},"page":"1283-1291","source":"Crossref","is-referenced-by-count":62,"title":["Absence of C\u2013C motif chemokine ligand 5 in mice leads to decreased local macrophage recruitment and behavioral hypersensitivity in a murine neuropathic pain model"],"prefix":"10.1097","volume":"153","author":[{"given":"Jiin-Tarng","family":"Liou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui-Bih","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chih-Chieh","family":"Mao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying-Shu","family":"Lai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan-Ji","family":"Day","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R5-24-20210112","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.brainresbull.2005.03.015","article-title":"Intracisternal administration of chemokines facilitated formalin-induced behavioral responses in the orofacial area of freely moving rats.","volume":"66","author":"Ahn","year":"2005","journal-title":"Brain Res Bull"},{"key":"R10-24-20210112","doi-asserted-by":"crossref","first-page":"552","DOI":"10.4049\/jimmunol.166.1.552","article-title":"The chemokine RANTES is a crucial mediator of the progression from acute to chronic colitis in the rat.","volume":"166","author":"Ajuebor","year":"2001","journal-title":"J Immunol"},{"key":"R15-24-20210112","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.ejphar.2008.07.009","article-title":"Elevated level of the proinflammatory chemokine, RANTESCCL5, in the periaqueductal grey causes hyperalgesia in rats.","volume":"592","author":"Benamar","year":"2008","journal-title":"Eur J Pharmacol"},{"key":"R20-24-20210112","doi-asserted-by":"crossref","first-page":"2650","DOI":"10.4049\/jimmunol.164.5.2650","article-title":"Role of CC chemokines (macrophage inflammatory protein-1, monocyte chemoattractant protein-1, RANTES) in acute lung injury in rats.","volume":"164","author":"Bless","year":"2000","journal-title":"J Immunol"},{"key":"R25-24-20210112","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1097\/00000542-200401000-00024","article-title":"Mobilization of opioid-containing polymorphonuclear cells by hematopoietic growth factors and influence on inflammatory pain.","volume":"100","author":"Brack","year":"2004","journal-title":"Anesthesiology"},{"key":"R30-24-20210112","doi-asserted-by":"crossref","first-page":"335","DOI":"10.4049\/jimmunol.180.1.335","article-title":"Macrophages driven to a novel state of activation have anti-inflammatory properties in mice.","volume":"180","author":"Brem-Exner","year":"2008","journal-title":"J Immunol"},{"key":"R35-24-20210112","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1002\/eji.200737485","article-title":"CNS-infiltrating CD4 T lymphocytes contribute to murine spinal nerve transection-induced neuropathic pain.","volume":"38","author":"Cao","year":"2008","journal-title":"Eur J Immunol"},{"key":"R40-24-20210112","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/S0165-5728(97)00196-3","article-title":"Adrenergic regulation of macrophage-derived tumor necrosis factor-alpha generation during a chronic polyarthritis pain model.","volume":"82","author":"Chou","year":"1998","journal-title":"J Neuroimmunol"},{"key":"R45-24-20210112","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1002\/(SICI)1096-9896(199711)183:3<352::AID-PATH938>3.0.CO;2-L","article-title":"RANTES is a pro-inflammatory chemokine and chemoattracts basophil cells to extravascular sites.","volume":"183","author":"Conti","year":"1997","journal-title":"J Pathol"},{"key":"R50-24-20210112","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1046\/j.1365-2141.1998.01060.x","article-title":"Mast cell recruitment after subcutaneous injection of RANTES in the sole of the rat paw.","volume":"103","author":"Conti","year":"1998","journal-title":"Br J Haematol"},{"key":"R55-24-20210112","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.1038\/sj.bjp.0703434","article-title":"Cytokine-mediated inflammatory hyperalgesia limited by interleukin-1 receptor antagonist.","volume":"130","author":"Cunha","year":"2000","journal-title":"Br J Pharmacol"},{"key":"R60-24-20210112","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1471-2377-6-1","article-title":"Prostanoid receptor EP1 and Cox-2 in injured human nerves and a rat model of nerve injury: a time-course study.","volume":"6","author":"Durrenberger","year":"2006","journal-title":"BMC Neurol"},{"key":"R65-24-20210112","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.4049\/jimmunol.167.3.1637","article-title":"RANTES-induced chemokine cascade in dendritic cells.","volume":"167","author":"Fischer","year":"2001","journal-title":"J Immunol"},{"key":"R70-24-20210112","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1016\/0306-4522(93)90314-6","article-title":"Distribution and axonal relations of macrophages in a neuroma.","volume":"55","author":"Frison","year":"1993","journal-title":"Neuroscience"},{"key":"R75-24-20210112","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/S0304-3959(00)00333-X","article-title":"Thalidomide treatment in chronic constrictive neuropathy decreases endoneurial tumor necrosis factor-alpha, increases interleukin-10 and has long-term effects on spinal cord dorsal horn met-enkephalin.","volume":"88","author":"George","year":"2000","journal-title":"Pain"},{"key":"R80-24-20210112","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1038\/84209","article-title":"Chemokines and disease.","volume":"2","author":"Gerard","year":"2001","journal-title":"Nat Immunol"},{"key":"R85-24-20210112","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1084\/jem.188.2.317","article-title":"Opiates transdeactivate chemokine receptors: delta and mu opiate receptor-mediated heterologous desensitization.","volume":"188","author":"Grimm","year":"1998","journal-title":"J Exp Med"},{"key":"R90-24-20210112","doi-asserted-by":"crossref","first-page":"1752","DOI":"10.1002\/eji.200324698","article-title":"Interferon gamma suppresses glucocorticoid augmentation of macrophage clearance of apoptotic cells.","volume":"34","author":"Heasman","year":"2004","journal-title":"Eur J Immunol"},{"key":"R95-24-20210112","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1111\/j.1365-2249.2006.03028.x","article-title":"Balance of inflammatory response in stable gingivitis and progressive periodontitis lesions.","volume":"144","author":"Honda","year":"2006","journal-title":"Clin Exp Immunol"},{"key":"R100-24-20210112","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1016\/S0014-4886(03)00307-8","article-title":"Distinct functional types of macrophage in dorsal root ganglia and spinal nerves proximal to sciatic and spinal nerve transections in the rat.","volume":"184","author":"Hu","year":"2003","journal-title":"Exp Neurol"},{"key":"R105-24-20210112","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1681\/ASN.V112262","article-title":"Interleukin-10 inhibits macrophage-induced glomerular injury.","volume":"11","author":"Huang","year":"2000","journal-title":"J Am Soc Nephrol"},{"key":"R110-24-20210112","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1161\/ATVBAHA.109.197442","article-title":"CCL5 promotes macrophage recruitment and survival in human adipose tissue.","volume":"30","author":"Keophiphath","year":"2010","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"R115-24-20210112","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1046\/j.1523-1755.1998.00733.x","article-title":"Interleukin-4 deficiency enhances Th1 responses and crescentic glomerulonephritis in mice.","volume":"53","author":"Kitching","year":"1998","journal-title":"Kidney Int"},{"key":"R120-24-20210112","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1016\/j.expneurol.2006.03.014","article-title":"T cell infiltration after chronic constriction injury of mouse sciatic nerve is associated with interleukin-17 expression.","volume":"200","author":"Kleinschnitz","year":"2006","journal-title":"Exp Neurol"},{"key":"R125-24-20210112","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1097\/WNR.0b013e32834cd76a","article-title":"Site-specific subtypes of macrophages recruited after peripheral nerve injury.","volume":"22","author":"Komori","year":"2011","journal-title":"Neuroreport"},{"key":"R130-24-20210112","doi-asserted-by":"crossref","first-page":"43901","DOI":"10.1074\/jbc.M107543200","article-title":"Regulation of mu-opioid receptor gene transcription by interleukin-4 and influence of an allelic variation within a STAT6 transcription factor binding site.","volume":"276","author":"Kraus","year":"2001","journal-title":"J Biol Chem"},{"key":"R135-24-20210112","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1016\/j.bbi.2010.04.001","article-title":"T lymphocytes containing beta-endorphin ameliorate mechanical hypersensitivity following nerve injury.","volume":"24","author":"Labuz","year":"2010","journal-title":"Brain Behav Immun"},{"key":"R140-24-20210112","doi-asserted-by":"crossref","first-page":"1830","DOI":"10.1213\/01.ane.0000287652.42309.5c","article-title":"Inhibition of the cyclic adenosine monophosphate pathway attenuates neuropathic pain and reduces phosphorylation of cyclic adenosine monophosphate response element-binding in the spinal cord after partial sciatic nerve ligation in rats.","volume":"105","author":"Liou","year":"2007","journal-title":"Anesth Analg"},{"key":"R145-24-20210112","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1097\/ALN.0b013e31820b8b1e","article-title":"Inflammation confers dual effects on nociceptive processing in chronic neuropathic pain model.","volume":"114","author":"Liou","year":"2011","journal-title":"Anesthesiology"},{"key":"R150-24-20210112","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.jneuroim.2010.10.014","article-title":"Exogenous granulocyte colony-stimulating factor exacerbate pain-related behaviors after peripheral nerve injury.","volume":"232","author":"Liou","year":"2011","journal-title":"J Neuroimmunol"},{"key":"R155-24-20210112","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2-DeltaDeltaCT method.","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"R160-24-20210112","doi-asserted-by":"crossref","first-page":"3557","DOI":"10.4049\/jimmunol.168.7.3557","article-title":"Analysis of the gene expression profile activated by the CC chemokine ligand 5RANTES and by lipopolysaccharide in human monocytes.","volume":"168","author":"Locati","year":"2002","journal-title":"J Immunol"},{"key":"R165-24-20210112","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1006\/abio.1993.1504","article-title":"A fluorescence-based protein assay for use with a microplate reader.","volume":"214","author":"Lorenzen","year":"1993","journal-title":"Anal Biochem"},{"key":"R170-24-20210112","doi-asserted-by":"crossref","first-page":"6061","DOI":"10.1073\/pnas.0700295104","article-title":"Naloxone acts as a potent analgesic in transgenic mouse models of sickle cell anemia.","volume":"104","author":"Lunzer","year":"2007","journal-title":"Proc Natl Acad Sci USA"},{"key":"R175-24-20210112","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S0165-5728(97)00081-7","article-title":"Pro-opiomelanocortin gene expression and protein processing in rat mononuclear leukocytes.","volume":"78","author":"Lyons","year":"1997","journal-title":"J Neuroimmunol"},{"key":"R180-24-20210112","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1038\/4017","article-title":"Pain control in inflammation governed by selectins.","volume":"4","author":"Machelska","year":"1998","journal-title":"Nat Med"},{"key":"R185-24-20210112","doi-asserted-by":"crossref","first-page":"5588","DOI":"10.1523\/JNEUROSCI.22-13-05588.2002","article-title":"Opioid control of inflammatory pain regulated by intercellular adhesion molecule-1.","volume":"22","author":"Machelska","year":"2002","journal-title":"J Neurosci"},{"key":"R190-24-20210112","doi-asserted-by":"crossref","first-page":"8117","DOI":"10.4049\/jimmunol.178.12.8117","article-title":"TNF-alpha inhibits macrophage clearance of apoptotic cells via cytosolic phospholipase A2 and oxidant-dependent mechanisms.","volume":"178","author":"McPhillips","year":"2007","journal-title":"J Immunol"},{"key":"R195-24-20210112","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1096\/fj.08-121228","article-title":"Macrophage phagocytosis of apoptotic neutrophils is critically regulated by the opposing actions of pro-inflammatory and anti-inflammatory agents: key role for TNF-alpha.","volume":"23","author":"Michlewska","year":"2009","journal-title":"FASEB J"},{"key":"R200-24-20210112","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.pain.2006.07.009","article-title":"Repeated intrathecal injections of plasmid DNA encoding interleukin-10 produce prolonged reversal of neuropathic pain.","volume":"126","author":"Milligan","year":"2006","journal-title":"Pain"},{"key":"R205-24-20210112","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.brainresrev.2005.11.004","article-title":"Immune and inflammatory mechanisms in neuropathic pain.","volume":"51","author":"Moalem","year":"2006","journal-title":"Brain Res Rev"},{"key":"R210-24-20210112","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1016\/j.neuroscience.2004.08.035","article-title":"T lymphocytes play a role in neuropathic pain following peripheral nerve injury in rats.","volume":"129","author":"Moalem","year":"2004","journal-title":"Neuroscience"},{"key":"R215-24-20210112","doi-asserted-by":"crossref","first-page":"5027","DOI":"10.1523\/JNEUROSCI.21-14-05027.2001","article-title":"Chemokines and glycoprotein120 produce pain hypersensitivity by directly exciting primary nociceptive neurons.","volume":"21","author":"Oh","year":"2001","journal-title":"J Neurosci"},{"key":"R220-24-20210112","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1006\/exnr.2001.7677","article-title":"Pro- and anti-inflammatory cytokine gene expression in rat sciatic nerve chronic constriction injury model of neuropathic pain.","volume":"169","author":"Okamoto","year":"2001","journal-title":"Exp Neurol"},{"key":"R225-24-20210112","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/S0306-4522(00)00396-1","article-title":"Hyperalgesia due to nerve injury: role of neutrophils.","volume":"101","author":"Perkins","year":"2000","journal-title":"Neuroscience"},{"key":"R230-24-20210112","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1084\/jem.165.4.1218","article-title":"The macrophage response to central and peripheral nerve injury. A possible role for macrophages in regeneration.","volume":"165","author":"Perry","year":"1987","journal-title":"J Exp Med"},{"key":"R235-24-20210112","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/S0165-2478(97)00075-8","article-title":"Effect of a CC chemokine receptor antagonist on collagen induced arthritis in DBA1 mice.","volume":"57","author":"Plater-Zyberk","year":"1997","journal-title":"Immunol Lett"},{"key":"R240-24-20210112","doi-asserted-by":"crossref","first-page":"14978","DOI":"10.1073\/pnas.0809784106","article-title":"Tolerance and M2 (alternative) macrophage polarization are related processes orchestrated by p50 nuclear factor kappaB.","volume":"106","author":"Porta","year":"2009","journal-title":"Proc Natl Acad Sci USA"},{"key":"R245-24-20210112","first-page":"4134","article-title":"Interleukin 10 transfected into Chinese hamster ovary cells prevents tumor growth and macrophage infiltration.","volume":"53","author":"Richter","year":"1993","journal-title":"Cancer Res"},{"key":"R250-24-20210112","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1097\/00000542-200108000-00036","article-title":"Opioid peptide-expressing leukocytes: identification, recruitment, and simultaneously increasing inhibition of inflammatory pain.","volume":"95","author":"Rittner","year":"2001","journal-title":"Anesthesiology"},{"key":"R255-24-20210112","doi-asserted-by":"crossref","first-page":"180","DOI":"10.4049\/jimmunol.154.1.180","article-title":"Multiple defects in innate and adaptive immunologic function in NODLtSz-scid mice.","volume":"154","author":"Shultz","year":"1995","journal-title":"J Immunol"},{"key":"R260-24-20210112","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.jneuroim.2006.11.033","article-title":"Lymphocytes upregulate signal sequence-encoding proopiomelanocortin mRNA and beta-endorphin during painful inflammation in vivo.","volume":"183","author":"Sitte","year":"2007","journal-title":"J Neuroimmunol"},{"key":"R265-24-20210112","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1189\/jlb.0704414","article-title":"Recombinant guinea pig CCL5 (RANTES) differentially modulates cytokine production in alveolar and peritoneal macrophages.","volume":"76","author":"Skwor","year":"2004","journal-title":"J Leukoc Biol"},{"key":"R270-24-20210112","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.bbi.2008.09.004","article-title":"Anti-inflammatory cytokine gene therapy decreases sensory and motor dysfunction in experimental Multiple Sclerosis: MOG-EAE behavioral and anatomical symptom treatment with cytokine gene therapy.","volume":"23","author":"Sloane","year":"2009","journal-title":"Brain Behav Immun"},{"key":"R275-24-20210112","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1038\/nm908","article-title":"Attacking pain at its source. new perspectives on opioids.","volume":"9","author":"Stein","year":"2003","journal-title":"Nat Med"},{"key":"R280-24-20210112","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/j.ejheart.2008.06.007","article-title":"Interleukin-10 improves left ventricular function in rats with heart failure subsequent to myocardial infarction.","volume":"10","author":"Stumpf","year":"2008","journal-title":"Eur J Heart Fail"},{"key":"R285-24-20210112","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1213\/01.ane.0000275190.42912.37","article-title":"Pathophysiology of peripheral neuropathic pain: immune cells and molecules.","volume":"105","author":"Thacker","year":"2007","journal-title":"Anesth Analg"},{"key":"R290-24-20210112","doi-asserted-by":"crossref","first-page":"1975","DOI":"10.1001\/archneur.58.12.1975","article-title":"Investigating chemokines and chemokine receptors in patients with multiple sclerosis: opportunities and challenges.","volume":"58","author":"Trebst","year":"2001","journal-title":"Arch Neurol"},{"key":"R295-24-20210112","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/S0165-5728(03)00126-7","article-title":"Evidence for endogenous interleukin-10 during nociception.","volume":"139","author":"Tu","year":"2003","journal-title":"J Neuroimmunol"},{"key":"R300-24-20210112","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1126\/science.178.4063.871","article-title":"Fluorescamine: a reagent for assay of amino acids, peptides, proteins, and primary amines in the picomole range.","volume":"178","author":"Udenfriend","year":"1972","journal-title":"Science"},{"key":"R305-24-20210112","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1152\/physrev.00011.2002","article-title":"Beyond neurons: evidence that immune and glial cells contribute to pathological pain states.","volume":"82","author":"Watkins","year":"2002","journal-title":"Physiol Rev"},{"key":"R310-24-20210112","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1097\/00019052-200106000-00018","article-title":"Immunopathogenesis of HIV-associated dementia.","volume":"14","author":"Wesselingh","year":"2001","journal-title":"Curr Opin Neurol"},{"key":"R315-24-20210112","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1038\/labinvest.3780067","article-title":"Neutrophils: molecules, functions and pathophysiological aspects.","volume":"80","author":"Witko-Sarsat","year":"2000","journal-title":"Lab Invest"},{"key":"R320-24-20210112","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/0304-3959(83)90201-4","article-title":"Ethical guidelines for investigations of experimental pain in conscious animals.","volume":"16","author":"Zimmermann","year":"1983","journal-title":"Pain"}],"container-title":["Pain"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/journals.lww.com\/00006396-201206000-00024","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,21]],"date-time":"2023-06-21T22:12:19Z","timestamp":1687385539000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/00006396-201206000-00024"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,6]]},"references-count":64,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2012]]}},"URL":"https:\/\/doi.org\/10.1016\/j.pain.2012.03.008","relation":{},"ISSN":["0304-3959"],"issn-type":[{"value":"0304-3959","type":"print"}],"subject":[],"published":{"date-parts":[[2012,6]]}}}