{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T01:22:42Z","timestamp":1792718562068,"version":"4.5.0"},"reference-count":33,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","license":[{"start":{"date-parts":[[2013,3,1]],"date-time":"2013-03-01T00:00:00Z","timestamp":1362096000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,3]]},"DOI":"10.1016\/j.pain.2012.10.018","type":"journal-article","created":{"date-parts":[[2012,11,2]],"date-time":"2012-11-02T04:18:14Z","timestamp":1351829894000},"page":"350-360","source":"Crossref","is-referenced-by-count":97,"title":["Antinociceptive effects of the N-acylethanolamine acid amidase inhibitor ARN077 in rodent pain models"],"prefix":"10.1097","volume":"154","author":[{"given":"Oscar","family":"Sasso","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillermo","family":"Moreno-Sanz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cataldo","family":"Martucci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"Realini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauro","family":"Dionisi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luisa","family":"Mengatto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Duranti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Glauco","family":"Tarozzo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgio","family":"Tarzia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Mor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosalia","family":"Bertorelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelo","family":"Reggiani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniele","family":"Piomelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-8-20210112","doi-asserted-by":"crossref","first-page":"30429","DOI":"10.1074\/jbc.M305051200","article-title":"Activation of TRPV1 by the satiety factor oleoylethanolamide.","volume":"278","author":"Ahern","year":"2003","journal-title":"J Biol Chem"},{"key":"R2-8-20210112","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1021\/ml300056y","article-title":"-Lactones inhibit N-1432 acylethanolamine acid amidase by S-acylation of the catalytic N-terminal cysteine.","volume":"3","author":"Armirotti","year":"2012","journal-title":"ACS Med Chem Lett"},{"key":"R3-8-20210112","doi-asserted-by":"crossref","first-page":"2755","DOI":"10.1016\/j.jchromb.2009.01.008","article-title":"Lipidomic analysis of endocannabinoid metabolism in biological samples.","volume":"877","author":"Astarita","year":"2009","journal-title":"J Chromatogr B Analyt Technol Biomed Life Sci"},{"key":"R4-8-20210112","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/0304-3959(88)90209-6","article-title":"A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man.","volume":"33","author":"Bennett","year":"1988","journal-title":"PAIN"},{"key":"R5-8-20210112","doi-asserted-by":"crossref","first-page":"3315","DOI":"10.1074\/jbc.272.6.3315","article-title":"Biosynthesis, uptake, and degradation of anandamide and palmitoylethanolamide in leukocytes.","volume":"272","author":"Bisogno","year":"1997","journal-title":"J Biol Chem"},{"key":"R6-8-20210112","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1038\/28393","article-title":"Control of pain initiation by endogenous cannabinoids.","volume":"394","author":"Calignano","year":"1998","journal-title":"Nature"},{"key":"R7-8-20210112","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1038\/nn.2632","article-title":"Anandamide suppresses pain initiation through a peripheral endocannabinoid mechanism.","volume":"13","author":"Clapper","year":"2010","journal-title":"Nat Neurosci"},{"key":"R8-8-20210112","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1038\/384083a0","article-title":"Molecular characterization of an enzyme that degrades neuromodulatory fatty-acid amides.","volume":"384","author":"Cravatt","year":"1996","journal-title":"Nature"},{"key":"R9-8-20210112","doi-asserted-by":"crossref","first-page":"6030","DOI":"10.1074\/jbc.270.11.6030","article-title":"Anandamide amidohydrolase activity in rat brain microsomes. Identification and partial characterization.","volume":"270","author":"Desarnaud","year":"1995","journal-title":"J Biol Chem"},{"key":"R10-8-20210112","doi-asserted-by":"crossref","first-page":"4824","DOI":"10.1021\/jm300349j","article-title":"N-(2-Oxo-3-oxetanyl)carbamic acid esters as N-acylethanolamine acid amidase inhibitors: synthesis and structure-activity and structure-property relationships.","volume":"55","author":"Duranti","year":"2012","journal-title":"J Med Chem"},{"key":"R11-8-20210112","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1038\/nature01921","article-title":"Oleylethanolamide regulates feeding and body weight through activation of the nuclear receptor PPAR-alpha.","volume":"425","author":"Fu","year":"2003","journal-title":"Nature"},{"key":"R12-8-20210112","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1111\/j.1460-9568.2004.03428.x","article-title":"Segregation of two endocannabinoid-hydrolyzing enzymes into pre- and postsynaptic compartments in the rat hippocampus, cerebellum and amygdala.","volume":"20","author":"Gulyas","year":"2004","journal-title":"Eur J Neurosci"},{"key":"R13-8-20210112","doi-asserted-by":"crossref","first-page":"27849","DOI":"10.1074\/jbc.M404087200","article-title":"Oleoylethanolamide stimulates lipolysis by activating the nuclear receptor peroxisome proliferator-activated receptor alpha (PPAR-alpha).","volume":"279","author":"Guzman","year":"2004","journal-title":"J Biol Chem"},{"key":"R14-8-20210112","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/0304-3959(88)90026-7","article-title":"A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia.","volume":"32","author":"Hargreaves","year":"1988","journal-title":"PAIN"},{"key":"R15-8-20210112","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.neuropharm.2008.04.018","article-title":"Inhibition of fatty acid amide hydrolase and cyclooxygenase-2 increases levels of endocannabinoid related molecules and produces analgesia via peroxisome proliferator-activated receptor-alpha in a model of inflammatory pain.","volume":"55","author":"Jhaveri","year":"2008","journal-title":"Neuropharmacology"},{"key":"R16-8-20210112","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1038\/nm803","article-title":"Modulation of anxiety through blockade of anandamide hydrolysis.","volume":"9","author":"Kathuria","year":"2003","journal-title":"Nat Med"},{"key":"R17-8-20210112","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/j.neuropharm.2007.10.021","article-title":"AM404, an anandamide transport inhibitor, reduces plasma extravasation in a model of neuropathic pain in rat: role for cannabinoid receptors.","volume":"54","author":"La Rana","year":"2008","journal-title":"Neuropharmacology"},{"key":"R18-8-20210112","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1124\/jpet.106.111385","article-title":"Rapid broad-spectrum analgesia through activation of peroxisome proliferator-activated receptor-alpha.","volume":"319","author":"LoVerme","year":"2006","journal-title":"J Pharmacol Exp Ther"},{"key":"R19-8-20210112","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1124\/mol.104.006353","article-title":"The nuclear receptor peroxisome proliferator-activated receptor-alpha mediates the anti-inflammatory actions of palmitoylethanolamide.","volume":"67","author":"Lo Verme","year":"2005","journal-title":"Mol Pharmacol"},{"key":"R20-8-20210112","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1016\/j.bbalip.2007.02.004","article-title":"Peroxisome proliferator-activated receptors (PPARs) in skin health, repair and disease.","volume":"1771","author":"Michalik","year":"2007","journal-title":"Biochim Biophys Acta"},{"key":"R22-8-20210112","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1038\/35102582","article-title":"An anorexic lipid mediator regulated by feeding.","volume":"414","author":"Rodriguez de Fonseca","year":"2001","journal-title":"Nature"},{"key":"R23-8-20210112","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1007\/s00213-012-2662-8","article-title":"Alteration of neuropathic and visceral pain in female C57BL6J mice lacking the PPAR- gene.","volume":"222","author":"Ruiz-Medina","year":"2012","journal-title":"Psychopharmacology (Berl)"},{"key":"R24-8-20210112","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.ejphar.2007.03.007","article-title":"Synergistic antinociception by the cannabinoid receptor agonist anandamide and the PPAR-alpha receptor agonist GW7647.","volume":"566","author":"Russo","year":"2007","journal-title":"Eur J Pharmacol"},{"key":"R25-8-20210112","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1038\/bjp.2008.335","article-title":"Inhibition of fatty acid amide hydrolase produces PPAR-alpha-mediated analgesia in a rat model of inflammatory pain.","volume":"155","author":"Sagar","year":"2008","journal-title":"Br J Pharmacol"},{"key":"R26-8-20210112","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/j.phrs.2012.02.012","article-title":"Peripheral FAAH inhibition causes profound antinociception and protects against indomethacin-induced gastric lesions.","volume":"65","author":"Sasso","year":"2012","journal-title":"Pharmacol Res"},{"key":"R27-8-20210112","doi-asserted-by":"crossref","first-page":"5770","DOI":"10.1021\/jm100582w","article-title":"Synthesis and structure-activity relationships of N-(2-oxo-3-oxetanyl)amides as N-acylethanolamine-hydrolyzing acid amidase inhibitors.","volume":"53","author":"Solorzano","year":"2010","journal-title":"J Med Chem"},{"key":"R28-8-20210112","doi-asserted-by":"crossref","first-page":"20966","DOI":"10.1073\/pnas.0907417106","article-title":"Selective N-acylethanolamine-hydrolyzing acid amidase inhibition reveals a key role for endogenous palmitoylethanolamide in inflammation.","volume":"106","author":"Solorzano","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R29-8-20210112","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.pain.2007.03.008","article-title":"Analgesic properties of oleoylethanolamide (OEA) in visceral and inflammatory pain.","volume":"133","author":"Suardiaz","year":"2007","journal-title":"PAIN"},{"key":"R30-8-20210112","doi-asserted-by":"crossref","first-page":"2352","DOI":"10.1021\/jm021119g","article-title":"Design, synthesis, and structure-activity relationships of alkylcarbamic acid aryl esters, a new class of fatty acid amide hydrolase inhibitors.","volume":"46","author":"Tarzia","year":"2003","journal-title":"J Med Chem"},{"key":"R31-8-20210112","doi-asserted-by":"crossref","first-page":"11082","DOI":"10.1074\/jbc.M413473200","article-title":"Molecular characterization of N-acylethanolamine-hydrolyzing acid amidase, a novel member of the choloylglycine hydrolase family with structural and functional similarity to acid ceramidase.","volume":"280","author":"Tsuboi","year":"2005","journal-title":"J Biol Chem"},{"key":"R32-8-20210112","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/j.bbalip.2007.03.005","article-title":"Predominant expression of lysosomal N-acylethanolamine-hydrolyzing acid amidase in macrophages revealed by immunochemical studies.","volume":"1771","author":"Tsuboi","year":"2007","journal-title":"Biochim Biophys Acta"},{"key":"R33-8-20210112","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1038\/415813a","article-title":"Structural basis for antagonist-mediated recruitment of nuclear co-repressors by PPAR-alpha.","volume":"415","author":"Xu","year":"2002","journal-title":"Nature"},{"key":"R34-8-20210112","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1124\/mol.110.070201","article-title":"Proinflammatory stimuli control N-acylphosphatidylethanolamine-specific phospholipase D expression in macrophages.","volume":"79","author":"Zhu","year":"2011","journal-title":"Mol Pharmacol"}],"container-title":["Pain"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/10.1016\/j.pain.2012.10.018","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,16]],"date-time":"2021-06-16T04:44:57Z","timestamp":1623818697000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/00006396-201303000-00008"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,3]]},"references-count":33,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2013]]}},"URL":"https:\/\/doi.org\/10.1016\/j.pain.2012.10.018","relation":{},"ISSN":["0304-3959"],"issn-type":[{"value":"0304-3959","type":"print"}],"subject":[],"published":{"date-parts":[[2013,3]]}}}