{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T23:03:00Z","timestamp":1791327780637,"version":"4.3.1"},"reference-count":49,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,2]]},"DOI":"10.1016\/j.pain.2012.10.023","type":"journal-article","created":{"date-parts":[[2012,11,5]],"date-time":"2012-11-05T18:07:44Z","timestamp":1352138864000},"page":"283-293","source":"Crossref","is-referenced-by-count":119,"title":["State-dependent properties of a new T-type calcium channel blocker enhance CaV3.2 selectivity and support analgesic effects"],"prefix":"10.1097","volume":"154","author":[{"given":"Amaury","family":"Francois","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Kerckhove","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathieu","family":"Meleine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdelkrim","family":"Alloui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Barrere","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agathe","family":"Gelot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor N.","family":"Uebele","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John J.","family":"Renger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alain","family":"Eschalier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denis","family":"Ardid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel","family":"Bourinet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-18-20210112","doi-asserted-by":"crossref","first-page":"8589","DOI":"10.1523\/JNEUROSCI.19-19-08589.1999","article-title":"Membrane potential oscillations in dorsal root ganglion neurons: role in normal electrogenesis and neuropathic pain.","volume":"19","author":"Amir","year":"1999","journal-title":"J Neurosci"},{"key":"R2-18-20210112","doi-asserted-by":"crossref","first-page":"13106","DOI":"10.1523\/JNEUROSCI.2919-09.2009","article-title":"T-type calcium channel inhibition underlies the analgesic effects of the endogenous lipoamino acids.","volume":"29","author":"Barbara","year":"2009","journal-title":"J Neurosci"},{"key":"R3-18-20210112","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1038\/nn1180","article-title":"Agonist-independent modulation of N-type calcium channels by ORL1 receptors.","volume":"7","author":"Beedle","year":"2004","journal-title":"Nat Neurosci"},{"key":"R4-18-20210112","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1016\/S0026-895X(25)10504-X","article-title":"Voltage-dependent blockade of diverse types of voltage-gated Ca2 channels expressed in Xenopus oocytes by the Ca2 channel antagonist mibefradil (Ro 40-5967).","volume":"48","author":"Bezprozvanny","year":"1995","journal-title":"Mol Pharmacol"},{"key":"R5-18-20210112","doi-asserted-by":"crossref","first-page":"1996","DOI":"10.1053\/j.gastro.2005.03.082","article-title":"Rectal instillation of butyrate provides a novel clinically relevant model of noninflammatory colonic hypersensitivity in rats.","volume":"128","author":"Bourdu","year":"2005","journal-title":"Gastroenterology"},{"key":"R6-18-20210112","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1038\/sj.emboj.7600515","article-title":"Silencing of the CaV3.2 T-type calcium channel gene in sensory neurons demonstrates its major role in nociception.","volume":"24","author":"Bourinet","year":"2005","journal-title":"Embo J"},{"key":"R7-18-20210112","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1113\/jphysiol.2001.013269","article-title":"Specific contribution of human T-type calcium channel isotypes (alpha(1G), alpha(1H) and alpha(1I)) to neuronal excitability.","volume":"540","author":"Chemin","year":"2002","journal-title":"J Physiol"},{"key":"R8-18-20210112","doi-asserted-by":"crossref","first-page":"7033","DOI":"10.1093\/emboj\/20.24.7033","article-title":"Direct inhibition of T-type calcium channels by the endogenous cannabinoid anandamide.","volume":"20","author":"Chemin","year":"2001","journal-title":"Embo J"},{"key":"R9-18-20210112","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.1126\/science.1089268","article-title":"Abnormal coronary function in mice deficient in alpha1H T-type Ca2 channels.","volume":"302","author":"Chen","year":"2003","journal-title":"Science"},{"key":"R10-18-20210112","doi-asserted-by":"crossref","first-page":"10360","DOI":"10.1523\/JNEUROSCI.1041-10.2010","article-title":"Ca(v)3.2 T-type Ca2 channel-dependent activation of ERK in paraventricular thalamus modulates acid-induced chronic muscle pain.","volume":"30","author":"Chen","year":"2010","journal-title":"J Neurosci"},{"key":"R11-18-20210112","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1124\/mol.111.073205","article-title":"TTA-P2 is a potent and selective blocker of T-type calcium channels in rat sensory neurons and a novel antinociceptive agent.","volume":"80","author":"Choe","year":"2011","journal-title":"Mol Pharmacol"},{"key":"R12-18-20210112","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1111\/j.1601-183X.2006.00268.x","article-title":"Attenuated pain responses in mice lacking Ca(v)3.2 T-type channels.","volume":"6","author":"Choi","year":"2007","journal-title":"Genes Brain Behav"},{"key":"R13-18-20210112","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/emmm.201100134","article-title":"Oxaliplatin-induced cold hypersensitivity is due to remodelling of ion channel expression in nociceptors.","volume":"3","author":"Descoeur","year":"2011","journal-title":"EMBO Mol Med"},{"key":"R14-18-20210112","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1523\/JNEUROSCI.4305-09.2010","article-title":"Selective T-type calcium channel block in thalamic neurons reveals channel redundancy and physiological impact of I(T)window.","volume":"30","author":"Dreyfus","year":"2009","journal-title":"J Neurosci"},{"key":"R15-18-20210112","doi-asserted-by":"crossref","first-page":"8480","DOI":"10.1523\/JNEUROSCI.1598-04.2004","article-title":"Role of T-type calcium current in identified D-hair mechanoreceptor neurons studied in vitro.","volume":"24","author":"Dubreuil","year":"2004","journal-title":"J Neurosci"},{"key":"R16-18-20210112","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.ddmec.2006.10.001","article-title":"Contributions of T-type Ca channels to the pathophysiology of pain signaling.","volume":"3","author":"Hildebrand","year":"2006","journal-title":"Drug Discov Today Dis Mech"},{"key":"R17-18-20210112","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1146\/annurev.pa.24.040184.002131","article-title":"Antiarrhythmic agents: the modulated receptor mechanism of action of sodium and calcium channel-blocking drugs.","volume":"24","author":"Hondeghem","year":"1984","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"R18-18-20210112","doi-asserted-by":"crossref","first-page":"9374","DOI":"10.1523\/JNEUROSCI.0068-12.2012","article-title":"Presynaptic CaV3.2 channels regulate excitatory neurotransmission in nociceptive dorsal horn neurons.","volume":"32","author":"Jacus","year":"2012","journal-title":"J Neurosci"},{"key":"R19-18-20210112","doi-asserted-by":"crossref","first-page":"3151","DOI":"10.1152\/jn.01031.2007","article-title":"Upregulation of the T-type calcium current in small rat sensory neurons after chronic constrictive injury of the sciatic nerve.","volume":"99","author":"Jagodic","year":"2008","journal-title":"J Neurophysiol"},{"key":"R20-18-20210112","doi-asserted-by":"crossref","first-page":"3305","DOI":"10.1523\/JNEUROSCI.4866-06.2007","article-title":"Cell-specific alterations of T-type calcium current in painful diabetic neuropathy enhance excitability of sensory neurons.","volume":"27","author":"Jagodic","year":"2007","journal-title":"J Neurosci"},{"key":"R21-18-20210112","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0028-3908(99)00153-7","article-title":"Determinants of voltage-dependent inactivation affect Mibefradil block of calcium channels.","volume":"39","author":"Jimenez","year":"2000","journal-title":"Neuropharmacology"},{"key":"R22-18-20210112","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1126\/science.1088886","article-title":"Thalamic control of visceral nociception mediated by T-type Ca2 channels.","volume":"302","author":"Kim","year":"2003","journal-title":"Science"},{"key":"R23-18-20210112","doi-asserted-by":"crossref","first-page":"4171","DOI":"10.1046\/j.1460-9568.1999.00849.x","article-title":"Comparison of the Ca2 currents induced by expression of three cloned alpha1 subunits, alpha1G, alpha1H and alpha1I, of low-voltage-activated T-type Ca2 channels.","volume":"11","author":"Klockner","year":"1999","journal-title":"Eur J Neurosci"},{"key":"R24-18-20210112","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1124\/jpet.110.171058","article-title":"In vitro characterization of T-type calcium channel antagonist TTA-A2 and in vivo effects on arousal in mice.","volume":"335","author":"Kraus","year":"2010","journal-title":"J Pharmacol Exp Ther"},{"key":"R25-18-20210112","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/1744-8069-7-43","article-title":"Involvement of the CaV3.2 T-type calcium channel in thalamic neuron discharge patterns.","volume":"7","author":"Liao","year":"2011","journal-title":"Mol Pain"},{"key":"R26-18-20210112","doi-asserted-by":"crossref","first-page":"11268","DOI":"10.1073\/pnas.1100869108","article-title":"T-type calcium channels contribute to colonic hypersensitivity in a rat model of irritable bowel syndrome.","volume":"108","author":"Marger","year":"2011","journal-title":"Proc Natl Acad Sci USA"},{"key":"R27-18-20210112","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/S0022-3565(24)38902-5","article-title":"Mibefradil block of cloned T-type calcium channels.","volume":"295","author":"Martin","year":"2000","journal-title":"J Pharmacol Exp Ther"},{"key":"R28-18-20210112","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1136\/gut.2007.144543","article-title":"Luminal hydrogen sulfide plays a pro-nociceptive role in mouse colon.","volume":"58","author":"Matsunami","year":"2009","journal-title":"Gut"},{"key":"R29-18-20210112","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1124\/mol.54.6.1080","article-title":"Mibefradil inhibition of T-type calcium channels in cerebellar purkinje neurons.","volume":"54","author":"McDonough","year":"1998","journal-title":"Mol Pharmacol"},{"key":"R30-18-20210112","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.pain.2009.06.012","article-title":"In vivo silencing of the Ca(v)3.2 T-type calcium channels in sensory neurons alleviates hyperalgesia in rats with streptozocin-induced diabetic neuropathy.","volume":"145","author":"Messinger","year":"2009","journal-title":"PAIN"},{"key":"R31-18-20210112","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/S1016-8478(23)17576-5","article-title":"Attenuated neuropathic pain in Ca(v)3.1 null mice.","volume":"25","author":"Na","year":"2008","journal-title":"Mol Cells"},{"key":"R32-18-20210112","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/0304-3959(77)90135-X","article-title":"Noxious thermal input from the rat tail: modulation by descending inhibitory influences.","volume":"4","author":"Necker","year":"1978","journal-title":"PAIN"},{"key":"R33-18-20210112","doi-asserted-by":"crossref","first-page":"8766","DOI":"10.1523\/JNEUROSCI.2527-05.2005","article-title":"The endogenous redox agent l-cysteine induces T-type Ca2 channel-dependent sensitization of a novel subpopulation of rat peripheral nociceptors.","volume":"25","author":"Nelson","year":"2005","journal-title":"J Neurosci"},{"key":"R34-18-20210112","doi-asserted-by":"crossref","first-page":"8250","DOI":"10.1523\/JNEUROSCI.1800-07.2007","article-title":"Reducing agents sensitize C-type nociceptors by relieving high-affinity zinc inhibition of T-type calcium channels.","volume":"27","author":"Nelson","year":"2007","journal-title":"J Neurosci"},{"key":"R35-18-20210112","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.neuroscience.2011.05.004","article-title":"Inhibition of T-type calcium channels and hydrogen sulfide-forming enzyme reverses paclitaxel-evoked neuropathic hyperalgesia in rats.","volume":"188","author":"Okubo","year":"2011","journal-title":"Neuroscience"},{"key":"R36-18-20210112","doi-asserted-by":"crossref","first-page":"14857","DOI":"10.1073\/pnas.1009532107","article-title":"T-type channels control the opioidergic descending analgesia at the low threshold-spiking GABAergic neurons in the periaqueductal gray.","volume":"107","author":"Park","year":"2010","journal-title":"Proc Natl Acad Sci USA"},{"key":"R37-18-20210112","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1152\/physrev.00018.2002","article-title":"Molecular physiology of low-voltage-activated T-type calcium channels.","volume":"83","author":"Perez-Reyes","year":"2003","journal-title":"Physiol Rev"},{"key":"R38-18-20210112","doi-asserted-by":"crossref","first-page":"16124","DOI":"10.1074\/jbc.M707104200","article-title":"Inhibition of recombinant human T-type calcium channels by Delta9-tetrahydrocannabinol and cannabidiol.","volume":"283","author":"Ross","year":"2008","journal-title":"J Biol Chem"},{"key":"R39-18-20210112","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.coph.2007.12.003","article-title":"T-type Ca2 channels as therapeutic targets in the nervous system.","volume":"8","author":"Shin","year":"2008","journal-title":"Curr Opin Pharmacol"},{"key":"R40-18-20210112","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1038\/nn1076","article-title":"A T-type calcium channel required for normal function of a mammalian mechanoreceptor.","volume":"6","author":"Shin","year":"2003","journal-title":"Nat Neurosci"},{"key":"R41-18-20210112","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.pain.2010.04.022","article-title":"Upregulation of Ca(v)3.2 T-type calcium channels targeted by endogenous hydrogen sulfide contributes to maintenance of neuropathic pain.","volume":"150","author":"Takahashi","year":"2010","journal-title":"PAIN"},{"key":"R42-18-20210112","doi-asserted-by":"crossref","first-page":"1895","DOI":"10.1523\/JNEUROSCI.19-06-01895.1999","article-title":"Differential distribution of three members of a gene family encoding low voltage-activated (T-type) calcium channels.","volume":"19","author":"Talley","year":"1999","journal-title":"J Neurosci"},{"key":"R43-18-20210112","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S0896-6273(01)00338-5","article-title":"Redox modulation of T-type calcium channels in rat peripheral nociceptors.","volume":"31","author":"Todorovic","year":"2001","journal-title":"Neuron"},{"key":"R44-18-20210112","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.pain.2004.01.026","article-title":"Redox modulation of peripheral T-type Ca2 channels in vivo: alteration of nerve injury-induced thermal hyperalgesia.","volume":"109","author":"Todorovic","year":"2004","journal-title":"PAIN"},{"key":"R45-18-20210112","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.1172\/JCI36954","article-title":"Antagonism of T-type calcium channels inhibits high-fat diet - induced weight gain in mice.","volume":"119","author":"Uebele","year":"2009","journal-title":"J Clin Invest"},{"key":"R46-18-20210112","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1007\/s12013-009-9057-4","article-title":"Positive allosteric interaction of structurally diverse T-type calcium channel antagonists.","volume":"55","author":"Uebele","year":"2009","journal-title":"Cell Biochem Biophys"},{"key":"R47-18-20210112","doi-asserted-by":"crossref","first-page":"2229","DOI":"10.1113\/jphysiol.2010.203463","article-title":"The CaV3.2 T-type calcium channel regulates temporal coding in mouse mechanoreceptors.","volume":"589","author":"Wang","year":"2011","journal-title":"J Physiol"},{"key":"R48-18-20210112","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.brainresrev.2008.12.021","article-title":"Role of voltage-gated calcium channels in ascending pain pathways.","volume":"60","author":"Zamponi","year":"2009","journal-title":"Brain Res Rev"},{"key":"R49-18-20210112","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/0304-3959(83)90201-4","article-title":"Ethical guidelines for investigations of experimental pain in conscious animals.","volume":"16","author":"Zimmermann","year":"1983","journal-title":"PAIN"}],"container-title":["Pain"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/10.1016\/j.pain.2012.10.023","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,20]],"date-time":"2025-04-20T04:28:54Z","timestamp":1745123334000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/00006396-201302000-00018"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,2]]},"references-count":49,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013]]}},"URL":"https:\/\/doi.org\/10.1016\/j.pain.2012.10.023","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.717974159.793474072","asserted-by":"object"}]},"ISSN":["0304-3959"],"issn-type":[{"value":"0304-3959","type":"print"}],"subject":[],"published":{"date-parts":[[2013,2]]}}}