{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T04:45:57Z","timestamp":1784868357798,"version":"3.55.0"},"reference-count":53,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["painjournalonline.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2014,1]]},"DOI":"10.1016\/j.pain.2013.09.016","type":"journal-article","created":{"date-parts":[[2013,9,21]],"date-time":"2013-09-21T01:32:03Z","timestamp":1379727123000},"page":"108-117","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"title":["A pilot trial of intravenous pamidronate for chronic low back pain"],"prefix":"10.1097","volume":"155","author":[{"given":"Marco","family":"Pappagallo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brenda","family":"Breuer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hung-Mo","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James B.","family":"Moberly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Tai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Noto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Sanchez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo L.","family":"Manfredi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-17-20210126","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1093\/rheumatology\/39.5.567","article-title":"Use of pamidronate for acute pain relief following osteoporotic vertebral fractures.","volume":"39","author":"Abdulla","year":"2000","journal-title":"Rheumatology"},{"key":"R2-17-20210126","doi-asserted-by":"crossref","first-page":"2684","DOI":"10.1002\/art.24783","article-title":"Decreased physical function and increased pain sensitivity in mice deficient for type IX collagen.","volume":"60","author":"Allen","year":"2009","journal-title":"Arthritis Rheum"},{"key":"R3-17-20210126","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/S0140-6736(99)01312-4","article-title":"Epidemiological features of chronic low-back pain.","volume":"354","author":"Andersson","year":"1999","journal-title":"Lancet"},{"key":"R4-17-20210126","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.1007\/s00198-006-0169-z","article-title":"Intravenous pamidronate for pain relief in recent osteoporotic vertebral compression fracture: a randomized double-blind controlled study.","volume":"17","author":"Armingeat","year":"2006","journal-title":"Osteoporos Int"},{"key":"R5-17-20210126","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1056\/NEJM199602223340802","article-title":"Efficacy of pamidronate in reducing skeletal events in patients with advanced multiple myeloma.","volume":"334","author":"Berenson","year":"1996","journal-title":"N Engl J Med"},{"key":"R6-17-20210126","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.ejpain.2007.06.005","article-title":"Effects of the bisphosphonate ibandronate on hyperalgesia, substance P, and cytokine levels in a rat model of persistent inflammatory pain.","volume":"12","author":"Bianchi","year":"2008","journal-title":"Eur J Pain"},{"key":"R7-17-20210126","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/S0304-3959(00)00447-4","article-title":"Analgesic effect of bisphosphonates in mice.","volume":"91","author":"Bonabello","year":"2001","journal-title":"PAIN"},{"key":"R8-17-20210126","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/S8756-3282(03)00229-1","article-title":"Long-term analgesic effect of clodronate in rodents.","volume":"33","author":"Bonabello","year":"2003","journal-title":"Bone"},{"key":"R9-17-20210126","first-page":"1571","article-title":"Prevalence of disabilities and associated health conditions among adultsUnited States, 1999.","volume":"285","year":"2001","journal-title":"JAMA"},{"key":"R10-17-20210126","doi-asserted-by":"crossref","first-page":"1746","DOI":"10.1359\/jbmr.1997.12.10.1746","article-title":"Long-term effects of intravenous pamidronate in fibrous dysplasia of bone.","volume":"12","author":"Chapurlat","year":"1997","journal-title":"J Bone Miner Res"},{"key":"R11-17-20210126","doi-asserted-by":"crossref","first-page":"478","DOI":"10.7326\/0003-4819-147-7-200710020-00006","article-title":"Clinical Efficacy Assessment Subcommittee of the American College of Physicians, American College of Physicians, American Pain Society Low Back Pain Guidelines Panel. Diagnosis and treatment of low back pain: a joint clinical practice guideline from the American College of Physicians and the American Pain Society.","volume":"147","author":"Chou","year":"2007","journal-title":"Ann Intern Med"},{"key":"R12-17-20210126","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/BF02238763","article-title":"Treatment of severe, recalcitrant reflex sympathetic dystrophy: assessment of efficacy and safety of the second generation bisphosphonate pamidronate.","volume":"16","author":"Cortet","year":"1997","journal-title":"Clin Rheumatol"},{"key":"R13-17-20210126","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1148\/radiol.10091467","article-title":"Subchondral cystlike lesions develop longitudinally in areas of bone marrow edema-like lesions in patients with or at risk for knee osteoarthritis: detection with MR imaging - the MOST study.","volume":"256","author":"Crema","year":"2010","journal-title":"Radiology"},{"key":"R14-17-20210126","doi-asserted-by":"crossref","first-page":"2940","DOI":"10.1097\/00007632-200011150-00017","article-title":"The Oswestry disability index.","volume":"25","author":"Fairbank","year":"2000","journal-title":"Spine"},{"key":"R15-17-20210126","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/S0304-3959(00)00339-0","article-title":"Defining the clinically important difference in pain outcome measures.","volume":"88","author":"Farrar","year":"2000","journal-title":"PAIN"},{"key":"R16-17-20210126","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.jpain.2009.06.007","article-title":"The clinical importance of changes in the 0 to 10 numeric rating scale for worst, least, and average pain intensity: analyses of data from clinical trials of duloxetine in pain disorders.","volume":"11","author":"Farrar","year":"2010","journal-title":"J Pain"},{"key":"R17-17-20210126","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.jpainsymman.2005.08.018","article-title":"Use of the cumulative proportion of responders analysis graph to present pain data over a range of cut-off points: making clinical trial data more understandable.","volume":"31","author":"Farrar","year":"2006","journal-title":"J Pain Symptom Manage"},{"key":"R18-17-20210126","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1007\/s10067-009-1112-4","article-title":"An open study of pamidronate in the treatment of refractory degenerative lumbar spinal stenosis.","volume":"28","author":"Feld","year":"2009","journal-title":"Clin Rheumatol"},{"key":"R19-17-20210126","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1001\/archinternmed.2008.543","article-title":"The rising prevalence of chronic low back pain.","volume":"169","author":"Freburger","year":"2009","journal-title":"Arch Intern Med"},{"key":"R20-17-20210126","doi-asserted-by":"crossref","first-page":"2201","DOI":"10.1002\/1529-0131(200109)44:9<2201::AID-ART374>3.0.CO;2-E","article-title":"The molecular mechanism of action of the antiresorptive and anti-inflammatory drug clodronate: evidence for the formation in vivo of a metabolite that inhibits bone resorption and causes osteoclast and macrophage apoptosis.","volume":"44","author":"Frith","year":"2001","journal-title":"Arthritis Rheum"},{"key":"R21-17-20210126","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1007\/s100670050099","article-title":"Analgesic effect of intravenous pamidronate on chronic back pain due to osteoporotic vertebral fractures.","volume":"18","author":"Gangji","year":"1999","journal-title":"Clin Rheumatol"},{"key":"R22-17-20210126","first-page":"707","article-title":"Childhood chronic recurrent multifocal osteomyelitis: pamidronate therapy decreases pain and improves vertebral shape.","volume":"35","author":"Gleeson","year":"2008","journal-title":"J Rheumatol"},{"key":"R23-17-20210126","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0378-5173(01)00654-8","article-title":"Mode of administration-dependent pharmacokinetics of bisphosphonates and bioavailability determination.","volume":"220","author":"Hoffman","year":"2001","journal-title":"Int J Pharm"},{"key":"R24-17-20210126","doi-asserted-by":"crossref","first-page":"1785","DOI":"10.1056\/NEJM199612123352401","article-title":"Efficacy of pamidronate in reducing skeletal complications in patients with breast cancer and lytic bone metastases. Protocol 19 Aredia Breast Cancer Study Group.","volume":"335","author":"Hortobagyi","year":"1996","journal-title":"N Engl J Med"},{"key":"R25-17-20210126","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.neuropharm.2006.03.015","article-title":"Antiallodynic effect of etidronate, a bisphosphonate, in rats with adjuvant-induced arthritis: involvement of ATP-sensitive K channels.","volume":"51","author":"Kawabata","year":"2006","journal-title":"Neuropharmacology"},{"key":"R26-17-20210126","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1007\/s10067-005-0159-0","article-title":"Comparison of the analgesic efficacy of pamidronate and synthetic human calcitonin in osteoporotic vertebral fractures: a double-blind controlled study.","volume":"25","author":"Laroche","year":"2006","journal-title":"Clin Rheumatol"},{"key":"R27-17-20210126","doi-asserted-by":"crossref","first-page":"107","DOI":"10.2165\/00044011-200525020-00003","article-title":"Pharmacokinetic considerations in determining the terminal elimination half-lives of bisphosphonates.","volume":"25","author":"Lasseter","year":"2005","journal-title":"Clin Drug Investig"},{"key":"R28-17-20210126","first-page":"440","article-title":"Neuropeptidergic regulation of bone resorption and bone formation.","volume":"2","author":"Lerner","year":"2002","journal-title":"J Musculoskelet Neuronal Interact"},{"key":"R29-17-20210126","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/8756-3282(95)00445-9","article-title":"Bisphosphonates: a review of their pharmacokinetic properties.","volume":"18","author":"Lin","year":"1996","journal-title":"Bone"},{"key":"R30-17-20210126","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1002\/(SICI)1097-0142(20000301)88:5<1082::AID-CNCR20>3.0.CO;2-Z","article-title":"Pamidronate prevents skeletal complications and is effective palliative treatment in women with breast carcinoma and osteolytic bone metastases: long term follow-up of two randomized, placebo-controlled trials.","volume":"88","author":"Lipton","year":"2000","journal-title":"Cancer"},{"key":"R31-17-20210126","doi-asserted-by":"crossref","first-page":"211","DOI":"10.3109\/03009749409103063","article-title":"Double blind radiological assessment of continuous oral pamidronic acid in patients with rheumatoid arthritis.","volume":"23","author":"Maccagno","year":"1994","journal-title":"Scand J Rheumatol"},{"key":"R32-17-20210126","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/S0306-4522(02)00165-3","article-title":"Origins of skeletal pain: sensory and sympathetic innervation of the mouse femur.","volume":"113","author":"Mach","year":"2002","journal-title":"Neuroscience"},{"key":"R33-17-20210126","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1002\/art.10139","article-title":"A six-month randomized, controlled, double-blind, dose-response comparison of intravenous pamidronate (60 mg versus 10 mg) in the treatment of nonsteroidal anti-inflammatory drug-refractory ankylosing spondylitis.","volume":"46","author":"Maksymowych","year":"2002","journal-title":"Arthritis Rheum"},{"key":"R34-17-20210126","doi-asserted-by":"crossref","first-page":"E35","DOI":"10.36076\/ppj.2009\/12\/E35","article-title":"Comprehensive review of epidemiology, scope, and impact of spinal pain.","volume":"12","author":"Manchikanti","year":"2009","journal-title":"Pain Physician"},{"key":"R35-17-20210126","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/1546-0096-7-2","article-title":"Dramatic pain relief and resolution of bone inflammation following pamidronate in 9 pediatric patients with persistent chronic recurrent multifocal osteomyelitis (CRMO).","volume":"7","author":"Miettunen","year":"2009","journal-title":"Pediatr Rheumatol Online J"},{"key":"R36-17-20210126","doi-asserted-by":"crossref","first-page":"3703","DOI":"10.1002\/art.25014","article-title":"Denuded subchondral bone and knee pain in persons with knee osteoarthritis.","volume":"60","author":"Moisio","year":"2009","journal-title":"Arthritis Rheum"},{"key":"R37-17-20210126","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1016\/j.bone.2006.04.033","article-title":"Osteoclasts play a part in pain due to the inflammation adjacent to bone.","volume":"39","author":"Nagae","year":"2006","journal-title":"Bone"},{"key":"R39-17-20210126","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1177\/1078155207080806","article-title":"Significance and impact of bisphosphonate-induced acute phase responses.","volume":"13","author":"Olson","year":"2007","journal-title":"J Oncol Pharm Pract"},{"key":"R40-17-20210126","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1016\/S0885-3924(03)00201-X","article-title":"Treatment of chronic mechanical spinal pain with intravenous pamidronate: a review of medical records.","volume":"26","author":"Pappagallo","year":"2003","journal-title":"J Pain Symptom Manage"},{"key":"R41-17-20210126","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/j.jbspin.2007.04.007","article-title":"Efficacy of pamidronate in erosive degenerative disk disease: a pilot study.","volume":"74","author":"Poujol","year":"2007","journal-title":"Joint Bone Spine"},{"key":"R42-17-20210126","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/S0079-6123(08)61085-7","article-title":"Tissue acidosis in nociception and pain.","volume":"113","author":"Reeh","year":"1996","journal-title":"Prog Brain Res"},{"key":"R43-17-20210126","doi-asserted-by":"crossref","first-page":"4380","DOI":"10.1210\/jc.2010-0597","article-title":"Characterization of and risk factors for the acute-phase response after zoledronic acid.","volume":"95","author":"Reid","year":"2010","journal-title":"J Clin Endocrinol Metab"},{"key":"R44-17-20210126","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1111\/j.1526-4637.2004.04038.x","article-title":"Efficacy of pamidronate in complex regional pain syndrome type I.","volume":"5","author":"Robinson","year":"2004","journal-title":"Pain Med"},{"key":"R45-17-20210126","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/S8756-3282(02)00672-5","article-title":"Osteoclastic acidification pathways during bone resorption.","volume":"30","author":"Rousselle","year":"2002","journal-title":"Bone"},{"key":"R46-17-20210126","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1016\/S0026-895X(25)09541-0","article-title":"Characteristics of clodronate-induced apoptosis in osteoclasts and macrophages.","volume":"50","author":"Selander","year":"1996","journal-title":"Mol Pharmacol"},{"key":"R47-17-20210126","doi-asserted-by":"crossref","first-page":"2337","DOI":"10.1007\/s00198-010-1448-2","article-title":"Effect of acetaminophen and fluvastatin on post-dose symptoms following infusion of zoledronic acid.","volume":"22","author":"Silverman","year":"2011","journal-title":"Osteoporos Int"},{"key":"R48-17-20210126","doi-asserted-by":"crossref","first-page":"2412","DOI":"10.1097\/00007632-199811150-00011","article-title":"Psychometric characteristics and clinical usefulness of physical performance tests in patients with low back pain.","volume":"23","author":"Simmonds","year":"1998","journal-title":"Spine"},{"key":"R49-17-20210126","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1007\/s10067-009-1256-2","article-title":"Pamidronate treatment in rheumatology practice: a comprehensive review.","volume":"28","author":"Slobodin","year":"2009","journal-title":"Clin Rheumatol"},{"key":"R50-17-20210126","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1016\/j.joca.2010.06.007","article-title":"Inhibition of osteoclasts prevents cartilage loss and pain in a rat model of degenerative joint disease.","volume":"18","author":"Strassle","year":"2010","journal-title":"Osteoarthritis Cartilage"},{"key":"R51-17-20210126","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1007\/s10067-003-0762-x","article-title":"Patterns of pain in Pagets disease of bone and their outcomes on treatment with pamidronate.","volume":"22","author":"Vasireddy","year":"2003","journal-title":"Clin Rheumatol"},{"key":"R52-17-20210126","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/S0304-3959(02)00040-4","article-title":"Disease modifying and anti-nociceptive effects of the bisphosphonate, zoledronic acid in a model of bone cancer pain.","volume":"100","author":"Walker","year":"2002","journal-title":"PAIN"},{"key":"R53-17-20210126","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1100\/tsw.2008.33","article-title":"Complex regional pain syndrome (CRPSRSD) and neuropathic pain: role of intravenous bisphosphonates as analgesics.","volume":"8","author":"Yanow","year":"2008","journal-title":"ScientificWorldJournal"},{"key":"R54-17-20210126","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.bone.2010.07.009","article-title":"Involvement of acidic microenvironment in the pathophysiology of cancer-associated bone pain.","volume":"48","author":"Yoneda","year":"2011","journal-title":"Bone"}],"container-title":["Pain"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/10.1016\/j.pain.2013.09.016","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,30]],"date-time":"2025-04-30T10:48:28Z","timestamp":1746010108000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/00006396-201401000-00017"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,1]]},"references-count":53,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014]]}},"URL":"https:\/\/doi.org\/10.1016\/j.pain.2013.09.016","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.718118536.793486314","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.718118536.793486201","asserted-by":"object"}]},"ISSN":["0304-3959"],"issn-type":[{"value":"0304-3959","type":"print"}],"subject":[],"published":{"date-parts":[[2014,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A pilot trial of intravenous pamidronate for chronic low back pain","name":"articletitle","label":"Article Title"},{"value":"PAIN\u00ae","name":"journaltitle","label":"Journal Title"},{"value":"http:\/\/dx.doi.org\/10.1016\/j.pain.2013.09.016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 International Association for the Study of Pain. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}