{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T15:43:31Z","timestamp":1791215011439,"version":"4.1.0"},"reference-count":75,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["painjournalonline.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2014,2]]},"DOI":"10.1016\/j.pain.2013.10.024","type":"journal-article","created":{"date-parts":[[2013,10,28]],"date-time":"2013-10-28T17:45:21Z","timestamp":1382982321000},"page":"356-366","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"title":["Analgesic treatment with pregabalin does not prevent persistent pain after peripheral nerve injury in the rat"],"prefix":"10.1097","volume":"155","author":[{"given":"Fang","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Whang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William T.","family":"Derry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Vardeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joachim","family":"Scholz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-19-20210126","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.pain.2010.03.025","article-title":"Heterogeneous sensory processing in persistent postherniotomy pain.","volume":"150","author":"Aasvang","year":"2010","journal-title":"PAIN"},{"key":"R2-19-20210126","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1097\/ALN.0b013e31821f6545","article-title":"Pregabalin suppresses spinal neuronal hyperexcitability and visceral hypersensitivity in the absence of peripheral pathophysiology.","volume":"115","author":"Bannister","year":"2011","journal-title":"Anesthesiology"},{"key":"R3-19-20210126","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1016\/S1474-4422(10)70143-5","article-title":"Neuropathic pain: diagnosis, pathophysiological mechanisms, and treatment.","volume":"9","author":"Baron","year":"2010","journal-title":"Lancet Neurol"},{"key":"R4-19-20210126","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1213\/ANE.0b013e318277a270","article-title":"Preventive analgesia by local anesthetics: the reduction of postoperative pain by peripheral nerve blocks and intravenous drugs.","volume":"116","author":"Barreveld","year":"2013","journal-title":"Anesth Analg"},{"key":"R5-19-20210126","doi-asserted-by":"crossref","first-page":"4076","DOI":"10.1523\/JNEUROSCI.0356-09.2009","article-title":"The increased trafficking of the calcium channel subunit 2-1 to presynaptic terminals in neuropathic pain is inhibited by the 2 ligand pregabalin.","volume":"29","author":"Bauer","year":"2009","journal-title":"J Neurosci"},{"key":"R6-19-20210126","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.pain.2008.08.008","article-title":"Descending facilitation from the brainstem determines behavioural and neuronal hypersensitivity following nerve injury and efficacy of pregabalin.","volume":"140","author":"Bee","year":"2008","journal-title":"PAIN"},{"key":"R7-19-20210126","doi-asserted-by":"crossref","first-page":"661","DOI":"10.2165\/11536200-000000000-00000","article-title":"A comparison of the pharmacokinetics and pharmacodynamics of pregabalin and gabapentin.","volume":"49","author":"Bockbrader","year":"2010","journal-title":"Clin Pharmacokinet"},{"key":"R8-19-20210126","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.pain.2008.05.004","article-title":"Injury discharges regulate calcium channel -2--1 subunit upregulation in the dorsal horn that contributes to initiation of neuropathic pain.","volume":"139","author":"Boroujerdi","year":"2009","journal-title":"PAIN"},{"key":"R9-19-20210126","doi-asserted-by":"crossref","first-page":"S33","DOI":"10.1016\/j.pain.2010.11.005","article-title":"Pathophysiology of postoperative pain.","volume":"152","author":"Brennan","year":"2011","journal-title":"PAIN"},{"key":"R10-19-20210126","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1038\/nrn2652","article-title":"Tests to assess motor phenotype in mice: a users guide.","volume":"10","author":"Brooks","year":"2009","journal-title":"Nat Rev Neurosci"},{"key":"R11-19-20210126","doi-asserted-by":"crossref","first-page":"5129","DOI":"10.1523\/JNEUROSCI.22-12-05129.2002","article-title":"Time-dependent descending facilitation from the rostral ventromedial medulla maintains, but does not initiate, neuropathic pain.","volume":"22","author":"Burgess","year":"2002","journal-title":"J Neurosci"},{"key":"R12-19-20210126","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/S0304-3959(01)00410-9","article-title":"Attenuation of hyperalgesia in a rat model of neuropathic pain after intrathecal pre- or post-treatment with a neurokinin-1 antagonist.","volume":"95","author":"Cahill","year":"2002","journal-title":"PAIN"},{"key":"R13-19-20210126","doi-asserted-by":"crossref","first-page":"11230","DOI":"10.1073\/pnas.0504183102","article-title":"The metal-ion-dependent adhesion site in the Von Willebrand factor-A domain of 2 subunits is key to trafficking voltage-gated Ca2 channels.","volume":"102","author":"Canti","year":"2005","journal-title":"Proc Natl Acad Sci USA"},{"key":"R14-19-20210126","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1097\/00000542-199510000-00017","article-title":"Prolonged alleviation of tactile allodynia by intravenous lidocaine in neuropathic rats.","volume":"83","author":"Chaplan","year":"1995","journal-title":"Anesthesiology"},{"key":"R15-19-20210126","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1093\/bja\/aer063","article-title":"Chronic intrathecal infusion of gabapentin prevents nerve ligation-induced pain in rats.","volume":"106","author":"Chu","year":"2011","journal-title":"Br J Anaesth"},{"key":"R16-19-20210126","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1213\/ANE.0b013e318249d36e","article-title":"The prevention of chronic postsurgical pain using gabapentin and pregabalin: a combined systematic review and meta-analysis.","volume":"115","author":"Clarke","year":"2012","journal-title":"Anesth Analg"},{"key":"R17-19-20210126","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1038\/nature04223","article-title":"BDNF from microglia causes the shift in neuronal anion gradient underlying neuropathic pain.","volume":"438","author":"Coull","year":"2005","journal-title":"Nature"},{"key":"R18-19-20210126","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1097\/ACO.0b013e328345afd9","article-title":"Preventive analgesia.","volume":"24","author":"Dahl","year":"2011","journal-title":"Curr Opin Anaesthesiol"},{"key":"R19-19-20210126","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S0304-3959(00)00276-1","article-title":"Spared nerve injury: an animal model of persistent peripheral neuropathic pain.","volume":"87","author":"Decosterd","year":"2000","journal-title":"PAIN"},{"key":"R20-19-20210126","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1038\/nrn3311","article-title":"Calcium channel auxiliary 2 and subunits: trafficking and one step beyond.","volume":"13","author":"Dolphin","year":"2012","journal-title":"Nat Rev Neurosci"},{"key":"R21-19-20210126","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.tips.2006.12.006","article-title":"Ca2 channel 2 ligands: novel modulators of neurotransmission.","volume":"28","author":"Dooley","year":"2007","journal-title":"Trends Pharmacol Sci"},{"key":"R22-19-20210126","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.pain.2007.08.033","article-title":"Pharmacologic management of neuropathic pain: evidence-based recommendations.","volume":"132","author":"Dworkin","year":"2007","journal-title":"PAIN"},{"key":"R23-19-20210126","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/j.cell.2009.09.025","article-title":"Gabapentin receptor 2-1 is a neuronal thrombospondin receptor responsible for excitatory CNS synaptogenesis.","volume":"139","author":"Eroglu","year":"2009","journal-title":"Cell"},{"key":"R24-19-20210126","doi-asserted-by":"crossref","first-page":"17537","DOI":"10.1073\/pnas.0409066103","article-title":"Identification of the -2--1 subunit of voltage-dependent calcium channels as a molecular target for pain mediating the analgesic actions of pregabalin.","volume":"103","author":"Field","year":"2006","journal-title":"Proc Natl Acad Sci USA"},{"key":"R25-19-20210126","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/j.pain.2010.06.019","article-title":"The evidence for pharmacological treatment of neuropathic pain.","volume":"150","author":"Finnerup","year":"2010","journal-title":"PAIN"},{"key":"R26-19-20210126","doi-asserted-by":"crossref","first-page":"8370","DOI":"10.1523\/JNEUROSCI.23-23-08370.2003","article-title":"Enhanced evoked excitatory transmitter release in experimental neuropathy requires descending facilitation.","volume":"23","author":"Gardell","year":"2003","journal-title":"J Neurosci"},{"key":"R27-19-20210126","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.pain.2012.09.010","article-title":"The neuropathic component in persistent postsurgical pain: a systematic literature review.","volume":"154","author":"Haroutiunian","year":"2013","journal-title":"PAIN"},{"key":"R28-19-20210126","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.pain.2009.03.022","article-title":"Brief, low frequency stimulation of rat peripheral C-fibres evokes prolonged microglial-induced central sensitization in adults but not in neonates.","volume":"144","author":"Hathway","year":"2009","journal-title":"PAIN"},{"key":"R29-19-20210126","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1097\/01.anes.0000267605.40258.98","article-title":"Oral gabapentin activates spinal cholinergic circuits to reduce hypersensitivity after peripheral nerve injury and interacts synergistically with oral donepezil.","volume":"106","author":"Hayashida","year":"2007","journal-title":"Anesthesiology"},{"key":"R30-19-20210126","doi-asserted-by":"crossref","first-page":"3628","DOI":"10.1073\/pnas.0708930105","article-title":"Pharmacological disruption of calcium channel trafficking by the 2 ligand gabapentin.","volume":"105","author":"Hendrich","year":"2008","journal-title":"Proc Natl Acad Sci USA"},{"key":"R31-19-20210126","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1038\/nature11033","article-title":"A2 expression sets presynaptic calcium channel abundance and release probability.","volume":"486","author":"Hoppa","year":"2012","journal-title":"Nature"},{"key":"R32-19-20210126","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1213\/00000539-199802000-00025","article-title":"The effect of intrathecal gabapentin and 3-isobutyl -aminobutyric acid on the hyperalgesia observed after thermal injury in the rat.","volume":"86","author":"Jun","year":"1998","journal-title":"Anesth Analg"},{"key":"R33-19-20210126","doi-asserted-by":"crossref","first-page":"1618","DOI":"10.1016\/S0140-6736(06)68700-X","article-title":"Persistent postsurgical pain: risk factors and prevention.","volume":"367","author":"Kehlet","year":"2006","journal-title":"Lancet"},{"key":"R34-19-20210126","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1111\/j.1533-2500.2011.00480.x","article-title":"Preoperative gabapentin for acute post-thoracotomy analgesia: a randomized, double-blinded, active placebo-controlled study.","volume":"12","author":"Kinney","year":"2012","journal-title":"Pain Pract"},{"key":"R35-19-20210126","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1111\/j.1471-4159.2010.06625.x","article-title":"Evidence that pregabalin reduces neuropathic pain by inhibiting the spinal release of glutamate.","volume":"113","author":"Kumar","year":"2010","journal-title":"J Neurochem"},{"key":"R36-19-20210126","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1016\/j.jpain.2009.06.012","article-title":"Central sensitization: a generator of pain hypersensitivity by central neural plasticity.","volume":"10","author":"Latremoliere","year":"2009","journal-title":"J Pain"},{"key":"R37-19-20210126","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/S0304-3959(03)00221-5","article-title":"Perioperative administration of the 2-adrenoceptor agonist clonidine at the site of nerve injury reduces the development of mechanical hypersensitivity and modulates local cytokine expression.","volume":"105","author":"Lavandhomme","year":"2003","journal-title":"PAIN"},{"key":"R38-19-20210126","doi-asserted-by":"crossref","first-page":"8494","DOI":"10.1523\/JNEUROSCI.2982-04.2004","article-title":"Spinal dorsal horn calcium channel 2-1 subunit upregulation contributes to peripheral nerve injury-induced tactile allodynia.","volume":"24","author":"Li","year":"2004","journal-title":"J Neurosci"},{"key":"R39-19-20210126","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.pain.2006.04.022","article-title":"Calcium channel 21 subunit mediates spinal hyperexcitability in pain modulation.","volume":"125","author":"Li","year":"2006","journal-title":"PAIN"},{"key":"R40-19-20210126","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1002\/(SICI)1098-1136(199807)23:3<221::AID-GLIA5>3.0.CO;2-7","article-title":"Glial cell responses, complement, and clusterin in the central nervous system following dorsal root transection.","volume":"23","author":"Liu","year":"1998","journal-title":"Glia"},{"key":"R41-19-20210126","doi-asserted-by":"crossref","first-page":"1868","DOI":"10.1523\/JNEUROSCI.21-06-01868.2001","article-title":"Upregulation of dorsal root ganglion 2 calcium channel subunit and its correlation with allodynia in spinal nerve-injured rats.","volume":"21","author":"Luo","year":"2001","journal-title":"J Neurosci"},{"key":"R42-19-20210126","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1093\/bja\/aes360","article-title":"High-dose remifentanil prevents development of thermal hyperalgesia in a neuropathic pain model.","volume":"110","author":"Manering","year":"2013","journal-title":"Br J Anaesth"},{"key":"R43-19-20210126","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/1744-8069-8-3","article-title":"Comparison of central versus peripheral delivery of pregabalin in neuropathic pain states.","volume":"8","author":"Martinez","year":"2012","journal-title":"Mol Pain"},{"key":"R44-19-20210126","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/1471-2253-7-6","article-title":"Gabapentin and postoperative pain: a qualitative and quantitative systematic review, with focus on procedure.","volume":"7","author":"Mathiesen","year":"2007","journal-title":"BMC Anesthesiol"},{"key":"R45-19-20210126","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1097\/00000542-200203000-00032","article-title":"A qualitative and quantitative systematic review of preemptive analgesia for postoperative pain relief: the role of timing of analgesia.","volume":"96","author":"Moiniche","year":"2002","journal-title":"Anesthesiology"},{"key":"R46-19-20210126","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/0306-4522(86)90023-0","article-title":"Laminar distribution and somatotopic organization of primary afferent fibers from hindlimb nerves in the dorsal horn. A study by transganglionic transport of horseradish peroxidase in the rat.","volume":"19","author":"Molander","year":"1986","journal-title":"Neuroscience"},{"key":"R47-19-20210126","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1254\/jphs.11102FP","article-title":"Spinal mechanism underlying the antiallodynic effect of gabapentin studied in the mouse spinal nerve ligation model.","volume":"118","author":"Morimoto","year":"2012","journal-title":"J Pharmacol Sci"},{"key":"R48-19-20210126","doi-asserted-by":"crossref","first-page":"2015","DOI":"10.1016\/j.lfs.2007.02.045","article-title":"Role of spinal voltage-dependent calcium channel 2-1 subunit in the expression of a neuropathic pain-like state in mice.","volume":"80","author":"Narita","year":"2007","journal-title":"Life Sci"},{"key":"R49-19-20210126","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0169-328X(01)00188-7","article-title":"Dorsal root ganglion neurons show increased expression of the calcium channel 2-1 subunit following partial sciatic nerve injury.","volume":"95","author":"Newton","year":"2001","journal-title":"Brain Res Mol Brain Res"},{"key":"R50-19-20210126","doi-asserted-by":"crossref","first-page":"3779","DOI":"10.1172\/JCI43766","article-title":"Central modulation of pain.","volume":"120","author":"Ossipov","year":"2010","journal-title":"J Clin Invest"},{"key":"R51-19-20210126","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1016\/S0022-3565(24)38054-1","article-title":"Gabapentin suppresses ectopic nerve discharges and reverses allodynia in neuropathic rats.","volume":"288","author":"Pan","year":"1999","journal-title":"J Pharmacol Exp Ther"},{"key":"R52-19-20210126","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1097\/00002508-200203000-00007","article-title":"Long-term use of gabapentin for treatment of pain after traumatic spinal cord injury.","volume":"18","author":"Putzke","year":"2002","journal-title":"Clin J Pain"},{"key":"R54-19-20210126","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1097\/ALN.0b013e3182a10fbf","article-title":"Intrathecal gabapentin to treat chronic intractable noncancer pain.","volume":"119","author":"Rauck","year":"2013","journal-title":"Anesthesiology"},{"key":"R55-19-20210126","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.pain.2007.11.019","article-title":"Low-dose methotrexate reduces peripheral nerve injury-evoked spinal microglial activation and neuropathic pain behavior in rats.","volume":"138","author":"Scholz","year":"2008","journal-title":"PAIN"},{"key":"R56-19-20210126","doi-asserted-by":"crossref","first-page":"7317","DOI":"10.1523\/JNEUROSCI.1526-05.2005","article-title":"Blocking caspase activity prevents transsynaptic neuronal apoptosis and the loss of inhibition in lamina II of the dorsal horn after peripheral nerve injury.","volume":"25","author":"Scholz","year":"2005","journal-title":"J Neurosci"},{"key":"R57-19-20210126","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1038\/nn1992","article-title":"The neuropathic pain triad: neurons, immune cells and glia.","volume":"10","author":"Scholz","year":"2007","journal-title":"Nat Neurosci"},{"key":"R58-19-20210126","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1097\/ALN.0b013e3181cf4266","article-title":"Preclinical research on persistent postsurgical pain: what we dont know, but should start studying.","volume":"112","author":"Scholz","year":"2010","journal-title":"Anesthesiology"},{"key":"R59-19-20210126","doi-asserted-by":"crossref","first-page":"17555","DOI":"10.1073\/pnas.1214634109","article-title":"Prolonged nerve blockade delays the onset of neuropathic pain.","volume":"109","author":"Shankarappa","year":"2012","journal-title":"Proc Natl Acad Sci USA"},{"key":"R60-19-20210126","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/0304-3959(94)00120-4","article-title":"Pre-injury lidocaine treatment prevents thermal hyperalgesia and cutaneous thermal abnormalities in a rat model of peripheral neuropathy.","volume":"61","author":"Sotgiu","year":"1995","journal-title":"PAIN"},{"key":"R61-19-20210126","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1111\/j.1460-9568.2004.03832.x","article-title":"Presynaptic NMDA autoreceptors facilitate axon excitability: a new molecular target for the anticonvulsant gabapentin.","volume":"21","author":"Suarez","year":"2005","journal-title":"Eur J Neurosci"},{"key":"R62-19-20210126","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1186\/1744-8069-5-53","article-title":"Large A-fiber activity is required for microglial proliferation and p38 MAPK activation in the spinal cord: different effects of resiniferatoxin and bupivacaine on spinal microglial changes after spared nerve injury.","volume":"5","author":"Suter","year":"2009","journal-title":"Mol Pain"},{"key":"R63-19-20210126","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1097\/00000542-200312000-00025","article-title":"Development of neuropathic pain in the rat spared nerve injury model is not prevented by a peripheral nerve block.","volume":"99","author":"Suter","year":"2003","journal-title":"Anesthesiology"},{"key":"R64-19-20210126","first-page":"124898","article-title":"Perioperative nerve blockade: clues from the bench.","volume":"2011","author":"Suter","year":"2011","journal-title":"Anesthesiol Res Pract"},{"key":"R65-19-20210126","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1038\/nn966","article-title":"Superficial NK1-expressing neurons control spinal excitability through activation of descending pathways.","volume":"5","author":"Suzuki","year":"2002","journal-title":"Nat Neurosci"},{"key":"R66-19-20210126","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1213\/ANE.0b013e31820f2a16","article-title":"The effects of intrathecal and systemic gabapentin on spinal substance P release.","volume":"112","author":"Takasusuki","year":"2011","journal-title":"Anesth Analg"},{"key":"R67-19-20210126","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1016\/j.neuroscience.2008.05.053","article-title":"Immunostaining of rat brain, spinal cord, sensory neurons and skeletal muscle for calcium channel 2 type 1 protein.","volume":"155","author":"Taylor","year":"2008","journal-title":"Neuroscience"},{"key":"R68-19-20210126","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1016\/j.neuron.2012.02.008","article-title":"Deconstructing the neuropathic pain phenotype to reveal neural mechanisms.","volume":"73","author":"von Hehn","year":"2012","journal-title":"Neuron"},{"key":"R69-19-20210126","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.ejpain.2010.07.004","article-title":"Persistent pain and sensory changes following cosmetic breast augmentation.","volume":"15","author":"von Sperling","year":"2011","journal-title":"Eur J Pain"},{"key":"R70-19-20210126","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1097\/01.anes.0000270759.11086.e7","article-title":"Nerve conduction blockade in the sciatic nerve prevents but does not reverse the activation of p38 mitogen-activated protein kinase in spinal microglia in the rat spared nerve injury model.","volume":"107","author":"Wen","year":"2007","journal-title":"Anesthesiology"},{"key":"R71-19-20210126","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.pain.2005.07.005","article-title":"NMDA receptor antagonist treatment at the time of nerve injury prevents injury-induced changes in spinal NR1 and NR2B subunit expression and increases the sensitivity of residual pain behaviours to subsequently administered NMDA receptor antagonists.","volume":"117","author":"Wilson","year":"2005","journal-title":"PAIN"},{"key":"R72-19-20210126","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1002\/cne.902510407","article-title":"Somatotopic organization of cutaneous afferent terminals and dorsal horn neuronal receptive fields in the superficial and deep laminae of the rat lumbar spinal cord.","volume":"251","author":"Woolf","year":"1986","journal-title":"J Comp Neurol"},{"key":"R73-19-20210126","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.pain.2005.04.017","article-title":"Neuropathic pain: early spontaneous afferent activity is the trigger.","volume":"116","author":"Xie","year":"2005","journal-title":"PAIN"},{"key":"R74-19-20210126","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1016\/j.neuroscience.2009.03.016","article-title":"Early blockade of injured primary sensory afferents reduces glial cell activation in two rat neuropathic pain models.","volume":"160","author":"Xie","year":"2009","journal-title":"Neuroscience"},{"key":"R75-19-20210126","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1097\/ALN.0b013e318254e6fd","article-title":"Gabapentin inhibits -amino butyric acid release in the locus coeruleus but not in the spinal dorsal horn after peripheral nerve injury in rats.","volume":"116","author":"Yoshizumi","year":"2012","journal-title":"Anesthesiology"},{"key":"R76-19-20210126","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1093\/bja\/aer027","article-title":"Efficacy of pregabalin in acute postoperative pain: a meta-analysis.","volume":"106","author":"Zhang","year":"2011","journal-title":"Br J Anaesth"}],"container-title":["Pain"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/10.1016\/j.pain.2013.10.024","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,30]],"date-time":"2025-04-30T18:36:21Z","timestamp":1746038181000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/00006396-201402000-00019"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,2]]},"references-count":75,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014]]}},"URL":"https:\/\/doi.org\/10.1016\/j.pain.2013.10.024","relation":{},"ISSN":["0304-3959"],"issn-type":[{"value":"0304-3959","type":"print"}],"subject":[],"published":{"date-parts":[[2014,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Analgesic treatment with pregabalin does not prevent persistent pain after peripheral nerve injury in the rat","name":"articletitle","label":"Article Title"},{"value":"PAIN\u00ae","name":"journaltitle","label":"Journal Title"},{"value":"http:\/\/dx.doi.org\/10.1016\/j.pain.2013.10.024","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 International Association for the Study of Pain. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}