{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T09:51:53Z","timestamp":1785750713308,"version":"3.56.0"},"reference-count":47,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["painjournalonline.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2014,4]]},"DOI":"10.1016\/j.pain.2013.12.030","type":"journal-article","created":{"date-parts":[[2014,1,7]],"date-time":"2014-01-07T10:45:43Z","timestamp":1389091543000},"page":"723-732","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":36,"title":["Differential regulation of peripheral IL-1\u03b2-induced mechanical allodynia and thermal hyperalgesia in rats"],"prefix":"10.1097","volume":"155","author":[{"given":"Min J.","family":"Kim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang Y.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kui Y.","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soon H.","family":"Nam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun J.","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young J.","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong C.","family":"Bae","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong K.","family":"Ahn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-12-20210112","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.neulet.2003.12.097","article-title":"Peripheral glutamate receptors participate in interleukin-1beta-induced mechanical allodynia in the orofacial area of rats.","volume":"357","author":"Ahn","year":"2004","journal-title":"Neurosci Lett"},{"key":"R2-12-20210112","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.pain.2005.07.017","article-title":"Role of peripheral group I and II metabotropic glutamate receptors in IL-1beta-induced mechanical allodynia in the orofacial area of conscious rats.","volume":"118","author":"Ahn","year":"2005","journal-title":"PAIN"},{"key":"R3-12-20210112","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.pain.2009.07.012","article-title":"Intratrigeminal ganglionic injection of LPA causes neuropathic pain-like behavior and demyelination in rats.","volume":"146","author":"Ahn","year":"2009","journal-title":"PAIN"},{"key":"R4-12-20210112","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1016\/j.ejpain.2008.07.008","article-title":"Compression of the trigeminal ganglion produces prolonged nociceptive behavior in rats.","volume":"13","author":"Ahn","year":"2009","journal-title":"Eur J Pain"},{"key":"R5-12-20210112","doi-asserted-by":"crossref","first-page":"14062","DOI":"10.1523\/JNEUROSCI.3795-08.2008","article-title":"Nociceptors are interleukin-1beta sensors.","volume":"28","author":"Binshtok","year":"2008","journal-title":"J Neurosci"},{"key":"R6-12-20210112","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1038\/18906","article-title":"A capsaicin-receptor homologue with a high threshold for noxious heat.","volume":"398","author":"Caterina","year":"1999","journal-title":"Nature"},{"key":"R7-12-20210112","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1038\/39807","article-title":"The capsaicin receptor: a heat-activated ion channel in the pain pathway.","volume":"389","author":"Caterina","year":"1997","journal-title":"Nature"},{"key":"R8-12-20210112","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/0304-3940(93)90275-P","article-title":"Enhancement of the N-methyl-d-aspartate response in spinal dorsal horn neurons by cAMP-dependent protein kinase.","volume":"161","author":"Cerne","year":"1993","journal-title":"Neurosci Lett"},{"key":"R9-12-20210112","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/S0165-5728(01)00324-1","article-title":"Expression of interleukin-1 beta in rat dorsal root ganglia.","volume":"118","author":"Copray","year":"2001","journal-title":"J Neuroimmunol"},{"key":"R10-12-20210112","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1111\/j.1476-5381.1991.tb12502.x","article-title":"Interleukin-8 as a mediator of sympathetic pain.","volume":"104","author":"Cunha","year":"1991","journal-title":"Br J Pharmacol"},{"key":"R11-12-20210112","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/sj.bjp.0702601","article-title":"Pharmacological modulation of secondary mediator systemscyclic AMP and cyclic GMPon inflammatory hyperalgesia.","volume":"127","author":"Cunha","year":"1999","journal-title":"Br J Pharmacol"},{"key":"R12-12-20210112","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.ejphar.2004.08.004","article-title":"Endothelins induce ETB receptor-mediated mechanical hypernociception in rat hindpaw: roles of cAMP and protein kinase C.","volume":"501","author":"Cunha","year":"2004","journal-title":"Eur J Pharmacol"},{"key":"R13-12-20210112","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1038\/35012076","article-title":"Vanilloid receptor-1 is essential for inflammatory thermal hyperalgesia.","volume":"405","author":"Davis","year":"2000","journal-title":"Nature"},{"key":"R14-12-20210112","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/S0306-4522(01)00425-0","article-title":"Role of protein kinase Cepsilon and protein kinase A in a model of paclitaxel-induced painful peripheral neuropathy in the rat.","volume":"108","author":"Dina","year":"2001","journal-title":"Neuroscience"},{"key":"R15-12-20210112","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.pain.2005.02.028","article-title":"Primary afferent second messenger cascades interact with specific integrin subunits in producing inflammatory hyperalgesia.","volume":"115","author":"Dina","year":"2005","journal-title":"PAIN"},{"key":"R16-12-20210112","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1096\/fasebj.2.2.3277884","article-title":"Biology of interleukin 1.","volume":"2","author":"Dinarello","year":"1988","journal-title":"FASEB J"},{"key":"R17-12-20210112","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1038\/334698a0","article-title":"Interleukin-1 beta as a potent hyperalgesic agent antagonized by a tripeptide analogue.","volume":"334","author":"Ferreira","year":"1988","journal-title":"Nature"},{"key":"R18-12-20210112","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1111\/j.1476-5381.1989.tb16860.x","article-title":"Inhibition by neuropeptides of interleukin-1 beta-induced, prostaglandin-independent hyperalgesia.","volume":"98","author":"Follenfant","year":"1989","journal-title":"Br J Pharmacol"},{"key":"R19-12-20210112","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/0006-8993(94)90960-1","article-title":"Cutaneous hyperalgesia induced by peripheral injection of interleukin-1 beta in the rat.","volume":"657","author":"Fukuoka","year":"1994","journal-title":"Brain Res"},{"key":"R20-12-20210112","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1046\/j.1460-9568.1999.00503.x","article-title":"Immunocytochemical localization of the vanilloid receptor 1 (VR1): relationship to neuropeptides, the P2X3 purinoceptor and IB4 binding sites.","volume":"11","author":"Guo","year":"1999","journal-title":"Eur J Neurosci"},{"key":"R21-12-20210112","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1124\/jpet.105.083915","article-title":"A-425619 1-isoquinolin-5-yl-3-(4-trifluoromethyl-benzyl)-urea, a novel transient receptor potential type V1 receptor antagonist, relieves pathophysiological pain associated with inflammation and tissue injury in rats.","volume":"314","author":"Honore","year":"2005","journal-title":"J Pharmacol Exp Ther"},{"key":"R22-12-20210112","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.neuron.2007.07.008","article-title":"Signaling pathways in sensitization: toward a nociceptor cell biology.","volume":"55","author":"Hucho","year":"2007","journal-title":"Neuron"},{"key":"R23-12-20210112","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.ejpain.2010.07.001","article-title":"Peripheral N-methyl-d-aspartate receptors contribute to mechanical hypersensitivity in a rat model of inflammatory temporomandibular joint pain.","volume":"15","author":"Ivanusic","year":"2011","journal-title":"Eur J Pain"},{"key":"R24-12-20210112","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0896-6273(02)00908-X","article-title":"P38 MAPK activation by NGF in primary sensory neurons after inflammation increases TRPV1 levels and maintains heat hyperalgesia.","volume":"36","author":"Ji","year":"2002","journal-title":"Neuron"},{"key":"R25-12-20210112","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1172\/JCI20449","article-title":"Deletion of vanilloid receptor 1-expressing primary afferent neurons for pain control.","volume":"113","author":"Karai","year":"2004","journal-title":"J Clin Invest"},{"key":"R26-12-20210112","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1016\/j.neuron.2012.02.039","article-title":"TRPV1 in GABAergic interneurons mediates neuropathic mechanical allodynia and disinhibition of the nociceptive circuitry in the spinal cord.","volume":"74","author":"Kim","year":"2012","journal-title":"Neuron"},{"key":"R27-12-20210112","doi-asserted-by":"crossref","first-page":"2853","DOI":"10.1152\/jn.1999.82.6.2853","article-title":"Inhibition of rapid heat responses in nociceptive primary sensory neurons of rats by vanilloid receptor antagonists.","volume":"82","author":"Kirschstein","year":"1999","journal-title":"J Neurophysiol"},{"key":"R28-12-20210112","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1016\/S0306-4522(98)00535-1","article-title":"Noxious heat activates all capsaicin-sensitive and also a sub-population of capsaicin-insensitive dorsal root ganglion neurons.","volume":"88","author":"Nagy","year":"1999","journal-title":"Neuroscience"},{"key":"R29-12-20210112","doi-asserted-by":"crossref","first-page":"1478","DOI":"10.1152\/jn.00509.2005","article-title":"Chronic IL-1beta signaling potentiates voltage-dependent sodium currents in trigeminal nociceptive neurons.","volume":"95","author":"Liu","year":"2006","journal-title":"J Neurophysiol"},{"key":"R30-12-20210112","doi-asserted-by":"crossref","first-page":"3693","DOI":"10.1097\/00001756-200112040-00018","article-title":"Vanilloid receptor homologue, VRL1, is expressed by both A- and C-fiber sensory neurons.","volume":"12","author":"Ma","year":"2001","journal-title":"Neuroreport"},{"key":"R31-12-20210112","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1096\/fj.02-0101com","article-title":"IL-1 beta potentiates heat-activated currents in rat sensory neurons: involvement of IL-1RI, tyrosine kinase, and protein kinase C.","volume":"16","author":"Obreja","year":"2002","journal-title":"FASEB J"},{"key":"R32-12-20210112","doi-asserted-by":"crossref","first-page":"2911","DOI":"10.1523\/JNEUROSCI.23-07-02911.2003","article-title":"Resiniferatoxin induces paradoxical changes in thermal and mechanical sensitivities in rats: mechanism of action.","volume":"23","author":"Pan","year":"2003","journal-title":"J Neurosci"},{"key":"R33-12-20210112","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.pain.2009.03.016","article-title":"Molecular mechanism for local anesthetic action of eugenol in the rat trigeminal system.","volume":"144","author":"Park","year":"2009","journal-title":"PAIN"},{"key":"R34-12-20210112","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1053\/eujp.2000.0177","article-title":"Intrathecally administered endotoxin or cytokines produce allodynia, hyperalgesia and changes in spinal cord neuronal responses to nociceptive stimuli in the rat.","volume":"4","author":"Reeve","year":"2000","journal-title":"Eur J Pain"},{"key":"R35-12-20210112","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1111\/j.1476-5381.1995.tb15035.x","article-title":"Contribution of interleukin-1 beta to the inflammation-induced increase in nerve growth factor levels and inflammatory hyperalgesia.","volume":"115","author":"Safieh-Garabedian","year":"1995","journal-title":"Br J Pharmacol"},{"key":"R36-12-20210112","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.neulet.2008.03.052","article-title":"Effect of cytokines on neuronal excitability.","volume":"437","author":"Schafers","year":"2008","journal-title":"Neurosci Lett"},{"key":"R37-12-20210112","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1007\/BF01965025","article-title":"Interleukin-1 enhances pain reflexes. Mediation through increased prostaglandin E2 levels.","volume":"25","author":"Schweizer","year":"1988","journal-title":"Agents Actions"},{"key":"R38-12-20210112","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1038\/sj.bjp.0704434","article-title":"In vivo evidence for a role of protein kinase C in peripheral nociceptive processing.","volume":"135","author":"Souza","year":"2002","journal-title":"Br J Pharmacol"},{"key":"R39-12-20210112","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/S0022-3565(25)30862-1","article-title":"Conduction-blocking concentration of anesthetics increase with nerve axon diameter: studies with alcohol, lidocaine and tetrodotoxin on single myelinated fibers.","volume":"201","author":"Staiman","year":"1977","journal-title":"J Pharmacol Exp Ther"},{"key":"R40-12-20210112","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.brainres.2004.04.068","article-title":"Intrathecal interleukin-1beta administration induces thermal hyperalgesia by activating inducible nitric oxide synthase expression in the rat spinal cord.","volume":"1015","author":"Sung","year":"2004","journal-title":"Brain Res"},{"key":"R41-12-20210112","doi-asserted-by":"crossref","first-page":"522","DOI":"10.3171\/jns.2005.102.3.0522","article-title":"Selective ablation of nociceptive neurons for elimination of hyperalgesia and neurogenic inflammation.","volume":"102","author":"Tender","year":"2005","journal-title":"J Neurosurg"},{"key":"R42-12-20210112","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/S0896-6273(00)80564-4","article-title":"The cloned capsaicin receptor integrates multiple pain-producing stimuli.","volume":"21","author":"Tominaga","year":"1998","journal-title":"Neuron"},{"key":"R43-12-20210112","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/0301-0082(92)90027-C","article-title":"Peripheral and central mechanisms of cutaneous hyperalgesia.","volume":"38","author":"Treede","year":"1992","journal-title":"Prog Neurobiol"},{"key":"R44-12-20210112","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S0361-9230(99)00277-4","article-title":"Peripheral NMDA and non-NMDA receptors contribute to nociception: an electrophysiological study.","volume":"52","author":"Wang","year":"2000","journal-title":"Brain Res Bull"},{"key":"R45-12-20210112","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/0006-8993(94)91566-0","article-title":"Characterization of cytokine-induced hyperalgesia.","volume":"654","author":"Watkins","year":"1994","journal-title":"Brain Res"},{"key":"R46-12-20210112","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/S0006-8993(96)01444-8","article-title":"Effects of the capsaicin analogue resiniferatoxin on spinal nociceptive mechanisms in the rat: behavioral, electrophysiological and in situ hybridization studies.","volume":"752","author":"Xu","year":"1997","journal-title":"Brain Res"},{"key":"R47-12-20210112","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/S0361-9230(02)00806-7","article-title":"Differential effect of peripheral glutamate (NMDA, non-NMDA) receptor antagonists on bee venom-induced spontaneous nociception and sensitization.","volume":"58","author":"You","year":"2002","journal-title":"Brain Res Bull"}],"container-title":["Pain"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/10.1016\/j.pain.2013.12.030","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T11:30:55Z","timestamp":1746099055000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/00006396-201404000-00012"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,4]]},"references-count":47,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2014]]}},"URL":"https:\/\/doi.org\/10.1016\/j.pain.2013.12.030","relation":{},"ISSN":["0304-3959"],"issn-type":[{"value":"0304-3959","type":"print"}],"subject":[],"published":{"date-parts":[[2014,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Differential regulation of peripheral IL-1\u03b2-induced mechanical allodynia and thermal hyperalgesia in rats","name":"articletitle","label":"Article Title"},{"value":"PAIN\u00ae","name":"journaltitle","label":"Journal Title"},{"value":"http:\/\/dx.doi.org\/10.1016\/j.pain.2013.12.030","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 International Association for the Study of Pain. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}