{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T19:23:40Z","timestamp":1791314620121,"version":"4.3.1"},"reference-count":91,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["painjournalonline.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2014,5]]},"DOI":"10.1016\/j.pain.2014.01.026","type":"journal-article","created":{"date-parts":[[2014,2,3]],"date-time":"2014-02-03T19:31:50Z","timestamp":1391455910000},"page":"954-967","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":92,"title":["Blood-nerve barrier dysfunction contributes to the generation of neuropathic pain and allows targeting of injured nerves for pain relief"],"prefix":"10.1097","volume":"155","author":[{"given":"Tony K.Y.","family":"Lim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang Qun","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiliary Claire","family":"Martin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giamal","family":"Luheshi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serge","family":"Rivest","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-19-20210126","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.nbd.2009.07.030","article-title":"Structure and function of the blood-brain barrier.","volume":"37","author":"Abbott","year":"2010","journal-title":"Neurobiol Dis"},{"key":"R2-19-20210126","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1097\/00000542-200607000-00024","article-title":"Permeability of injured and intact peripheral nerves and dorsal root ganglia.","volume":"105","author":"Abram","year":"2006","journal-title":"Anesthesiology"},{"key":"R3-19-20210126","doi-asserted-by":"crossref","first-page":"2925","DOI":"10.2174\/092986707782360015","article-title":"Fibrinogen signal transduction as a mediator and therapeutic target in inflammation: lessons from multiple sclerosis.","volume":"14","author":"Adams","year":"2007","journal-title":"Curr Med Chem"},{"key":"R4-19-20210126","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1083\/jcb.149.5.1157","article-title":"Tissue plasminogen activator-mediated fibrinolysis protects against axonal degeneration and demyelination after sciatic nerve injury.","volume":"149","author":"Akassoglou","year":"2000","journal-title":"J Cell Biol"},{"key":"R5-19-20210126","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/S0896-6273(02)00617-7","article-title":"Fibrin inhibits peripheral nerve remyelination by regulating Schwann cell differentiation.","volume":"33","author":"Akassoglou","year":"2002","journal-title":"Neuron"},{"key":"R6-19-20210126","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1523\/JNEUROSCI.15-01-00165.1995","article-title":"Perineurial defect and peripheral opioid analgesia in inflammation.","volume":"15","author":"Antonijevic","year":"1995","journal-title":"J Neurosci"},{"key":"R7-19-20210126","doi-asserted-by":"crossref","first-page":"1977","DOI":"10.1073\/pnas.0808698106","article-title":"VEGF-mediated disruption of endothelial CLN-5 promotes blood-brain barrier breakdown.","volume":"106","author":"Argaw","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R8-19-20210126","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/0304-3959(88)90209-6","article-title":"A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man.","volume":"33","author":"Bennett","year":"1988","journal-title":"PAIN"},{"key":"R9-19-20210126","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.mcn.2007.09.007","article-title":"Transcriptional and functional profiles of voltage-gated Na() channels in injured and non-injured DRG neurons in the SNI model of neuropathic pain.","volume":"37","author":"Berta","year":"2008","journal-title":"Mol Cell Neurosci"},{"key":"R10-19-20210126","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/j.nurt.2009.08.001","article-title":"Sodium channel blockers for the treatment of neuropathic pain.","volume":"6","author":"Bhattacharya","year":"2009","journal-title":"Neurotherapeutics"},{"key":"R11-19-20210126","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1016\/j.archoralbio.2006.11.011","article-title":"Na(v)1.7 sodium channel expression in human lingual nerve neuromas.","volume":"52","author":"Bird","year":"2007","journal-title":"Arch Oral Biol"},{"key":"R12-19-20210126","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1002\/ana.21527","article-title":"Multiple sodium channel isoforms and mitogen-activated protein kinases are present in painful human neuromas.","volume":"64","author":"Black","year":"2008","journal-title":"Ann Neurol"},{"key":"R13-19-20210126","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1016\/S0306-4522(98)00058-X","article-title":"Loss of the tight junction proteins occludin and zonula occludens-1 from cerebral vascular endothelium during neutrophil-induced blood-brain barrier breakdown in vivo.","volume":"86","author":"Bolton","year":"1998","journal-title":"Neuroscience"},{"key":"R15-19-20210126","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0165-0270(94)90144-9","article-title":"Quantitative assessment of tactile allodynia in the rat paw.","volume":"53","author":"Chaplan","year":"1994","journal-title":"J Neurosci Methods"},{"key":"R16-19-20210126","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.jneuroim.2005.02.012","article-title":"Differential expression of cytokines in the brain and serum during endotoxin tolerance.","volume":"163","author":"Chen","year":"2005","journal-title":"J Neuroimmunol"},{"key":"R17-19-20210126","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.nbd.2004.09.006","article-title":"Skin denervation, neuropathology, and neuropathic pain in a laser-induced focal neuropathy.","volume":"18","author":"Chiang","year":"2005","journal-title":"Neurobiol Dis"},{"key":"R18-19-20210126","doi-asserted-by":"crossref","first-page":"6043","DOI":"10.2174\/138161212803582540","article-title":"Non-analgesic effects of opioids: opioid-induced nausea and vomiting: mechanisms and strategies for their limitation.","volume":"18","author":"Coluzzi","year":"2012","journal-title":"Curr Pharm Des"},{"key":"R19-19-20210126","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1097\/00001756-200103050-00014","article-title":"Plasticity of TTX-sensitive sodium channels PN1 and brain III in injured human nerves.","volume":"12","author":"Coward","year":"2001","journal-title":"Neuroreport"},{"key":"R20-19-20210126","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1006\/mvre.1993.1042","article-title":"Microscopic visualization of the retina by angiography with high-molecular-weight fluorescein-labeled dextrans in the mouse.","volume":"46","author":"DAmato","year":"1993","journal-title":"Microvasc Res"},{"key":"R21-19-20210126","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1016\/j.apmr.2007.08.004","article-title":"Clinical correlates of elevated serum concentrations of cytokines and autoantibodies in patients with spinal cord injury.","volume":"88","author":"Davies","year":"2007","journal-title":"Arch Phys Med Rehabil"},{"key":"R22-19-20210126","doi-asserted-by":"crossref","first-page":"743","DOI":"10.2174\/1381612043453036","article-title":"Peripherally restricted opioid agonists as novel analgesic agents.","volume":"10","author":"DeHaven-Hudkins","year":"2004","journal-title":"Curr Pharm Des"},{"key":"R23-19-20210126","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1177\/0022034511400225","article-title":"LPS sensitizes TRPV1 via activation of TLR4 in trigeminal sensory neurons.","volume":"90","author":"Diogenes","year":"2011","journal-title":"J Dent Res"},{"key":"R24-19-20210126","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1113\/jphysiol.2002.026559","article-title":"Sensory and electrophysiological properties of guinea-pig sensory neurones expressing Nav 1.7 (PN1) Na channel alpha subunit protein.","volume":"546","author":"Djouhri","year":"2003","journal-title":"J Physiol"},{"key":"R25-19-20210126","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1023\/A:1006907608230","article-title":"Increased blood-brain barrier permeability and endothelial abnormalities induced by vascular endothelial growth factor.","volume":"27","author":"Dobrogowska","year":"1998","journal-title":"J Neurocytol"},{"key":"R26-19-20210126","first-page":"1029","article-title":"Vascular permeability factorvascular endothelial growth factor, microvascular hyperpermeability, and angiogenesis.","volume":"146","author":"Dvorak","year":"1995","journal-title":"Am J Pathol"},{"key":"R27-19-20210126","doi-asserted-by":"crossref","first-page":"10819","DOI":"10.1523\/JNEUROSCI.1642-11.2011","article-title":"Peripheral nerve injury alters blood-spinal cord barrier functional and molecular integrity through a selective inflammatory pathway.","volume":"31","author":"Echeverry","year":"2011","journal-title":"J Neurosci"},{"key":"R28-19-20210126","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.expneurol.2012.11.013","article-title":"Selectively reducing cytokinechemokine expressing macrophages in injured nerves impairs the development of neuropathic pain.","volume":"240","author":"Echeverry","year":"2013","journal-title":"Exp Neurol"},{"key":"R29-19-20210126","doi-asserted-by":"crossref","first-page":"2972","DOI":"10.4049\/jimmunol.150.7.2972","article-title":"Integrin regulation of leukocyte inflammatory functions. CD11bCD18 enhancement of the tumor necrosis factor-alpha responses of monocytes.","volume":"150","author":"Fan","year":"1993","journal-title":"J Immunol"},{"key":"R30-19-20210126","doi-asserted-by":"crossref","first-page":"29745","DOI":"10.1074\/jbc.273.45.29745","article-title":"The tight junction protein ZO-1 establishes a link between the transmembrane protein occludin and the actin cytoskeleton.","volume":"273","author":"Fanning","year":"1998","journal-title":"J Biol Chem"},{"key":"R32-19-20210126","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.joen.2007.07.001","article-title":"Lipopolysaccharide from Porphyromonas gingivalis sensitizes capsaicin-sensitive nociceptors.","volume":"37","author":"Ferraz","year":"2011","journal-title":"J Endod"},{"key":"R33-19-20210126","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1006\/mvre.2001.2367","article-title":"Hypoxia-induced hyperpermeability in brain microvessel endothelial cells involves VEGF-mediated changes in the expression of zonula occludens-1.","volume":"63","author":"Fischer","year":"2002","journal-title":"Microvasc Res"},{"key":"R34-19-20210126","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1186\/1742-2094-8-110","article-title":"Wallerian degeneration: gaining perspective on inflammatory events after peripheral nerve injury.","volume":"8","author":"Gaudet","year":"2011","journal-title":"J Neuroinflamm"},{"key":"R35-19-20210126","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1046\/j.1529-8027.2001.006001111.x","article-title":"Sciatic inflammatory neuritis (SIN): behavioral allodynia is paralleled by peri-sciatic proinflammatory cytokine and superoxide production.","volume":"6","author":"Gazda","year":"2001","journal-title":"J Peripher Nerv Syst"},{"key":"R36-19-20210126","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/S1074-7613(03)00174-2","article-title":"Blood monocytes consist of two principal subsets with distinct migratory properties.","volume":"19","author":"Geissmann","year":"2003","journal-title":"Immunity"},{"key":"R37-19-20210126","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1002\/glia.21041","article-title":"Toll-like receptor expression in the peripheral nerve.","volume":"58","author":"Goethals","year":"2010","journal-title":"Glia"},{"key":"R38-19-20210126","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.pain.2008.01.004","article-title":"Peripherally acting mu-opioid receptor agonist attenuates neuropathic pain in rats after L5 spinal nerve injury.","volume":"138","author":"Guan","year":"2008","journal-title":"PAIN"},{"key":"R39-19-20210126","doi-asserted-by":"crossref","first-page":"E2018","DOI":"10.1073\/pnas.1120800109","article-title":"Transient opening of the perineurial barrier for analgesic drug delivery.","volume":"109","author":"Hackel","year":"2012","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R40-19-20210126","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1006\/exnr.2001.7808","article-title":"Do denervated peripheral nerve trunks become ischemic? The impact of chronic denervation on vasa nervorum.","volume":"172","author":"Hoke","year":"2001","journal-title":"Exp Neurol"},{"key":"R41-19-20210126","doi-asserted-by":"crossref","first-page":"6010","DOI":"10.2174\/138161212803582388","article-title":"Non-analgesic effects of opioids: management of opioid-induced constipation by peripheral opioid receptor antagonists: prevention or withdrawal?","volume":"18","author":"Holzer","year":"2012","journal-title":"Curr Pharm Des"},{"key":"R42-19-20210126","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1136\/jnnp-2012-302312","article-title":"Biology of the blood-nerve barrier and its alteration in immune mediated neuropathies.","volume":"84","author":"Kanda","year":"2013","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"R43-19-20210126","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.brainres.2011.06.022","article-title":"Detailed characterization of neuro-immune responses following neuropathic injury in mice.","volume":"1405","author":"Kim","year":"2011","journal-title":"Brain Res"},{"key":"R44-19-20210126","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/j.jpain.2010.08.003","article-title":"Interleukin-17 contributes to neuroinflammation and neuropathic pain following peripheral nerve injury in mice.","volume":"12","author":"Kim","year":"2011","journal-title":"J Pain"},{"key":"R45-19-20210126","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/S0304-3940(02)00127-1","article-title":"Changes in three subtypes of tetrodotoxin sensitive sodium channel expression in the axotomized dorsal root ganglion in the rat.","volume":"323","author":"Kim","year":"2002","journal-title":"Neurosci Lett"},{"key":"R46-19-20210126","doi-asserted-by":"crossref","first-page":"1686","DOI":"10.1002\/stem.87","article-title":"Bone marrow mononuclear cells have neurovascular tropism and improve diabetic neuropathy.","volume":"27","author":"Kim","year":"2009","journal-title":"Stem Cells"},{"key":"R47-19-20210126","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1590\/S0034-70942009000300004","article-title":"Proinflammatory cytokines in patients with neuropathic pain treated with Tramadol.","volume":"59","author":"Kraychete","year":"2009","journal-title":"Rev Bras Anestesiol"},{"key":"R48-19-20210126","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1016\/j.bbi.2012.03.004","article-title":"Heterogeneity of macrophages in injured trigeminal nerves: cytokinechemokine expressing vs. phagocytic macrophages.","volume":"26","author":"Lee","year":"2012","journal-title":"Brain Behav Immun"},{"key":"R49-19-20210126","doi-asserted-by":"crossref","first-page":"2231","DOI":"10.1016\/S0002-9440(10)61170-4","article-title":"Synergistic up-regulation of vascular endothelial growth factor expression in murine macrophages by adenosine A(2A) receptor agonists and endotoxin.","volume":"160","author":"Leibovich","year":"2002","journal-title":"Am J Pathol"},{"key":"R50-19-20210126","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method.","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"R51-19-20210126","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/B978-0-12-394307-1.00003-5","article-title":"Hypoxia and hypoxia signaling in tissue repair and fibrosis.","volume":"296","author":"Lokmic","year":"2012","journal-title":"Int Rev Cell Mol Biol"},{"key":"R52-19-20210126","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/S0304-3959(98)00045-1","article-title":"Partial sciatic nerve injury in the mouse as a model of neuropathic pain: behavioral and neuroanatomical correlates.","volume":"76","author":"Malmberg","year":"1998","journal-title":"PAIN"},{"key":"R53-19-20210126","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1177\/019262339001800123","article-title":"Role of the blood-nerve barrier in experimental nerve edema.","volume":"18","author":"Mizisin","year":"1990","journal-title":"Toxicol Pathol"},{"key":"R54-19-20210126","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1007\/BF01191724","article-title":"MHC-positive, ramified macrophages in the normal and injured rat peripheral nervous system.","volume":"21","author":"Monaco","year":"1992","journal-title":"J Neurocytol"},{"key":"R55-19-20210126","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/0304-3959(95)00077-1","article-title":"Fixed-diameter polyethylene cuffs applied to the rat sciatic nerve induce a painful neuropathy: ultrastructural morphometric analysis of axonal alterations.","volume":"64","author":"Mosconi","year":"1996","journal-title":"PAIN"},{"key":"R56-19-20210126","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1097\/01.LAB.0000056993.28149.BF","article-title":"Macrophage response to peripheral nerve injury: the quantitative contribution of resident and hematogenous macrophages.","volume":"83","author":"Mueller","year":"2003","journal-title":"Lab Invest"},{"key":"R57-19-20210126","doi-asserted-by":"crossref","first-page":"2187","DOI":"10.1016\/S0002-9440(10)63070-2","article-title":"Rapid response of identified resident endoneurial macrophages to nerve injury.","volume":"159","author":"Mueller","year":"2001","journal-title":"Am J Pathol"},{"key":"R58-19-20210126","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1097\/00005072-198305000-00001","article-title":"Endoneurial fluid is hypertonic. Results of microanalysis and its significance in neuropathy.","volume":"42","author":"Myers","year":"1983","journal-title":"J Neuropathol Exp Neurol"},{"key":"R59-19-20210126","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1136\/jnnp.48.12.1265","article-title":"Laser injury of peripheral nerve: a model for focal endoneurial damage.","volume":"48","author":"Myers","year":"1985","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"R60-19-20210126","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1002\/ana.410100512","article-title":"Biophysical and pathological effects of cryogenic nerve lesion.","volume":"10","author":"Myers","year":"1981","journal-title":"Ann Neurol"},{"key":"R61-19-20210126","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1097\/00000542-199302000-00015","article-title":"The role of focal nerve ischemia and Wallerian degeneration in peripheral nerve injury producing hyperesthesia.","volume":"78","author":"Myers","year":"1993","journal-title":"Anesthesiology"},{"key":"R62-19-20210126","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.brainres.2003.10.067","article-title":"The recovery of blood-nerve barrier in crush nerve injurya quantitative analysis utilizing immunohistochemistry.","volume":"1001","author":"Omura","year":"2004","journal-title":"Brain Res"},{"key":"R63-19-20210126","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.expneurol.2011.05.005","article-title":"Nav1.7 accumulates and co-localizes with phosphorylated ERK12 within transected axons in early experimental neuromas.","volume":"230","author":"Persson","year":"2011","journal-title":"Exp Neurol"},{"key":"R64-19-20210126","doi-asserted-by":"crossref","first-page":"2218","DOI":"10.1073\/pnas.89.6.2218","article-title":"Increased permeability across the blood-nerve barrier of albumin glycated in vitro and in vivo from patients with diabetic polyneuropathy.","volume":"89","author":"Poduslo","year":"1992","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R65-19-20210126","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/S0304-3959(01)00363-3","article-title":"A painful peripheral neuropathy in the rat produced by the chemotherapeutic drug, paclitaxel.","volume":"94","author":"Polomano","year":"2001","journal-title":"PAIN"},{"key":"R66-19-20210126","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1097\/00005072-198111000-00003","article-title":"Endoneurial fluid pressure in experimental models of diabetic neuropathy.","volume":"40","author":"Powell","year":"1981","journal-title":"J Neuropathol Exp Neurol"},{"key":"R67-19-20210126","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1002\/ana.410050610","article-title":"Endoneurial fluid pressure in wallerian degeneration.","volume":"5","author":"Powell","year":"1979","journal-title":"Ann Neurol"},{"key":"R68-19-20210126","doi-asserted-by":"crossref","first-page":"6417","DOI":"10.4049\/jimmunol.1001241","article-title":"Painful pathways induced by TLR stimulation of dorsal root ganglion neurons.","volume":"186","author":"Qi","year":"2011","journal-title":"J Immunol"},{"key":"R69-19-20210126","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/S0021-9150(02)00044-8","article-title":"Effect of genetic background and diet on plasma fibrinogen in mice. Possible relation with susceptibility to atherosclerosis.","volume":"164","author":"Rezaee","year":"2002","journal-title":"Atherosclerosis"},{"key":"R70-19-20210126","doi-asserted-by":"crossref","first-page":"1476","DOI":"10.1124\/mol.108.047670","article-title":"ProTx-II, a selective inhibitor of NaV1.7 sodium channels, blocks action potential propagation in nociceptors.","volume":"74","author":"Schmalhofer","year":"2008","journal-title":"Mol Pharmacol"},{"key":"R71-19-20210126","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/0892-0362(96)00088-8","article-title":"Evaluation of brain and nerve pathology in rats chronically dosed with ddI or isoniazid.","volume":"18","author":"Schmued","year":"1996","journal-title":"Neurotoxicol Teratol"},{"key":"R72-19-20210126","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1002\/mus.880120803","article-title":"The blood-nerve barrier in Wallerian degeneration: a sequential long-term study.","volume":"12","author":"Seitz","year":"1989","journal-title":"Muscle Nerve"},{"key":"R73-19-20210126","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/0304-3959(90)91074-S","article-title":"A novel behavioral model of neuropathic pain disorders produced in rats by partial sciatic nerve injury.","volume":"43","author":"Seltzer","year":"1990","journal-title":"PAIN"},{"key":"R74-19-20210126","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1126\/science.6823562","article-title":"Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid.","volume":"219","author":"Senger","year":"1983","journal-title":"Science"},{"key":"R75-19-20210126","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1016\/j.pain.2011.01.006","article-title":"Statins alleviate experimental nerve injury-induced neuropathic pain.","volume":"152","author":"Shi","year":"2011","journal-title":"PAIN"},{"key":"R76-19-20210126","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1002\/jcp.22337","article-title":"Peripheral nerve pericytes modify the blood-nerve barrier function and tight junctional molecules through the secretion of various soluble factors.","volume":"226","author":"Shimizu","year":"2011","journal-title":"J Cell Physiol"},{"key":"R77-19-20210126","doi-asserted-by":"crossref","first-page":"2887","DOI":"10.4049\/jimmunol.167.5.2887","article-title":"Fibrinogen stimulates macrophage chemokine secretion through toll-like receptor 4.","volume":"167","author":"Smiley","year":"2001","journal-title":"J Immunol"},{"key":"R78-19-20210126","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1007\/BF00686200","article-title":"A transient hypertensive opening of the blood-brain barrier can lead to brain damage. Extravasation of serum proteins and cellular changes in rats subjected to aortic compression.","volume":"75","author":"Sokrab","year":"1988","journal-title":"Acta Neuropathol"},{"key":"R79-19-20210126","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1006\/S0014-4886(96)92000-2","article-title":"Vascular pathology in CCI neuropathy: a quantitative temporal study.","volume":"141","author":"Sommer","year":"1996","journal-title":"Exp Neurol"},{"key":"R80-19-20210126","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/S0006-8993(97)01327-9","article-title":"Painful mononeuropathy in C57BLWld mice with delayed wallerian degeneration: differential effects of cytokine production and nerve regeneration on thermal and mechanical hypersensitivity.","volume":"784","author":"Sommer","year":"1998","journal-title":"Brain Res"},{"key":"R81-19-20210126","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1046\/j.1529-8027.2000.00012.x","article-title":"Epineurial application of TNF elicits an acute mechanical hyperalgesia in the awake rat.","volume":"5","author":"Sorkin","year":"2000","journal-title":"J Peripher Nerv Syst"},{"key":"R82-19-20210126","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1182\/blood.V99.3.1053","article-title":"Roles for thrombin and fibrin(ogen) in cytokinechemokine production and macrophage adhesion in vivo.","volume":"99","author":"Szaba","year":"2002","journal-title":"Blood"},{"key":"R83-19-20210126","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1007\/BF01920648","article-title":"Penetration barrier to sodium fluorescein and fluorescein-labelled dextrans of various molecular sizes in brain capillaries.","volume":"35","author":"Tervo","year":"1979","journal-title":"Experientia"},{"key":"R84-19-20210126","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1679\/aohc.62.459","article-title":"Immunolocalization of tight junction proteins, occludin and ZO-1, and glucose transporter GLUT1 in the cells of the blood-nerve barrier.","volume":"62","author":"Tserentsoodol","year":"1999","journal-title":"Arch Histol Cytol"},{"key":"R85-19-20210126","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1177\/154405910608500108","article-title":"Trigeminal nociceptors express TLR-4 and CD14: a mechanism for pain due to infection.","volume":"85","author":"Wadachi","year":"2006","journal-title":"J Dent Res"},{"key":"R86-19-20210126","doi-asserted-by":"crossref","first-page":"2897","DOI":"10.1097\/00001756-199611250-00018","article-title":"Endoneurial injection of TNF-alpha produces neuropathic pain behaviors.","volume":"7","author":"Wagner","year":"1996","journal-title":"Neuroreport"},{"key":"R87-19-20210126","doi-asserted-by":"crossref","first-page":"1514","DOI":"10.2527\/1997.7561514x","article-title":"Time course of increased plasma cytokines, cortisol, and urea nitrogen in pigs following intraperitoneal injection of lipopolysaccharide.","volume":"75","author":"Webel","year":"1997","journal-title":"J Anim Sci"},{"key":"R88-19-20210126","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1007\/978-1-60761-938-3_6","article-title":"The blood-nerve barrier: structure and functional significance.","volume":"686","author":"Weerasuriya","year":"2011","journal-title":"Methods Mol Biol"},{"key":"R89-19-20210126","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/0165-5728(92)90260-R","article-title":"Changes in plasma cytokines associated with peripheral nerve injury.","volume":"39","author":"Wells","year":"1992","journal-title":"J Neuroimmunol"},{"key":"R90-19-20210126","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/S0002-9440(10)65601-5","article-title":"Production of vascular endothelial growth factor by murine macrophages: regulation by hypoxia, lactate, and the inducible nitric oxide synthase pathway.","volume":"153","author":"Xiong","year":"1998","journal-title":"Am J Pathol"},{"key":"R91-19-20210126","first-page":"469","article-title":"Serum levels of proinflammatory cytokines in diabetic patients with peripheral neuropathic pain and the correlation among them.","volume":"89","author":"Yu","year":"2009","journal-title":"Zhonghua Yi Xue Za Zhi"},{"key":"R92-19-20210126","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.pain.2005.04.018","article-title":"Intraneural injection of interleukin-1beta and tumor necrosis factor-alpha into rat sciatic nerve at physiological doses induces signs of neuropathic pain.","volume":"116","author":"Zelenka","year":"2005","journal-title":"PAIN"},{"key":"R93-19-20210126","doi-asserted-by":"crossref","first-page":"12396","DOI":"10.1523\/JNEUROSCI.3016-07.2007","article-title":"Expression of CCR2 in both resident and bone marrow-derived microglia plays a critical role in neuropathic pain.","volume":"27","author":"Zhang","year":"2007","journal-title":"J Neurosci"}],"container-title":["Pain"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/10.1016\/j.pain.2014.01.026","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,10]],"date-time":"2023-07-10T06:32:40Z","timestamp":1688970760000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/00006396-201405000-00019"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5]]},"references-count":91,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2014]]}},"URL":"https:\/\/doi.org\/10.1016\/j.pain.2014.01.026","relation":{},"ISSN":["0304-3959"],"issn-type":[{"value":"0304-3959","type":"print"}],"subject":[],"published":{"date-parts":[[2014,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Blood-nerve barrier dysfunction contributes to the generation of neuropathic pain and allows targeting of injured nerves for pain relief","name":"articletitle","label":"Article Title"},{"value":"PAIN\u00ae","name":"journaltitle","label":"Journal Title"},{"value":"http:\/\/dx.doi.org\/10.1016\/j.pain.2014.01.026","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 International Association for the Study of Pain. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}