{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T23:58:52Z","timestamp":1790380732730,"version":"4.1.0"},"reference-count":57,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","license":[{"start":{"date-parts":[[2014,7,1]],"date-time":"2014-07-01T00:00:00Z","timestamp":1404172800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["painjournalonline.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2014,7]]},"DOI":"10.1016\/j.pain.2014.03.010","type":"journal-article","created":{"date-parts":[[2014,3,22]],"date-time":"2014-03-22T23:47:29Z","timestamp":1395532049000},"page":"1222-1228","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"title":["Inhibition of c-Kit signaling is associated with reduced heat and cold pain sensitivity in humans"],"prefix":"10.1097","volume":"155","author":[{"given":"Marta","family":"Ceko","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nevena","family":"Milenkovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp","family":"le Coutre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f6rg","family":"Westermann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary R.","family":"Lewin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-10-20210126","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1182\/blood-2013-05-501569","article-title":"European LeukemiaNet recommendations for the management of chronic myeloid leukemia: 2013.","volume":"122","author":"Baccarani","year":"2013","journal-title":"Blood"},{"key":"R2-10-20210126","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1016\/0955-0674(91)90111-B","article-title":"The kit ligand encoded at the murine steel locus: a pleiotropic growth and differentiation factor.","volume":"3","author":"Besmer","year":"1991","journal-title":"Curr Opin Cell Biol"},{"key":"R3-10-20210126","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/S0304-3959(98)00062-1","article-title":"Effects of antihyperalgesic drugs on experimentally induced hyperalgesia in man.","volume":"76","author":"Bickel","year":"1998","journal-title":"PAIN"},{"key":"R4-10-20210126","doi-asserted-by":"crossref","first-page":"2361","DOI":"10.1212\/WNL.44.12.2361","article-title":"The limit of tactile spatial resolution in humans: grating orientation discrimination at the lip, tongue, and finger.","volume":"44","author":"Van Boven","year":"1994","journal-title":"Neurology"},{"key":"R5-10-20210126","first-page":"480","article-title":"The kit receptor and its ligand, steel factor, as regulators of hemopoiesis.","volume":"3","author":"Broxmeyer","year":"1991","journal-title":"Cancer Cells"},{"key":"R6-10-20210126","first-page":"M11","article-title":"Bcr-Abl inhibition as a modality of CML therapeutics.","volume":"1551","author":"Buchdunger","year":"2001","journal-title":"Biochim Biophys Acta"},{"key":"R7-10-20210126","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1146\/annurev.neuro.24.1.487","article-title":"The vanilloid receptor: a molecular gateway to the pain pathway.","volume":"24","author":"Caterina","year":"2001","journal-title":"Annu Rev Neurosci"},{"key":"R8-10-20210126","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.pain.2007.06.006","article-title":"The effects of the TRPV1 antagonist SB-705498 on TRPV1 receptor-mediated activity and inflammatory hyperalgesia in humans.","volume":"132","author":"Chizh","year":"2007","journal-title":"PAIN"},{"key":"R9-10-20210126","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/s00213-009-1703-4","article-title":"Evaluation of potential sex differences in the subjective and analgesic effects of morphine in normal, healthy volunteers.","volume":"208","author":"Comer","year":"2010","journal-title":"Psychopharmacology (Berl)"},{"key":"R10-10-20210126","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1056\/NEJMoa020461","article-title":"Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors.","volume":"347","author":"Demetri","year":"2002","journal-title":"N Engl J Med"},{"key":"R11-10-20210126","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1212\/WNL.48.2.501","article-title":"Intradermal recombinant human nerve growth factor induces pressure allodynia and lowered heat-pain threshold in humans.","volume":"48","author":"Dyck","year":"1997","journal-title":"Neurology"},{"key":"R12-10-20210126","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.jpain.2008.12.001","article-title":"3rd. Sex, gender, and pain: a review of recent clinical and experimental findings.","volume":"10","author":"Fillingim","year":"2009","journal-title":"J Pain"},{"key":"R13-10-20210126","doi-asserted-by":"crossref","first-page":"e1001318","DOI":"10.1371\/journal.pbio.1001318","article-title":"A genetic basis for mechanosensory traits in humans.","volume":"10","author":"Frenzel","year":"2012","journal-title":"PLoS Biol"},{"key":"R14-10-20210126","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1046\/j.1460-9568.2003.02775.x","article-title":"Mechanisms of sensitization of the response of single dorsal root ganglion cells from adult rat to noxious heat.","volume":"18","author":"Galoyan","year":"2003","journal-title":"Eur J Neurosci"},{"key":"R15-10-20210126","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.pain.2008.01.024","article-title":"Pharmacological blockade of the vanilloid receptor TRPV1 elicits marked hyperthermia in humans.","volume":"136","author":"Gavva","year":"2008","journal-title":"PAIN"},{"key":"R17-10-20210126","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1097\/00001503-200010000-00015","article-title":"Neurotrophins, nociceptors and pain.","volume":"13","author":"Heppenstall","year":"2000","journal-title":"Curr Opin Anaesthesiol"},{"key":"R18-10-20210126","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/0165-3806(94)00205-E","article-title":"Characterization of c-kit-positive neurons in the dorsal root ganglion of mouse.","volume":"85","author":"Hirata","year":"1995","journal-title":"Brain Res Dev Brain Res"},{"key":"R19-10-20210126","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/S1470-2045(02)00899-9","article-title":"Management of malignant gastrointestinal stromal tumours.","volume":"3","author":"Joensuu","year":"2002","journal-title":"Lancet Oncol"},{"key":"R20-10-20210126","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1152\/jn.1981.46.6.1177","article-title":"Tactile spatial resolution. I. Two-point discrimination, gap detection, grating resolution, and letter recognition.","volume":"46","author":"Johnson","year":"1981","journal-title":"J Neurophysiol"},{"key":"R21-10-20210126","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/0304-3959(88)90156-X","article-title":"Morphine and ibuprofen compared using the cold pressor test.","volume":"34","author":"Jones","year":"1988","journal-title":"PAIN"},{"key":"R22-10-20210126","doi-asserted-by":"crossref","first-page":"2425","DOI":"10.1002\/j.1460-2075.1991.tb07782.x","article-title":"Embryonic RNA expression patterns of the c-kit receptor and its cognate ligand suggest multiple functional roles in mouse development.","volume":"10","author":"Keshet","year":"1991","journal-title":"EMBO J"},{"key":"R23-10-20210126","doi-asserted-by":"crossref","first-page":"3948","DOI":"10.1182\/blood-2005-06-2209","article-title":"NS-187, a potent and selective dual Bcr-AblLyn tyrosine kinase inhibitor, is a novel agent for imatinib-resistant leukemia.","volume":"106","author":"Kimura","year":"2005","journal-title":"Blood"},{"key":"R24-10-20210126","doi-asserted-by":"crossref","first-page":"1698","DOI":"10.1046\/j.1460-9568.1999.00590.x","article-title":"Neutralization of endogenous NGF prevents the sensitization of nociceptors supplying inflamed skin.","volume":"11","author":"Koltzenburg","year":"1999","journal-title":"Eur J Neurosci"},{"key":"R25-10-20210126","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1111\/j.1365-2036.2011.04629.x","article-title":"Randomised clinical trial: the efficacy of a transient receptor potential vanilloid 1 antagonist AZD1386 in human oesophageal pain.","volume":"33","author":"Krarup","year":"2011","journal-title":"Aliment Pharmacol Ther"},{"key":"R26-10-20210126","doi-asserted-by":"crossref","first-page":"2834","DOI":"10.1182\/blood.V78.11.2834.2834","article-title":"Proliferation of human myeloid leukemia cell line associated with the tyrosine-phosphorylation and activation of the proto-oncogene c-kit product.","volume":"78","author":"Kuriu","year":"1991","journal-title":"Blood"},{"key":"R27-10-20210126","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/0166-2236(93)90092-Z","article-title":"Nerve growth factor and nociception.","volume":"16","author":"Lewin","year":"1993","journal-title":"Trends Neurosci"},{"key":"R28-10-20210126","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1111\/ejn.12466","article-title":"Pro-neurotrophins, sortilin, and nociception.","volume":"39","author":"Lewin","year":"2014","journal-title":"Eur J Neurosci"},{"key":"R29-10-20210126","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/j.neuron.2007.04.027","article-title":"A hierarchical NGF signaling cascade controls Ret-dependent and Ret-independent events during development of nonpeptidergic DRG neurons.","volume":"54","author":"Luo","year":"2007","journal-title":"Neuron"},{"key":"R30-10-20210126","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/1744-8069-5-23","article-title":"Intrathecal delivery of PDGF produces tactile allodynia through its receptors in spinal microglia.","volume":"5","author":"Masuda","year":"2009","journal-title":"Mol Pain"},{"key":"R31-10-20210126","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1016\/j.neuron.2007.10.040","article-title":"Nociceptive tuning by stem cell factorc-Kit signaling.","volume":"56","author":"Milenkovic","year":"2007","journal-title":"Neuron"},{"key":"R32-10-20210126","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1038\/nrd3871","article-title":"Protein kinase C, an elusive therapeutic target?","volume":"11","author":"Mochly-Rosen","year":"2012","journal-title":"Nat Rev Drug Discov"},{"key":"R33-10-20210126","doi-asserted-by":"crossref","first-page":"10000","DOI":"10.1523\/JNEUROSCI.2507-05.2005","article-title":"Protease-activated receptor-1 and platelet-derived growth factor in spinal cord neurons are implicated in neuropathic pain after nerve injury.","volume":"25","author":"Narita","year":"2005","journal-title":"J Neurosci"},{"key":"R34-10-20210126","doi-asserted-by":"crossref","first-page":"2525","DOI":"10.1158\/1078-0432.CCR-03-0155","article-title":"Plasma and cerebrospinal fluid pharmacokinetics of imatinib after administration to nonhuman primates.","volume":"10","author":"Neville","year":"2004","journal-title":"Clin Cancer Res"},{"key":"R35-10-20210126","doi-asserted-by":"crossref","first-page":"3041","DOI":"10.1093\/brain\/awm233","article-title":"Heritability of responses to painful stimuli in women: a classical twin study.","volume":"130","author":"Norbury","year":"2007","journal-title":"Brain"},{"key":"R37-10-20210126","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1182\/blood.V80.5.1199.1199","article-title":"Effects of human stem cell factor (c-kit ligand) on proliferation of myeloid leukemia cells: heterogeneity in response and synergy with other hematopoietic growth factors.","volume":"80","author":"Pietsch","year":"1992","journal-title":"Blood"},{"key":"R38-10-20210126","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.drugalcdep.2005.09.007","article-title":"Opioids and abnormal pain perception: new evidence from a study of chronic opioid addicts and healthy subjects.","volume":"82","author":"Pud","year":"2006","journal-title":"Drug Alcohol Depend"},{"key":"R39-10-20210126","doi-asserted-by":"crossref","first-page":"4055","DOI":"10.1182\/blood-2007-07-102061","article-title":"Chemical proteomic profiles of the BCR-ABL inhibitors imatinib, nilotinib, and dasatinib reveal novel kinase and nonkinase targets.","volume":"110","author":"Rix","year":"2007","journal-title":"Blood"},{"key":"R40-10-20210126","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1111\/j.1365-2125.2011.04040.x","article-title":"An investigation of the safety and pharmacokinetics of the novel TRPV1 antagonist XEN-D0501 in healthy subjects.","volume":"72","author":"Round","year":"2011","journal-title":"Br J Clin Pharmacol"},{"key":"R41-10-20210126","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1016\/j.pain.2011.01.051","article-title":"Oral and cutaneous thermosensory profile of selective TRPV1 inhibition by ABT-102 in a randomized healthy volunteer trial.","volume":"152","author":"Rowbotham","year":"2011","journal-title":"PAIN"},{"key":"R42-10-20210126","first-page":"8118","article-title":"KIT activation is a ubiquitous feature of gastrointestinal stromal tumors.","volume":"61","author":"Rubin","year":"2001","journal-title":"Cancer Res"},{"key":"R43-10-20210126","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.pain.2009.11.022","article-title":"NGF induces non-inflammatory localized and lasting mechanical and thermal hypersensitivity in human skin.","volume":"148","author":"Rukwied","year":"2010","journal-title":"PAIN"},{"key":"R44-10-20210126","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1056\/NEJM199904293401706","article-title":"Chronic myeloid leukemia.","volume":"340","author":"Sawyers","year":"1999","journal-title":"N Engl J Med"},{"key":"R45-10-20210126","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.neubiorev.2009.10.003","article-title":"Thermoreceptors and thermosensitive afferents.","volume":"34","author":"Schepers","year":"2010","journal-title":"Neurosci Biobehav Rev"},{"key":"R46-10-20210126","doi-asserted-by":"crossref","first-page":"2931","DOI":"10.1152\/jn.2001.86.6.2931","article-title":"Acute sensitization by NGF of the response of small-diameter sensory neurons to capsaicin.","volume":"86","author":"Shu","year":"2001","journal-title":"J Neurophysiol"},{"key":"R47-10-20210126","doi-asserted-by":"crossref","first-page":"7693","DOI":"10.1073\/pnas.96.14.7693","article-title":"Neurotrophins and hyperalgesia.","volume":"96","author":"Shu","year":"1999","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R48-10-20210126","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/0304-3940(96)12838-X","article-title":"Excitation of rat cutaneous nociceptors by noxious cold.","volume":"213","author":"Simone","year":"1996","journal-title":"Neurosci Lett"},{"key":"R49-10-20210126","doi-asserted-by":"crossref","first-page":"2049","DOI":"10.1152\/jn.1997.77.4.2049","article-title":"Responses of cutaneous A-fiber nociceptors to noxious cold.","volume":"77","author":"Simone","year":"1997","journal-title":"J Neurophysiol"},{"key":"R50-10-20210126","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/S0896-6273(00)81003-X","article-title":"Tackling pain at the source: new ideas about nociceptors.","volume":"20","author":"Snider","year":"1998","journal-title":"Neuron"},{"key":"R51-10-20210126","doi-asserted-by":"crossref","first-page":"2351","DOI":"10.3109\/10428194.2012.695779","article-title":"Off-target effects of BCR-ABL1 inhibitors and their potential long-term implications in patients with chronic myeloid leukemia.","volume":"53","author":"Steegmann","year":"2012","journal-title":"Leuk Lymphoma"},{"key":"R52-10-20210126","doi-asserted-by":"crossref","first-page":"6497","DOI":"10.1523\/JNEUROSCI.19-15-06497.1999","article-title":"Isolectin B(4)-positive and -negative nociceptors are functionally distinct.","volume":"19","author":"Stucky","year":"1999","journal-title":"J Neurosci"},{"key":"R53-10-20210126","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1113\/jphysiol.2002.027656","article-title":"GFR alpha2neurturin signalling regulates noxious heat transduction in isolectin B4-binding mouse sensory neurons.","volume":"545","author":"Stucky","year":"2002","journal-title":"J Physiol (Lond)"},{"key":"R54-10-20210126","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.pain.2009.04.011","article-title":"The c-kit signaling pathway is involved in the development of persistent pain.","volume":"144","author":"Sun","year":"2009","journal-title":"PAIN"},{"key":"R55-10-20210126","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.pain.2004.11.002","article-title":"Rofecoxib attenuates both primary and secondary inflammatory hyperalgesia: a randomized, double blinded, placebo controlled crossover trial in the UV-B pain model.","volume":"113","author":"Sycha","year":"2005","journal-title":"PAIN"},{"key":"R56-10-20210126","first-page":"4297","article-title":"Effect of c-kit mutation on prognosis of gastrointestinal stromal tumors.","volume":"59","author":"Taniguchi","year":"1999","journal-title":"Cancer Res"},{"key":"R57-10-20210126","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/0301-0082(92)90027-C","article-title":"Peripheral and central mechanisms of cutaneous hyperalgesia.","volume":"38","author":"Treede","year":"1992","journal-title":"Prog Neurobiol"},{"key":"R58-10-20210126","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1038\/nm.2633","article-title":"Blockade of PDGFR- activation eliminates morphine analgesic tolerance.","volume":"18","author":"Wang","year":"2012","journal-title":"Nat Med"},{"key":"R59-10-20210126","doi-asserted-by":"crossref","first-page":"4514","DOI":"10.1200\/JCO.2004.10.125","article-title":"Prevalence of KIT expression in human tumors.","volume":"22","author":"Went","year":"2004","journal-title":"J Clin Oncol"}],"container-title":["Pain"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/10.1016\/j.pain.2014.03.010","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,16]],"date-time":"2021-06-16T04:49:11Z","timestamp":1623818951000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/00006396-201407000-00010"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,7]]},"references-count":57,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2014]]}},"URL":"https:\/\/doi.org\/10.1016\/j.pain.2014.03.010","relation":{},"ISSN":["0304-3959"],"issn-type":[{"value":"0304-3959","type":"print"}],"subject":[],"published":{"date-parts":[[2014,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Inhibition of c-Kit signaling is associated with reduced heat and cold pain sensitivity in humans","name":"articletitle","label":"Article Title"},{"value":"PAIN\u00ae","name":"journaltitle","label":"Journal Title"},{"value":"http:\/\/dx.doi.org\/10.1016\/j.pain.2014.03.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 International Association for the Study of Pain. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}