{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,10]],"date-time":"2026-05-10T08:17:34Z","timestamp":1778401054335,"version":"3.51.4"},"reference-count":42,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","license":[{"start":{"date-parts":[[2014,7,1]],"date-time":"2014-07-01T00:00:00Z","timestamp":1404172800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["painjournalonline.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2014,7]]},"DOI":"10.1016\/j.pain.2014.04.004","type":"journal-article","created":{"date-parts":[[2014,4,8]],"date-time":"2014-04-08T16:15:26Z","timestamp":1396973726000},"page":"1293-1302","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":44,"title":["Lack of interleukin-17 leads to a modulated micro-environment and amelioration of mechanical hypersensitivity after peripheral nerve injury in mice"],"prefix":"10.1097","volume":"155","author":[{"given":"Yuan-Ji","family":"Day","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiin-Tarng","family":"Liou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiou-Mei","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi-Chiao","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chih-Chieh","family":"Mao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"An-Hsun","family":"Chou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chia-Chih","family":"Liao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hung-Chen","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"R1-19-20210126","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1111\/1523-1747.ep12506462","article-title":"Measurement of cutaneous inflammation: estimation of neutrophil content with an enzyme marker.","volume":"78","author":"Bradley","year":"1982","journal-title":"J Invest Dermatol"},{"key":"R2-19-20210126","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1172\/JCI119506","article-title":"Immune cell-derived beta-endorphin. Production, release, and control of inflammatory pain in rats.","volume":"100","author":"Cabot","year":"1997","journal-title":"J Clin Invest"},{"key":"R3-19-20210126","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1038\/nn.3144","article-title":"Neurogenic inflammation and the peripheral nervous system in host defense and immunopathology.","volume":"15","author":"Chiu","year":"2012","journal-title":"Nat Neurosci"},{"key":"R4-19-20210126","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.ejpain.2010.07.012","article-title":"Chronic blockade of interleukin-1 (IL-1) prevents and attenuates neuropathic pain behavior and spontaneous ectopic neuronal activity following nerve injury.","volume":"15","author":"Gabay","year":"2011","journal-title":"Eur J Pain"},{"key":"R5-19-20210126","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1080\/08820130802457503","article-title":"Myeloperoxidase as inflammatory marker of periodontal disease: experimental study in rats.","volume":"38","author":"Gomes","year":"2009","journal-title":"Immunol Invest"},{"key":"R6-19-20210126","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.exppara.2008.11.004","article-title":"Leishmania major: interleukin-13 increases the infection-induced hyperalgesia and the levels of interleukin-1beta and interleukin-12 in rats.","volume":"121","author":"Haber","year":"2009","journal-title":"Exp Parasitol"},{"key":"R7-19-20210126","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1111\/j.1365-2249.2006.03028.x","article-title":"Balance of inflammatory response in stable gingivitis and progressive periodontitis lesions.","volume":"144","author":"Honda","year":"2006","journal-title":"Clin Exp Immunol"},{"key":"R8-19-20210126","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1111\/j.1600-065X.2008.00699.x","article-title":"The roles of IL-17A in inflammatory immune responses and host defense against pathogens.","volume":"226","author":"Iwakura","year":"2008","journal-title":"Immunol Rev"},{"key":"R9-19-20210126","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/j.jpain.2010.08.003","article-title":"Interleukin-17 contributes to neuroinflammation and neuropathic pain following peripheral nerve injury in mice.","volume":"12","author":"Kim","year":"2011","journal-title":"J Pain"},{"key":"R10-19-20210126","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.bbi.2007.07.009","article-title":"IL-1 beta signaling is required for mechanical allodynia induced by nerve injury and for the ensuing reduction in spinal cord neuronal GRK2.","volume":"22","author":"Kleibeuker","year":"2008","journal-title":"Brain Behav Immun"},{"key":"R11-19-20210126","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1016\/j.expneurol.2006.03.014","article-title":"T cell infiltration after chronic constriction injury of mouse sciatic nerve is associated with interleukin-17 expression.","volume":"200","author":"Kleinschnitz","year":"2006","journal-title":"Exp Neurol"},{"key":"R12-19-20210126","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1146\/annurev.immunol.021908.132710","article-title":"IL-17 and Th17 cells.","volume":"27","author":"Korn","year":"2009","journal-title":"Annu Rev Immunol"},{"key":"R13-19-20210126","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1016\/0016-5085(84)90202-6","article-title":"Quantitative assay for acute intestinal inflammation based on myeloperoxidase activity. Assessment of inflammation in rat and hamster models.","volume":"87","author":"Krawisz","year":"1984","journal-title":"Gastroenterology"},{"key":"R14-19-20210126","doi-asserted-by":"crossref","first-page":"2150","DOI":"10.1016\/j.pain.2013.06.042","article-title":"P-selectin is required for neutrophils and macrophage infiltration into injured site and contributes to generation of behavioral hypersensitivity following peripheral nerve injury in mice.","volume":"154","author":"Liou","year":"2013","journal-title":"PAIN"},{"key":"R15-19-20210126","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.jneuroim.2010.10.014","article-title":"Exogenous granulocyte colony-stimulating factor exacerbate pain-related behaviors after peripheral nerve injury.","volume":"232","author":"Liou","year":"2011","journal-title":"J Neuroimmunol"},{"key":"R16-19-20210126","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1016\/j.pain.2012.03.008","article-title":"Absence of C-C motif chemokine ligand 5 in mice leads to decreased local macrophage recruitment and behavioral hypersensitivity in a murine neuropathic pain model.","volume":"153","author":"Liou","year":"2012","journal-title":"PAIN"},{"key":"R17-19-20210126","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1097\/ALN.0b013e31820b8b1e","article-title":"Inflammation confers dual effects on nociceptive processing in a chronic neuropathic pain model.","volume":"114","author":"Liou","year":"2010","journal-title":"Anesthesiology"},{"key":"R18-19-20210126","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1006\/abio.1993.1504","article-title":"A fluorescence-based protein assay for use with a microplate reader.","volume":"214","author":"Lorenzen","year":"1993","journal-title":"Anal Biochem"},{"key":"R19-19-20210126","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1179\/016164107X204738","article-title":"Bumetanide administration attenuated traumatic brain injury through IL-1 overexpression.","volume":"29","author":"Lu","year":"2007","journal-title":"Neurol Res"},{"key":"R20-19-20210126","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S0165-5728(97)00081-7","article-title":"Pro-opiomelanocortin gene expression and protein processing in rat mononuclear leukocytes.","volume":"78","author":"Lyons","year":"1997","journal-title":"J Neuroimmunol"},{"key":"R21-19-20210126","doi-asserted-by":"crossref","first-page":"1838","DOI":"10.1016\/j.pain.2011.03.035","article-title":"IL-17 induces hyperalgesia via TNF-dependent neutrophil infiltration.","volume":"152","author":"McNamee","year":"2011","journal-title":"PAIN"},{"key":"R22-19-20210126","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/S0165-5728(02)00049-8","article-title":"Immunohistochemical localization of endomorphin-1 and endomorphin-2 in immune cells and spinal cord in a model of inflammatory pain.","volume":"126","author":"Mousa","year":"2002","journal-title":"J Neuroimmunol"},{"key":"R23-19-20210126","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.neulet.2011.01.079","article-title":"Interleukin-17 levels in rat models of nerve damage and neuropathic pain.","volume":"493","author":"Noma","year":"2011","journal-title":"Neurosci Lett"},{"key":"R24-19-20210126","doi-asserted-by":"crossref","first-page":"1662","DOI":"10.1002\/hep.24253","article-title":"Paneth cell-derived interleukin-17A causes multiorgan dysfunction after hepatic ischemia and reperfusion injury.","volume":"53","author":"Park","year":"2011","journal-title":"Hepatology"},{"key":"R25-19-20210126","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.pain.2009.11.006","article-title":"IL-17 mediates articular hypernociception in antigen-induced arthritis in mice.","volume":"148","author":"Pinto","year":"2010","journal-title":"PAIN"},{"key":"R26-19-20210126","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1093\/brain\/awm041","article-title":"Promoting anatomical plasticity and recovery of function after traumatic injury to the central or peripheral nervous system.","volume":"130","author":"Priestley","year":"2007","journal-title":"Brain"},{"key":"R27-19-20210126","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S0987-7053(00)88865-6","article-title":"Neurophysiological studies of thin myelinated (A delta) and unmyelinated (C) fibers: application to peripheral neuropathies.","volume":"30","author":"Santiago","year":"2000","journal-title":"Neurophysiol Clin"},{"key":"R28-19-20210126","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1097\/00000542-200301000-00030","article-title":"Modulation of peripheral endogenous opioid analgesia by central afferent blockade.","volume":"98","author":"Schmitt","year":"2003","journal-title":"Anesthesiology"},{"key":"R29-19-20210126","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1038\/nm.1999","article-title":"Pivotal role of cerebral interleukin-17-producing gammadeltaT cells in the delayed phase of ischemic brain injury.","volume":"15","author":"Shichita","year":"2009","journal-title":"Nat Med"},{"key":"R30-19-20210126","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1038\/nm.3045","article-title":"Dual role of immunomodulation by anticancer chemotherapy.","volume":"19","author":"Shurin","year":"2013","journal-title":"Nat Med"},{"key":"R31-19-20210126","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.jneuroim.2006.11.033","article-title":"Lymphocytes upregulate signal sequence-encoding proopiomelanocortin mRNA and beta-endorphin during painful inflammation in vivo.","volume":"183","author":"Sitte","year":"2007","journal-title":"J Neuroimmunol"},{"key":"R32-19-20210126","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.bbi.2008.09.004","article-title":"Anti-inflammatory cytokine gene therapy decreases sensory and motor dysfunction in experimental multiple sclerosis: MOG-EAE behavioral and anatomical symptom treatment with cytokine gene therapy.","volume":"23","author":"Sloane","year":"2009","journal-title":"Brain Behav Immun"},{"key":"R33-19-20210126","doi-asserted-by":"crossref","first-page":"1873","DOI":"10.1016\/S0024-3205(03)00549-6","article-title":"Opioid receptor interactions: local and nonlocal, symmetric and asymmetric, physical and functional.","volume":"73","author":"Smith","year":"2003","journal-title":"Life Sci"},{"key":"R34-19-20210126","doi-asserted-by":"crossref","first-page":"4759","DOI":"10.4049\/jimmunol.170.9.4759","article-title":"IL-1-driven endogenous IL-10 production protects against the systemic and local acute inflammatory response following intestinal reperfusion injury.","volume":"170","author":"Souza","year":"2003","journal-title":"J Immunol"},{"key":"R35-19-20210126","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/S0165-5728(03)00126-7","article-title":"Evidence for endogenous interleukin-10 during nociception.","volume":"139","author":"Tu","year":"2003","journal-title":"J Neuroimmunol"},{"key":"R36-19-20210126","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1126\/science.178.4063.871","article-title":"Fluorescamine: a reagent for assay of amino acids, peptides, proteins, and primary amines in the picomole range.","volume":"178","author":"Udenfriend","year":"1972","journal-title":"Science"},{"key":"R37-19-20210126","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/j.cytogfr.2010.10.003","article-title":"Interleukin 17 in vascular inflammation.","volume":"21","author":"von Vietinghoff","year":"2010","journal-title":"Cytokine Growth Factor Rev"},{"key":"R38-19-20210126","doi-asserted-by":"crossref","first-page":"10265","DOI":"10.1074\/jbc.M110.188268","article-title":"Cortisol synthesis in epidermis is induced by IL-1 and tissue injury.","volume":"286","author":"Vukelic","year":"2011","journal-title":"J Biol Chem"},{"key":"R39-19-20210126","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1002\/art.30139","article-title":"Anti-interleukin-17 therapy for degenerated and herniated human intervertebral disc tissues? Comment on the article by Shamji MF, Setton LA, Jarvis W, So S, Chen J, Jing L.","volume":"63","author":"Wang","year":"2011","journal-title":"Arthritis Rheum"},{"key":"R40-19-20210126","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/j.bbi.2006.12.001","article-title":"Immune and glial regulation of pain.","volume":"21","author":"Watkins","year":"2007","journal-title":"Brain Behav Immun"},{"key":"R41-19-20210126","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1152\/physrev.00011.2002","article-title":"Beyond neurons: evidence that immune and glial cells contribute to pathological pain states.","volume":"82","author":"Watkins","year":"2002","journal-title":"Physiol Rev"},{"key":"R42-19-20210126","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/0304-3959(83)90201-4","article-title":"Ethical guidelines for investigations of experimental pain in conscious animals.","volume":"16","author":"Zimmermann","year":"1983","journal-title":"PAIN"}],"container-title":["Pain"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/10.1016\/j.pain.2014.04.004","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,16]],"date-time":"2021-06-16T04:49:20Z","timestamp":1623818960000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/00006396-201407000-00019"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,7]]},"references-count":42,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2014]]}},"URL":"https:\/\/doi.org\/10.1016\/j.pain.2014.04.004","relation":{},"ISSN":["0304-3959"],"issn-type":[{"value":"0304-3959","type":"print"}],"subject":[],"published":{"date-parts":[[2014,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Lack of interleukin-17 leads to a modulated micro-environment and amelioration of mechanical hypersensitivity after peripheral nerve injury in mice","name":"articletitle","label":"Article Title"},{"value":"PAIN\u00ae","name":"journaltitle","label":"Journal Title"},{"value":"http:\/\/dx.doi.org\/10.1016\/j.pain.2014.04.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 International Association for the Study of Pain. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}