{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:39:36Z","timestamp":1792784376467,"version":"4.5.0"},"reference-count":52,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","license":[{"start":{"date-parts":[[2014,10,1]],"date-time":"2014-10-01T00:00:00Z","timestamp":1412121600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Italian Ministry of Instruction, University and Research (MIUR)"},{"DOI":"10.13039\/501100004434","name":"University of Florence","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004434","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["GM48677"],"award-info":[{"award-number":["GM48677"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["GM103801"],"award-info":[{"award-number":["GM103801"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["painjournalonline.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2014,10]]},"DOI":"10.1016\/j.pain.2014.06.023","type":"journal-article","created":{"date-parts":[[2014,7,5]],"date-time":"2014-07-05T05:02:12Z","timestamp":1404536532000},"page":"1986-1995","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":106,"title":["\u03b1-Conotoxin RgIA protects against the development of nerve injury-induced chronic pain and prevents both neuronal and glial derangement"],"prefix":"10.1097","volume":"155","author":[{"given":"Lorenzo","family":"Di Cesare Mannelli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenzo","family":"Cinci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Micheli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Zanardelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Pacini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"McIntosh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla","family":"Ghelardini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-15-20210126","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1152\/physrev.00015.2008","article-title":"Mammalian nicotinic acetylcholine receptors: from structure to function.","volume":"89","author":"Albuquerque","year":"2009","journal-title":"Physiol Rev"},{"key":"R2-15-20210126","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1055\/s-0032-1329204","article-title":"Neuropathic pain therapy: from bench to bedside.","volume":"32","author":"Backonja","year":"2012","journal-title":"Semin Neurol"},{"key":"R3-15-20210126","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1126\/science.279.5347.77","article-title":"Broad-spectrum, non-opioid analgesic activity by selective modulation of neuronal nicotinic acetylcholine receptors.","volume":"279","author":"Bannon","year":"1998","journal-title":"Science"},{"key":"R4-15-20210126","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1016\/S1474-4422(10)70143-5","article-title":"Neuropathic pain: diagnosis, pathophysiological mechanisms, and treatment.","volume":"9","author":"Baron","year":"2010","journal-title":"Lancet Neurol"},{"key":"R5-15-20210126","doi-asserted-by":"crossref","first-page":"119","DOI":"10.2174\/157488911795933901","article-title":"Analgesic and antineuropathic drugs acting through central cholinergic mechanisms.","volume":"6","author":"Bartolini","year":"2011","journal-title":"Rec Pat CNS Drug Disc"},{"key":"R6-15-20210126","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/0304-3959(88)90209-6","article-title":"A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man.","volume":"33","author":"Bennett","year":"1988","journal-title":"PAIN"},{"key":"R7-15-20210126","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1213\/ane.0b013e3181813508","article-title":"Nicotine and postoperative management of pain.","volume":"107","author":"Benowitz","year":"2008","journal-title":"Anesth Analg"},{"key":"R8-15-20210126","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1016\/j.nurt.2009.07.001","article-title":"Targeting neuroprotection as an alternative approach to preventing and treating neuropathic pain.","volume":"6","author":"Bordet","year":"2009","journal-title":"Neurotherapeutics"},{"key":"R9-15-20210126","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1016\/S1063-4584(03)00163-8","article-title":"Weight bearing as a measure of disease progression and efficacy of anti-inflammatory compounds in a model of monosodium iodoacetate-induced osteoarthritis.","volume":"11","author":"Bove","year":"2003","journal-title":"Osteoarthritis Cartilage"},{"key":"R10-15-20210126","first-page":"218","article-title":"Motor dysfunction and reflex sympathetic dystrophy. Bilateral motor denervation in an experimental model.","volume":"64","author":"Bullens","year":"1998","journal-title":"Acta Orthop Belg"},{"key":"R11-15-20210126","doi-asserted-by":"crossref","first-page":"51","DOI":"10.4161\/chan.4.1.10281","article-title":"Analgesic -conotoxins Vc1.1 and RgIA inhibit N-type calcium channels in sensory neurons of 9 nicotinic receptor knockout mice.","volume":"4","author":"Callaghan","year":"2010","journal-title":"Channels"},{"key":"R13-15-20210126","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/S0304-3959(00)00331-6","article-title":"Possible role of inflammatory mediators in tactile hypersensitivity in rat models of mononeuropathy.","volume":"88","author":"Cui","year":"2000","journal-title":"PAIN"},{"key":"R14-15-20210126","doi-asserted-by":"crossref","first-page":"328797","DOI":"10.1155\/2013\/328797","article-title":"Palmitoylethanolamide is a disease-modifying agent in peripheral neuropathy: pain relief and neuroprotection share a PPAR-alpha-mediated mechanism.","volume":"2013","author":"Di Cesare Mannelli","year":"2013","journal-title":"Mediators Inflamm"},{"key":"R15-15-20210126","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1002\/jnr.21815","article-title":"Neuroprotective effects of acetyl-L-carnitine on neuropathic pain and apoptosis: a role for the nicotinic receptor.","volume":"87","author":"Di Cesare Mannelli","year":"2009","journal-title":"J Neurosci Res"},{"key":"R16-15-20210126","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.1016\/j.jpain.2013.08.002","article-title":"Morphological features and glia involvement in rat oxaliplatin-dependent neuropathic pain.","volume":"14","author":"Di Cesare Mannelli","year":"2013","journal-title":"J Pain"},{"key":"R17-15-20210126","first-page":"37","article-title":"Involvement of 7 nAChR subtype in rat oxaliplatin-induced neuropathy: effects of selective activation.","volume":"79C","author":"Di Cesare Mannelli","year":"2013","journal-title":"Neuropharmacology"},{"key":"R18-15-20210126","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.ejphar.2013.04.022","article-title":"Nicotine is a pain reliever in trauma- and chemotherapy-induced neuropathy models.","volume":"711","author":"Di Cesare Mannelli","year":"2013","journal-title":"Eur J Pharmacol"},{"key":"R19-15-20210126","doi-asserted-by":"crossref","first-page":"2407","DOI":"10.4049\/jimmunol.141.7.2407","article-title":"Release of reactive nitrogen intermediates and reactive oxygen intermediates from mouse peritoneal macrophages. Comparison of activating cytokines and evidence for independent production.","volume":"141","author":"Ding","year":"1988","journal-title":"J Immunol"},{"key":"R20-15-20210126","doi-asserted-by":"crossref","first-page":"5754","DOI":"10.1523\/JNEUROSCI.5007-09.2010","article-title":"SOCS3-Mediated blockade of JAKSTAT3 signaling pathway reveals its major contribution to spinal cord neuroinflammation and mechanical allodynia after peripheral nerve injury.","volume":"30","author":"Dominguez","year":"2010","journal-title":"J Neurosci"},{"key":"R21-15-20210126","doi-asserted-by":"crossref","first-page":"10819","DOI":"10.1523\/JNEUROSCI.1642-11.2011","article-title":"Peripheral nerve injury alters blood-spinal cord barrier functional and molecular integrity through a selective inflammatory pathway.","volume":"31","author":"Echeverry","year":"2011","journal-title":"J Neurosci"},{"key":"R22-15-20210126","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/0092-8674(94)90555-X","article-title":"Alpha9: an acetylcholine receptor with novel pharmacological properties expressed in rat cochlear hair cells.","volume":"79","author":"Elgoyhen","year":"1994","journal-title":"Cell"},{"key":"R23-15-20210126","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1016\/j.bcp.2009.05.023","article-title":"The nicotinic receptor of cochlear hair cells: a possible pharmacotherapeutic target?","volume":"78","author":"Elgoyhen","year":"2009","journal-title":"Biochem Pharmacol"},{"key":"R24-15-20210126","doi-asserted-by":"crossref","first-page":"3501","DOI":"10.1073\/pnas.051622798","article-title":"Alpha10: a determinant of nicotinic cholinergic receptor function in mammalian vestibular and cochlear mechanosensory hair cells.","volume":"98","author":"Elgoyhen","year":"2001","journal-title":"Proc Natl Acad Sci USA"},{"key":"R25-15-20210126","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1021\/bi0520129","article-title":"Alpha-RgIA: a novel conotoxin that specifically and potently blocks the alpha9alpha10 nAChR.","volume":"45","author":"Ellison","year":"2006","journal-title":"Biochemistry"},{"key":"R26-15-20210126","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1016\/j.bcp.2004.06.037","article-title":"GABA(B) receptor alterations as indicators of physiological and pharmacological function.","volume":"68","author":"Enna","year":"2004","journal-title":"Biochem Pharmacol"},{"key":"R27-15-20210126","doi-asserted-by":"crossref","first-page":"351","DOI":"10.33549\/physiolres.930513","article-title":"GABAB receptor agonist baclofen has non-specific antinociceptive effect in the model of peripheral neuropathy in the rat.","volume":"53","author":"Franek","year":"2004","journal-title":"Physiol Res"},{"key":"R28-15-20210126","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.brainresrev.2008.12.007","article-title":"4th, Pin JP. Metabotropic receptors for glutamate and GABA in pain.","volume":"60","author":"Goudet","year":"2009","journal-title":"Brain Res Rev"},{"key":"R29-15-20210126","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.autneu.2004.05.008","article-title":"Nicotinic acetylcholine receptor subtypes in nociceptive dorsal root ganglion neurons of the adult rat.","volume":"113","author":"Haberberger","year":"2004","journal-title":"Auton Neurosci"},{"key":"R30-15-20210126","doi-asserted-by":"crossref","first-page":"2204","DOI":"10.1016\/j.pain.2011.06.017","article-title":"A new definition of neuropathic pain.","volume":"152","author":"Jensen","year":"2011","journal-title":"PAIN"},{"key":"R31-15-20210126","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1002\/jnr.10022","article-title":"Relationship between the increased cell surface alpha7 nicotinic receptor expression and neuroprotection induced by several nicotinic receptor agonists.","volume":"66","author":"Jonnala","year":"2001","journal-title":"J Neurosci Res"},{"key":"R32-15-20210126","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/j.lfs.2003.09.037","article-title":"The lymphocytic cholinergic system and its contribution to the regulation of immune activity.","volume":"74","author":"Kawashima","year":"2003","journal-title":"Life Sci"},{"key":"R33-15-20210126","doi-asserted-by":"crossref","first-page":"13435","DOI":"10.1523\/JNEUROSCI.3257-09.2009","article-title":"Identification of two distinct macrophage subsets with divergent effects causing either neurotoxicity or regeneration in the injured mouse spinal cord.","volume":"29","author":"Kigerl","year":"2009","journal-title":"J Neurosci"},{"key":"R34-15-20210126","doi-asserted-by":"crossref","first-page":"14975","DOI":"10.1074\/jbc.M607277200","article-title":"A critical role of toll-like receptor 2 in nerve injury-induced spinal cord glial cell activation and pain hypersensitivity.","volume":"282","author":"Kim","year":"2007","journal-title":"J Biol Chem"},{"key":"R35-15-20210126","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1111\/j.1476-5381.1988.tb10310.x","article-title":"k-Opioid agonist produce antinociception after i.v. and i.c.v. but not intrathecal administration in the rat.","volume":"93","author":"Leighton","year":"1988","journal-title":"Br J Pharmacol"},{"key":"R36-15-20210126","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1016\/j.toxicon.2006.07.023","article-title":"Therapeutic applications of conotoxins that target the neuronal nicotinic acetylcholine receptor.","volume":"48","author":"Livett","year":"2006","journal-title":"Toxicon"},{"key":"R37-15-20210126","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1016\/j.jpain.2012.08.009","article-title":"Systemic administration of an alpha-7 nicotinic acetylcholine agonist reverses neuropathic pain in male Sprague Dawley rats.","volume":"13","author":"Loram","year":"2012","journal-title":"J Pain"},{"key":"R38-15-20210126","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.nbd.2009.09.021","article-title":"1-(2,4-dichlorophenyl)-6-methyl-N-cyclohexylamine-1,4-dihydroindeno1,2-cpyrazole-3-carboxamide, a novel CB2 agonist, alleviates neuropathic pain through functional microglial changes in mice.","volume":"37","author":"Luongo","year":"2010","journal-title":"Neurobiol Dis"},{"key":"R39-15-20210126","doi-asserted-by":"crossref","first-page":"10838","DOI":"10.1523\/JNEUROSCI.22-24-10838.2002","article-title":"Efferent protection from acoustic injury is mediated via alpha9 nicotinic acetylcholine receptors on outer hair cells.","volume":"22","author":"Maison","year":"2002","journal-title":"J Neurosci"},{"key":"R40-15-20210126","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/j.bcp.2009.05.020","article-title":"Alpha9 nicotinic acetylcholine receptors and the treatment of pain.","volume":"78","author":"McIntosh","year":"2009","journal-title":"Biochem Pharmacol"},{"key":"R42-15-20210126","doi-asserted-by":"crossref","first-page":"2202","DOI":"10.1016\/j.neuropharm.2012.01.016","article-title":"Intrathecal -conotoxins Vc1.1, AuIB and MII acting on distinct nicotinic receptor subtypes reverse signs of neuropathic pain.","volume":"62","author":"Napier","year":"2012","journal-title":"Neuropharmacol"},{"key":"R43-15-20210126","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1007\/s10162-012-0365-9","article-title":"Endothelial cell, pericyte, and perivascular resident macrophage-type melanocyte interactions regulate cochlear intrastrial fluid-blood barrier permeability.","volume":"14","author":"Neng","year":"2013","journal-title":"J Assoc Res Otolaryngol"},{"key":"R44-15-20210126","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1016\/j.pain.2010.06.014","article-title":"Protective effect of alpha7 nAChR: behavioural and morphological features on neuropathy.","volume":"150","author":"Pacini","year":"2010","journal-title":"PAIN"},{"key":"R45-15-20210126","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.pain.2009.06.013","article-title":"A randomized, double-blind, placebo-controlled trial evaluating the efficacy and safety of ABT-594 in patients with diabetic peripheral neuropathic pain.","volume":"146","author":"Rowbotham","year":"2009","journal-title":"PAIN"},{"key":"R46-15-20210126","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.pain.2009.09.003","article-title":"Oxaliplatin-induced neuropathy in the rat: involvement of oxalate in cold hyperalgesia but not mechanical allodynia.","volume":"147","author":"Sakurai","year":"2009","journal-title":"PAIN"},{"key":"R47-15-20210126","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.brainres.2005.08.009","article-title":"Alphaconotoxin Vc1.1 alleviates neuropathic pain and accelerates functional recovery of injured neurones.","volume":"1059","author":"Satkunanathan","year":"2005","journal-title":"Brain Res"},{"key":"R48-15-20210126","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1038\/nn1992","article-title":"The neuropathic pain triad: neurons, immune cells and glia.","volume":"10","author":"Scholz","year":"2007","journal-title":"Nat Neurosci"},{"key":"R50-15-20210126","doi-asserted-by":"crossref","first-page":"2074","DOI":"10.1002\/jnr.23101","article-title":"Possible neuroprotective property of nicotinic acetylcholine receptors in association with predominant upregulation of glial cell line-derived neurotrophic factor in astrocytes.","volume":"90","author":"Takarada","year":"2012","journal-title":"J Neurosci Res"},{"key":"R51-15-20210126","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1038\/nrd1797","article-title":"The vagus nerve and the nicotinic anti-inflammatory pathway.","volume":"4","author":"Ulloa","year":"2005","journal-title":"Nat Rev Drug Discov"},{"key":"R52-15-20210126","doi-asserted-by":"crossref","first-page":"17880","DOI":"10.1073\/pnas.0608715103","article-title":"Molecular mechanism for analgesia involving specific antagonism of alpha9alpha10 nicotinic acetylcholine receptors.","volume":"103","author":"Vincler","year":"2006","journal-title":"Proc Natl Acad Sci USA"},{"key":"R53-15-20210126","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1016\/j.neuron.2012.02.008","article-title":"Deconstructing the neuropathic pain phenotype to reveal neural mechanisms.","volume":"73","author":"von Hehn","year":"2012","journal-title":"Neuron"},{"key":"R54-15-20210126","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1213\/ANE.0b013e31825a3c72","article-title":"Novel small molecule 910 nicotinic receptor antagonist prevents and reverses chemotherapy-evoked neuropathic pain in rats.","volume":"115","author":"Wala","year":"2012","journal-title":"Anesth Analg"},{"key":"R55-15-20210126","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1038\/306686a0","article-title":"Evidence for a central component of post-injury pain hypersensitivity.","volume":"306","author":"Woolf","year":"1983","journal-title":"Nature"}],"container-title":["Pain"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/10.1016\/j.pain.2014.06.023","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,14]],"date-time":"2023-07-14T20:56:00Z","timestamp":1689368160000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/00006396-201410000-00015"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,10]]},"references-count":52,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2014]]}},"URL":"https:\/\/doi.org\/10.1016\/j.pain.2014.06.023","relation":{},"ISSN":["0304-3959"],"issn-type":[{"value":"0304-3959","type":"print"}],"subject":[],"published":{"date-parts":[[2014,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"\u03b1-Conotoxin RgIA protects against the development of nerve injury-induced chronic pain and prevents both neuronal and glial derangement","name":"articletitle","label":"Article Title"},{"value":"PAIN\u00ae","name":"journaltitle","label":"Journal Title"},{"value":"http:\/\/dx.doi.org\/10.1016\/j.pain.2014.06.023","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 International Association for the Study of Pain. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}