{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T18:24:24Z","timestamp":1790706264031,"version":"4.1.0"},"reference-count":40,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"12","license":[{"start":{"date-parts":[[2014,12,1]],"date-time":"2014-12-01T00:00:00Z","timestamp":1417392000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Ministry of Health of the Government","award":["EC11-387"],"award-info":[{"award-number":["EC11-387"]}]}],"content-domain":{"domain":["painjournalonline.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2014,12]]},"DOI":"10.1016\/j.pain.2014.09.004","type":"journal-article","created":{"date-parts":[[2014,9,16]],"date-time":"2014-09-16T04:08:50Z","timestamp":1410840530000},"page":"2517-2525","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":79,"title":["Efficacy of memantine in the treatment of fibromyalgia: A double-blind, randomised, controlled trial with 6-month follow-up"],"prefix":"10.1097","volume":"155","author":[{"given":"B\u00e1rbara","family":"Olivan-Bl\u00e1zquez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Herrera-Mercadal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Puebla-Guedea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mari-Cruz","family":"P\u00e9rez-Yus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Andr\u00e9s","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Fayed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yolanda","family":"L\u00f3pez-Del-Hoyo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa","family":"Magallon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miquel","family":"Roca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Garcia-Campayo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-13-20210126","first-page":"79","article-title":"La version espanola del EuroQol: descripcion y aplicaciones.","volume":"112","author":"Badia","year":"1999","journal-title":"Med Clin (Barc)"},{"key":"R2-13-20210126","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/j.semarthrit.2008.12.003","article-title":"Prevalence of fibromyalgia: a survey in five European countries.","volume":"39","author":"Branco","year":"2010","journal-title":"Semin Arthritis Rheum"},{"key":"R3-13-20210126","first-page":"16","article-title":"Drugs to treat fibromyalgia: the transatlantic difference.","volume":"11","author":"Briley","year":"2010","journal-title":"Curr Opin Invest Drugs"},{"key":"R4-13-20210126","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1001\/jama.2013.879","article-title":"Reporting of patient-reported outcomes in randomized trials: the CONSORT PRO extension.","volume":"309","author":"Calvert","year":"2013","journal-title":"JAMA"},{"key":"R6-13-20210126","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1523\/JNEUROSCI.08-01-00185.1988","article-title":"Pharmacology of glutamate neurotoxicity in cortical cell culture: attenuation by NMDA antagonists.","volume":"8","author":"Choi","year":"1988","journal-title":"J Neurosci"},{"key":"R7-13-20210126","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.pain.2009.08.019","article-title":"Interpreting the clinical importance of group differences in chronic pain clinical trials: IMMPACT recommendations.","volume":"146","author":"Dworkin","year":"2009","journal-title":"PAIN"},{"key":"R8-13-20210126","doi-asserted-by":"crossref","first-page":"R134","DOI":"10.1186\/ar3072","article-title":"Localized 1H-NMR spectroscopy in patients with fibromyalgia: a controlled study of changes in cerebral glutamateglutamine, inositol, choline, and N-acetylaspartate.","volume":"12","author":"Fayed","year":"2010","journal-title":"Arthritis Res Ther"},{"key":"R9-13-20210126","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1157\/13074161","article-title":"Pain in Spanish rheumatology outpatient offices: EPIDOR epidemiological study.","volume":"205","author":"Gamero Ruiz","year":"2005","journal-title":"Rev Clin Esp"},{"key":"R10-13-20210126","doi-asserted-by":"crossref","first-page":"R81","DOI":"10.1186\/ar2455","article-title":"Effectiveness of treatments for fibromyalgia depending of level of care: a meta-analysis.","volume":"10","author":"Garcia Campayo","year":"2008","journal-title":"Arthritis Res Ther"},{"key":"R11-13-20210126","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/S0163-8343(02)00205-0","article-title":"Topiramate as a treatment for pain in multisomatoform disorder patients: an open trial.","volume":"24","author":"Garcia-Campayo","year":"2002","journal-title":"Gen Hosp Psychiatry"},{"key":"R12-13-20210126","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.jpsychires.2012.09.015","article-title":"Memantine add-on in moderate to severe obsessive-compulsive disorder: randomized double-blind placebo-controlled study.","volume":"47","author":"Ghaleiha","year":"2013","journal-title":"J Psychiatr Res"},{"key":"R13-13-20210126","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1097\/YIC.0b013e32835c8c8c","article-title":"Memantine reduces stealing behavior and impulsivity in kleptomania: a pilot study.","volume":"28","author":"Grant","year":"2013","journal-title":"Int Clin Psychopharmacol"},{"key":"R15-13-20210126","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1186\/ar3136","article-title":"Elevated excitatory neurotransmitter levels in the fibromyalgia brain.","volume":"12","author":"Harris","year":"2010","journal-title":"Arthritis Res Ther"},{"key":"R16-13-20210126","doi-asserted-by":"crossref","first-page":"3146","DOI":"10.1002\/art.24849","article-title":"Elevated insular glutamate in fibromyalgia is associated with experimental pain.","volume":"60","author":"Harris","year":"2009","journal-title":"Arthritis Rheum"},{"key":"R17-13-20210126","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.coph.2005.09.007","article-title":"Mechanism of action of memantine.","volume":"6","author":"Johnson","year":"2006","journal-title":"Curr Opin Pharmacol"},{"key":"R18-13-20210126","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1002\/gps.2384","article-title":"A review comparing the safety and tolerability of memantine with the acetylcholinesterase inhibitors.","volume":"25","author":"Jones","year":"2010","journal-title":"Int J Geriatr Psychiatry"},{"key":"R19-13-20210126","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1016\/j.jpsychires.2013.04.013","article-title":"NMDA receptor antagonists interventions in schizophrenia: meta-analysis of randomized, placebo-controlled trials.","volume":"47","author":"Kishi","year":"2013","journal-title":"J Psychiatr Res"},{"key":"R20-13-20210126","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.jad.2011.09.040","article-title":"The sustained mood-stabilizing effect of memantine in the management of treatment resistant bipolar disorders: findings from a 12-month naturalistic trial.","volume":"136","author":"Koukopoulos","year":"2012","journal-title":"J Affect Disord"},{"key":"R21-13-20210126","doi-asserted-by":"crossref","first-page":"1728","DOI":"10.1056\/NEJM198806303182605","article-title":"An assessment of clinically useful measures of the consequences of treatment.","volume":"318","author":"Laupacis","year":"1988","journal-title":"N Engl J Med"},{"key":"R22-13-20210126","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1600-0447.1987.tb10566.x","article-title":"The UKU side effect rating scale. A new comprehensive rating scale for psychotropic drugs and a cross-sectional study of side effects in neuroleptic-treated patients.","volume":"334","author":"Lingjaerde","year":"1987","journal-title":"Acta Psychiatr Scand Suppl"},{"key":"R23-13-20210126","first-page":"767","article-title":"Revalidation and standardization of the cognition mini-exam (first Spanish version of the Mini-Mental Status Examination) in the general geriatric population.","volume":"112","author":"Lobo","year":"1999","journal-title":"Med Clin (Barc)"},{"key":"R24-13-20210126","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/S0304-3959(02)00456-6","article-title":"Efficacy of the NMDA-receptor antagonist memantine in patients with chronic phantom limb painresults of a randomized double-blinded, placebo-controlled trial.","volume":"103","author":"Maier","year":"2003","journal-title":"PAIN"},{"key":"R25-13-20210126","doi-asserted-by":"crossref","first-page":"c869","DOI":"10.1136\/bmj.c869","article-title":"CONSORT 2010 explanation and elaboration: updated guidelines for reporting parallel group randomised trials.","volume":"340","author":"Moher","year":"2010","journal-title":"BMJ"},{"key":"R26-13-20210126","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/j.ejphar.2013.06.020","article-title":"Memantine, a promising drug for the prevention of neuropathic pain in rat.","volume":"721","author":"Morel","year":"2013","journal-title":"Eur J Pharmacol"},{"key":"R27-13-20210126","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1159\/000343479","article-title":"Systematic review and meta-analysis of combination therapy with cholinesterase inhibitors and memantine in Alzheimers disease and other dementias.","volume":"2","author":"Muayqil","year":"2012","journal-title":"Dement Geriatr Cogn Disord Extra"},{"key":"R28-13-20210126","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1097\/00000539-200010000-00036","article-title":"Memantine (a N-methyl-d-aspartate receptor antagonist) in the treatment of neuropathic pain after amputation or surgery: a randomized, double-blinded, cross-over study.","volume":"91","author":"Nikolajsen","year":"2000","journal-title":"Anesth Analg"},{"key":"R29-13-20210126","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1136\/annrheumdis-2011-201249","article-title":"Comparative efficacy of pharmacological and non-pharmacological interventions in fibromyalgia syndrome: network meta-analysis.","volume":"72","author":"Nuesch","year":"2013","journal-title":"Ann Rheum Dis"},{"key":"R30-13-20210126","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/1745-6215-14-3","article-title":"Evaluation of the efficacy of memantine in the treatment of fibromyalgia: study protocol for a doubled-blind randomized controlled trial with six-month follow-up.","volume":"14","author":"Olivan-Blazquez","year":"2013","journal-title":"Trials"},{"key":"R31-13-20210126","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1358\/dot.2012.48.7.1832873","article-title":"Glutamatergic approaches in major depressive disorder: focus on ketamine, memantine and riluzole.","volume":"48","author":"Owen","year":"2012","journal-title":"Drugs Today (Barc)"},{"key":"R32-13-20210126","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.mehy.2009.01.052","article-title":"Combined use of pregabalin and memantine in fibromyalgia syndrome treatment: a novel analgesic and neuroprotective strategy?","volume":"73","author":"Recla","year":"2009","journal-title":"Med Hypotheses"},{"key":"R33-13-20210126","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1056\/NEJMoa013128","article-title":"Memantine in moderate-to-severe Alzheimers disease.","volume":"348","author":"Reisberg","year":"2003","journal-title":"N Engl J Med"},{"key":"R34-13-20210126","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1001\/archneur.63.1.49","article-title":"A 24-week open-label extension of memantine in moderate to severe Alzheimers disease.","volume":"63","author":"Reisberg","year":"2006","journal-title":"Arch Neurol"},{"key":"R35-13-20210126","first-page":"554","article-title":"The Fibromyalgia Impact Questionnaire: a validated Spanish version to assess the health status in women with fibromyalgia.","volume":"22","author":"Rivera","year":"2004","journal-title":"Clin Exp Rheumatol"},{"key":"R36-13-20210126","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1097\/AJP.0b013e31802f67a7","article-title":"Memantine treatment of complex regional pain syndrome: a preliminary report of six cases.","volume":"23","author":"Sinis","year":"2007","journal-title":"Clin J Pain"},{"key":"R37-13-20210126","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1038\/clpt.1983.159","article-title":"Studies with different types of visual analogue scales for measurement of pain.","volume":"34","author":"Sriwatanakul","year":"1983","journal-title":"Clin Pharmacol Ther"},{"key":"R38-13-20210126","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/S0022-3999(02)00628-1","article-title":"Neuropsychological impairment in fibromyalgia: relation to depression, fatigue, and pain.","volume":"55","author":"Suhr","year":"2003","journal-title":"J Psychosom Res"},{"key":"R39-13-20210126","first-page":"233","article-title":"Uso clinico del HAD (Hospital Anxiety and Depression Scale) en poblacion psiquiatrica: un estudio de su sensibilidad, fiabilidad y validez.","volume":"13","author":"Tejero","year":"1986","journal-title":"Rev Dep Psiquiatr Fac Med Barc"},{"key":"R40-13-20210126","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1002\/art.27430","article-title":"Increased glutamateglutamine compounds in the brains of patients with fibromyalgia: a magnetic resonance spectroscopy study.","volume":"62","author":"Valdes","year":"2010","journal-title":"Arthritis Rheum"},{"key":"R41-13-20210126","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1097\/01.rhu.0000249770.86652.3b","article-title":"Sphygmomanometry-evoked allodynia- as imple bedside test indicative of fibromyalgia: a multicenter developmental study.","volume":"12","author":"Vargas","year":"2006","journal-title":"J Clin Rheumatol"},{"key":"R42-13-20210126","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1002\/art.1780330203","article-title":"American College of Rheumatology 1990. Criteria for the classification of fibromyalgia. Report of the Multicenter Criteria Committee.","volume":"33","author":"Wolfe","year":"1990","journal-title":"Arthritis Rheum"}],"container-title":["Pain"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/10.1016\/j.pain.2014.09.004","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,2]],"date-time":"2024-06-02T14:31:40Z","timestamp":1717338700000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/00006396-201412000-00013"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,12]]},"references-count":40,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2014]]}},"URL":"https:\/\/doi.org\/10.1016\/j.pain.2014.09.004","relation":{},"ISSN":["0304-3959"],"issn-type":[{"value":"0304-3959","type":"print"}],"subject":[],"published":{"date-parts":[[2014,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Efficacy of memantine in the treatment of fibromyalgia: A double-blind, randomised, controlled trial with 6-month follow-up","name":"articletitle","label":"Article Title"},{"value":"PAIN\u00ae","name":"journaltitle","label":"Journal Title"},{"value":"http:\/\/dx.doi.org\/10.1016\/j.pain.2014.09.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 International Association for the Study of Pain. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}