{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T04:12:35Z","timestamp":1789186355867,"version":"build-2803163510"},"reference-count":97,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2015,7,1]],"date-time":"2015-07-01T00:00:00Z","timestamp":1435708800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["pancreatology.net","clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pancreatology"],"published-print":{"date-parts":[[2015,7]]},"DOI":"10.1016\/j.pan.2015.05.476","type":"journal-article","created":{"date-parts":[[2015,6,18]],"date-time":"2015-06-18T13:31:28Z","timestamp":1434634288000},"page":"S23-S31","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":38,"special_numbering":"S","title":["Genetic susceptibility factors for alcohol-induced chronic pancreatitis"],"prefix":"10.1016","volume":"15","author":[{"given":"Ali A.","family":"Aghdassi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F. Ulrich","family":"Weiss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Mayerle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus M.","family":"Lerch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Simon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.pan.2015.05.476_bib1","doi-asserted-by":"crossref","first-page":"g2992","DOI":"10.1136\/bmj.g2992","article-title":"Too many germans are addicted to alcohol or tobacco, says report","volume":"348","author":"Stafford","year":"2014","journal-title":"BMJ"},{"key":"10.1016\/j.pan.2015.05.476_bib2","series-title":"Fachserie 12","author":"Statistisches bundesamt","year":"2013"},{"key":"10.1016\/j.pan.2015.05.476_bib3","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1111\/j.1530-0277.2010.01408.x","article-title":"Investigating the pathobiology of alcoholic pancreatitis","volume":"35","author":"Pandol","year":"2011","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1016\/j.pan.2015.05.476_bib4","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.dld.2008.07.316","article-title":"Chronic pancreatitis: report from a multicenter italian survey (pancroinfaisp) on 893 patients","volume":"41","author":"Frulloni","year":"2009","journal-title":"Dig Liver Dis"},{"key":"10.1016\/j.pan.2015.05.476_bib5","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1093\/aje\/kwn222","article-title":"Risk of pancreatitis according to alcohol drinking habits: a population-based cohort study","volume":"168","author":"Kristiansen","year":"2008","journal-title":"Am J Epidemiol"},{"key":"10.1016\/j.pan.2015.05.476_bib6","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1159\/000198221","article-title":"Multicenter survey of the etiology of pancreatic diseases. Relationship between the relative risk of developing chronic pancreaitis and alcohol, protein and lipid consumption","volume":"18","author":"Durbec","year":"1978","journal-title":"Digestion"},{"key":"10.1016\/j.pan.2015.05.476_bib7","first-page":"221","article-title":"Balance of expression of genes coding for extracellular matrix proteins and extracellular matrix degrading proteases in chronic pancreatitis","volume":"32","author":"Gress","year":"1994","journal-title":"Z\u00a0fur Gastroenterol"},{"key":"10.1016\/j.pan.2015.05.476_bib8","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1053\/j.gastro.2005.08.002","article-title":"Extracellular cleavage of e-cadherin by leukocyte elastase during acute experimental pancreatitis in rats","volume":"129","author":"Mayerle","year":"2005","journal-title":"Gastroenterology"},{"issue":"Suppl.\u00a03","key":"10.1016\/j.pan.2015.05.476_bib9","doi-asserted-by":"crossref","first-page":"S10","DOI":"10.1111\/j.1440-1746.2006.04571.x","article-title":"Cell death in pancreatitis: effects of alcohol","volume":"21","author":"Gukovskaya","year":"2006","journal-title":"J\u00a0Gastroenterol Hepatol"},{"key":"10.1016\/j.pan.2015.05.476_bib10","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1136\/gutjnl-2011-300771","article-title":"Tumour necrosis factor alpha secretion induces protease activation and acinar cell necrosis in acute experimental pancreatitis in mice","volume":"62","author":"Sendler","year":"2013","journal-title":"Gut"},{"key":"10.1016\/j.pan.2015.05.476_bib11","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1016\/S0016-5085(00)70148-X","article-title":"Does alcohol directly stimulate pancreatic fibrogenesis? Studies with rat pancreatic stellate cells","volume":"118","author":"Apte","year":"2000","journal-title":"Gastroenterology"},{"key":"10.1016\/j.pan.2015.05.476_bib12","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.1053\/j.gastro.2003.09.021","article-title":"Nonoxidative ethanol metabolites alter extracellular matrix protein content in rat pancreas","volume":"125","author":"Lugea","year":"2003","journal-title":"Gastroenterology"},{"key":"10.1016\/j.pan.2015.05.476_bib13","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.cgh.2010.10.015","article-title":"Alcohol and smoking as risk factors in an epidemiology study of patients with chronic pancreatitis","volume":"9","author":"Cote","year":"2011","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1016\/j.pan.2015.05.476_bib14","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1001\/archinternmed.2009.125","article-title":"Alcohol consumption, cigarette smoking, and the risk of recurrent acute and chronic pancreatitis","volume":"169","author":"Yadav","year":"2009","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.pan.2015.05.476_bib15","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/j.ypmed.2003.11.027","article-title":"A\u00a0meta-analysis of alcohol consumption and the risk of 15 diseases","volume":"38","author":"Corrao","year":"2004","journal-title":"Prev Med"},{"key":"10.1016\/j.pan.2015.05.476_bib16","first-page":"387","article-title":"Alcohol as a risk factor for pancreatitis. A\u00a0systematic review and meta-analysis","volume":"10","author":"Irving","year":"2009","journal-title":"JOP"},{"key":"10.1016\/j.pan.2015.05.476_bib17","doi-asserted-by":"crossref","first-page":"147","DOI":"10.4291\/wjgp.v5.i3.147","article-title":"Molecular mechanisms of alcohol associated pancreatitis","volume":"5","author":"Clemens","year":"2014","journal-title":"World J Gastrointest Pathophysiol"},{"key":"10.1016\/j.pan.2015.05.476_bib18","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1053\/j.gastro.2013.01.068","article-title":"The epidemiology of pancreatitis and pancreatic cancer","volume":"144","author":"Yadav","year":"2013","journal-title":"Gastroenterology"},{"key":"10.1016\/j.pan.2015.05.476_bib19","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1023\/A:1023768829772","article-title":"Limited contribution of the spink1 n34s mutation to the risk and severity of alcoholic chronic pancreatitis: a report from the united states","volume":"48","author":"Schneider","year":"2003","journal-title":"Dig Dis Sci"},{"key":"10.1016\/j.pan.2015.05.476_bib20","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/S0016-5085(52)80120-9","article-title":"Pedigree of a family with hereditary chronic relapsing pancreatitis","volume":"21","author":"Comfort","year":"1952","journal-title":"Gastroenterology"},{"key":"10.1016\/j.pan.2015.05.476_bib21","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1038\/ng1096-141","article-title":"Hereditary pancreatitis is caused by a mutation in the cationic trypsinogen gene","volume":"14","author":"Whitcomb","year":"1996","journal-title":"Nat Genet"},{"key":"10.1016\/j.pan.2015.05.476_bib22","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1016\/0140-6736(93)90942-A","article-title":"Sphincter stenosis and gallstone migration through the biliary tract","volume":"341","author":"Hernandez","year":"1993","journal-title":"Lancet"},{"key":"10.1016\/j.pan.2015.05.476_bib23","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1172\/JCI115091","article-title":"Apical secretion of lysosomal enzymes in rabbit pancreas occurs via a secretagogue regulated pathway and is increased after pancreatic duct obstruction","volume":"87","author":"Hirano","year":"1991","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.pan.2015.05.476_bib24","first-page":"763","article-title":"Direct detection of premature protease activation in living pancreatic acinar cells. Laboratory investigation","volume":"78","author":"Kruger","year":"1998","journal-title":"A\u00a0J Tech Methods Pathol"},{"key":"10.1016\/j.pan.2015.05.476_bib25","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/0016-5085(92)91114-J","article-title":"Acute necrotizing pancreatitis in the opossum: earliest morphological changes involve acinar cells","volume":"103","author":"Lerch","year":"1992","journal-title":"Gastroenterology"},{"key":"10.1016\/j.pan.2015.05.476_bib26","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1016\/S0002-9343(01)00958-5","article-title":"Clinical characterization of patients with hereditary pancreatitis and mutations in the cationic trypsinogen gene","volume":"111","author":"Keim","year":"2001","journal-title":"Am J Med"},{"key":"10.1016\/j.pan.2015.05.476_bib27","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/0016-5085(81)90007-X","article-title":"Characterization of human exocrine pancreatic proteins by two-dimensional isoelectric focusing\/sodium dodecyl sulfate gel electrophoresis","volume":"80","author":"Scheele","year":"1981","journal-title":"Gastroenterology"},{"key":"10.1016\/j.pan.2015.05.476_bib28","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1053\/gast.1997.v113.pm9322498","article-title":"Mutations in the cationic trypsinogen gene are associated with recurrent acute and chronic pancreatitis","volume":"113","author":"Gorry","year":"1997","journal-title":"Gastroenterology"},{"key":"10.1016\/j.pan.2015.05.476_bib29","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1159\/000055840","article-title":"Consensus committees of the european registry of hereditary pancreatic diseases MM-CPSGIAoP: genetic testing for hereditary pancreatitis: guidelines for indications, counselling, consent and privacy issues","volume":"1","author":"Ellis","year":"2001","journal-title":"Pancreatology"},{"key":"10.1016\/j.pan.2015.05.476_bib30","doi-asserted-by":"crossref","first-page":"2122","DOI":"10.1001\/jama.288.17.2122","article-title":"Spontaneous and sporadic trypsinogen mutations in idiopathic pancreatitis","volume":"288","author":"Simon","year":"2002","journal-title":"JAMA"},{"key":"10.1016\/j.pan.2015.05.476_bib31","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1053\/gast.2000.9312","article-title":"Chronic pancreatitis associated with an activation peptide mutation that facilitates trypsin activation","volume":"119","author":"Teich","year":"2000","journal-title":"Gastroenterology"},{"key":"10.1016\/j.pan.2015.05.476_bib32","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/S0016-5085(99)70543-3","article-title":"A\u00a0signal peptide cleavage site mutation in the cationic trypsinogen gene is strongly associated with chronic pancreatitis","volume":"117","author":"Witt","year":"1999","journal-title":"Gastroenterology"},{"key":"10.1016\/j.pan.2015.05.476_bib33","first-page":"228","article-title":"Mutations in the cationic trypsinogen gene and evidence for genetic heterogeneity in hereditary pancreatitis","volume":"36","author":"Ferec","year":"1999","journal-title":"J\u00a0Med Genet"},{"key":"10.1016\/j.pan.2015.05.476_bib34","doi-asserted-by":"crossref","first-page":"5404","DOI":"10.1074\/jbc.M108073200","article-title":"Hereditary pancreatitis caused by a novel prss1 mutation (arg-122--> cys) that alters autoactivation and autodegradation of cationic trypsinogen","volume":"277","author":"Simon","year":"2002","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.pan.2015.05.476_bib35","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1136\/gut.44.3.413","article-title":"Screening for mutations of the cationic trypsinogen gene: are they of relevance in chronic alcoholic pancreatitis?","volume":"44","author":"Teich","year":"1999","journal-title":"Gut"},{"key":"10.1016\/j.pan.2015.05.476_bib36","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1038\/sj.ejhg.5201035","article-title":"Mutation analysis of the cystic fibrosis transmembrane conductance regulator (cftr) gene, the cationic trypsinogen (prss1) gene, and the serine protease inhibitor, kazal type 1 (spink1) gene in patients with alcoholic chronic pancreatitis","volume":"11","author":"Perri","year":"2003","journal-title":"Eur J Hum Genet"},{"key":"10.1016\/j.pan.2015.05.476_bib37","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1002\/1096-8628(20000911)94:2<120::AID-AJMG4>3.0.CO;2-N","article-title":"Mutation analysis of the cystic fibrosis and cationic trypsinogen genes in patients with alcohol-related pancreatitis","volume":"94","author":"Monaghan","year":"2000","journal-title":"Am J Med Genet"},{"key":"10.1016\/j.pan.2015.05.476_bib38","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1159\/000048839","article-title":"Mutations of the cationic trypsinogen gene in hereditary and non-hereditary pancreatitis","volume":"64","author":"O'Reilly","year":"2001","journal-title":"Digestion"},{"key":"10.1016\/j.pan.2015.05.476_bib39","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1007\/s10620-010-1349-4","article-title":"The prevalence of cationic trypsinogen (prss1) and serine protease inhibitor, kazal type 1 (spink1) gene mutations in polish patients with alcoholic and idiopathic chronic pancreatitis","volume":"56","author":"Gasiorowska","year":"2011","journal-title":"Dig Dis Sci"},{"key":"10.1016\/j.pan.2015.05.476_bib40","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1159\/000152001","article-title":"Multicenter approach to recurrent acute and chronic pancreatitis in the united states: the north american pancreatitis study 2 (naps2)","volume":"8","author":"Whitcomb","year":"2008","journal-title":"Pancreatology"},{"key":"10.1016\/j.pan.2015.05.476_bib41","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1038\/ng.2466","article-title":"Common genetic variants in the cldn2 and prss1-prss2 loci alter risk for alcohol-related and sporadic pancreatitis","volume":"44","author":"Whitcomb","year":"2012","journal-title":"Nat Genet"},{"key":"10.1016\/j.pan.2015.05.476_bib42","article-title":"Polymorphisms at prss1-prss2 and cldn2-morc4 loci associate with alcoholic and non-alcoholic chronic pancreatitis in a european replication study","author":"Derikx","year":"2014","journal-title":"Gut"},{"key":"10.1016\/j.pan.2015.05.476_bib43","doi-asserted-by":"crossref","first-page":"e40","DOI":"10.1136\/jmg.40.4.e40","article-title":"Spink1 mutations and phenotypic expression in patients with pancreatitis associated with trypsinogen mutations","volume":"40","author":"Weiss","year":"2003","journal-title":"J\u00a0Med Genet"},{"key":"10.1016\/j.pan.2015.05.476_bib44","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/76088","article-title":"Mutations in the gene encoding the serine protease inhibitor, kazal type 1 are associated with chronic pancreatitis","volume":"25","author":"Witt","year":"2000","journal-title":"Nat Genet"},{"key":"10.1016\/j.pan.2015.05.476_bib45","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1053\/gast.2000.18017","article-title":"Spink1\/psti polymorphisms act as disease modifiers in familial and idiopathic chronic pancreatitis","volume":"119","author":"Pfutzer","year":"2000","journal-title":"Gastroenterology"},{"key":"10.1016\/j.pan.2015.05.476_bib46","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1136\/jmg.39.5.347","article-title":"Mutations in the pancreatic secretory trypsin inhibitor gene (psti\/spink1) rather than the cationic trypsinogen gene (prss1) are significantly associated with tropical calcific pancreatitis","volume":"39","author":"Chandak","year":"2002","journal-title":"J\u00a0Med Genet"},{"key":"10.1016\/j.pan.2015.05.476_bib47","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1136\/gut.50.5.675","article-title":"The n34s mutation of spink1 (psti) is associated with a familial pattern of idiopathic chronic pancreatitis but does not cause the disease","volume":"50","author":"Threadgold","year":"2002","journal-title":"Gut"},{"key":"10.1016\/j.pan.2015.05.476_bib48","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1136\/gut.50.5.687","article-title":"Mutations in serine protease inhibitor kazal type 1 are strongly associated with chronic pancreatitis","volume":"50","author":"Drenth","year":"2002","journal-title":"Gut"},{"key":"10.1016\/j.pan.2015.05.476_bib49","doi-asserted-by":"crossref","first-page":"2716","DOI":"10.1001\/jama.285.21.2716-a","article-title":"Mutation in the spink1 trypsin inhibitor gene, alcohol use, and chronic pancreatitis","volume":"285","author":"Witt","year":"2001","journal-title":"JAMA"},{"key":"10.1016\/j.pan.2015.05.476_bib50","doi-asserted-by":"crossref","first-page":"e2003","DOI":"10.1371\/journal.pone.0002003","article-title":"Pathways to injury in chronic pancreatitis: decoding the role of the high-risk spink1 n34s haplotype using meta-analysis","volume":"3","author":"Aoun","year":"2008","journal-title":"PLoS One"},{"key":"10.1016\/j.pan.2015.05.476_bib51","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.biocel.2014.04.001","article-title":"Understanding how cystic fibrosis mutations disrupt cftr function: from single molecules to animal models","volume":"52","author":"Wang","year":"2014","journal-title":"Int J Biochem Cell Biol"},{"key":"10.1016\/j.pan.2015.05.476_bib52","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.1136\/gut.2005.064808","article-title":"Complete cystic fibrosis transmembrane conductance regulator gene sequencing in patients with idiopathic chronic pancreatitis and controls","volume":"54","author":"Weiss","year":"2005","journal-title":"Gut"},{"key":"10.1016\/j.pan.2015.05.476_bib53","doi-asserted-by":"crossref","first-page":"a009746","DOI":"10.1101\/cshperspect.a009746","article-title":"The cystic fibrosis of exocrine pancreas","volume":"3","author":"Wilschanski","year":"2013","journal-title":"Cold Spring Harb Perspect Med"},{"key":"10.1016\/j.pan.2015.05.476_bib54","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1056\/NEJM199809033391002","article-title":"Relation between mutations of the cystic fibrosis gene and idiopathic pancreatitis","volume":"339","author":"Cohn","year":"1998","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.pan.2015.05.476_bib55","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1056\/NEJM199809033391001","article-title":"Mutations of the cystic fibrosis gene in patients with chronic pancreatitis","volume":"339","author":"Sharer","year":"1998","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.pan.2015.05.476_bib56","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1111\/j.1440-1746.1998.tb00675.x","article-title":"Cystic fibrosis genotypes and alcoholic pancreatitis","volume":"13","author":"Norton","year":"1998","journal-title":"J\u00a0Gastroenterol Hepatol"},{"key":"10.1016\/j.pan.2015.05.476_bib57","doi-asserted-by":"crossref","first-page":"2416","DOI":"10.1023\/A:1020579119691","article-title":"Germline mutations in cftr and psti genes in chronic pancreatitis patients","volume":"47","author":"Gaia","year":"2002","journal-title":"Dig Dis Sci"},{"key":"10.1016\/j.pan.2015.05.476_bib58","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1136\/gut.48.1.70","article-title":"Cystic fibrosis transmembrane regulator (cftr) deltaf508 mutation and 5t allele in patients with chronic pancreatitis and exocrine pancreatic cancer. Pankras ii study group","volume":"48","author":"Malats","year":"2001","journal-title":"Gut"},{"issue":"Suppl.\u00a01","key":"10.1016\/j.pan.2015.05.476_bib59","doi-asserted-by":"crossref","first-page":"S34","DOI":"10.1111\/j.1530-0277.2008.00757.x","article-title":"Association analyses of genetic polymorphisms of gstm1, gstt1, nqo1, nat2, lpl, prss1, psti, and cftr with chronic alcoholic pancreatitis in japan","volume":"34","author":"Maruyama","year":"2010","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1016\/j.pan.2015.05.476_bib60","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1159\/000178889","article-title":"Cftr polymorphisms in patients with alcoholic chronic pancreatitis","volume":"9","author":"da Costa","year":"2009","journal-title":"Pancreatology"},{"key":"10.1016\/j.pan.2015.05.476_bib61","doi-asserted-by":"crossref","DOI":"10.1053\/j.gastro.2014.11.002","article-title":"Alcohol disrupts levels and function of the cystic fibrosis transmembrane conductance regulator to promote development of pancreatitis","volume":"148","author":"Maleth","year":"2015","journal-title":"Gastroenterology"},{"key":"10.1016\/j.pan.2015.05.476_bib62","doi-asserted-by":"crossref","first-page":"11227","DOI":"10.1073\/pnas.0703714104","article-title":"Chymotrypsin c (caldecrin) promotes degradation of human cationic trypsin: identity with rinderknecht's enzyme y","volume":"104","author":"Szmola","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.pan.2015.05.476_bib63","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1038\/ng.2007.44","article-title":"Chymotrypsin c (ctrc) variants that diminish activity or secretion are associated with chronic pancreatitis","volume":"40","author":"Rosendahl","year":"2008","journal-title":"Nat Genet"},{"key":"10.1016\/j.pan.2015.05.476_bib64","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1159\/000199437","article-title":"Association of novel chymotrypsin c gene variations and haplotypes in patients with chronic pancreatitis in chinese in taiwan","volume":"9","author":"Chang","year":"2009","journal-title":"Pancreatology"},{"key":"10.1016\/j.pan.2015.05.476_bib65","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1002\/hep.21023","article-title":"Do alcohol-metabolizing enzyme gene polymorphisms increase the risk of alcoholism and alcoholic liver disease?","volume":"43","author":"Zintzaras","year":"2006","journal-title":"Hepatology"},{"key":"10.1016\/j.pan.2015.05.476_bib66","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/S0369-8114(01)00242-5","article-title":"Genetic polymorphisms of alcohol metabolizing enzymes","volume":"49","author":"Agarwal","year":"2001","journal-title":"Pathol Biol Paris"},{"key":"10.1016\/j.pan.2015.05.476_bib67","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1080\/00365520600965723","article-title":"Alcohol dehydrogenase and aldehyde dehydrogenase gene polymorphism in alcohol liver cirrhosis and alcohol chronic pancreatitis among polish individuals","volume":"42","author":"Cichoz-Lach","year":"2007","journal-title":"Scand J Gastroenterol"},{"key":"10.1016\/j.pan.2015.05.476_bib68","first-page":"5","article-title":"The genetics of alcohol metabolism: role of alcohol dehydrogenase and aldehyde dehydrogenase variants","volume":"30","author":"Edenberg","year":"2007","journal-title":"Alcohol Res Health J Natl Inst Alcohol Abuse Alcohol"},{"key":"10.1016\/j.pan.2015.05.476_bib69","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1111\/j.1530-0277.2006.00139.x","article-title":"Functional assessment of human alcohol dehydrogenase family in ethanol metabolism: significance of first-pass metabolism","volume":"30","author":"Lee","year":"2006","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1016\/j.pan.2015.05.476_bib70","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.cbi.2011.01.028","article-title":"Mammalian alcohol dehydrogenases \u2013 a comparative investigation at gene and protein levels","volume":"191","author":"Hoog","year":"2011","journal-title":"Chem Biol Interact"},{"key":"10.1016\/j.pan.2015.05.476_bib71","first-page":"236","article-title":"Induction of cytochrome p-4502e1 in the human liver by ethanol is caused by a corresponding increase in encoding messenger rna","volume":"17","author":"Takahashi","year":"1993","journal-title":"Hepatology"},{"key":"10.1016\/j.pan.2015.05.476_bib72","doi-asserted-by":"crossref","first-page":"289A","DOI":"10.1111\/j.1530-0277.1996.tb01794.x","article-title":"Genotypes of alcohol-metabolizing enzymes and the risk for alcoholic chronic pancreatitis in japanese alcoholics","volume":"20","author":"Matsumoto","year":"1996","journal-title":"Alcohol Clin Exp Res"},{"issue":"Suppl.\u00a01","key":"10.1016\/j.pan.2015.05.476_bib73","doi-asserted-by":"crossref","first-page":"S69","DOI":"10.1111\/j.1440-1746.2007.05288.x","article-title":"Association analysis among polymorphisms of the various genes and chronic alcoholic pancreatitis","volume":"23","author":"Maruyama","year":"2008","journal-title":"J\u00a0Gastroenterol Hepatol"},{"key":"10.1016\/j.pan.2015.05.476_bib74","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1111\/acer.12108","article-title":"Genetic polymorphisms of alcohol dehydrogenase-1b and aldehyde dehydrogenase-2 and liver cirrhosis, chronic calcific pancreatitis, diabetes mellitus, and hypertension among japanese alcoholic men","volume":"37","author":"Yokoyama","year":"2013","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1016\/j.pan.2015.05.476_bib75","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1002\/hep.1840060330","article-title":"Genetic polymorphism of human liver alcohol and aldehyde dehydrogenases, and their relationship to alcohol metabolism and alcoholism","volume":"6","author":"Bosron","year":"1986","journal-title":"Hepatology"},{"issue":"Suppl.\u00a01","key":"10.1016\/j.pan.2015.05.476_bib76","doi-asserted-by":"crossref","first-page":"S82","DOI":"10.1111\/j.1440-1746.2007.05291.x","article-title":"Spink1, adh2, and aldh2 gene variants and alcoholic chronic pancreatitis in japan","volume":"23","author":"Shimosegawa","year":"2008","journal-title":"J\u00a0Gastroenterol Hepatol"},{"key":"10.1016\/j.pan.2015.05.476_bib77","doi-asserted-by":"crossref","first-page":"85S","DOI":"10.1111\/j.1530-0277.1999.tb04541.x","article-title":"Genotypes of alcohol-metabolizing enzymes in relation to alcoholic chronic pancreatitis in japan","volume":"23","author":"Maruyama","year":"1999","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1016\/j.pan.2015.05.476_bib78","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1093\/alcalc\/agh001","article-title":"Genetic polymorphisms in alcohol-metabolizing enzymes and chronic pancreatitis","volume":"39","author":"Verlaan","year":"2004","journal-title":"Alcohol Alcohol"},{"key":"10.1016\/j.pan.2015.05.476_bib79","doi-asserted-by":"crossref","DOI":"10.1016\/j.gastrohep.2014.11.009","article-title":"Genetic polymorphisms in alcohol dehydrogenase, aldehyde dehydrogenase and alcoholic chronic pancreatitis susceptibility: a meta-analysis","author":"Zhong","year":"2014","journal-title":"Gastroenterol Hepatol"},{"key":"10.1016\/j.pan.2015.05.476_bib80","doi-asserted-by":"crossref","first-page":"2117","DOI":"10.1111\/j.1360-0443.2012.03970.x","article-title":"Association of alcohol dehydrogenase polymorphisms and life-style factors with excessive alcohol intake within the spanish population (epic-spain)","volume":"107","author":"Munoz","year":"2012","journal-title":"Addiction"},{"key":"10.1016\/j.pan.2015.05.476_bib81","doi-asserted-by":"crossref","first-page":"6445","DOI":"10.3748\/wjg.v11.i41.6445","article-title":"Cytochrome p450 2e1 high activity polymorphism in alcohol abuse and end-organ disease","volume":"11","author":"Cartmell","year":"2005","journal-title":"World J Gastroenterol WJG"},{"key":"10.1016\/j.pan.2015.05.476_bib82","first-page":"1","article-title":"Localization, sequence analysis, and ethnic distribution of a 96-bp insertion in the promoter of the human cyp2e1 gene","volume":"432","author":"Fritsche","year":"2000","journal-title":"Mutat Res"},{"key":"10.1016\/j.pan.2015.05.476_bib83","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1097\/00006676-200311000-00007","article-title":"Role of alcohol metabolism in alcoholic pancreatitis","volume":"27","author":"Wilson","year":"2003","journal-title":"Pancreas"},{"issue":"5","key":"10.1016\/j.pan.2015.05.476_bib84","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1038\/ng.3249","article-title":"A\u00a0recombined allele of the lipase gene cel and its pseudogene celp confers susceptibility to chronic pancreatitis","volume":"47","author":"Fjeld","year":"2015","journal-title":"Nat Genet"},{"key":"10.1016\/j.pan.2015.05.476_bib85","doi-asserted-by":"crossref","first-page":"10738","DOI":"10.1073\/pnas.0403431101","article-title":"Ethanol toxicity in pancreatic acinar cells: mediation by nonoxidative fatty acid metabolites","volume":"101","author":"Criddle","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.pan.2015.05.476_bib86","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1136\/gutjnl-2012-304058","article-title":"Fatty\u00a0acid ethyl ester synthase inhibition ameliorates ethanol-induced ca2+-dependent mitochondrial dysfunction and acute pancreatitis","volume":"63","author":"Huang","year":"2014","journal-title":"Gut"},{"key":"10.1016\/j.pan.2015.05.476_bib87","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1007\/s00424-013-1333-x","article-title":"Ethanol and its non-oxidative metabolites profoundly inhibit cftr function in pancreatic epithelial cells which is prevented by atp supplementation","volume":"466","author":"Judak","year":"2014","journal-title":"Pflugers Archiv Eur J Physiol"},{"key":"10.1016\/j.pan.2015.05.476_bib88","doi-asserted-by":"crossref","first-page":"e87","DOI":"10.1097\/01.mpa.0000160960.21580.mL","article-title":"Carboxylester lipase gene polymorphism as a risk of alcohol-induced pancreatitis","volume":"30","author":"Miyasaka","year":"2005","journal-title":"Pancreas"},{"key":"10.1016\/j.pan.2015.05.476_bib89","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.pan.2012.12.059","article-title":"The number of tandem repeats in the carboxyl-ester lipase (cel) gene as a risk factor in alcoholic and idiopathic chronic pancreatitis","volume":"13","author":"Ragvin","year":"2013","journal-title":"Pancreatology"},{"key":"10.1016\/j.pan.2015.05.476_bib90","doi-asserted-by":"crossref","first-page":"3007","DOI":"10.1172\/JCI24912","article-title":"Hemin-activated macrophages home to the pancreas and protect from acute pancreatitis via heme oxygenase-1 induction","volume":"115","author":"Nakamichi","year":"2005","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.pan.2015.05.476_bib91","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1136\/gut.2010.230136","article-title":"Breaking down haem attenuates acute pancreatitis: a new treatment option?","volume":"60","author":"Mayerle","year":"2011","journal-title":"Gut"},{"key":"10.1016\/j.pan.2015.05.476_bib92","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1182\/blood-2002-12-3733","article-title":"Microsatellite polymorphism in heme oxygenase-1 gene promoter is associated with susceptibility to oxidant-induced apoptosis in lymphoblastoid cell lines","volume":"102","author":"Hirai","year":"2003","journal-title":"Blood"},{"key":"10.1016\/j.pan.2015.05.476_bib93","doi-asserted-by":"crossref","first-page":"e37981","DOI":"10.1371\/journal.pone.0037981","article-title":"Genetic analyses of heme oxygenase 1 (hmox1) in different forms of pancreatitis","volume":"7","author":"Weis","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.pan.2015.05.476_bib94","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1002\/hep.24017","article-title":"Genetic variation in the pnpla3 gene is associated with alcoholic liver injury in caucasians","volume":"53","author":"Stickel","year":"2011","journal-title":"Hepatology"},{"key":"10.1016\/j.pan.2015.05.476_bib95","doi-asserted-by":"crossref","first-page":"e29433","DOI":"10.1371\/journal.pone.0029433","article-title":"A\u00a0common variant of pnpla3 (p.I148m) is not associated with alcoholic chronic pancreatitis","volume":"7","author":"Rosendahl","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.pan.2015.05.476_bib96","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1111\/j.1749-6632.1967.tb51007.x","article-title":"The abo blood group antigens and their secretion by healthy and diseased gastric mucosa","volume":"140","author":"Hoskins","year":"1967","journal-title":"Ann N Y Acad Sci"},{"issue":"4","key":"10.1016\/j.pan.2015.05.476_bib97","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1136\/gutjnl-2014-306930","article-title":"Fucosyltransferase 2 (fut2) non-secretor status and blood group b are associated with elevated serum lipase activity in asymptomatic subjects, and an increased risk for chronic pancreatitis: a genetic association study","volume":"64","author":"Weiss","year":"2015","journal-title":"Gut"}],"container-title":["Pancreatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1424390315005876?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1424390315005876?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,27]],"date-time":"2019-08-27T07:16:32Z","timestamp":1566890192000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1424390315005876"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7]]},"references-count":97,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2015,7]]}},"alternative-id":["S1424390315005876"],"URL":"https:\/\/doi.org\/10.1016\/j.pan.2015.05.476","relation":{},"ISSN":["1424-3903"],"issn-type":[{"value":"1424-3903","type":"print"}],"subject":[],"published":{"date-parts":[[2015,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Genetic susceptibility factors for alcohol-induced chronic pancreatitis","name":"articletitle","label":"Article Title"},{"value":"Pancreatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pan.2015.05.476","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 IAP and EPC. Published by Elsevier, a division of Reed Elsevier India, Pvt. Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}