{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T19:37:15Z","timestamp":1786995435738,"version":"build-2736575974"},"reference-count":35,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2016,7,1]],"date-time":"2016-07-01T00:00:00Z","timestamp":1467331200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"The Children's Memorial Health Institute","award":["S143\/2015"],"award-info":[{"award-number":["S143\/2015"]}]}],"content-domain":{"domain":["pancreatology.net","clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pancreatology"],"published-print":{"date-parts":[[2016,7]]},"DOI":"10.1016\/j.pan.2016.04.009","type":"journal-article","created":{"date-parts":[[2016,5,7]],"date-time":"2016-05-07T14:23:04Z","timestamp":1462630984000},"page":"535-541","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"title":["The clinical course of hereditary pancreatitis in children \u2013 A comprehensive analysis of 41 cases"],"prefix":"10.1016","volume":"16","author":[{"given":"Grzegorz","family":"Oracz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elwira","family":"Kolodziejczyk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnieszka","family":"Sobczynska-Tomaszewska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karolina","family":"Wejnarska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maciej","family":"Dadalski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alicja Monika","family":"Grabarczyk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaroslaw","family":"Kierkus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marek","family":"Woynarowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katarzyna","family":"Wertheim-Tysarowska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jozef","family":"Ryzko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerzy","family":"Bal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnieszka Magdalena","family":"Rygiel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.pan.2016.04.009_bib1","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1007\/s11894-004-0014-5","article-title":"Pancreatitis in childhood","volume":"6","author":"Lowe","year":"2004","journal-title":"Curr Gastroenterol Rep"},{"key":"10.1016\/j.pan.2016.04.009_bib2","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1097\/MPA.0b013e318214fe42","article-title":"The etiology of acute recurrent pancreatitis in children: a challenge for pediatricians","volume":"40","author":"Lucidi","year":"2011","journal-title":"Pancreas"},{"key":"10.1016\/j.pan.2016.04.009_bib3","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1097\/01.mpg.0000232570.48773.df","article-title":"Analysis of CFTR, SPINK1, PRSS1 and AAT mutations in children with acute or chronic pancreatitis","volume":"43","author":"Sobczynska-Tomaszewska","year":"2006","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"10.1016\/j.pan.2016.04.009_bib4","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1097\/00005176-200311000-00017","article-title":"Pancreatitis in children","volume":"37","author":"Werlin","year":"2003","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"10.1016\/j.pan.2016.04.009_bib5","first-page":"286","article-title":"The clinical course of chronic pancreatitis associated with lipid disturbances in children","volume":"7","author":"Oracz","year":"2012","journal-title":"Prz Gastroenterol"},{"key":"10.1016\/j.pan.2016.04.009_bib6","first-page":"339","article-title":"Guidelines for diagnosis and treatment of chronic pancreatitis. Recommendations of the Working Group of the Polish National Consultant in Gastroenterology and the Polish Pancreatic Club","volume":"6","author":"Zuk","year":"2011","journal-title":"Prz Gastroenterol"},{"key":"10.1016\/j.pan.2016.04.009_bib7","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/S0016-5085(52)80120-9","article-title":"Pedigree of a family with hereditary chronic relapsing pancreatitis","volume":"21","author":"Comfort","year":"1952","journal-title":"Gastroenterology"},{"key":"10.1016\/j.pan.2016.04.009_bib8","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1136\/gut.2008.149179","article-title":"The natural history of hereditary pancreatitis: a national series","volume":"58","author":"Rebours","year":"2009","journal-title":"Gut"},{"key":"10.1016\/j.pan.2016.04.009_bib9","doi-asserted-by":"crossref","first-page":"1876","DOI":"10.1038\/ajg.2010.193","article-title":"Genetic, epidemiological and clinical aspects of hereditary pancreatitis: a population-based cohort study in Denmark","volume":"105","author":"Joergensen","year":"2010","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.pan.2016.04.009_bib10","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1038\/ng1096-141","article-title":"Hereditary pancreatitis is caused by a mutation in the cationic trypsinogen gene","volume":"14","author":"Whitcomb","year":"1996","journal-title":"Nat Genet"},{"key":"10.1016\/j.pan.2016.04.009_bib11","first-page":"228","article-title":"Mutations in the cationic trypsinogen gene and evidence for genetic heterogeneity in hereditary pancreatitis","volume":"36","author":"Ferec","year":"1999","journal-title":"J Med Genet"},{"key":"10.1016\/j.pan.2016.04.009_bib12","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1002\/humu.20343","article-title":"Mutations of Human Cationic Trypsinogen (PRSS1) and Chronic Pancreatitis","volume":"27","author":"Teich","year":"2006","journal-title":"Hum Mutat"},{"key":"10.1016\/j.pan.2016.04.009_bib13","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/76088","article-title":"Mutations in the gene encoding the serine protease inhibitor, Kazal type 1 are associated with chronic pancreatitis","volume":"25","author":"Witt","year":"2000","journal-title":"Nat Genet"},{"key":"10.1016\/j.pan.2016.04.009_bib14","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1056\/NEJM199809033391002","article-title":"Relation between mutations of the cystic fibrosis gene and idiopathic pancreatitis","volume":"339","author":"Cohn","year":"1998","journal-title":"N Engl J Med"},{"key":"10.1016\/j.pan.2016.04.009_bib15","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1038\/ng.2007.44","article-title":"Chymotrypsin C (CTRC) alterations that diminish activity or secretion are associated with chronic pancreatitis","volume":"40","author":"Rosendahl","year":"2008","journal-title":"Nat Genet"},{"key":"10.1016\/j.pan.2016.04.009_bib16","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1038\/ng.2730","article-title":"Variants in CPA1 are strongly associated with early onset chronic pancreatitis","volume":"45","author":"Witt","year":"2013","journal-title":"Nat Genet"},{"key":"10.1016\/j.pan.2016.04.009_bib17","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/S1542-3565(04)00013-8","article-title":"Clinical and genetic characteristics of hereditary pancreatitis in Europe","volume":"2","author":"Howes","year":"2004","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1016\/j.pan.2016.04.009_bib18","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.dld.2011.08.003","article-title":"An overview of Hereditary Pancreatitis","volume":"44","author":"Rebours","year":"2012","journal-title":"Dig Liv Dis"},{"key":"10.1016\/j.pan.2016.04.009_bib19","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1093\/jnci\/89.6.442","article-title":"Hereditary pancreatitis and the risk of pancreatic cancer. International Hereditary Pancreatitis Study Group","volume":"89","author":"Lowenfels","year":"1997","journal-title":"J Nat Cancer Inst"},{"key":"10.1016\/j.pan.2016.04.009_bib20","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1016\/S0002-9343(01)00958-5","article-title":"Clinical characterization of patients with hereditary pancreatitis and mutations in the cationic trypsinogen gene","volume":"111","author":"Keim","year":"2001","journal-title":"Am J Med"},{"key":"10.1016\/j.pan.2016.04.009_bib21","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1136\/gutjnl-2011-300645","article-title":"CFTR, SPINK1, CTRC and PRSS1 variants in chronic pancreatitis: is the role of mutated CFTR overestimated?","volume":"62","author":"Rosendahl","year":"2012","journal-title":"Gut"},{"key":"10.1016\/j.pan.2016.04.009_bib22","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/S0025-6196(12)60193-1","article-title":"Long-term follow-up of young patients with chronic hereditary or idiopathic pancreatitis","volume":"68","author":"Konzen","year":"1993","journal-title":"Mayo Clin Proc"},{"key":"10.1016\/j.pan.2016.04.009_bib23","doi-asserted-by":"crossref","first-page":"2078","DOI":"10.1016\/j.jpedsurg.2009.05.023","article-title":"Hereditary pancreatitis in children: surgical implications with special regard to genetic background","volume":"44","author":"Schmitt","year":"2009","journal-title":"J Pediatr Surg"},{"key":"10.1016\/j.pan.2016.04.009_bib24","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1159\/000055843","article-title":"Gene mutations in children with chronic pancreatitis","volume":"1","author":"Witt","year":"2001","journal-title":"Pancreatology"},{"key":"10.1016\/j.pan.2016.04.009_bib25","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1097\/MPG.0b013e31820e2126","article-title":"High incidence of PRSS1 and SPINK1 mutations in Korean children with acute recurrent and chronic pancreatitis","volume":"52","author":"Lee","year":"2011","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"10.1016\/j.pan.2016.04.009_bib26","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.pan.2014.04.030","article-title":"The nutritional status and factors contributing to malnutrition in children with chronic pancreatitis","volume":"14","author":"Kolodziejczyk","year":"2014","journal-title":"Pancreatology"},{"key":"10.1016\/j.pan.2016.04.009_bib27","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1097\/MPG.0b013e31823f0269","article-title":"Genetic prevalence and characteristics in children with recurrent pancreatitis","volume":"54","author":"Sultan","year":"2012","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"10.1016\/j.pan.2016.04.009_bib28","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1097\/MPA.0000000000000198","article-title":"Clinical features and endoscopic treatment of Chinese patients with Hereditary Pancreatitis","volume":"44","author":"Sun","year":"2015","journal-title":"Pancreas"},{"key":"10.1016\/j.pan.2016.04.009_bib29","first-page":"A324","article-title":"Dutch patients with Hereditary Pancreatitis; high mutation frequency, relatively little pain","volume":"153","author":"Derikx","year":"2009","journal-title":"Ned Tijdschr Geneeskd"},{"key":"10.1016\/j.pan.2016.04.009_bib30","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1159\/000055844","article-title":"Hereditary Pancreatitis in North America: The Pittsburgh-Midwest Multi-Center Pancreatic Study Group Study","volume":"1","author":"Applebaum-Shapiro","year":"2001","journal-title":"Pancreatology"},{"key":"10.1016\/j.pan.2016.04.009_bib31","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1097\/MPG.0000000000000623","article-title":"Genetic and electrophysiological characteristics of recurrent acute pancretatitis","volume":"60","author":"Werlin","year":"2015","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"10.1016\/j.pan.2016.04.009_bib32","first-page":"249","article-title":"Hereditary pancreatitis: clinical features and inheritance characteristics of the R122C mutation in the cationic trypsinogen gene (PRSS1) in six Spanish families","volume":"10","author":"de las Heras-Castano","year":"2009","journal-title":"J Pancreas (Online)"},{"key":"10.1016\/j.pan.2016.04.009_bib33","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1016\/j.gie.2014.04.001","article-title":"Efficiency of pancreatic duct stenting therapy in children with chronic pancreatitis","volume":"80","author":"Oracz","year":"2014","journal-title":"Gastrointest Endosc"},{"key":"10.1016\/j.pan.2016.04.009_bib34","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1136\/jmg.15.3.189","article-title":"Hereditary pancreatitis in England and Wales","volume":"15","author":"Sibert","year":"1978","journal-title":"J Med Genet."},{"key":"10.1016\/j.pan.2016.04.009_bib35","first-page":"146","article-title":"The course of genetically determined chronic pancreatitis","volume":"4","author":"Keim","year":"2003","journal-title":"J Pancreas (Online)"}],"container-title":["Pancreatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1424390316300230?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1424390316300230?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,9,7]],"date-time":"2019-09-07T07:54:09Z","timestamp":1567842849000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1424390316300230"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7]]},"references-count":35,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2016,7]]}},"alternative-id":["S1424390316300230"],"URL":"https:\/\/doi.org\/10.1016\/j.pan.2016.04.009","relation":{},"ISSN":["1424-3903"],"issn-type":[{"value":"1424-3903","type":"print"}],"subject":[],"published":{"date-parts":[[2016,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The clinical course of hereditary pancreatitis in children \u2013 A comprehensive analysis of 41 cases","name":"articletitle","label":"Article Title"},{"value":"Pancreatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pan.2016.04.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 IAP and EPC. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}