{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T06:14:40Z","timestamp":1761718480888},"reference-count":40,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2016,7,1]],"date-time":"2016-07-01T00:00:00Z","timestamp":1467331200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["pancreatology.net","clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pancreatology"],"published-print":{"date-parts":[[2016,7]]},"DOI":"10.1016\/j.pan.2016.04.031","type":"journal-article","created":{"date-parts":[[2016,5,12]],"date-time":"2016-05-12T13:52:28Z","timestamp":1463061148000},"page":"632-639","update-policy":"http:\/\/dx.doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"title":["The utility of hyperthermic intra-abdominal chemotherapy with\u00a0gemcitabine for the inhibition of tumor progression in an\u00a0experimental model of pancreatic peritoneal carcinomatosis, in\u00a0relation to their behavior with pancreatic cancer stem cells CD133+ CXCR4+"],"prefix":"10.1016","volume":"16","author":[{"given":"Esther Pilar","family":"Garc\u00eda-Santos","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Padilla-Valverde","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pedro","family":"Villarejo-Campos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Murillo-L\u00e1zaro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esther","family":"Fern\u00e1ndez-Grande","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teodoro","family":"Palomino-Mu\u00f1oz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Rodr\u00edguez-Mart\u00ednez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariano","family":"Amo-Salas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paloma","family":"Nu\u00f1ez-Guerrero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susana","family":"S\u00e1nchez-Garc\u00eda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alejandro","family":"Puerto-Puerto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jes\u00fas","family":"Mart\u00edn-Fern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"13","key":"10.1016\/j.pan.2016.04.031_bib1","first-page":"1417","article-title":"Pancreatic cancer: translational research aspects and clinical implications","volume":"18","author":"Ansari","year":"2012","journal-title":"WJS"},{"key":"10.1016\/j.pan.2016.04.031_bib2","series-title":"Cancer facts & figures","author":"American Cancer Society","year":"2013"},{"issue":"9","key":"10.1016\/j.pan.2016.04.031_bib3","doi-asserted-by":"crossref","first-page":"4715","DOI":"10.1158\/0008-5472.CAN-05-3830","article-title":"Survival signaling by Notch1: mammalian target of rapamycin (mTOR)-dependent inhibition of p53","volume":"66","author":"Mungamuri","year":"2006","journal-title":"Cancer Res"},{"issue":"4","key":"10.1016\/j.pan.2016.04.031_bib4","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.bbadis.2009.02.007","article-title":"Pancreatic cancer stem cells: fact or fiction?","volume":"1792","author":"Bhagwandin","year":"2009","journal-title":"Biochim Biophys Acta"},{"issue":"6859","key":"10.1016\/j.pan.2016.04.031_bib5","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1038\/35102167","article-title":"Stem cells, cancer, and cancer stem cells","volume":"414","author":"Reya","year":"2001","journal-title":"Nature"},{"issue":"16","key":"10.1016\/j.pan.2016.04.031_bib6","first-page":"4403","article-title":"Human acute myeloid leukemia CD34+\/CD38 progenitor cells have decreased sensitivity to chemotherapy and Fas induced apoptosis, reduced immunogenicity, and impaired dendritic cell transformation capacities","volume":"60","author":"Costello","year":"2000","journal-title":"Cancer Res"},{"issue":"4","key":"10.1016\/j.pan.2016.04.031_bib7","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1038\/nrc1590","article-title":"Tumour stem cells and drug resistance","volume":"5","author":"Dean","year":"2005","journal-title":"Nat Rev Cancer"},{"issue":"7","key":"10.1016\/j.pan.2016.04.031_bib8","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1038\/nm0797-730","article-title":"Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell","volume":"3","author":"Bonnet","year":"1997","journal-title":"Nat Med"},{"issue":"1","key":"10.1016\/j.pan.2016.04.031_bib9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00423-009-0502-z","article-title":"Pancreatic cancer stem cells: new understanding of tumorigenesis, clinical implications","volume":"395","author":"Ischenko","year":"2010","journal-title":"Langenbecks Arch Surg"},{"key":"10.1016\/j.pan.2016.04.031_bib10","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.semcancer.2010.03.004","article-title":"Cancer stem cells in solid tumors","volume":"20","author":"Hermann","year":"2010","journal-title":"Semin Cancer Biol"},{"issue":"2","key":"10.1016\/j.pan.2016.04.031_bib11","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1245\/s10434-007-9695-y","article-title":"Origin of cancer stem cells: the role of self-renewal and differentiation","volume":"15","author":"Wu","year":"2008","journal-title":"Ann Surg Oncol"},{"issue":"31","key":"10.1016\/j.pan.2016.04.031_bib12","doi-asserted-by":"crossref","first-page":"10790","DOI":"10.3748\/wjg.v20.i31.10790","article-title":"Cancer stem cells: involvement in pancreatic cancer pathogenesis and perspectives on cancer therapeutics","volume":"20","author":"Tanase","year":"2014","journal-title":"World J Gastroenterol"},{"issue":"3","key":"10.1016\/j.pan.2016.04.031_bib13","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1158\/0008-5472.CAN-06-2030","article-title":"Pancreatic cancer stem cells","volume":"67","author":"Li","year":"2007","journal-title":"Cancer Res"},{"issue":"14","key":"10.1016\/j.pan.2016.04.031_bib14","doi-asserted-by":"crossref","first-page":"3357","DOI":"10.1002\/cncr.25121","article-title":"Enhanced cell migration and invasion of CD133 pancreatic cancer cells cocultured with pancreatic stromal cells","volume":"116","author":"Moriyama","year":"2010","journal-title":"Cancer"},{"issue":"8","key":"10.1016\/j.pan.2016.04.031_bib15","first-page":"754","article-title":"Expression of the stem cell markers CD133 and nestin in pancreatic ductal adenocarcinoma and clinical relevance","volume":"5","author":"Kim","year":"2012","journal-title":"Int J Clin Exp Pathol"},{"issue":"22","key":"10.1016\/j.pan.2016.04.031_bib16","doi-asserted-by":"crossref","first-page":"8420","DOI":"10.1158\/0008-5472.CAN-04-1343","article-title":"Increased survival, proliferation, and migration in metastatic human pancreatic tumor cells expressing functional CXCR4","volume":"64","author":"Marchesi","year":"2004","journal-title":"Cancer Res"},{"issue":"9","key":"10.1016\/j.pan.2016.04.031_bib17","doi-asserted-by":"crossref","first-page":"5403","DOI":"10.7314\/APJCP.2013.14.9.5403","article-title":"CXCL12-CXCR4 promotes proliferation and invasion of pancreatic cancer cells","volume":"14","author":"Shen","year":"2013","journal-title":"Asian Pac J Cancer Prev"},{"key":"10.1016\/j.pan.2016.04.031_bib18","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1038\/ctg.2012.18","article-title":"CXCR4 expression predicts early liver recurrence and poor survival after resection of pancreatic adenocarcinoma","volume":"3","author":"Liao","year":"2012","journal-title":"Clin Transl Gastroenterol"},{"issue":"14","key":"10.1016\/j.pan.2016.04.031_bib19","doi-asserted-by":"crossref","first-page":"2169","DOI":"10.1016\/j.molimm.2006.01.005","article-title":"Cannabinoid receptor CB2 modulates the CXCL12-CXCR4-mediated chemotaxis of T lymphocytes","volume":"43","author":"Ghosh","year":"2006","journal-title":"Mol Immunol"},{"issue":"4","key":"10.1016\/j.pan.2016.04.031_bib20","doi-asserted-by":"crossref","first-page":"497","DOI":"10.2174\/092986711794480159","article-title":"The CXCL12-CXCR4 axis as a therapeutic target in cancer and HIV-1 infection","volume":"18","author":"Patrussi","year":"2011","journal-title":"Curr Med Chem"},{"key":"10.1016\/j.pan.2016.04.031_bib21","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/S1359-6101(01)00014-4","article-title":"Chemokine receptors","volume":"12","author":"Horuk","year":"2001","journal-title":"Cytokine Growth Factor Rev"},{"key":"10.1016\/j.pan.2016.04.031_bib22","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1186\/1471-2407-6-162","article-title":"Histological response of peritoneal carcinomatosis after hyperthermic intraperitoneal chemoperfusion (HIPEC) in experimental investigations","volume":"6","author":"Pelz","year":"2006","journal-title":"BMC Cancer"},{"key":"10.1016\/j.pan.2016.04.031_bib23","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1007\/s00384-006-0246-y","article-title":"Hyperthermic intraperitoneal chemoperfusion (HIPEC) decrease wound strength of colonic anastomosis in a rat model","volume":"22","author":"Pelz","year":"2007","journal-title":"Int J Colorectal Dis"},{"key":"10.1016\/j.pan.2016.04.031_bib24","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1002\/jso.10000","article-title":"Intraoperative and early postoperative chemotherapy into the abdominal cavity using gemcitabine may prevent postoperative occurrence of peritoneal carcinomatosis","volume":"79","author":"Ridwelski","year":"2002","journal-title":"J\u00a0Surg Oncol"},{"key":"10.1016\/j.pan.2016.04.031_bib25","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1007\/s002800000214","article-title":"Impact of carrier solutions on pharmacokinetics of intraperitoneal chemotherapy","volume":"47","author":"Pestieu","year":"2001","journal-title":"Cancer Chemother Pharmacol"},{"key":"10.1016\/j.pan.2016.04.031_bib26","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1002\/jso.21332","article-title":"Results of cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for peritoneal carcinomatosis from colorectal cancer","volume":"100","author":"Glockzin","year":"2009","journal-title":"J\u00a0Surg Oncol"},{"issue":"3\u20134","key":"10.1016\/j.pan.2016.04.031_bib27","first-page":"57","article-title":"Management of peritoneal carcinomatosis","volume":"16","author":"Sugarbaker","year":"1989","journal-title":"Acta Med Austriaca"},{"key":"10.1016\/j.pan.2016.04.031_bib28","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1186\/1471-2407-14-687","article-title":"Immunohistochemical analysis of cancer stem cell markers in pancreatic adenocarcinoma patients after neoadjuvant chemoradiotherapy","volume":"14","author":"Mizukami","year":"2014","journal-title":"BMC Cancer"},{"issue":"4","key":"10.1016\/j.pan.2016.04.031_bib29","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/S1470-2045(04)01425-1","article-title":"Peritoneal carcinomatosis from digestive tract cancer: new management by cytoreductive surgery and intraperitoneal chemohyperthermia","volume":"5","author":"Glehen","year":"2004","journal-title":"Lancet Oncol"},{"issue":"6","key":"10.1016\/j.pan.2016.04.031_bib30","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1097\/SLA.0b013e3181a45d86","article-title":"Should the treatment of peritoneal carcinomatosis by cytoreductive surgery and hyperthermic intraperitoneal chemotherapy still be regarded as a highly morbid procedure: a systematic review of morbidity and mortality","volume":"249","author":"Chua","year":"2009","journal-title":"Ann Surg"},{"key":"10.1016\/j.pan.2016.04.031_bib31","first-page":"357","article-title":"Cytoreduction and intraperitoneal chemotherapy for carcinomatosis from gastric cancer","volume":"134","author":"Yonemura","year":"2007","journal-title":"Cancer Treat Res"},{"key":"10.1016\/j.pan.2016.04.031_bib32","doi-asserted-by":"crossref","first-page":"3737","DOI":"10.1200\/JCO.2003.04.187","article-title":"Randomized trial of cytoreduction and hyperthermic intraperitoneal chemotherapy versus systemic chemotherapy and palliative surgery in patients with peritoneal carcinomatosis of colorectal cancer","volume":"21","author":"Verwaal","year":"2003","journal-title":"J\u00a0Clin Oncol"},{"key":"10.1016\/j.pan.2016.04.031_bib33","first-page":"798","article-title":"Intrinsic gemcitabine resistance in a novel pancreatic cancer cell line is associated with cancer stem cell-like phenotype","volume":"40","author":"Gang","year":"2012","journal-title":"Int J Oncol"},{"issue":"11","key":"10.1016\/j.pan.2016.04.031_bib34","doi-asserted-by":"crossref","first-page":"1610","DOI":"10.1016\/j.freeradbiomed.2011.03.007","article-title":"Pharmacologic ascorbate synergizes with gemcitabine in preclinical models of pancreatic cancer","volume":"50","author":"Espey","year":"2011","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.pan.2016.04.031_bib35","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.ctrv.2008.10.002","article-title":"Markers involved in resistance to cytotoxics and targeted therapeutics in pancreatic cancer","volume":"35","author":"El Maalouf","year":"2009","journal-title":"Cancer Treat Rev"},{"key":"10.1016\/j.pan.2016.04.031_bib36","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.molonc.2010.06.002","article-title":"Pancreatic cancer stem cells \u2013update and future perspectives","volume":"4","author":"Lonardo","year":"2010","journal-title":"Mol Oncol"},{"key":"10.1016\/j.pan.2016.04.031_bib37","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.pan.2015.02.011","article-title":"The epithelial to mesenchymal transition in pancreatic cancer: a systematic review","volume":"15","author":"Beuran","year":"2015","journal-title":"Pancreatology"},{"key":"10.1016\/j.pan.2016.04.031_bib38","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.1136\/gut.2008.150052","article-title":"Recent progress on normal and malignant pancreatic stem\/progenitor cell research: therapeutic implications for the treatment of type 1 or 2 diabetes mellitus and aggressive pancreatic cancer","volume":"57","author":"Mimeault","year":"2008","journal-title":"Gut"},{"key":"10.1016\/j.pan.2016.04.031_bib39","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1186\/1471-2407-12-354","article-title":"Human pancreatic adenocarcinoma contains a side population resistant to gemcitabine","volume":"12","author":"Van den Broeck","year":"2012","journal-title":"BMC Cancer"},{"key":"10.1016\/j.pan.2016.04.031_bib40","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1038\/bjc.2014.152","article-title":"Novel role of pancreatic differentiation 2 in facilitating self-renewal and drug resistance of pancreatic stem cells","volume":"111","author":"Paz","year":"2014","journal-title":"BJC"}],"container-title":["Pancreatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S142439031630045X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S142439031630045X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,11]],"date-time":"2018-09-11T22:57:55Z","timestamp":1536706675000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S142439031630045X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7]]},"references-count":40,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2016,7]]}},"alternative-id":["S142439031630045X"],"URL":"https:\/\/doi.org\/10.1016\/j.pan.2016.04.031","relation":{},"ISSN":["1424-3903"],"issn-type":[{"value":"1424-3903","type":"print"}],"subject":[],"published":{"date-parts":[[2016,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The utility of hyperthermic intra-abdominal chemotherapy with\u00a0gemcitabine for the inhibition of tumor progression in an\u00a0experimental model of pancreatic peritoneal carcinomatosis, in\u00a0relation to their behavior with pancreatic cancer stem cells CD133+ CXCR4+","name":"articletitle","label":"Article Title"},{"value":"Pancreatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pan.2016.04.031","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 IAP and EPC. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}