{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T02:53:40Z","timestamp":1791341620471,"version":"4.3.1"},"reference-count":44,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pancreatology"],"published-print":{"date-parts":[[2020,6]]},"DOI":"10.1016\/j.pan.2020.04.004","type":"journal-article","created":{"date-parts":[[2020,4,20]],"date-time":"2020-04-20T12:16:09Z","timestamp":1587384969000},"page":"698-708","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"title":["Nicotine promotes tumor progression and epithelial-mesenchymal transition by regulating the miR-155-5p\/NDFIP1 axis in pancreatic ductal adenocarcinoma"],"prefix":"10.1016","volume":"20","author":[{"given":"Qiwen","family":"Ben","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunwei","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiyi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duowu","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaozong","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.pan.2020.04.004_bib1","first-page":"5","article-title":"Cancer statistics, 2015","volume":"65","author":"Siegel","year":"2015","journal-title":"CA A Cancer J Clin"},{"key":"10.1016\/j.pan.2020.04.004_bib2","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1515\/reveh-2012-0003","article-title":"Cigarette smoking in China: public health, science, and policy","volume":"27","author":"Au","year":"2012","journal-title":"Rev Environ Health"},{"key":"10.1016\/j.pan.2020.04.004_bib3","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1093\/ije\/dyu240","article-title":"Risk factors for pancreatic cancer: a summary review of meta-analytical studies","volume":"44","author":"Maisonneuve","year":"2015","journal-title":"Int J Epidemiol"},{"key":"10.1016\/j.pan.2020.04.004_bib4","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1093\/jjco\/hyq185","article-title":"Cigarette smoking and other lifestyle factors in relation to the risk of pancreatic cancer death: a prospective cohort study in Japan","volume":"41","author":"Nakamura","year":"2011","journal-title":"Jpn J Clin Oncol"},{"key":"10.1016\/j.pan.2020.04.004_bib5","article-title":"Are risk factors associated with outcomes in pancreatic cancer?","volume":"7","author":"Wang","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.pan.2020.04.004_bib6","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1158\/1078-0432.CCR-15-1256","article-title":"Nicotine reduces survival via augmentation of paracrine HGF-MET signaling in the pancreatic cancer microenvironment","volume":"22","author":"Delitto","year":"2016","journal-title":"Clin Canc Res"},{"key":"10.1016\/j.pan.2020.04.004_bib7","doi-asserted-by":"crossref","first-page":"2733","DOI":"10.1002\/ijc.27827","article-title":"DNA and protein adducts in human tissues resulting from exposure to tobacco smoke","volume":"131","author":"Phillips","year":"2012","journal-title":"Int J Canc"},{"key":"10.1016\/j.pan.2020.04.004_bib8","doi-asserted-by":"crossref","first-page":"613","DOI":"10.3390\/ijerph8020613","article-title":"Hazardous compounds in tobacco smoke","volume":"8","author":"Talhout","year":"2011","journal-title":"Int J Environ Res Publ Health"},{"key":"10.1016\/j.pan.2020.04.004_bib9","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1021\/tx0101088","article-title":"Identification of tobacco-derived compounds in human pancreatic juice","volume":"15","author":"Prokopczyk","year":"2002","journal-title":"Chem Res Toxicol"},{"key":"10.1016\/j.pan.2020.04.004_bib10","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1053\/j.gastro.2014.08.002","article-title":"Nicotine promotes initiation and progression of KRAS-induced pancreatic cancer via Gata6-dependent dedifferentiation of acinar cells in mice","volume":"147","author":"Hermann","year":"2014","journal-title":"Gastroenterology"},{"key":"10.1016\/j.pan.2020.04.004_bib11","doi-asserted-by":"crossref","first-page":"2052","DOI":"10.1038\/onc.2014.154","article-title":"Smoking accelerates pancreatic cancer progression by promoting differentiation of MDSCs and inducing HB-EGF expression in macrophages","volume":"34","author":"Kumar","year":"2015","journal-title":"Oncogene"},{"key":"10.1016\/j.pan.2020.04.004_bib12","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1053\/j.gastro.2018.05.041","article-title":"Cigarette smoke induces stem cell features of pancreatic cancer cells via PAF1","volume":"155","author":"Nimmakayala","year":"2018","journal-title":"Gastroenterology"},{"key":"10.1016\/j.pan.2020.04.004_bib13","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1038\/onc.2012.163","article-title":"Nicotine\/cigarette smoke promotes metastasis of pancreatic cancer through alpha7nAChR-mediated MUC4 upregulation","volume":"32","author":"Momi","year":"2013","journal-title":"Oncogene"},{"key":"10.1016\/j.pan.2020.04.004_bib14","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.biopha.2016.06.006","article-title":"Up-regulated microRNA-155 expression is associated with poor prognosis in cervical cancer patients","volume":"83","author":"Fang","year":"2016","journal-title":"Biomed Pharmacother"},{"key":"10.1016\/j.pan.2020.04.004_bib15","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1111\/cas.13177","article-title":"MicroRNA-155-5p promotes hepatocellular carcinoma progression by suppressing PTEN through the PI3K\/Akt pathway","volume":"108","author":"Fu","year":"2017","journal-title":"Canc Sci"},{"key":"10.1016\/j.pan.2020.04.004_bib16","first-page":"1960","article-title":"microRNA-155 is downregulated in gastric cancer cells and involved in cell metastasis","volume":"27","author":"Li","year":"2012","journal-title":"Oncol Rep"},{"key":"10.1016\/j.pan.2020.04.004_bib17","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1016\/j.febslet.2013.03.023","article-title":"MicroRNA-155 is a novel suppressor of ovarian cancer-initiating cells that targets CLDN1","volume":"587","author":"Qin","year":"2013","journal-title":"FEBS Lett"},{"key":"10.1016\/j.pan.2020.04.004_bib18","doi-asserted-by":"crossref","first-page":"42339","DOI":"10.1038\/srep42339","article-title":"MicroRNA-155 controls exosome synthesis and promotes gemcitabine resistance in pancreatic ductal adenocarcinoma","volume":"7","author":"Mikamori","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.pan.2020.04.004_bib19","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1002\/ijc.24687","article-title":"Elevated expression of microRNAs 155, 203, 210 and 222 in pancreatic tumors is associated with poorer survival","volume":"126","author":"Greither","year":"2010","journal-title":"Int J Canc"},{"key":"10.1016\/j.pan.2020.04.004_bib20","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1159\/000231984","article-title":"Aberrant MicroRNA-155 expression is an early event in the multistep progression of pancreatic adenocarcinoma","volume":"10","author":"Ryu","year":"2010","journal-title":"Pancreatology"},{"key":"10.1016\/j.pan.2020.04.004_bib21","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.1111\/cas.12747","article-title":"Pancreatic cancer-secreted miR-155 implicates in the conversion from normal fibroblasts to cancer-associated fibroblasts","volume":"106","author":"Pang","year":"2015","journal-title":"Canc Sci"},{"key":"10.1016\/j.pan.2020.04.004_bib22","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.oraloncology.2017.07.009","article-title":"A\u00a0comprehensive study of smoking-specific microRNA alterations in head and neck squamous cell carcinoma","volume":"72","author":"Krishnan","year":"2017","journal-title":"Oral Oncol"},{"key":"10.1016\/j.pan.2020.04.004_bib23","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1089\/omi.2017.0045","article-title":"Long-term cigarette smoke exposure and changes in MiRNA expression and proteome in non-small-cell lung cancer","volume":"21","author":"Advani","year":"2017","journal-title":"OMICS"},{"key":"10.1016\/j.pan.2020.04.004_bib24","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1002\/jcp.26933","article-title":"Nicotine downregulates microRNA-200c to promote metastasis and the epithelial-mesenchymal transition in human colorectal cancer cells","volume":"234","author":"Lei","year":"2019","journal-title":"J\u00a0Cell Physiol"},{"key":"10.1016\/j.pan.2020.04.004_bib25","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1016\/j.ymthe.2018.01.023","article-title":"miR-296-3p negatively regulated by nicotine stimulates cytoplasmic translocation of c-Myc via MK2 to suppress chemotherapy resistance","volume":"26","author":"Deng","year":"2018","journal-title":"Mol Ther"},{"key":"10.1016\/j.pan.2020.04.004_bib26","series-title":"AJCC cancer staging handbook","author":"Edge","year":"2010"},{"key":"10.1016\/j.pan.2020.04.004_bib27","series-title":"Pathology and genetics of tumours of the digestive system","author":"Hamilton","year":"2000"},{"key":"10.1016\/j.pan.2020.04.004_bib28","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1200\/JCO.2005.01.5180","article-title":"EZH2 expression is associated with high proliferation rate and aggressive tumor subgroups in cutaneous melanoma and cancers of the endometrium, prostate, and breast","volume":"24","author":"Bachmann","year":"2006","journal-title":"J\u00a0Clin Oncol"},{"key":"10.1016\/j.pan.2020.04.004_bib29","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1186\/s12943-017-0675-y","article-title":"MicroRNA-1296 inhibits metastasis and epithelial-mesenchymal transition of hepatocellular carcinoma by targeting SRPK1-mediated PI3K\/AKT pathway","volume":"16","author":"Xu","year":"2017","journal-title":"Mol Canc"},{"key":"10.1016\/j.pan.2020.04.004_bib30","doi-asserted-by":"crossref","first-page":"D92","DOI":"10.1093\/nar\/gkt1248","article-title":"starBase v2.0: decoding miRNA-ceRNA, miRNA-ncRNA and protein-RNA interaction networks from large-scale CLIP-Seq data","volume":"42","author":"Li","year":"2014","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.pan.2020.04.004_bib31","doi-asserted-by":"crossref","first-page":"28","DOI":"10.2174\/2211536607666171213123907","article-title":"Chronic exposure to cigarette smoke and chewing tobacco alters expression of microRNAs in esophageal epithelial cells","volume":"7","author":"Khan","year":"2018","journal-title":"MicroRNA"},{"key":"10.1016\/j.pan.2020.04.004_bib32","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1136\/bmj.280.6219.972","article-title":"Relation of nicotine yield of cigarettes to blood nicotine concentrations in smokers","volume":"280","author":"Russell","year":"1980","journal-title":"Br Med J"},{"key":"10.1016\/j.pan.2020.04.004_bib33","doi-asserted-by":"crossref","first-page":"1822","DOI":"10.1200\/JCO.2016.71.2026","article-title":"Cigarette smoking and pancreatic cancer survival","volume":"35","author":"Yuan","year":"2017","journal-title":"J\u00a0Clin Oncol"},{"key":"10.1016\/j.pan.2020.04.004_bib34","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1093\/aje\/kwn301","article-title":"Optimal serum cotinine levels for distinguishing cigarette smokers and nonsmokers within different racial\/ethnic groups in the United States between 1999 and 2004","volume":"169","author":"Benowitz","year":"2009","journal-title":"Am J Epidemiol"},{"key":"10.1016\/j.pan.2020.04.004_bib35","first-page":"421","article-title":"Molecular prognostic markers in pancreatic cancer","volume":"7","author":"Coppola","year":"2000","journal-title":"Canc Control"},{"key":"10.1016\/j.pan.2020.04.004_bib36","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1002\/ijc.23894","article-title":"Nicotine induces cell proliferation, invasion and epithelial-mesenchymal transition in a variety of human cancer cell lines","volume":"124","author":"Dasgupta","year":"2009","journal-title":"Int J Canc"},{"key":"10.1016\/j.pan.2020.04.004_bib37","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1038\/s41419-019-1577-2","article-title":"Elevation of O-GlcNAc and GFAT expression by nicotine exposure promotes epithelial-mesenchymal transition and invasion in breast cancer cells","volume":"10","author":"Zhang","year":"2019","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.pan.2020.04.004_bib38","doi-asserted-by":"crossref","first-page":"7063","DOI":"10.1007\/s13277-014-1968-z","article-title":"Nicotine upregulates microRNA-21 and promotes TGF-beta-dependent epithelial-mesenchymal transition of esophageal cancer cells","volume":"35","author":"Zhang","year":"2014","journal-title":"Tumour Biol"},{"key":"10.1016\/j.pan.2020.04.004_bib39","doi-asserted-by":"crossref","first-page":"7392","DOI":"10.1038\/sj.onc.1205800","article-title":"Selective clonal expansion and microenvironmental permissiveness in tobacco carcinogenesis","volume":"21","author":"Rubin","year":"2002","journal-title":"Oncogene"},{"key":"10.1016\/j.pan.2020.04.004_bib40","doi-asserted-by":"crossref","first-page":"218","DOI":"10.12659\/MSMBR.918134","article-title":"Exosome-mediated MiR-155 transfer contributes to hepatocellular carcinoma cell proliferation by targeting PTEN","volume":"25","author":"Sun","year":"2019","journal-title":"Med Sci Monit Basic Res"},{"key":"10.1016\/j.pan.2020.04.004_bib41","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.ejphar.2019.03.034","article-title":"Inhibition of miR-140-3p or miR-155-5p by antagomir treatment sensitize chordoma cells to chemotherapy drug treatment by increasing PTEN expression","volume":"854","author":"Zhao","year":"2019","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.pan.2020.04.004_bib42","first-page":"32","article-title":"miR-155 affects osteosarcoma MG-63 cell autophagy induced by adriamycin through regulating PTEN-PI3K\/AKT\/mTOR signaling pathway","volume":"33","author":"Wang","year":"2018","journal-title":"Cancer Biother Radiopharm"},{"key":"10.1016\/j.pan.2020.04.004_bib43","first-page":"119","article-title":"Ndfip1 represses cell proliferation by controlling Pten localization and signaling specificity","volume":"7","author":"Howitt","year":"2015","journal-title":"J\u00a0Mol Cell Biol"},{"key":"10.1016\/j.pan.2020.04.004_bib44","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1177\/1533034617737923","article-title":"MiR-155 promotes uveal melanoma cell proliferation and invasion by regulating NDFIP1 expression","volume":"16","author":"Peng","year":"2017","journal-title":"Technol Canc Res Treat"}],"container-title":["Pancreatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1424390320301332?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1424390320301332?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T16:11:15Z","timestamp":1761408675000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1424390320301332"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6]]},"references-count":44,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,6]]}},"alternative-id":["S1424390320301332"],"URL":"https:\/\/doi.org\/10.1016\/j.pan.2020.04.004","relation":{},"ISSN":["1424-3903"],"issn-type":[{"value":"1424-3903","type":"print"}],"subject":[],"published":{"date-parts":[[2020,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Nicotine promotes tumor progression and epithelial-mesenchymal transition by regulating the miR-155-5p\/NDFIP1 axis in pancreatic ductal adenocarcinoma","name":"articletitle","label":"Article Title"},{"value":"Pancreatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pan.2020.04.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 IAP and EPC. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}