{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T17:09:50Z","timestamp":1792602590386,"version":"4.5.0"},"reference-count":32,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pancreatology"],"published-print":{"date-parts":[[2020,7]]},"DOI":"10.1016\/j.pan.2020.04.020","type":"journal-article","created":{"date-parts":[[2020,5,19]],"date-time":"2020-05-19T07:31:16Z","timestamp":1589873476000},"page":"880-886","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"title":["Liver and pancreas: \u2018Castor and Pollux\u2019 regarding the relationship between hepatic steatosis and pancreas exocrine insufficiency"],"prefix":"10.1016","volume":"20","author":[{"given":"Salih","family":"Boga","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali Riza","family":"Koksal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u0130lker","family":"Sen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muge","family":"Kurul Yeniay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muveddet Banu","family":"Yilmaz Ozguven","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erdinc","family":"Serin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sukru Mehmet","family":"Erturk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huseyin","family":"Alkim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Canan","family":"Alkim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.pan.2020.04.020_bib1","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/j.jhep.2018.10.033","article-title":"Non-alcoholic fatty liver disease - a global public health perspective","volume":"70","author":"Younossi","year":"2019","journal-title":"J\u00a0Hepatol"},{"issue":"1","key":"10.1016\/j.pan.2020.04.020_bib2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1463-1326.2006.00590.x","article-title":"Ectopic fat accumulation and metabolic syndrome","volume":"9","author":"Rasouli","year":"2007","journal-title":"Diabetes Obes Metabol"},{"issue":"6","key":"10.1016\/j.pan.2020.04.020_bib3","doi-asserted-by":"crossref","first-page":"2672","DOI":"10.1002\/hep.30251","article-title":"Global perspectives on nonalcoholic fatty liver disease and nonalcoholic steatohepatitis","volume":"69","author":"Younossi","year":"2019","journal-title":"Hepatology"},{"key":"10.1016\/j.pan.2020.04.020_bib4","first-page":"1869","article-title":"World J Clinical implications of fatty pancreas: correlations between fatty pancreas and metabolic syndrome","volume":"15","author":"Lee","year":"2009","journal-title":"Gastroenterol"},{"issue":"12","key":"10.1016\/j.pan.2020.04.020_bib5","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1186\/1475-2840-12-77","article-title":"Association between non-alcoholic fatty pancreatic disease (nafpd) and the metabolic syndrome: case\u2014control retrospective study","volume":"20","author":"Wu","year":"2013","journal-title":"Cardiovasc Diabetol"},{"issue":"1","key":"10.1016\/j.pan.2020.04.020_bib6","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1111\/j.1365-2036.2012.05121.x","article-title":"Correlation between liver histology and novel magnetic resonance imaging in adult pa-tients with non-alcoholic fatty liver disease\u2014MRI accurately quantifies hepatic steatosis in NAFLD","volume":"36","author":"Permutt","year":"2012","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.pan.2020.04.020_bib7","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1148\/radiol.13121360","article-title":"Hepatic steatosis: quantification by proton density fat fraction with MR imaging versus liver biopsy","volume":"267","author":"Idilman","year":"2013","journal-title":"Radiology"},{"issue":"6","key":"10.1016\/j.pan.2020.04.020_bib8","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1111\/apt.12237","article-title":"Association between novel MRI-estimated pancreatic fat and liver histology-determined steatosis and fibrosis in non-alcoholic fatty liver disease","volume":"37","author":"Patel","year":"2013","journal-title":"Aliment Pharmacol Ther"},{"issue":"6","key":"10.1016\/j.pan.2020.04.020_bib9","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.1007\/s00261-015-0385-0","article-title":"Quantification of liver, pancreas, kidney, and vertebral body MRI-PDFF in non-alcoholic fatty liver disease","volume":"40","author":"Idilman","year":"2015","journal-title":"Abdom Imag"},{"issue":"4","key":"10.1016\/j.pan.2020.04.020_bib10","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1038\/ajg.2014.1","article-title":"Fatty pancreas, insulin resistance, and \u03b2-cell function: a population study using fat-water magnetic resonance imaging","volume":"109","author":"Wong","year":"2014","journal-title":"Am J Gastroenterol"},{"issue":"11","key":"10.1016\/j.pan.2020.04.020_bib11","doi-asserted-by":"crossref","first-page":"2916","DOI":"10.2337\/dc07-0326","article-title":"Pancreatic fat content and beta-cell func-tion in men with and without type 2 diabetes","volume":"30","author":"Tushuizen","year":"2007","journal-title":"Diabetes Care"},{"issue":"11","key":"10.1016\/j.pan.2020.04.020_bib12","doi-asserted-by":"crossref","first-page":"2377","DOI":"10.2337\/dc12-0701","article-title":"Pancreatic steatosis and its relationship to beta-cell dysfunction in humans: racial and ethnic variations","volume":"35","author":"Szczepaniak","year":"2012","journal-title":"Diabetes Care"},{"issue":"4","key":"10.1016\/j.pan.2020.04.020_bib13","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1136\/gut.39.4.580","article-title":"Faecal elastase 1: a novel, highly sensitive, and specific tubeless pancreatic function test","volume":"39","author":"L\u00f6ser","year":"1996","journal-title":"Gut"},{"issue":"5","key":"10.1016\/j.pan.2020.04.020_bib14","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1007\/s10620-017-4524-z","article-title":"Potential for screening for pancreatic exocrine insufficiency using the fecal elastase-1 test","volume":"62","author":"Dom\u00ednguez-Mu\u00f1oz","year":"2017","journal-title":"Dig Dis Sci"},{"key":"10.1016\/j.pan.2020.04.020_bib15","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/s005920070011","article-title":"Pancreatic exocrine function in patients with type 1 and type 2 diabetes mellitus","volume":"37","author":"Hardt","year":"2000","journal-title":"Acta Diabetol"},{"key":"10.1016\/j.pan.2020.04.020_bib16","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1080\/003655201750422657","article-title":"Low faecal elastase 1 concentrations in type 2 diabetes mellitus","volume":"36","author":"Rathmann","year":"2001","journal-title":"Scand J Gastroenterol"},{"key":"10.1016\/j.pan.2020.04.020_bib17","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1159\/000073655","article-title":"High prevalence of exocrine pancreatic insufficiency in diabetes mellitus. A multicenter study screening fecal elastase 1 concentrations in 1,021 diabetic patients","volume":"3","author":"Hardt","year":"2003","journal-title":"Pancreatology"},{"key":"10.1016\/j.pan.2020.04.020_bib18","doi-asserted-by":"crossref","first-page":"761950","DOI":"10.1155\/2011\/761950","article-title":"Exocrine pancreatic insufficiency in diabetes mellitus: a complication of diabetic neuropathy or a different type of diabetes?","volume":"2011","author":"Hardt","year":"2011","journal-title":"Exp Diabetes Res"},{"issue":"5","key":"10.1016\/j.pan.2020.04.020_bib19","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/j.pan.2014.07.004","article-title":"Prevalence of exocrine pancreatic insufficiency in type 2 diabetes mellitus with poor glycemic control","volume":"14","author":"Terzin","year":"2014","journal-title":"Pancreatology"},{"key":"10.1016\/j.pan.2020.04.020_bib20","first-page":"303e6","article-title":"Diffuse primary fat replacement of the pancreas: an unusual cause of steatorrhea","volume":"31","author":"Aubert","year":"2007","journal-title":"Gastroenterol Clin Biol"},{"key":"10.1016\/j.pan.2020.04.020_bib21","doi-asserted-by":"crossref","first-page":"580e2","DOI":"10.1097\/00006676-198810000-00012","article-title":"Lipomatosis of the pancreas: an unusual cause of massive steatorrhea","volume":"3","author":"Lozano","year":"1988","journal-title":"Pancreas"},{"key":"10.1016\/j.pan.2020.04.020_bib22","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1002\/hep.20701","article-title":"Nonalcoholic Steatohepatitis Clinical Research Network. Design and validation of a histological scoring system for nonalcoholic fatty liver disease","volume":"41","author":"Kleiner","year":"2005","journal-title":"Hepatology"},{"issue":"2","key":"10.1016\/j.pan.2020.04.020_bib23","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1002\/hep.27173","article-title":"Utility and appropriateness of the fatty liver inhibition of progression (FLIP) algorithm and steatosis, activity, and fibrosis (SAF) score in the evaluation of biopsies of nonalcoholic fatty liver disease","volume":"60","author":"Bedossa","year":"2014","journal-title":"Hepatology"},{"key":"10.1016\/j.pan.2020.04.020_bib24","first-page":"595649","article-title":"Exocrine pancreatic insufficiency in diabetic patients: prevalence, mechanisms, and treatment","volume":"2015","author":"Piciucchi","year":"2015","journal-title":"Internet J Endocrinol"},{"issue":"6","key":"10.1016\/j.pan.2020.04.020_bib25","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1016\/j.pan.2015.09.014","article-title":"Inverse association of HbA1c with faecal elastase 1 in people without diabetes","volume":"15","author":"Rathmann","year":"2015","journal-title":"Pancreatology"},{"key":"10.1016\/j.pan.2020.04.020_bib26","doi-asserted-by":"crossref","first-page":"169e77","DOI":"10.1038\/nrgastro.2011.4","article-title":"The clinical significance of pancreatic steatosis","volume":"8","author":"Smits","year":"2011","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1016\/j.pan.2020.04.020_bib27","series-title":"Beobachtung uber die Absonderung des Pankreas","first-page":"448","volume":"2","author":"Kuhne","year":"1882"},{"key":"10.1016\/j.pan.2020.04.020_bib28","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1679\/aohc.55.381","article-title":"The blood vascular bed of the human pancreas, with special reference to the insulo-acinar portal system. Scanning electron microscopy of corrosion casts","volume":"55","author":"Murakami","year":"1992","journal-title":"Arch Histol Cytol"},{"key":"10.1016\/j.pan.2020.04.020_bib29","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1002\/(SICI)1097-0029(19970601)37:5\/6<478::AID-JEMT10>3.0.CO;2-N","article-title":"Pancreatic insulo-acinar portal systems in humans, rats, and some other mammals: scanning electron microscopy of vascular casts","volume":"37","author":"Murakami","year":"1997","journal-title":"Microsc Res Tech"},{"key":"10.1016\/j.pan.2020.04.020_bib30","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1007\/BF00262221","article-title":"The pancreas in recent-onset type 1 (insulin-dependent) diabetes mellitus: insulin content of islets, insulitis and associated changes in the exocrine acinar tissue","volume":"26","author":"Foulis","year":"1984","journal-title":"Diabetologia"},{"issue":"8","key":"10.1016\/j.pan.2020.04.020_bib31","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1097\/MPA.0b013e3181f6fce2","article-title":"Nonalcoholic fatty liver disease is related to nonalcoholic fatty pancreas disease","volume":"39","author":"van Geenen","year":"2010","journal-title":"Pancreas"},{"key":"10.1016\/j.pan.2020.04.020_bib32","doi-asserted-by":"crossref","first-page":"498296","DOI":"10.1155\/2013\/498296","article-title":"Insulin resistance increases MRI-estimated pancreatic fat in nonalcoholic fatty liver disease and normal controls","volume":"2013","author":"Patel","year":"2013","journal-title":"Gastroenterol Res Pract"}],"container-title":["Pancreatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1424390320301502?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1424390320301502?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T16:09:37Z","timestamp":1761408577000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1424390320301502"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7]]},"references-count":32,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2020,7]]}},"alternative-id":["S1424390320301502"],"URL":"https:\/\/doi.org\/10.1016\/j.pan.2020.04.020","relation":{},"ISSN":["1424-3903"],"issn-type":[{"value":"1424-3903","type":"print"}],"subject":[],"published":{"date-parts":[[2020,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Liver and pancreas: \u2018Castor and Pollux\u2019 regarding the relationship between hepatic steatosis and pancreas exocrine insufficiency","name":"articletitle","label":"Article Title"},{"value":"Pancreatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pan.2020.04.020","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 IAP and EPC. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}