{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T02:12:57Z","timestamp":1778724777469,"version":"3.51.4"},"reference-count":22,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,4,6]],"date-time":"2021-04-06T00:00:00Z","timestamp":1617667200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pancreatology"],"published-print":{"date-parts":[[2021,8]]},"DOI":"10.1016\/j.pan.2021.03.015","type":"journal-article","created":{"date-parts":[[2021,3,28]],"date-time":"2021-03-28T01:26:58Z","timestamp":1616894818000},"page":"938-941","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["Examination of ATM, BRCA1, and BRCA2 promoter methylation in patients with pancreatic cancer"],"prefix":"10.1016","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0485-4030","authenticated-orcid":false,"given":"Cancan","family":"Zhou","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nancy","family":"Porter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Borges","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Gauthier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9444-2130","authenticated-orcid":false,"given":"Lindsey","family":"Ferguson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neha","family":"Nanda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9149-2247","authenticated-orcid":false,"given":"Jin","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6646-0200","authenticated-orcid":false,"given":"Daniel","family":"Laheru","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ralph H.","family":"Hruban","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4286-2296","authenticated-orcid":false,"given":"Michael","family":"Goggins","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alison P.","family":"Klein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8709-0664","authenticated-orcid":false,"given":"Nicholas J.","family":"Roberts","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.pan.2021.03.015_bib1","first-page":"135","article-title":"The american cancer society\u2019s facts & figures: 2020 edition","volume":"11","author":"Viale","year":"2020","journal-title":"J\u00a0Adv Pract Oncol"},{"key":"10.1016\/j.pan.2021.03.015_bib2","doi-asserted-by":"crossref","first-page":"58","DOI":"10.21037\/cco.2017.12.04","article-title":"Inherited pancreatic cancer","volume":"6","author":"Chen","year":"2017","journal-title":"Chin Clin Oncol"},{"key":"10.1016\/j.pan.2021.03.015_bib3","doi-asserted-by":"crossref","first-page":"2544","DOI":"10.1038\/s41379-020-0629-6","article-title":"The genetics of ductal adenocarcinoma of the pancreas in the year 2020: dramatic progress, but far to go","volume":"33","author":"Thompson","year":"2020","journal-title":"Mod Pathol"},{"key":"10.1016\/j.pan.2021.03.015_bib4","first-page":"7","article-title":"Cancer statistics, 2020","volume":"70","author":"Siegel","year":"2020","journal-title":"CA A Cancer J Clin"},{"key":"10.1016\/j.pan.2021.03.015_bib5","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1200\/JOP.18.00629","article-title":"Evaluating susceptibility to pancreatic cancer: asco clinical practice provisional clinical opinion summary","volume":"15","author":"Stoffel","year":"2019","journal-title":"J\u00a0Oncol Pract"},{"key":"10.1016\/j.pan.2021.03.015_bib6","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1056\/NEJMoa1903387","article-title":"Maintenance olaparib for germline brca-mutated metastatic pancreatic cancer","volume":"381","author":"Golan","year":"2019","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.pan.2021.03.015_bib7","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1126\/science.aan6733","article-title":"Mismatch repair deficiency predicts response of solid tumors to pd-1 blockade","volume":"357","author":"Le","year":"2017","journal-title":"Science"},{"key":"10.1016\/j.pan.2021.03.015_bib8","doi-asserted-by":"crossref","first-page":"3382","DOI":"10.1200\/JCO.2017.72.3502","article-title":"Deleterious germline mutations in patients with apparently sporadic pancreatic adenocarcinoma","volume":"35","author":"Shindo","year":"2017","journal-title":"J\u00a0Clin Oncol"},{"key":"10.1016\/j.pan.2021.03.015_bib9","doi-asserted-by":"crossref","first-page":"2401","DOI":"10.1001\/jama.2018.6228","article-title":"Association between inherited germline mutations in cancer predisposition genes and risk of pancreatic cancer","volume":"319","author":"Hu","year":"2018","journal-title":"J\u00a0Am Med Assoc"},{"key":"10.1016\/j.pan.2021.03.015_bib10","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1158\/2159-8290.CD-15-0402","article-title":"Whole genome sequencing defines the genetic heterogeneity of familial pancreatic cancer","volume":"6","author":"Roberts","year":"2016","journal-title":"Canc Discov"},{"key":"10.1016\/j.pan.2021.03.015_bib11","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1158\/1055-9965.EPI-18-1235","article-title":"Analysis of heritability and genetic architecture of pancreatic cancer: a panc4 study","volume":"28","author":"Chen","year":"2019","journal-title":"Cancer Epidemiol Biomark Prev"},{"key":"10.1016\/j.pan.2021.03.015_bib12","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1056\/NEJM200007133430201","article-title":"Environmental and heritable factors in the causation of cancer--analyses of cohorts of twins from Sweden, Denmark, and Finland","volume":"343","author":"Lichtenstein","year":"2000","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.pan.2021.03.015_bib13","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1007\/s10549-014-3209-y","article-title":"Epigenome-wide methylation in DNA from peripheral blood as a marker of risk for breast cancer","volume":"148","author":"Severi","year":"2014","journal-title":"Breast Canc Res Treat"},{"key":"10.1016\/j.pan.2021.03.015_bib14","doi-asserted-by":"crossref","first-page":"2304","DOI":"10.1158\/0008-5472.CAN-11-3157","article-title":"Intragenic atm methylation in peripheral blood DNA as a biomarker of breast cancer risk","volume":"72","author":"Brennan","year":"2012","journal-title":"Canc Res"},{"key":"10.1016\/j.pan.2021.03.015_bib15","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1093\/hmg\/ddp033","article-title":"Gene-body hypermethylation of atm in peripheral blood DNA of bilateral breast cancer patients","volume":"18","author":"Flanagan","year":"2009","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.pan.2021.03.015_bib16","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/s10549-010-1188-1","article-title":"Brca1 promoter methylation in peripheral blood cells is associated with increased risk of breast cancer with brca1 promoter methylation","volume":"129","author":"Iwamoto","year":"2011","journal-title":"Breast Canc Res Treat"},{"key":"10.1016\/j.pan.2021.03.015_bib17","doi-asserted-by":"crossref","first-page":"17869","DOI":"10.1038\/srep17869","article-title":"Association of brca1 promoter methylation with sporadic breast cancers: evidence from 40 studies","volume":"5","author":"Zhang","year":"2015","journal-title":"Sci Rep"},{"key":"10.1016\/j.pan.2021.03.015_bib18","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1158\/1940-6207.CAPR-10-0212","article-title":"Constitutional methylation of the brca1 promoter is specifically associated with brca1 mutation-associated pathology in early-onset breast cancer","volume":"4","author":"Wong","year":"2011","journal-title":"Canc Prev Res"},{"key":"10.1016\/j.pan.2021.03.015_bib19","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.ajhg.2018.07.002","article-title":"A\u00a0dominantly inherited 5\u2019 utr variant causing methylation-associated silencing of brca1 as a cause of breast and ovarian cancer","volume":"103","author":"Evans","year":"2018","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.pan.2021.03.015_bib20","first-page":"4151","article-title":"Epigenetic factors controlling the brca1 and brca2 genes in sporadic ovarian cancer","volume":"62","author":"Chan","year":"2002","journal-title":"Canc Res"},{"key":"10.1016\/j.pan.2021.03.015_bib21","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1093\/jnci\/92.7.564","article-title":"Promoter hypermethylation and brca1 inactivation in sporadic breast and ovarian tumors","volume":"92","author":"Esteller","year":"2000","journal-title":"J\u00a0Natl Cancer Inst"},{"key":"10.1016\/j.pan.2021.03.015_bib22","doi-asserted-by":"crossref","first-page":"R20","DOI":"10.1186\/bcr1657","article-title":"Gene promoter hypermethylation in ductal lavage fluid from healthy brca gene mutation carriers and mutation-negative controls","volume":"9","author":"Locke","year":"2007","journal-title":"Breast Cancer Res"}],"container-title":["Pancreatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1424390321001095?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1424390321001095?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T16:13:27Z","timestamp":1761408807000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1424390321001095"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8]]},"references-count":22,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,8]]}},"alternative-id":["S1424390321001095"],"URL":"https:\/\/doi.org\/10.1016\/j.pan.2021.03.015","relation":{},"ISSN":["1424-3903"],"issn-type":[{"value":"1424-3903","type":"print"}],"subject":[],"published":{"date-parts":[[2021,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Examination of ATM, BRCA1, and BRCA2 promoter methylation in patients with pancreatic cancer","name":"articletitle","label":"Article Title"},{"value":"Pancreatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pan.2021.03.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Authors. Published by Elsevier B.V. on behalf of IAP and EPC.","name":"copyright","label":"Copyright"}]}}