{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T10:44:57Z","timestamp":1768819497987,"version":"3.49.0"},"reference-count":35,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,11,6]],"date-time":"2021-11-06T00:00:00Z","timestamp":1636156800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP18K08677"],"award-info":[{"award-number":["JP18K08677"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014487","name":"Clovis Oncology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014487","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pancreatology"],"published-print":{"date-parts":[[2022,1]]},"DOI":"10.1016\/j.pan.2021.10.005","type":"journal-article","created":{"date-parts":[[2021,10,28]],"date-time":"2021-10-28T11:17:34Z","timestamp":1635419854000},"page":"123-129","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["Preoperative risk stratification of lymph node metastasis for non-functional pancreatic neuroendocrine neoplasm: An international dual-institutional study"],"prefix":"10.1016","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2815-6309","authenticated-orcid":false,"given":"Yosuke","family":"Kasai","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4001-4824","authenticated-orcid":false,"given":"Toshihiko","family":"Masui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric K.","family":"Nakakura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenzo","family":"Nakano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asahi","family":"Sato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5347-4686","authenticated-orcid":false,"given":"Yuichiro","family":"Uchida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akitada","family":"Yogo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuyuki","family":"Nagai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takayuki","family":"Anazawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2228-5823","authenticated-orcid":false,"given":"Thomas A.","family":"Hope","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grace E.","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia","family":"Whitman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0854-3766","authenticated-orcid":false,"given":"Bryan K.","family":"Le","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1536-9049","authenticated-orcid":false,"given":"Kyoichi","family":"Takaori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7754-6552","authenticated-orcid":false,"given":"Emily K.","family":"Bergsland","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3407-1918","authenticated-orcid":false,"given":"Etsuro","family":"Hatano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinji","family":"Uemoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"10","key":"10.1016\/j.pan.2021.10.005_bib1","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1001\/jamaoncol.2017.0589","article-title":"Trends in the incidence, prevalence, and survival outcomes in patients with neuroendocrine tumors in the United States","volume":"3","author":"Dasari","year":"2017","journal-title":"JAMA Oncol"},{"issue":"18","key":"10.1016\/j.pan.2021.10.005_bib2","doi-asserted-by":"crossref","first-page":"3063","DOI":"10.1200\/JCO.2007.15.4377","article-title":"One hundred years after \"carcinoid\": epidemiology of and prognostic factors for neuroendocrine tumors in 35,825 cases in the United States","volume":"26","author":"Yao","year":"2008","journal-title":"J\u00a0Clin Oncol"},{"issue":"1","key":"10.1016\/j.pan.2021.10.005_bib3","first-page":"7","article-title":"Cancer statistics","volume":"69","author":"Siegel","year":"2019","journal-title":"Ca - Cancer J Clin"},{"issue":"1","key":"10.1016\/j.pan.2021.10.005_bib4","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1007\/s00535-014-0934-2","article-title":"Epidemiological trends of pancreatic and gastrointestinal neuroendocrine tumors in Japan: a nationwide survey analysis","volume":"50","author":"Ito","year":"2015","journal-title":"J\u00a0Gastroenterol"},{"key":"10.1016\/j.pan.2021.10.005_bib5","article-title":"Multi-institutional development and external validation of a nomogram to predict recurrence after curative resection of pancreatic neuroendocrine tumors","author":"Pulvirenti","year":"2019","journal-title":"Ann Surg"},{"issue":"2","key":"10.1016\/j.pan.2021.10.005_bib6","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1159\/000443171","article-title":"ENETS consensus guidelines update for the management of patients with functional pancreatic neuroendocrine tumors and non-functional pancreatic neuroendocrine tumors","volume":"103","author":"Falconi","year":"2016","journal-title":"Neuroendocrinology"},{"issue":"1","key":"10.1016\/j.pan.2021.10.005_bib7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/MPA.0000000000001454","article-title":"the North American neuroendocrine tumor society consensus paper on the surgical management of pancreatic neuroendocrine tumors","volume":"49","author":"Howe","year":"2020","journal-title":"Pancreas"},{"issue":"7","key":"10.1016\/j.pan.2021.10.005_bib8","doi-asserted-by":"crossref","first-page":"2295","DOI":"10.1245\/s10434-012-2305-7","article-title":"Pancreatic neuroendocrine tumors: radiographic calcifications correlate with grade and metastasis","volume":"19","author":"Poultsides","year":"2012","journal-title":"Ann Surg Oncol"},{"issue":"10","key":"10.1016\/j.pan.2021.10.005_bib9","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1001\/jamasurg.2013.3376","article-title":"Pattern and clinical predictors of lymph node involvement in nonfunctioning pancreatic neuroendocrine tumors (NF-PanNETs)","volume":"148","author":"Partelli","year":"2013","journal-title":"JAMA Surg"},{"issue":"9","key":"10.1016\/j.pan.2021.10.005_bib10","doi-asserted-by":"crossref","first-page":"2882","DOI":"10.1245\/s10434-014-3701-y","article-title":"Basing treatment strategy for non-functional pancreatic neuroendocrine tumors on tumor size","volume":"21","author":"Kishi","year":"2014","journal-title":"Ann Surg Oncol"},{"issue":"4","key":"10.1016\/j.pan.2021.10.005_bib11","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1002\/jso.24338","article-title":"Pancreatic neuroendocrine tumors: preoperative factors that predict lymph node metastases to guide operative strategy","volume":"114","author":"Postlewait","year":"2016","journal-title":"J\u00a0Surg Oncol"},{"issue":"3","key":"10.1016\/j.pan.2021.10.005_bib12","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1016\/j.surg.2016.04.005","article-title":"Neuroendocrine tumors of the pancreas: degree of cystic component predicts prognosis","volume":"160","author":"Cloyd","year":"2016","journal-title":"Surgery"},{"issue":"4","key":"10.1016\/j.pan.2021.10.005_bib13","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1245\/s10434-016-5663-8","article-title":"Pancreatic duct involvement in well-differentiated neuroendocrine tumors is an independent poor prognostic factor","volume":"24","author":"Nanno","year":"2017","journal-title":"Ann Surg Oncol"},{"issue":"1","key":"10.1016\/j.pan.2021.10.005_bib14","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.surg.2019.03.008","article-title":"The conundrum of < 2-cm pancreatic neuroendocrine tumors: a preoperative risk score to predict lymph node metastases and guide surgical management","volume":"166","author":"Lopez-Aguiar","year":"2019","journal-title":"Surgery"},{"issue":"7","key":"10.1016\/j.pan.2021.10.005_bib15","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1002\/jso.25716","article-title":"Impact of tumor size and nodal status on recurrence of nonfunctional pancreatic neuroendocrine tumors \u22642cmafter curative resection :A multi -institutionalstudy of 392 cases","volume":"120","author":"Dong","year":"2019","journal-title":"J\u00a0Surg Oncol"},{"issue":"7","key":"10.1016\/j.pan.2021.10.005_bib16","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1007\/s00595-019-01779-9","article-title":"Predictive value of the Ki67 index for lymph node metastasis of small non-functioning pancreatic neuroendocrine neoplasms","volume":"49","author":"Masui","year":"2019","journal-title":"Surg Today"},{"issue":"2","key":"10.1016\/j.pan.2021.10.005_bib17","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1159\/000477213","article-title":"Accuracy of pancreatic neuroendocrine tumour grading by endoscopic ultrasound-guided fine needle aspiration: analysis of a large cohort and perspectives for improvement","volume":"106","author":"Boutsen","year":"2018","journal-title":"Neuroendocrinology"},{"issue":"1","key":"10.1016\/j.pan.2021.10.005_bib18","first-page":"32","article-title":"Evaluation of Ki-67 index in EUS-FNA specimens for the assessment of malignancy risk in pancreatic neuroendocrine tumors","volume":"46","author":"Hasegawa","year":"2014","journal-title":"Endoscopy"},{"issue":"1","key":"10.1016\/j.pan.2021.10.005_bib19","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1186\/s12902-019-0454-4","article-title":"Clinical significance of the preoperative main pancreatic duct dilation and neutrophil-to-lymphocyte ratio in pancreatic neuroendocrine tumors (PNETs) of the head after curative resection","volume":"19","author":"Zhou","year":"2019","journal-title":"BMC Endocr Disord"},{"issue":"2","key":"10.1016\/j.pan.2021.10.005_bib20","doi-asserted-by":"crossref","first-page":"475","DOI":"10.2214\/ajr.180.2.1800475","article-title":"CT and pathologic assessment of prospective nodal staging in patients with ductal adenocarcinoma of the head of the pancreas","volume":"180","author":"Roche","year":"2003","journal-title":"AJR Am J Roentgenol"},{"issue":"3","key":"10.1016\/j.pan.2021.10.005_bib21","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1198\/106186006X133933","article-title":"Unbiased recursive partitioning: a conditional inference framework","volume":"15","author":"Hothorn","year":"2006","journal-title":"J\u00a0Comput Graph Stat"},{"issue":"2","key":"10.1016\/j.pan.2021.10.005_bib22","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1097\/SLA.0b013e31828f3174","article-title":"A\u00a0single institution's 26-year experience with nonfunctional pancreatic neuroendocrine tumors: a validation of current staging systems and a new prognostic nomogram","volume":"259","author":"Ellison","year":"2014","journal-title":"Ann Surg"},{"issue":"2","key":"10.1016\/j.pan.2021.10.005_bib23","doi-asserted-by":"crossref","first-page":"e276","DOI":"10.1634\/theoncologist.2019-0466","article-title":"Surgery versus surveillance for well-differentiated, nonfunctional pancreatic neuroendocrine tumors: an 11-year analysis of the national cancer Database","volume":"25","author":"Assi","year":"2020","journal-title":"Oncol"},{"issue":"2","key":"10.1016\/j.pan.2021.10.005_bib24","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1097\/SLA.0000000000000348","article-title":"Regional lymphadenectomy is indicated in the surgical treatment of pancreatic neuroendocrine tumors (PNETs)","volume":"259","author":"Hashim","year":"2014","journal-title":"Ann Surg"},{"issue":"1","key":"10.1016\/j.pan.2021.10.005_bib25","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.surg.2014.03.026","article-title":"A\u00a0systematic review and meta-analysis of the clinicopathologic characteristics of cystic versus solid pancreatic neuroendocrine neoplasms","volume":"156","author":"Koh","year":"2014","journal-title":"Surgery"},{"issue":"11","key":"10.1016\/j.pan.2021.10.005_bib26","doi-asserted-by":"crossref","first-page":"1666","DOI":"10.1097\/PAS.0b013e31826a0048","article-title":"Cystic pancreatic neuroendocrine tumors: a clinicopathologic study","volume":"36","author":"Singhi","year":"2012","journal-title":"Am J Surg Pathol"},{"issue":"6","key":"10.1016\/j.pan.2021.10.005_bib27","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1200\/JCO.2015.64.0987","article-title":"Prospective study of 68Ga-dotatate positron emission tomography\/computed tomography for detecting gastro-entero-pancreatic neuroendocrine tumors and unknown primary sites","volume":"34","author":"Sadowski","year":"2016","journal-title":"J\u00a0Clin Oncol"},{"issue":"1","key":"10.1016\/j.pan.2021.10.005_bib28","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.surg.2015.05.040","article-title":"Liver-directed surgery of neuroendocrine metastases: what is the optimal strategy?","volume":"159","author":"Maxwell","year":"2016","journal-title":"Surgery"},{"issue":"1","key":"10.1016\/j.pan.2021.10.005_bib29","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.surg.2017.05.030","article-title":"Expanded criteria for debulking of liver metastasis also apply to pancreatic neuroendocrine tumors","volume":"163","author":"Morgan","year":"2018","journal-title":"Surgery"},{"issue":"2","key":"10.1016\/j.pan.2021.10.005_bib30","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1002\/jso.25811","article-title":"Residual tumor volume discriminates prognosis after surgery for neuroendocrine liver metastasis","volume":"121","author":"Kasai","year":"2020","journal-title":"J\u00a0Surg Oncol"},{"issue":"4","key":"10.1016\/j.pan.2021.10.005_bib31","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1080\/00365521.2020.1743352","article-title":"Risk factors for short recurrence-free survival after resection of pancreatic neuroendocrine tumor (PanNET) liver metastases: which patients should undergo resection?","volume":"55","author":"Masui","year":"2020","journal-title":"Scand J Gastroenterol"},{"issue":"3","key":"10.1016\/j.pan.2021.10.005_bib32","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1097\/SLA.0b013e31815b9cae","article-title":"Prognostic score predicting survival after resection of pancreatic neuroendocrine tumors: analysis of 3851 patients","volume":"247","author":"Bilimoria","year":"2008","journal-title":"Ann Surg"},{"issue":"12","key":"10.1016\/j.pan.2021.10.005_bib33","doi-asserted-by":"crossref","first-page":"1966","DOI":"10.1007\/s11605-016-3243-7","article-title":"Prognostic value of lymph node status and extent of lymphadenectomy in pancreatic neuroendocrine tumors confined to and extending beyond the pancreas","volume":"20","author":"Conrad","year":"2016","journal-title":"J\u00a0Gastrointest Surg"},{"issue":"51","key":"10.1016\/j.pan.2021.10.005_bib34","doi-asserted-by":"crossref","first-page":"89245","DOI":"10.18632\/oncotarget.19184","article-title":"Lymph node ratio, but not the total number of examined lymph nodes or lymph node metastasis, is a predictor of overall survival for pancreatic neuroendocrine neoplasms after surgical resection","volume":"8","author":"Liu","year":"2017","journal-title":"Oncotarget"},{"issue":"1","key":"10.1016\/j.pan.2021.10.005_bib35","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.surg.2019.04.061","article-title":"Operative resection in early stage pancreatic neuroendocrine tumors in the United States: are we over- or undertreating patients?","volume":"167","author":"Chivukula","year":"2020","journal-title":"Surgery"}],"container-title":["Pancreatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1424390321006086?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1424390321006086?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T16:14:47Z","timestamp":1761408887000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1424390321006086"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":35,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["S1424390321006086"],"URL":"https:\/\/doi.org\/10.1016\/j.pan.2021.10.005","relation":{},"ISSN":["1424-3903"],"issn-type":[{"value":"1424-3903","type":"print"}],"subject":[],"published":{"date-parts":[[2022,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Preoperative risk stratification of lymph node metastasis for non-functional pancreatic neuroendocrine neoplasm: An international dual-institutional study","name":"articletitle","label":"Article Title"},{"value":"Pancreatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pan.2021.10.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Authors. Published by Elsevier B.V. on behalf of IAP and EPC.","name":"copyright","label":"Copyright"}]}}